| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María Angeles Arevalo, María Santos-Galindo, Estefanía Acaz-Fonseca, Iñigo Azcoitia, Luis M Garcia-Segur. Gonadal hormones and the control of reactive gliosis. Hormones and behavior. vol 63. issue 2. 2013-07-19. PMID:22401743. |
activation of astrocytes and microglia after acute neural insults, such as stroke or traumatic cns injury, is considered to be an adaptive response that contributes to minimize neuronal damage. |
2013-07-19 |
2023-08-12 |
Not clear |
| Marcelo M Cardoso, Edna C S Franco, Celice C de Souza, Michelle C da Silva, Amauri Gouveia, Walace Gomes-Lea. Minocycline treatment and bone marrow mononuclear cell transplantation after endothelin-1 induced striatal ischemia. Inflammation. vol 36. issue 1. 2013-07-03. PMID:22945281. |
we explored whether the modulation of microglia activation with minocycline is beneficial to the therapeutic actions of bone marrow mononuclear cells (bmmcs) transplanted after experimental stroke. |
2013-07-03 |
2023-08-12 |
rat |
| Rachael L Terry, Daniel R Getts, Celine Deffrasnes, Caryn van Vreden, Iain L Campbell, Nicholas J C Kin. Inflammatory monocytes and the pathogenesis of viral encephalitis. Journal of neuroinflammation. vol 9. 2013-07-01. PMID:23244217. |
ly6chi/ccr2(hi) inflammatory monocytes have been identified as the circulating precursors of brain macrophages, dendritic cells and arguably microglia in experimental autoimmune encephalomyelitis; alzheimer's disease; stroke; and more recently in cns infection caused by herpes simplex virus, murine hepatitis virus, theiler's murine encephalomyelitis virus, japanese encephalitis virus and west nile virus. |
2013-07-01 |
2023-08-12 |
human |
| Ivan Bohacek, Pierre Cordeau, Mélanie Lalancette-Hébert, Dunja Gorup, Yuan-Cheng Weng, Srecko Gajovic, Jasna Kri. Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury. Journal of neuroinflammation. vol 9. 2013-06-17. PMID:22873409. |
using a live imaging approach, we have previously shown that microglia activation after stroke is characterized by marked and long-term induction of the toll-like receptor (tlr) 2 biophotonic signals. |
2013-06-17 |
2023-08-12 |
Not clear |
| Rubén Martín, Claudia Cordova, Maria L Niet. Secreted phospholipase A2-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding. Journal of neuroinflammation. vol 9. 2013-04-19. PMID:22747893. |
activation of microglia, the primary component of the innate immune response in the brain, is a hallmark of neuroinflammation in neurodegenerative disorders, including alzheimer's disease (ad) and other pathological conditions such as stroke or cns infection. |
2013-04-19 |
2023-08-12 |
Not clear |
| Karsten Ruscher, Ana R Inácio, Kristian Valind, Arman Rowshan Ravan, Enida Kuric, Tadeusz Wieloc. Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. PloS one. vol 7. issue 9. 2013-02-26. PMID:23028794. |
activation of the sigma-1 receptor (sig-1r) improves functional recovery in models of experimental stroke and is known to modulate microglia function. |
2013-02-26 |
2023-08-12 |
rat |
| Edna C S Franco, Marcelo M Cardoso, Amauri Gouvêia, Antonio Pereira, Walace Gomes-Lea. Modulation of microglial activation enhances neuroprotection and functional recovery derived from bone marrow mononuclear cell transplantation after cortical ischemia. Neuroscience research. vol 73. issue 2. 2013-02-19. PMID:22465414. |
activated microglia may exacerbate damage in neural disorders; however, it is unknown how they affect stem cells transplanted after stroke. |
2013-02-19 |
2023-08-12 |
rat |
| Claudia A McCarthy, Antony Vinh, Brad R S Broughton, Christopher G Sobey, Jennifer K Callaway, Robert E Widdo. Angiotensin II type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats. Hypertension (Dallas, Tex. : 1979). vol 60. issue 6. 2013-02-07. PMID:23090772. |
furthermore, we have demonstrated that at(2)r stimulation after stroke increased neuronal survival, decreased apoptosis, and caused an increase in the number of activated microglia in the core region of damage. |
2013-02-07 |
2023-08-12 |
rat |
| Jonas Hannestad, Jean-Dominique Gallezot, Thomas Schafbauer, Keunpoong Lim, Tracy Kloczynski, Evan D Morris, Richard E Carson, Yu-Shin Ding, Kelly P Cosgrov. Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates. NeuroImage. vol 63. issue 1. 2013-01-29. PMID:22776451. |
an important clinical question is whether the effects of systemic inflammation on microglia mediate the deleterious effects of systemic inflammation in diseases such as alzheimer's dementia, multiple sclerosis, and stroke. |
2013-01-29 |
2023-08-12 |
Not clear |
| Balázs Gulyás, Miklós Tóth, Martin Schain, Anu Airaksinen, Adám Vas, Konstantinos Kostulas, Per Lindström, Jan Hillert, Christer Halldi. Evolution of microglial activation in ischaemic core and peri-infarct regions after stroke: a PET study with the TSPO molecular imaging biomarker [((11))C]vinpocetine. Journal of the neurological sciences. vol 320. issue 1-2. 2013-01-14. PMID:22841414. |
already a week after stroke there was an increased radioligand uptake, indicating the up-regulation of tspo and the presence of activated microglia, in both the ischaemic core and the peri-infarct zone. |
2013-01-14 |
2023-08-12 |
Not clear |
| D Fernández-López, J Faustino, N Derugin, M Wendland, I Lizasoain, M A Moro, Z S Vexle. Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke. Neuroscience. vol 207. 2012-11-27. PMID:22285309. |
reduced infarct size and accumulation of microglia in rats treated with win 55,212-2 after neonatal stroke. |
2012-11-27 |
2023-08-12 |
rat |
| D Fernández-López, J Faustino, N Derugin, M Wendland, I Lizasoain, M A Moro, Z S Vexle. Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke. Neuroscience. vol 207. 2012-11-27. PMID:22285309. |
cumulatively, our results show that the cannabinoid agonist win protects against neonatal focal stroke in part due to inhibitory effects on microglia. |
2012-11-27 |
2023-08-12 |
rat |
| Kate Lykke Lambertsen, Knut Biber, Bente Finse. Inflammatory cytokines in experimental and human stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 32. issue 9. 2012-11-19. PMID:22739623. |
the fact that tnf and il-1, and suppossedly also il-6, are produced by microglia within the therapeutic window place these cells centrally in potential future stroke therapy. |
2012-11-19 |
2023-08-12 |
human |
| F J Ortega, J Gimeno-Bayon, J F Espinosa-Parrilla, J L Carrasco, M Batlle, M Pugliese, N Mahy, M J Rodrígue. ATP-dependent potassium channel blockade strengthens microglial neuroprotection after hypoxia-ischemia in rats. Experimental neurology. vol 235. issue 1. 2012-06-29. PMID:22387180. |
these findings provide that evidence for the key role of k(atp) channels in the control of microglial reactivity are consistent with a microglial effect of glibenclamide into the ischemic brain and suggest a neuroprotective role of microglia in the early stages of stroke. |
2012-06-29 |
2023-08-12 |
rat |
| Ya-Dan Wen, Hui-Ling Zhang, Zheng-Hong Qi. Inflammatory mechanism in ischemic neuronal injury. Neuroscience bulletin. vol 22. issue 3. 2012-06-25. PMID:17704846. |
this review summarizes data regarding roles of cell adhesion molecules, astrocytes, microglia and leukocytes in stroke. |
2012-06-25 |
2023-08-12 |
Not clear |
| Jin-Sun Park, Jin A Shin, Ji-Sun Jung, Jin-Won Hyun, Thi Kim Van Le, Dong-Hyun Kim, Eun-Mi Park, Hee-Sun Ki. Anti-inflammatory mechanism of compound K in activated microglia and its neuroprotective effect on experimental stroke in mice. The Journal of pharmacology and experimental therapeutics. vol 341. issue 1. 2012-05-04. PMID:22207656. |
anti-inflammatory mechanism of compound k in activated microglia and its neuroprotective effect on experimental stroke in mice. |
2012-05-04 |
2023-08-12 |
mouse |
| Chao Jiang, Kefei Cui, Jianping Wang, Yuanhong H. Microglia and cyclooxygenase-2: possible therapeutic targets of progesterone for stroke. International immunopharmacology. vol 11. issue 11. 2012-04-27. PMID:21843661. |
microglia and cyclooxygenase-2: possible therapeutic targets of progesterone for stroke. |
2012-04-27 |
2023-08-12 |
rat |
| Chao Jiang, Kefei Cui, Jianping Wang, Yuanhong H. Microglia and cyclooxygenase-2: possible therapeutic targets of progesterone for stroke. International immunopharmacology. vol 11. issue 11. 2012-04-27. PMID:21843661. |
although there have been reports about the neurotoxicity of activated microglia and cyclooxygenase-2 (cox-2) in animal models of ischemic stroke, the influence of prog on the activation of microglia and the expression of cox-2 after stroke has not been examined in detail. |
2012-04-27 |
2023-08-12 |
rat |
| Chao Jiang, Kefei Cui, Jianping Wang, Yuanhong H. Microglia and cyclooxygenase-2: possible therapeutic targets of progesterone for stroke. International immunopharmacology. vol 11. issue 11. 2012-04-27. PMID:21843661. |
these observations raised the possibility that prog can exert its neuroprotective effects by inhibiting the activation of microglia and the over expression of cox-2 after stroke. |
2012-04-27 |
2023-08-12 |
rat |
| Ursula Heldmann, Yutaka Mine, Zaal Kokaia, Christine T Ekdahl, Olle Lindval. Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. Experimental neurology. vol 229. issue 2. 2011-08-05. PMID:21419118. |
selective depletion of mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. |
2011-08-05 |
2023-08-12 |
rat |