| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mariella Adriana Terán, Elena Martínez, Ana L Reyes, Andrea Paolino, Marcelo Vital, Patricia Esperón, Jose P Pacheco, Eduardo Savi. Biological studies in animal models using [99mTc](CO)3 recombinant annexin V as diagnostic agent of apoptotic processes. Nuclear medicine and biology. vol 38. issue 2. 2011-05-25. PMID:21315284. |
there are many diseases associated with variations in the expression of apoptosis such as organ rejection after transplantation, myocardial ischemia or infarct and neurodegenerative diseases. |
2011-05-25 |
2023-08-12 |
Not clear |
| Masako Okamoto, Nae Saito, Hirotatsu Kojima, Takayoshi Okabe, Kohsuke Takeda, Hidenori Ichijo, Toshio Furuya, Tetsuo Nagan. Identification of novel ASK1 inhibitors using virtual screening. Bioorganic & medicinal chemistry. vol 19. issue 1. 2011-05-05. PMID:21134755. |
apoptosis signal-regulating kinase 1 (ask1, also called map3k5) is a mitogen-activated protein kinase kinase kinase (map3k) that plays important roles in stress-induced cell death and inflammation, and is expected as a new therapeutic target for cancer, cardiovascular diseases, and neurodegenerative diseases. |
2011-05-05 |
2023-08-12 |
Not clear |
| Ira Tabas, David Ro. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nature cell biology. vol 13. issue 3. 2011-04-27. PMID:21364565. |
in settings of chronic er stress, the associated apoptosis may contribute to pathophysiological processes involved in a number of prevalent diseases, including neurodegenerative diseases, diabetes, atherosclerosis and renal disease. |
2011-04-27 |
2023-08-12 |
Not clear |
| A Abdi, H Sadraie, L Dargahi, L Khalaj, A Ahmadian. Apoptosis inhibition can be threatening in Aβ-induced neuroinflammation, through promoting cell proliferation. Neurochemical research. vol 36. issue 1. 2011-04-18. PMID:20848191. |
neuronal apoptosis in neurodegenerative diseases is correlated with inflammatory reactions. |
2011-04-18 |
2023-08-12 |
rat |
| X-S Cheng, M-S Li, J Du, Q-Y Jiang, L Wang, S-Y Yan, D-M Yu, J-B Den. Neuronal apoptosis in the developing cerebellum. Anatomia, histologia, embryologia. vol 40. issue 1. 2011-04-14. PMID:21231956. |
the results of this study suggest that the key period of neuronal apoptosis in the cerebellar cortex is between p0 and p14, indicating that this developmental period could be susceptible to treatment for congenital neurodegenerative diseases. |
2011-04-14 |
2023-08-12 |
mouse |
| Mireia Niso-Santano, José M Bravo-San Pedro, Rubén Gómez-Sánchez, Vicente Climent, Germán Soler, José M Fuentes, Rosa A González-Pol. ASK1 overexpression accelerates paraquat-induced autophagy via endoplasmic reticulum stress. Toxicological sciences : an official journal of the Society of Toxicology. vol 119. issue 1. 2011-03-25. PMID:20929985. |
er stress-induced ask1 activation could play an important role both in neuronal apoptosis and an autophagic response in the pathogenesis of several neurodegenerative diseases, including parkinson's disease. |
2011-03-25 |
2023-08-12 |
Not clear |
| In Su Kim, Sushruta Koppula, Byung Wook Kim, Min Dong Song, Ju Yeon Jung, Gwang Lee, Hee Soon Lee, Dong-Kug Cho. A novel synthetic compound PHID (8-Phenyl-6a, 7, 8, 9, 9a, 10-hexahydro-6H-isoindolo [5, 6-g] quinoxaline-7, 9-dione) protects SH-SY5Y cells against MPP(+)-induced cytotoxicity through inhibition of reactive oxygen species generation and JNK signaling. European journal of pharmacology. vol 650. issue 1. 2011-03-24. PMID:20946892. |
the results indicate that phid protects against mpp(+)-induced apoptosis by blocking reactive oxygen species stimulation and jnk signaling pathways in sh-sy5y cells, implicating the novel compound in the prevention of progressive neurodegenerative diseases such as parkinson's disease. |
2011-03-24 |
2023-08-12 |
Not clear |
| E Esposito, S Cuzzocre. New therapeutic strategy for Parkinson's and Alzheimer's disease. Current medicinal chemistry. vol 17. issue 25. 2011-03-07. PMID:20586718. |
many potential pathways of neuronal cell death have been implicated in a mouse model of neurodegenerative disease, including excitotoxicity, toxicity from reactive oxygen species (superoxide anion, nitric oxide, hydroxyl radical), apoptosis (caspase-dependent and -independent pathways), necrosis and glial injury. |
2011-03-07 |
2023-08-12 |
mouse |
| Miranda Mladinic, Christophe Lefèvre, Elaine Del Bel, John Nicholls, Matthew Digb. Developmental changes of gene expression after spinal cord injury in neonatal opossums. Brain research. vol 1363. 2011-02-24. PMID:20849836. |
by contrast, at 13 days, up-regulation occurred of inhibitory molecules, including annexins, ephrins, and genes related to apoptosis and neurodegenerative diseases. |
2011-02-24 |
2023-08-12 |
Not clear |
| Sara Baratchi, Rupinder K Kanwar, Jagat R Kanwa. Survivin: a target from brain cancer to neurodegenerative disease. Critical reviews in biochemistry and molecular biology. vol 45. issue 6. 2011-02-24. PMID:20925597. |
due to the various roles of survivin during cell division and apoptosis, targeting this protein illustrates a new therapeutic window for the treatment of neurodegenerative diseases. |
2011-02-24 |
2023-08-12 |
Not clear |
| E A Tendi, R Cunsolo, D Bellia, R L Messina, S Paratore, P Calissano, S Cavallar. Drug target identification for neuronal apoptosis through a genome scale screening. Current medicinal chemistry. vol 17. issue 26. 2011-01-28. PMID:20858172. |
however, neuronal apoptosis subsequent to this developmental window is physiologically inappropriate for most systems and can contribute to neurodegenerative diseases. |
2011-01-28 |
2023-08-12 |
Not clear |
| Daniela Schifilliti, Giovanni Grasso, Alfredo Conti, Vincenzo Fodal. Anaesthetic-related neuroprotection: intravenous or inhalational agents? CNS drugs. vol 24. issue 11. 2011-01-26. PMID:20932063. |
taken as a whole, the available data appear to indicate that anaesthetic drugs such as barbiturates, propofol, xenon and most volatile anaesthetics (halothane, isoflurane, desflurane, sevoflurane) show neuroprotective effects that protect cerebral tissue from adverse events--such as apoptosis, degeneration, inflammation and energy failure--caused by chronic neurodegenerative diseases, ischaemia, stroke or nervous system trauma. |
2011-01-26 |
2023-08-12 |
Not clear |
| Mikhail A Kutuzov, Nelly Bennett, Alexandra V Andreev. Protein phosphatase with EF-hand domains 2 (PPEF2) is a potent negative regulator of apoptosis signal regulating kinase-1 (ASK1). The international journal of biochemistry & cell biology. vol 42. issue 11. 2011-01-18. PMID:20674765. |
apoptosis signal regulating kinase-1 (ask1) is a map kinase kinase kinase implicated in cancer, cardiovascular and neurodegenerative diseases. |
2011-01-18 |
2023-08-12 |
human |
| Shan Lu, Chunhua Lu, Qin Han, Jing Li, Zhijian Du, Lianming Liao, Robert Chunhua Zha. Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation. Toxicology. vol 279. issue 1-3. 2011-01-14. PMID:21040751. |
glutamate excitotoxicity has been implicated as one of the factors contributing to neuronal apoptosis and is involved in many neurodegenerative diseases. |
2011-01-14 |
2023-08-12 |
Not clear |
| Shan Lu, Chunhua Lu, Qin Han, Jing Li, Zhijian Du, Lianming Liao, Robert Chunhua Zha. Adipose-derived mesenchymal stem cells protect PC12 cells from glutamate excitotoxicity-induced apoptosis by upregulation of XIAP through PI3-K/Akt activation. Toxicology. vol 279. issue 1-3. 2011-01-14. PMID:21040751. |
these results suggest that amscs can effectively protect pc12 cells from glutamate excitotoxicity-induced apoptosis and support the hypothesis that amscs may be a useful treatment for stroke or neurodegenerative diseases which often involve excitotoxicity. |
2011-01-14 |
2023-08-12 |
Not clear |
| Nurit Keinan, Dalia Tyomkin, Varda Shoshan-Barmat. Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis. Molecular and cellular biology. vol 30. issue 24. 2011-01-13. PMID:20937774. |
thus, targeting the oligomeric status of vdac, and hence apoptosis, offers a therapeutic strategy for combating cancers and neurodegenerative diseases. |
2011-01-13 |
2023-08-12 |
Not clear |
| Takahiro Yaguchi, Tetsu Nagata, Tomoyuki Nishizak. 1,2-dilinoleoyl-sn-glycero-3-phosphoethanolamine ameliorates age-related spatial memory deterioration by preventing neuronal cell death. Behavioral and brain functions : BBF. vol 6. 2011-01-11. PMID:20831835. |
endoplasmic reticulum (er) stress-induced neuronal apoptosis, on the other hand, is a critical factor for pathogenesis of neurodegenerative diseases such as alzheimer disease and parkinson disease, senile dementia, and ischemic neuronal damage. |
2011-01-11 |
2023-08-12 |
Not clear |
| Laurent M Dejean, Shin-Young Ryu, Sonia Martinez-Caballero, Oscar Teijido, Pablo M Peixoto, Kathleen W Kinnall. MAC and Bcl-2 family proteins conspire in a deadly plot. Biochimica et biophysica acta. vol 1797. issue 6-7. 2011-01-10. PMID:20083086. |
apoptosis is also involved in many pathologies including cancer, neurodegenerative diseases, aging, and infarcts. |
2011-01-10 |
2023-08-12 |
Not clear |
| Marie-Pierre Hinault, America Farina Henriquez Cuendet, Rayees U H Mattoo, Mounir Mensi, Giovanni Dietler, Hilal A Lashuel, Pierre Goloubinof. Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones. The Journal of biological chemistry. vol 285. issue 49. 2010-12-30. PMID:20847048. |
together, our findings suggest that inhibition of the hsp70/hsp40 chaperone system by α-syn oligomers may contribute to the disruption of protein homeostasis in dopaminergic neurons, leading to apoptosis and tissue loss in parkinson disease and related neurodegenerative diseases. |
2010-12-30 |
2023-08-12 |
human |
| Tjakko J van Ham, James Mapes, David Kokel, Randall T Peterso. Live imaging of apoptotic cells in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 11. 2010-12-21. PMID:20601526. |
many debilitating diseases, including neurodegenerative diseases, involve apoptosis. |
2010-12-21 |
2023-08-12 |
zebrafish |