| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sean P Cregan, Valina L Dawson, Ruth S Slac. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene. vol 23. issue 16. 2004-05-06. PMID:15077142. |
continued study of the mechanisms of apoptosis including caspase-independent death processes are likely to reveal novel therapeutic targets for the treatment of diverse human pathologies including cancer, neurodegenerative diseases and acute injuries such as stroke or myocardial infarction. |
2004-05-06 |
2023-08-12 |
human |
| Ciara A Ryan, Guy S Salvese. Caspases and neuronal development. Biological chemistry. vol 384. issue 6. 2004-05-03. PMID:12887052. |
the basic mechanisms that underlie apoptosis in neurodegenerative diseases are uncertain, although they likely represent the subversion of normal developmental programs. |
2004-05-03 |
2023-08-12 |
Not clear |
| G L Russo, M Russ. Ins and outs of apoptosis in cardiovascular diseases. Nutrition, metabolism, and cardiovascular diseases : NMCD. vol 13. issue 5. 2004-04-05. PMID:14717062. |
apoptosis, also known as programmed cell death (pcd), is genetically programmed "cell suicide" that plays an essential role in physiological processes such as embryo development, synaptogenesis, tissue turnover and the negative selection of t-cells, as well as in many diseases, such as cancer, and autoimmune and neurodegenerative diseases. |
2004-04-05 |
2023-08-12 |
Not clear |
| T R Rosenstock, A C P Carvalho, A Jurkiewicz, R Frussa-Filho, S S Smail. Mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid. Journal of neurochemistry. vol 88. issue 5. 2004-03-30. PMID:15009678. |
mitochondrial calcium, oxidative stress and apoptosis in a neurodegenerative disease model induced by 3-nitropropionic acid. |
2004-03-30 |
2023-08-12 |
Not clear |
| Manuchair Ebadi, Sushil K Sharm. Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson's disease. Antioxidants & redox signaling. vol 5. issue 3. 2004-03-24. PMID:12880486. |
as apoptosis is critical to the progression of neurodegenerative disease, including pd, selegiline or selegiline-like compounds to be discovered in the future may be efficacious in treating pd. |
2004-03-24 |
2023-08-12 |
mouse |
| E A Martynov. [Regulation of caspase activity in apoptosis]. Bioorganicheskaia khimiia. vol 29. issue 5. 2004-03-01. PMID:14601408. |
in particular, the use of extracellular activators and inhibitors of caspases allows irreversible activation of apoptosis in tumor cells or the prevention of neuron death in neurodegenerative diseases. |
2004-03-01 |
2023-08-12 |
Not clear |
| Hyun Song, Young Choong Kim, Aree Moo. Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells. Biological & pharmaceutical bulletin. vol 26. issue 10. 2004-02-17. PMID:14519949. |
neuronal apoptosis may contribute to pathologic neuronal loss in certain disease states such as neurodegenerative diseases. |
2004-02-17 |
2023-08-12 |
rat |
| Jianfeng Li, Wenyan Li, Jialin Su, Weimin Liu, Bella T Altura, Burton M Altur. Hydrogen peroxide induces apoptosis in cerebral vascular smooth muscle cells: possible relation to neurodegenerative diseases and strokes. Brain research bulletin. vol 62. issue 2. 2004-02-06. PMID:14638383. |
hydrogen peroxide induces apoptosis in cerebral vascular smooth muscle cells: possible relation to neurodegenerative diseases and strokes. |
2004-02-06 |
2023-08-12 |
Not clear |
| Jianfeng Li, Wenyan Li, Jialin Su, Weimin Liu, Bella T Altura, Burton M Altur. Hydrogen peroxide induces apoptosis in cerebral vascular smooth muscle cells: possible relation to neurodegenerative diseases and strokes. Brain research bulletin. vol 62. issue 2. 2004-02-06. PMID:14638383. |
apoptosis has been suggested to play an important role in neurodegenerative diseases, traumatic brain injury and strokes. |
2004-02-06 |
2023-08-12 |
Not clear |
| David L Vaux, John Silk. HtrA2/Omi, a sheep in wolf's clothing. Cell. vol 115. issue 3. 2004-01-30. PMID:14636553. |
mammalian mitochondrial htra2/omi was originally described as an apoptosis inducer, but rather than having extra cells, mice with mutant htra2/omi suffer from a neurodegenerative disease due to progressive mitochondrial damage. |
2004-01-30 |
2023-08-12 |
mouse |
| Zoltán Urbányi, Lajos László, Thomas B Tomasi, Erzsébet Tóth, Eva Mekes, Miklós Sass, Tamás Pázmán. Serum amyloid P component induces neuronal apoptosis and beta-amyloid immunoreactivity. Brain research. vol 988. issue 1-2. 2003-12-10. PMID:14519527. |
this study supports the thesis that sap plays an important role in the pathomechanism of neurodegenerative diseases, including alzheimer's disease by inducing neuronal apoptosis. |
2003-12-10 |
2023-08-12 |
rat |
| A Cristina Rego, Catarina R Oliveir. Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases. Neurochemical research. vol 28. issue 10. 2003-11-18. PMID:14570402. |
mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases. |
2003-11-18 |
2023-08-12 |
Not clear |
| Jianfeng Li, Jialin Su, Wenyan Li, Weimin Liu, Bella T Altura, Burton M Altur. Peroxynitrite induces apoptosis in canine cerebral vascular muscle cells: possible relation to neurodegenerative diseases and strokes. Neuroscience letters. vol 350. issue 3. 2003-11-10. PMID:14550922. |
peroxynitrite induces apoptosis in canine cerebral vascular muscle cells: possible relation to neurodegenerative diseases and strokes. |
2003-11-10 |
2023-08-12 |
Not clear |
| Manisha Sonee, Johanna R Martens, Meredith R Evers, Suman K Mukherje. The effect of tertiary butylhydroperoxide and nicotinamide on human cortical neurons. Neurotoxicology. vol 24. issue 3. 2003-09-02. PMID:12782109. |
it is well known that the generation of oxygen radicals can cause neuronal death by both apoptosis and necrosis, which may lead to the onset of neurodegenerative diseases. |
2003-09-02 |
2023-08-12 |
human |
| Lucyna Antkiewicz-Michalu. Endogenous risk factors in Parkinson's disease: dopamine and tetrahydroisoquinolines. Polish journal of pharmacology. vol 54. issue 6. 2003-08-15. PMID:12866710. |
since pd is a slowly progressing neurodegenerative disease, it has been suggested that it could be connected with excitotoxicity and apoptosis. |
2003-08-15 |
2023-08-12 |
monkey |
| M Castedo, J-L Perfettini, T Roumier, G Kroeme. Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell death and differentiation. vol 9. issue 12. 2003-07-30. PMID:12478465. |
an unscheduled cdk1 activation may contribute to neuronal apoptosis occurring in neurodegenerative diseases. |
2003-07-30 |
2023-08-12 |
Not clear |
| M Jiménez del Rio, C Vélez-Pard. [Apoptosis in neurodegenerative diseases: facts and controversies]. Revista de neurologia. vol 32. issue 9. 2003-07-28. PMID:11424038. |
[apoptosis in neurodegenerative diseases: facts and controversies]. |
2003-07-28 |
2023-08-12 |
Not clear |
| Joseph F Sanchez, Lynn F Sniderhan, Andrea L Williamson, Shongshan Fan, Shikha Chakraborty-Sett, Sanjay B Maggirwa. Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling. Molecular and cellular biology. vol 23. issue 13. 2003-07-22. PMID:12808104. |
recent studies have revealed a positive correlation between astrocyte apoptosis and rapid disease progression in persons with neurodegenerative diseases. |
2003-07-22 |
2023-08-12 |
Not clear |
| A Tempestini, N Schiavone, L Papucci, E Witort, A Lapucci, M Cutrì, M Donnini, S Capacciol. The mechanisms of apoptosis in biology and medicine: a new focus for ophthalmology. European journal of ophthalmology. vol 13 Suppl 3. 2003-07-03. PMID:12749672. |
for instance, excesses of apoptosis lead to cell loss that accompanies neurodegenerative diseases, whereas genetically determined defects of apoptosis lead to the deregulated cell proliferation typical of cancer. |
2003-07-03 |
2023-08-12 |
human |
| Jennifer L Mazzola, Michael A Sirove. Subcellular alteration of glyceraldehyde-3-phosphate dehydrogenase in Alzheimer's disease fibroblasts. Journal of neuroscience research. vol 71. issue 2. 2003-06-25. PMID:12503091. |
the regulation of glyceraldehyde-3-phosphate dehydrogenase (gapdh) has been implicated both in age-related neurodegenerative disease and in apoptosis. |
2003-06-25 |
2023-08-12 |
Not clear |