| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark D Berry, Alan A Boulto. Apoptosis and human neurodegenerative diseases. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 2. 2003-05-29. PMID:12657359. |
apoptosis and human neurodegenerative diseases. |
2003-05-29 |
2023-08-12 |
human |
| Peter C Waldmeie. Prospects for antiapoptotic drug therapy of neurodegenerative diseases. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 2. 2003-05-29. PMID:12657369. |
the evidence for a role of apoptosis in the neurodegenerative diseases, alzheimer's disease (ad), parkinson's disease (pd) and amyotrophic lateral sclerosis (als), and in the more acute conditions of cerebral ischemia, traumatic brain injury (tbi), and spinal cord injury (sci) is reviewed with regard to potential intervention by means of small antiapoptotic molecules. |
2003-05-29 |
2023-08-12 |
mouse |
| Myriam Roussigne, Corinne Cayrol, Thomas Clouaire, François Amalric, Jean-Philippe Girar. THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies. Oncogene. vol 22. issue 16. 2003-05-23. PMID:12717420. |
here, we report that thap1 is a novel nuclear proapoptotic factor associated with pml nbs, which potentiates both serum withdrawal- and tnf alpha-induced apoptosis, and interacts with prostate-apoptosis-response-4 (par-4), a well characterized proapoptotic factor, previously linked to prostate cancer and neurodegenerative diseases. |
2003-05-23 |
2023-08-12 |
Not clear |
| Sonia Medina, Marcos Martínez, Angel Hernan. Antioxidants inhibit the human cortical neuron apoptosis induced by hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42. Free radical research. vol 36. issue 11. 2003-04-28. PMID:12592670. |
several substances related to the neurodegenerative diseases of alzheimer and parkinson, such as hydrogen peroxide, tumor necrosis factor alpha, dopamine and beta-amyloid peptide 1-42, have been shown to induce apoptosis in tumoral cell lines and rat neurons but not in human neurons. |
2003-04-28 |
2023-08-12 |
human |
| Jung-Chul Seo, Sang-Won Han, Chang-Sik Yin, Hyung-Kyun Koh, Chang-Hwan Kim, Ee-Hwa Kim, Kang-Hyun Leem, Hyang-Sook Lee, Hi-Joon Park, Soon-Ae Kim, Bong-Keun Choe, Hee-Jae Lee, Sung-Vin Yim, Chang-Ju Kim, Joo-Ho Chun. Evaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients. Experimental & molecular medicine. vol 34. issue 4. 2003-04-11. PMID:12515395. |
apoptosis has been implicated in the pathogenesis of neurodegenerative diseases such as stroke and alzheimer's disease. |
2003-04-11 |
2023-08-12 |
Not clear |
| Jun-Sub Choi, Jeong-A Kim, Choun-Ki Jo. Activation of MAPK and CREB by GM1 induces survival of RGCs in the retina with axotomized nerve. Investigative ophthalmology & visual science. vol 44. issue 4. 2003-04-10. PMID:12657617. |
neuronal cells undergo apoptosis when the supply of neurotrophic factor is limited by injury, trauma, or neurodegenerative disease. |
2003-04-10 |
2023-08-12 |
Not clear |
| Robert M Friedlande. Apoptosis and caspases in neurodegenerative diseases. The New England journal of medicine. vol 348. issue 14. 2003-04-09. PMID:12672865. |
apoptosis and caspases in neurodegenerative diseases. |
2003-04-09 |
2023-08-12 |
Not clear |
| Seiji Kikuchi, Kazuyoshi Shinpo, Sachiko Tsuji, Ichiro Yabe, Masaaki Niino, Kunio Tashir. Brefeldin A-induced neurotoxicity in cultured spinal cord neurons. Journal of neuroscience research. vol 71. issue 4. 2003-04-01. PMID:12548716. |
brefeldin a (bfa) is a fungus metabolite that is known to cause the disassembly of the golgi complex and apoptosis in exposed cells, both of which have been suggested as playing roles in the pathogenesis of neurodegenerative diseases, particularly amyotrophic lateral sclerosis (als). |
2003-04-01 |
2023-08-12 |
rat |
| X Ye, H C Meeker, P Kozlowski, R I Car. Increased c-Fos protein in the brains of scrapie-infected SAMP8, SAMR1, AKR and C57BL mice. Neuropathology and applied neurobiology. vol 28. issue 5. 2003-03-12. PMID:12366817. |
in many neurodegenerative diseases, activation of the p38 pathway and of the immediate-early gene termed c-fos appears to be required for the initiation of apoptosis. |
2003-03-12 |
2023-08-12 |
mouse |
| Nadia El-Guendy, Vivek M Rangneka. Apoptosis by Par-4 in cancer and neurodegenerative diseases. Experimental cell research. vol 283. issue 1. 2003-03-12. PMID:12565819. |
apoptosis by par-4 in cancer and neurodegenerative diseases. |
2003-03-12 |
2023-08-12 |
Not clear |
| Nadia El-Guendy, Vivek M Rangneka. Apoptosis by Par-4 in cancer and neurodegenerative diseases. Experimental cell research. vol 283. issue 1. 2003-03-12. PMID:12565819. |
cells that are resistant to apoptosis by par-4 alone, however, are greatly sensitized by par-4 to the action of other pro-apoptotic insults such as growth factor withdrawal, tumor necrosis factor, ionizing radiation, intracellular calcium elevation, or those involved in neurodegenerative diseases such as alzheimer's, parkinson's, huntington's, and stroke. |
2003-03-12 |
2023-08-12 |
Not clear |
| Nadia El-Guendy, Vivek M Rangneka. Apoptosis by Par-4 in cancer and neurodegenerative diseases. Experimental cell research. vol 283. issue 1. 2003-03-12. PMID:12565819. |
the unique ability of par-4 to induce apoptosis in cancer cells but not normal cells and the ability of par-4 antisense or dominant-negative mutant to abrogate apoptosis in neurodegenerative disease paradigms makes it an appealing candidate for molecular therapy of cancer and neuronal diseases. |
2003-03-12 |
2023-08-12 |
Not clear |
| Manuel B Graeber, Linda B Mora. Mechanisms of cell death in neurodegenerative diseases: fashion, fiction, and facts. Brain pathology (Zurich, Switzerland). vol 12. issue 3. 2003-02-14. PMID:12146806. |
in addition, with the exception of developmental conditions, there is essentially no evidence of apoptosis fulfilling the criteria of its classical definition in any of the important human neurodegenerative diseases, including alzheimer's, parkinson's, huntington's, amyotrophic lateral sclerosis, and creutzfeldt-jakob disease. |
2003-02-14 |
2023-08-12 |
human |
| H Shimizu, M Ohgoh, Y Momose, Y Nishizawa, H Ogur. Massive cell death of cerebellar granule neurons accompanied with caspase-3-like protease activation and subsequent motor discoordination after intracerebroventricular injection of vincristine in mice. Neuroscience. vol 115. issue 1. 2003-02-05. PMID:12401321. |
these vincristine-treated mice should be a useful in vivo model for examination of neuronal apoptosis, which might be involved in a variety of neurodegenerative diseases. |
2003-02-05 |
2023-08-12 |
mouse |
| Catherine M Cowan, A Jane Roskam. Apoptosis in the mature and developing olfactory neuroepithelium. Microscopy research and technique. vol 58. issue 3. 2003-01-29. PMID:12203699. |
neuronal apoptosis is important in the developmental sculpting of a normal nervous system and also in the loss of neurons caused by neurodegenerative disease, ischemia or trauma. |
2003-01-29 |
2023-08-12 |
Not clear |
| R Takahash. [Cell death protection by anti-apoptotic factor]. Rinsho shinkeigaku = Clinical neurology. vol 41. issue 12. 2002-11-08. PMID:12235797. |
regarding the involvement of apoptosis in neurodegenerative diseases, several lines of evidence indicated that caspases are involved in the pathogenesis of als and polyglutamine disease, suggesting the effectiveness of anti-apoptotic therapy for these diseases. |
2002-11-08 |
2023-08-12 |
human |
| Andrew J Danielsen, Nita J Maihl. The EGF/ErbB receptor family and apoptosis. Growth factors (Chur, Switzerland). vol 20. issue 1. 2002-10-28. PMID:11999214. |
the understanding of erbb receptor signaling as it relates to the avoidance of apoptosis had profound implications for the treatment of solid tumors originating in multiple tissues, as well as for the treatment of neurodegenerative disease. |
2002-10-28 |
2023-08-12 |
Not clear |
| Ricardo C Machado, Rodrigo N R Pereira, Mara S A Costa, Ricardo Guelerman P Ramo. "In vivo" toxicity of a truncated version of the Drosophila Rst-IrreC protein is dependent on the presence of a glutamine-rich region in its intracellular domain. Anais da Academia Brasileira de Ciencias. vol 74. issue 2. 2002-10-21. PMID:12098754. |
the results suggest the possibility that the opa-like domain and the carboxyl terminus act in concert to modulate rst-irrec function in apoptosis, and we discuss this implication in the context of the general mechanisms causing glutamine-rich neurodegenerative diseases in humans. |
2002-10-21 |
2023-08-12 |
drosophila_melanogaster |
| Kathleen A Gallo, Gary L Johnso. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nature reviews. Molecular cell biology. vol 3. issue 9. 2002-10-07. PMID:12209126. |
in mammalian cells, mlks are implicated in the control of apoptosis and are potential drug targets for many neurodegenerative diseases. |
2002-10-07 |
2023-08-12 |
caenorhabditis_elegans |
| Shuxian Hu, Wen S Sheng, James R Lokensgard, Phillip K Peterso. Morphine induces apoptosis of human microglia and neurons. Neuropharmacology. vol 42. issue 6. 2002-09-25. PMID:12015209. |
apoptosis plays a critical role in normal brain development and in a number of neurodegenerative diseases. |
2002-09-25 |
2023-08-12 |
human |