| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valérie Jolivel, Frank Bicker, Fabien Binamé, Robert Ploen, Stefanie Keller, René Gollan, Betty Jurek, Jérôme Birkenstock, Laura Poisa-Beiro, Julia Bruttger, Verena Opitz, Serge C Thal, Ari Waisman, Tobias Bäuerle, Michael K Schäfer, Frauke Zipp, Mirko H H Schmid. Perivascular microglia promote blood vessel disintegration in the ischemic penumbra. Acta neuropathologica. vol 129. issue 2. 2015-09-21. PMID:25500713. |
potentially, medication directed at inhibiting microglia activation within the first day after stroke could stabilize blood vessels in the penumbra, increase blood flow, and serve as a valuable treatment for patients suffering from ischemic stroke. |
2015-09-21 |
2023-08-13 |
mouse |
| Zareen Amtul, Shawn N Whitehead, Robin J Keeley, John Bechberger, Alicia L Fisher, Robert J McDonald, Christian C Naus, David G Munoz, David F Cechett. Comorbid rat model of ischemia and β-amyloid toxicity: striatal and cortical degeneration. Brain pathology (Zurich, Switzerland). vol 25. issue 1. 2015-08-12. PMID:24725245. |
the results demonstrated ventricular enlargement, striatal atrophy, substantial increases in β-amyloid, ramified microglia and increases in neuritic retraction in the combined models of stroke and abeta toxicity. |
2015-08-12 |
2023-08-13 |
rat |
| Emanuel Monteiro Candeias, Inês Carolina Sebastião, Susana Maria Cardoso, Sónia Catarina Correia, Cristina Isabel Carvalho, Ana Isabel Plácido, Maria Sancha Santos, Catarina Resende Oliveira, Paula Isabel Moreira, Ana Isabel Duart. Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide. World journal of diabetes. vol 6. issue 6. 2015-07-01. PMID:26131323. |
importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against t2d, stroke and alzheimer disease (ad), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in ad biomarkers. |
2015-07-01 |
2023-08-13 |
Not clear |
| Masahito Kawabori, Rachid Kacimi, Tiina Kauppinen, Cyrus Calosing, Jong Youl Kim, Christine L Hsieh, Mary C Nakamura, Midori A Yenar. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716838. |
triggering receptor expressed on myeloid cells 2 (trem2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. |
2015-06-29 |
2023-08-13 |
mouse |
| Labchan Rajbhandari, Million Adane Tegenge, Shiva Shrestha, Nishant Ganesh Kumar, Adeel Malik, Aditya Mithal, Suneil Hosmane, Arun Venkatesa. Toll-like receptor 4 deficiency impairs microglial phagocytosis of degenerating axons. Glia. vol 62. issue 12. 2015-06-19. PMID:25042766. |
microglia are rapidly activated in the central nervous system (cns) in response to a variety of injuries, including inflammation, trauma, and stroke. |
2015-06-19 |
2023-08-13 |
mouse |
| Maureen Walberer, Sabine U Jantzen, Heiko Backes, Maria A Rueger, Meike H Keuters, Bernd Neumaier, Mathias Hoehn, Gereon R Fink, Rudolf Graf, Michael Schroete. In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats. Brain research. vol 1581. 2015-05-21. PMID:24905627. |
neuroinflammation with microglia activation (ma) constitutes a key tissue response in acute stroke. |
2015-05-21 |
2023-08-13 |
rat |
| Stefano Fumagalli, Carlo Perego, Francesca Pischiutta, Elisa R Zanier, Maria-Grazia De Simon. The ischemic environment drives microglia and macrophage function. Frontiers in neurology. vol 6. 2015-04-23. PMID:25904895. |
we discuss the selective responses of microglia and macrophages to hypoxia after stroke and review relevant markers with the aim of defining the different subpopulations of myeloid cells that are recruited to the injured site. |
2015-04-23 |
2023-08-13 |
Not clear |
| Fiona E Burrows, Natasha Bray, Adam Denes, Stuart M Allan, Ingo Schiess. Delayed reperfusion deficits after experimental stroke account for increased pathophysiology. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 2. 2015-04-10. PMID:25407273. |
platelets, activated microglia, interleukin-1α, evidence of bbb breakdown and neuronal stress increase within the stroked hemisphere and correlate with the severity of the delayed reperfusion deficit but not with the Δhbo2 during stroke. |
2015-04-10 |
2023-08-13 |
mouse |
| Tracey A Ignatowski, Robert N Spengler, Krishnan M Dhandapani, Hedy Folkersma, Roger F Butterworth, Edward Tobinic. Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence. CNS drugs. vol 28. issue 8. 2015-03-30. PMID:24861337. |
activated microglia release tnf, which mediates neurotoxicity in the stroke penumbra. |
2015-03-30 |
2023-08-13 |
Not clear |
| Iván Ballesteros, María Isabel Cuartero, Ana Moraga, Juan de la Parra, Ignacio Lizasoain, María Ángeles Mor. Stereological and flow cytometry characterization of leukocyte subpopulations in models of transient or permanent cerebral ischemia. Journal of visualized experiments : JoVE. issue 94. 2015-03-09. PMID:25590380. |
microglia activation, as well as extravasation of haematogenous macrophages and neutrophils, is believed to play a pivotal role in brain injury after stroke. |
2015-03-09 |
2023-08-13 |
mouse |
| Egle Cekanaviciute, Nancy Fathali, Kristian P Doyle, Aaron M Williams, Jullet Han, Marion S Buckwalte. Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice. Glia. vol 62. issue 8. 2015-02-04. PMID:24733756. |
we have previously demonstrated that tgfβs signal to astrocytes, neurons and microglia in the stroke border days after stroke. |
2015-02-04 |
2023-08-13 |
mouse |
| Corinne Benakis, Lidia Garcia-Bonilla, Costantino Iadecola, Josef Anrathe. The role of microglia and myeloid immune cells in acute cerebral ischemia. Frontiers in cellular neuroscience. vol 8. 2015-02-02. PMID:25642168. |
in this review we aim to summarize recent literature concerning the origins, fate and role of microglia, monocytes and neutrophils in models of cerebral ischemia and to discuss their relevance for human stroke. |
2015-02-02 |
2023-08-13 |
human |
| Rajkumar Verma, Brett D Friedler, Nia M Harris, Louise D McCulloug. Pair housing reverses post-stroke depressive behavior in mice. Behavioural brain research. vol 269. 2015-01-15. PMID:24793492. |
however, a more detailed assessment of cellular expression showed a significant increase in the number of microglia that co-labeled with arginase-1 in the peri-infarct region in ph stroke mice compared to si mice. |
2015-01-15 |
2023-08-13 |
mouse |
| Y Chen, S J Won, Y Xu, R A Swanso. Targeting microglial activation in stroke therapy: pharmacological tools and gender effects. Current medicinal chemistry. vol 21. issue 19. 2015-01-09. PMID:24372213. |
microglia are the resident immune cells of the central nervous system, and they respond to stroke by assuming an activated phenotype that releases cytotoxic cytokines, reactive oxygen species, proteases, and other factors. |
2015-01-09 |
2023-08-12 |
Not clear |
| Kana Sugimoto, Ryutaro Nishioka, Airi Ikeda, Ayano Mise, Hisaaki Takahashi, Hajime Yano, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanak. Activated microglia in a rat stroke model express NG2 proteoglycan in peri-infarct tissue through the involvement of TGF-β1. Glia. vol 62. issue 2. 2014-09-26. PMID:24311432. |
activated microglia in a rat stroke model express ng2 proteoglycan in peri-infarct tissue through the involvement of tgf-β1. |
2014-09-26 |
2023-08-12 |
rat |
| Francisco J Ortega, Jana Vukovic, Manuel J Rodríguez, Perry F Bartlet. Blockade of microglial KATP -channel abrogates suppression of inflammatory-mediated inhibition of neural precursor cells. Glia. vol 62. issue 2. 2014-09-26. PMID:24311472. |
we demonstrated previously that reactive microglia foster k(atp) -channel expression and that blocking this channel using glibenclamide administration enhances striatal neurogenesis after stroke. |
2014-09-26 |
2023-08-12 |
mouse |
| Miriana Jlenia Quattromani, Pierre Cordeau, Karsten Ruscher, Jasna Kriz, Tadeusz Wieloc. Enriched housing down-regulates the Toll-like receptor 2 response in the mouse brain after experimental stroke. Neurobiology of disease. vol 66. 2014-09-24. PMID:24613658. |
in order to identify targets for late stroke treatment, we studied the dynamics of inflammation and the contribution of resident toll-like receptor 2 (tlr2) expressing microglia cells. |
2014-09-24 |
2023-08-12 |
mouse |
| Miriana Jlenia Quattromani, Pierre Cordeau, Karsten Ruscher, Jasna Kriz, Tadeusz Wieloc. Enriched housing down-regulates the Toll-like receptor 2 response in the mouse brain after experimental stroke. Neurobiology of disease. vol 66. 2014-09-24. PMID:24613658. |
tlr2-expressing microglia cells may provide targets for new stroke therapeutics. |
2014-09-24 |
2023-08-12 |
mouse |
| Ukpong B Eyo, Sam A Miner, Katelin E Ahlers, Long-Jun Wu, Michael E Daile. P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation. Neuropharmacology. vol 73. 2014-08-13. PMID:23770338. |
brain-resident microglia may promote tissue repair following stroke but, like other cells, they are vulnerable to ischemia. |
2014-08-13 |
2023-08-12 |
mouse |
| Paolo Gelosa, Davide Lecca, Marta Fumagalli, Dorota Wypych, Alice Pignieri, Mauro Cimino, Claudia Verderio, Malin Enerbäck, Elham Nikookhesal, Elena Tremoli, Maria P Abbracchio, Luigi Siron. Microglia is a key player in the reduction of stroke damage promoted by the new antithrombotic agent ticagrelor. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 6. 2014-07-21. PMID:24643079. |
microglia is a key player in the reduction of stroke damage promoted by the new antithrombotic agent ticagrelor. |
2014-07-21 |
2023-08-12 |
mouse |