| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clara Bourget, Kelsey V Adams, Cindi M Morshea. Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke. Journal of neuroinflammation. vol 19. issue 1. 2022-06-15. PMID:35705953. |
given metformin's demonstrated anti-inflammatory properties, we investigated its role in regulating the microglia activation and used a microglia ablation strategy to investigate the microglia-mediated outcomes in a mouse model of neonatal stroke. |
2022-06-15 |
2023-08-14 |
mouse |
| Sinai Kim, Wonhyo Lee, Huiju Jo, Seong-Keun Sonn, Se-Jin Jeong, Seungwoon Seo, Joowon Suh, Jing Jin, Hyae Yon Kweon, Tae Kyeong Kim, Shin Hye Moon, Sejin Jeon, Jong Woo Kim, Yu Ri Kim, Eun-Woo Lee, Hwa Kyoung Shin, Sung Ho Park, Goo Taeg O. The antioxidant enzyme Peroxiredoxin-1 controls stroke-associated microglia against acute ischemic stroke. Redox biology. vol 54. 2022-06-10. PMID:35688114. |
here, we identified a new type of microglia associated with stroke in the i/r injured brain. |
2022-06-10 |
2023-08-14 |
Not clear |
| Zhizhun Mo, Zhongyi Zeng, Yuxiang Liu, Linsheng Zeng, Jiansong Fang, Yinzhong M. Activation of Wnt/Beta-Catenin Signaling Pathway as a Promising Therapeutic Candidate for Cerebral Ischemia/Reperfusion Injury. Frontiers in pharmacology. vol 13. 2022-06-07. PMID:35668927. |
to better understand the therapeutic potential of wnt as a novel target for stroke, we reviewed the role of wnt signaling in the pathogenesis of stroke in different cell types, including endothelial cells, neurons, oligodendrocytes, and microglia. |
2022-06-07 |
2023-08-14 |
Not clear |
| Jong Youl Kim, Jiwon Kim, Meiying Huang, Renée Kosonen, Jong Eun Le. CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation. Frontiers in immunology. vol 13. 2022-05-31. PMID:35634277. |
microglia, resident macrophages in the brain, play major roles in neuroinflammation after an acute many neurological diseases, including stroke. |
2022-05-31 |
2023-08-13 |
Not clear |
| Jong Youl Kim, Jiwon Kim, Meiying Huang, Renée Kosonen, Jong Eun Le. CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation. Frontiers in immunology. vol 13. 2022-05-31. PMID:35634277. |
our recent animal stroke model showed that interleukin (il)-4 and il-13 released by microglia are converted into monocyte-derived macrophages. |
2022-05-31 |
2023-08-13 |
Not clear |
| Ping Li, Xue Luo, Zhen Luo, Gen-Lin He, Ting-Ting Shen, Xue-Ting Yu, Ze-Ze Wang, Yu-Long Tan, Xiao-Qian Liu, Xue-Sen Yan. Increased miR-155 in Microglial Exosomes Following Heat Stress Accelerates Neuronal Autophagy Frontiers in cellular neuroscience. vol 16. 2022-05-31. PMID:35634460. |
in our previous studies, both activated microglia and increased neuronal autophagy were found in the cortices of mice with heat stroke. |
2022-05-31 |
2023-08-13 |
mouse |
| Zhaoxia Wang, Xinming Li, Zhixing Shao, ZhengFang, Yueping Zha. Retracted Article: Elevation of USP4 antagonizes oxygen glucose deprivation/reoxygenation-evoked microglia activation and neuroinflammation-mediated neurotoxicity RSC advances. vol 9. issue 41. 2022-05-09. PMID:35530618. |
microglia activation after a stroke results in the release of pro-inflammatory cytokines that can further aggravate brain damage. |
2022-05-09 |
2023-08-13 |
Not clear |
| Wen-Yu Ma, Sha-Sha Wang, Qing-Lin Wu, Xin Zhou, Shi-Feng Chu, Nai-Hong Che. The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke. International immunopharmacology. vol 109. 2022-05-07. PMID:35525233. |
microglia are the earliest activated and the longest lasting immune cells after stroke, and they participate in almost all the pathological reactions after stroke. |
2022-05-07 |
2023-08-13 |
Not clear |
| Wen-Yu Ma, Sha-Sha Wang, Qing-Lin Wu, Xin Zhou, Shi-Feng Chu, Nai-Hong Che. The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke. International immunopharmacology. vol 109. 2022-05-07. PMID:35525233. |
however, trem2 does not provide a systematic summary of the functional transformation and intrinsic molecular mechanisms of microglia after stroke. |
2022-05-07 |
2023-08-13 |
Not clear |
| Wen-Yu Ma, Sha-Sha Wang, Qing-Lin Wu, Xin Zhou, Shi-Feng Chu, Nai-Hong Che. The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke. International immunopharmacology. vol 109. 2022-05-07. PMID:35525233. |
in this paper, we have summarized the functional changes of trem2 in microglia after stroke in recent years, and found that trem2 has important effects on energy metabolism, phagocytosis and anti-inflammatory function of microglia after stroke, suggesting that trem2 is a potential therapeutic target for the treatment of stroke. |
2022-05-07 |
2023-08-13 |
Not clear |
| Hai Xiao, Shuqin Han, Huricha Baigud. Regulation of microglia polarization RSC advances. vol 11. issue 52. 2022-05-02. PMID:35493551. |
regulation of microglia polarization the pro-inflammatory polarization of microglia after stroke is one of the major causes of secondary brain injury. |
2022-05-02 |
2023-08-13 |
Not clear |
| Irene F Ugidos, Cristiana Pistono, Paula Korhonen, Mireia Gómez-Budia, Valeriia Sitnikova, Pamela Klecki, Iveta Stanová, Jukka Jolkkonen, Tarja Mal. Sex Differences in Poststroke Inflammation: a Focus on Microglia Across the Lifespan. Stroke. vol 53. issue 5. 2022-04-25. PMID:35468000. |
poststroke neuroinflammation is geared largely by brain microglia and infiltrating peripheral immune cells and largely contributes to sex differences in the outcome of stroke. |
2022-04-25 |
2023-08-13 |
Not clear |
| Hubert Doleżyczek, Piotr Kasprzycki, Jakub Włodarczyk, Maciej Wojtkowski, Monika Malinowsk. Optical coherence tomography reveals heterogeneity of the brain tissue and vasculature in the ischemic region after photothrombotic stroke in mice. Acta neurobiologiae experimentalis. vol 82. issue 1. 2022-04-22. PMID:35451428. |
the goal of our research was analysis of vascularity of the ischemic area during 2‑week progress of stroke and correlating the hypo‑ and hyperreflective oct scattering areas with the location of activated microglia and astroglia. |
2022-04-22 |
2023-08-13 |
mouse |
| Confidence Dordoe, Xue Wang, Ping Lin, Zhengyi Wang, Jian Hu, Dongxue Wang, Yani Fang, Fei Liang, Shasha Ye, Jun Chen, Yeli Zhao, Ye Xiong, Yunjun Yang, Li Lin, Xianfeng L. Non-mitogenic fibroblast growth factor 1 protects against ischemic stroke by regulating microglia/macrophage polarization through Nrf2 and NF-κB pathways. Neuropharmacology. 2022-04-22. PMID:35452626. |
the present study aimed to investigate the effects and mechanism of the neuroprotective ability of nmfgf1 on microglia in mice after photothrombosis (pt) stroke model, to determine whether it could ameliorate ischemic injury in stroke experiment. |
2022-04-22 |
2023-08-13 |
mouse |
| Lulu Jin, Zhixin Zhu, Liangjie Hong, Zhefeng Qian, Fang Wang, Zhengwei Ma. ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation. Bioactive materials. vol 19. 2022-04-13. PMID:35415314. |
dga presented excellent therapeutic efficacy in stroke mice, as evidenced by the reduction of infarct volume, recovery of motor function, suppressed of m1 microglia activation and enhanced m2 activation, and induction of neurogenesis. |
2022-04-13 |
2023-08-13 |
mouse |
| Teng Wan, Yunling Huang, Xiaoyu Gao, Wanpeng Wu, Weiming Gu. Microglia Polarization: A Novel Target of Exosome for Stroke Treatment. Frontiers in cell and developmental biology. vol 10. 2022-03-31. PMID:35356292. |
microglia polarization: a novel target of exosome for stroke treatment. |
2022-03-31 |
2023-08-13 |
human |
| Teng Wan, Yunling Huang, Xiaoyu Gao, Wanpeng Wu, Weiming Gu. Microglia Polarization: A Novel Target of Exosome for Stroke Treatment. Frontiers in cell and developmental biology. vol 10. 2022-03-31. PMID:35356292. |
microglia are core members of central intrinsic immune regulatory cells, which play an important regulatory role in the pathogenesis and progression of stroke. |
2022-03-31 |
2023-08-13 |
human |
| Teng Wan, Yunling Huang, Xiaoyu Gao, Wanpeng Wu, Weiming Gu. Microglia Polarization: A Novel Target of Exosome for Stroke Treatment. Frontiers in cell and developmental biology. vol 10. 2022-03-31. PMID:35356292. |
this research reviews the role of exosomes in the regulation of microglia polarization and reveals their potential value in stroke treatment. |
2022-03-31 |
2023-08-13 |
human |
| Hongrui Zhu, Yi Guo, Ailing Huang, Huidan Shen, Yang Chen, Jingyi Song, Ao Guan, Liang Wu, Huiting Wang, Bin Den. HDAC3-Regulated PGE2 Production by Microglia Induces Phobic Anxiety Susceptibility After Stroke and Pointedly Exploiting a Signal-Targeted Gamma Visual Stimulation New Therapy. Frontiers in immunology. vol 13. 2022-03-07. PMID:35251047. |
hdac3-regulated pge2 production by microglia induces phobic anxiety susceptibility after stroke and pointedly exploiting a signal-targeted gamma visual stimulation new therapy. |
2022-03-07 |
2023-08-13 |
Not clear |
| Yi-Sha Guo, Mei Yuan, Yu Han, Xin-Ya Shen, Zhen-Kun Gao, Xia B. Effects of enriched environment on microglia and functional white matter recovery in rats with post stroke cognitive impairment. Neurochemistry international. 2022-02-05. PMID:35121010. |
effects of enriched environment on microglia and functional white matter recovery in rats with post stroke cognitive impairment. |
2022-02-05 |
2023-08-13 |
rat |