| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brinda Ravikumar, Zdenek Berger, Coralie Vacher, Cahir J O'Kane, David C Rubinsztei. Rapamycin pre-treatment protects against apoptosis. Human molecular genetics. vol 15. issue 7. 2006-09-19. PMID:16497721. |
thus, rapamycin (pro-autophagic) treatment may be useful in certain disease conditions (including various neurodegenerative diseases) where a slow but increased rate of apoptosis is evident, even if they are not associated with overt aggregate formation. |
2006-09-19 |
2023-08-12 |
mouse |
| Beata Sikorsk. Mechanisms of neuronal death in transmissible spongiform encephalopathies. Folia neuropathologica. vol 42 Suppl B. 2006-09-19. PMID:16903144. |
however, there is no direct and convincing evidence of apoptosis of nerve cells in most neurodegenerative diseases. |
2006-09-19 |
2023-08-12 |
Not clear |
| Kazuhiro Takum. [Mitochondrial dysfunction and apoptosis in neurodegenerative diseases]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 127. issue 5. 2006-08-18. PMID:16819239. |
[mitochondrial dysfunction and apoptosis in neurodegenerative diseases]. |
2006-08-18 |
2023-08-12 |
Not clear |
| Karin Thevissen, Isabelle E J A François, Joris Winderickx, Christophe Pannecouque, Bruno P A Cammu. Ceramide involvement in apoptosis and apoptotic diseases. Mini reviews in medicinal chemistry. vol 6. issue 6. 2006-08-11. PMID:16787381. |
apoptosis is implicated in a number of diseases, including neurodegenerative diseases and aids. |
2006-08-11 |
2023-08-12 |
Not clear |
| Paul C Chin, Santosh R D'Mell. Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis. Frontiers in bioscience : a journal and virtual library. vol 10. 2006-07-07. PMID:15574392. |
increasing evidence implicates aberrant apoptosis as a fundamental cause of neurodegenerative diseases. |
2006-07-07 |
2023-08-12 |
Not clear |
| Paul C Chin, Santosh R D'Mell. Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis. Frontiers in bioscience : a journal and virtual library. vol 10. 2006-07-07. PMID:15574392. |
this review discusses the major molecules and signaling pathways leading to neuronal survival or apoptosis with emphasis on several small molecule inhibitors that target neuronal survival with the hope of impeding the detrimental effects of neurodegenerative diseases. |
2006-07-07 |
2023-08-12 |
Not clear |
| E D Burg, C V Remillard, J X-J Yua. K+ channels in apoptosis. The Journal of membrane biology. vol 209. issue 1. 2006-07-06. PMID:16685597. |
in neurodegenerative diseases, uncontrolled apoptosis leads to loss of brain tissue. |
2006-07-06 |
2023-08-12 |
Not clear |
| Jue Judy Liu, Wenge Wang, David T Dicker, Wafik S El-Deir. Bioluminescent imaging of TRAIL-induced apoptosis through detection of caspase activation following cleavage of DEVD-aminoluciferin. Cancer biology & therapy. vol 4. issue 8. 2006-07-05. PMID:16177559. |
apoptosis, the most common and well-defined form of programmed cell death (pcd), is often impaired in cancer and neurodegenerative diseases and can limit conventional therapy. |
2006-07-05 |
2023-08-12 |
human |
| Y Zhu, P Hoell, B Ahlemeyer, J Krieglstei. PTEN: a crucial mediator of mitochondria-dependent apoptosis. Apoptosis : an international journal on programmed cell death. vol 11. issue 2. 2006-06-15. PMID:16502258. |
these findings demonstrated that pten is a crucial mediator of mitochondria-dependent apoptosis, and thus could become a molecular target for interfering with neurodegenerative diseases. |
2006-06-15 |
2023-08-12 |
rat |
| R N Saha, K Paha. HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis. Cell death and differentiation. vol 13. issue 4. 2006-06-05. PMID:16167067. |
gradual disclosure of the molecular basis of selective neuronal apoptosis during neurodegenerative diseases reveals active participation of acetylating and deacetylating agents during the process. |
2006-06-05 |
2023-08-12 |
Not clear |
| Claudio A Hetz, Claudio Sot. Stressing out the ER: a role of the unfolded protein response in prion-related disorders. Current molecular medicine. vol 6. issue 1. 2006-05-25. PMID:16472111. |
transmissible spongiform encephalopathies are fatal and infectious neurodegenerative diseases characterized by extensive neuronal apoptosis and the accumulation of an abnormally folded form of the cellular prion protein (prp), denoted prp(sc). |
2006-05-25 |
2023-08-12 |
Not clear |
| Yusuke Sekine, Kohsuke Takeda, Hidenori Ichij. The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases. Current molecular medicine. vol 6. issue 1. 2006-05-25. PMID:16472116. |
several lines of evidence suggest that er stress-induced apoptosis plays critical roles in the pathogenesis of neurodegenerative diseases such as alzheimer's disease, parkinson's disease, polyglutamine (polyq) diseases and amyotrophic lateral sclerosis (als). |
2006-05-25 |
2023-08-12 |
Not clear |
| Yusuke Sekine, Kohsuke Takeda, Hidenori Ichij. The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases. Current molecular medicine. vol 6. issue 1. 2006-05-25. PMID:16472116. |
recent studies have shown that the ask1-mapk cascades are involved in er stress-induced apoptosis and in the neuronal cell death in some model systems of neurodegenerative diseases. |
2006-05-25 |
2023-08-12 |
Not clear |
| YueMei Zhang, Bhagu R Bhavnan. Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release. BMC neuroscience. vol 6. 2006-04-06. PMID:15730564. |
apoptosis plays a key role in cell death observed in neurodegenerative diseases marked by a progressive loss of neurons as seen in alzheimer's disease. |
2006-04-06 |
2023-08-12 |
Not clear |
| Yi Wen, Shaohua Yang, Ran Liu, James W Simpkin. Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein. Brain research. vol 1022. issue 1-2. 2006-03-23. PMID:15353210. |
finally, our results also suggest that neuronal apoptosis may be a therapeutic target in preventing tauopathy-related neurodegenerative diseases. |
2006-03-23 |
2023-08-12 |
human |
| Nathalie Thiriet, Xiaolin Deng, Marcello Solinas, Bruce Ladenheim, Wendy Curtis, Steven R Goldberg, Richard D Palmiter, Jean Lud Cade. Neuropeptide Y protects against methamphetamine-induced neuronal apoptosis in the mouse striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 22. 2006-03-02. PMID:15930374. |
methamphetamine (meth) is an illicit drug that causes neuronal apoptosis in the mouse striatum, in a manner similar to the neuronal loss observed in neurodegenerative diseases. |
2006-03-02 |
2023-08-12 |
mouse |
| Cathy W Levenso. Trace metal regulation of neuronal apoptosis: from genes to behavior. Physiology & behavior. vol 86. issue 3. 2006-02-21. PMID:16125208. |
the genetically programmed form of neuronal death known as apoptosis plays a role in many neurodegenerative diseases including alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis (als) and huntington's disease. |
2006-02-21 |
2023-08-12 |
Not clear |
| Laurent M Dejean, Sonia Martinez-Caballero, Stephen Manon, Kathleen W Kinnall. Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins. Biochimica et biophysica acta. vol 1762. issue 2. 2006-02-16. PMID:16055309. |
programmed cell death or apoptosis is central to many physiological processes and pathological conditions such as organogenesis, tissue homeostasis, cancer, and neurodegenerative diseases. |
2006-02-16 |
2023-08-12 |
Not clear |
| Guo-Hua Fan, Chen Qi, Sheng-Di Che. Heat shock proteins reduce toxicity of 1-methyl-4-phenylpyridinium ion in SK-N-SH cells. Journal of neuroscience research. vol 82. issue 4. 2006-02-16. PMID:16235253. |
heat shock proteins (hsps) have many functions, including inhibition of apoptosis and necrosis, protection from oxidative stress, and maintenance of the mitochondrial membrane potential, that are related to neurodegenerative diseases. |
2006-02-16 |
2023-08-12 |
human |
| Xie Minjie, Wang Wei, Zhu Zhou, Yu Yongfe. Capillary electrophoresis analysis of hydrogen peroxide induced apoptosis in PC12 cells. Journal of pharmaceutical and biomedical analysis. vol 39. issue 5. 2006-02-08. PMID:16039084. |
results show that ce can distinguish cell apoptosis and necrosis, quantify the degree of apoptosis in cells and have advantages of high efficiency, fast sample analysis speed, minute sample consumption and reliable results, which provides an accessorial method in the research of multiple diseases with abnormal apoptosis such as cancer and neurodegenerative diseases. |
2006-02-08 |
2023-08-12 |
rat |