| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenyu Song, Marta Volosin, Andrea B Cragnolini, Barbara L Hempstead, Wilma J Friedma. ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 46. 2010-12-23. PMID:21084616. |
simultaneous activation of p75(ntr) by prongf and trkb signaling by bdnf elicited apoptosis despite trkb phosphorylation. |
2010-12-23 |
2023-08-12 |
rat |
| Toshiyuki Oshitari, Natsuyo Yoshida-Hata, Shuichi Yamamot. Effect of neurotrophic factors on neuronal apoptosis and neurite regeneration in cultured rat retinas exposed to high glucose. Brain research. vol 1346. 2010-10-19. PMID:20573599. |
the purpose of this study was to investigate the effect of brain-derived neurotrophic factor (bdnf), neurotrophin-4 (nt-4), and citicoline on neuronal apoptosis and neurite regeneration in cultured rat retinas exposed to high glucose (hg). |
2010-10-19 |
2023-08-12 |
rat |
| Xiu-Mei Yan, Guang-Qian L. [Expression of brain-derived neurotrophic factor and apoptosis in the brain of rats with repeated febrile seizures]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 12. issue 5. 2010-08-26. PMID:20497649. |
to study the changes of brain-derived neurotrophic factor (bdnf) following repeated febrile seizures in rats and its possible correlation with neurocyte apoptosis. |
2010-08-26 |
2023-08-12 |
rat |
| Li Kong, Xiaohong Zhou, Feng Li, Juni Yodoi, James McGinnis, Wei Ca. Neuroprotective effect of overexpression of thioredoxin on photoreceptor degeneration in Tubby mice. Neurobiology of disease. vol 38. issue 3. 2010-08-17. PMID:20298786. |
analysis of signal pathways showed that thioredoxin up-regulated neurotrophic factors bdnf and gdnf and activated survival signaling pathways akt, ras/raf1/ and the erks while inhibiting the ask1/jnk apoptosis pathway. |
2010-08-17 |
2023-08-12 |
mouse |
| Lindsey Willett, Yonglin Gao, Zhenmin Lei, Chengling Lu, Fred J Roisen, Welby I Winstead, Rif S El-Mallak. Effects of brain-derived neurotrophic factor on sodium-induced apoptosis in human olfactory neuroepithelial progenitor cells. Psychiatry research. vol 178. issue 2. 2010-08-12. PMID:20472302. |
since both elevated intracellular sodium and apoptosis are believed to contribute to cellular dysfunction in bipolar disorder, it is important to determine the effect of exogenous bdnf on apoptosis induced by the high levels of intracellular sodium seen in ill bipolar patients. |
2010-08-12 |
2023-08-12 |
human |
| Lindsey Willett, Yonglin Gao, Zhenmin Lei, Chengling Lu, Fred J Roisen, Welby I Winstead, Rif S El-Mallak. Effects of brain-derived neurotrophic factor on sodium-induced apoptosis in human olfactory neuroepithelial progenitor cells. Psychiatry research. vol 178. issue 2. 2010-08-12. PMID:20472302. |
bdnf 100ng/ml pretreatment or co-treatment attenuated the monensin-induced apoptosis. |
2010-08-12 |
2023-08-12 |
human |
| Lindsey Willett, Yonglin Gao, Zhenmin Lei, Chengling Lu, Fred J Roisen, Welby I Winstead, Rif S El-Mallak. Effects of brain-derived neurotrophic factor on sodium-induced apoptosis in human olfactory neuroepithelial progenitor cells. Psychiatry research. vol 178. issue 2. 2010-08-12. PMID:20472302. |
pretreatment with bdnf for 24h reduced monensin-induced apoptosis by 93%. |
2010-08-12 |
2023-08-12 |
human |
| Lindsey Willett, Yonglin Gao, Zhenmin Lei, Chengling Lu, Fred J Roisen, Welby I Winstead, Rif S El-Mallak. Effects of brain-derived neurotrophic factor on sodium-induced apoptosis in human olfactory neuroepithelial progenitor cells. Psychiatry research. vol 178. issue 2. 2010-08-12. PMID:20472302. |
co-treatment of bdnf and monensin increased intracellular sodium concentration and reduced apoptosis by 66%. |
2010-08-12 |
2023-08-12 |
human |
| Lindsey Willett, Yonglin Gao, Zhenmin Lei, Chengling Lu, Fred J Roisen, Welby I Winstead, Rif S El-Mallak. Effects of brain-derived neurotrophic factor on sodium-induced apoptosis in human olfactory neuroepithelial progenitor cells. Psychiatry research. vol 178. issue 2. 2010-08-12. PMID:20472302. |
treatment with bdnf greatly attenuates or prevents monensin-induced apoptosis. |
2010-08-12 |
2023-08-12 |
human |
| L Zhang, Y Liang, Y Liu, C-L Xion. The role of brain-derived neurotrophic factor in mouse oocyte maturation in vitro involves activation of protein kinase B. Theriogenology. vol 73. issue 8. 2010-08-06. PMID:20171721. |
however, bdnf did not affect apoptosis of the cumulus cells during oocyte maturation in vitro. |
2010-08-06 |
2023-08-12 |
mouse |
| Ning Li, Geng-tao Li. The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice. Acta pharmacologica Sinica. vol 31. issue 3. 2010-06-14. PMID:20154710. |
the aim of this study was to study the effects of compound flz, a novel cyclic derivative of squamosamide from annona glabra, on brain-derived neurotrophic factor (bdnf)/tropomyosin receptor kinase b (trkb)/camp response element-binding protein (creb) signaling and neuronal apoptosis in the hippocampus of the amyloid precursor protein (app)/presenilin-1 (ps1) double transgenic mice. |
2010-06-14 |
2023-08-12 |
mouse |
| Yongjun Zhang, Jing Zhao, Jing Wang, Xianting Jia. Brain-derived neurotrophic factor inhibits phenylalanine-induced neuronal apoptosis by preventing RhoA pathway activation. Neurochemical research. vol 35. issue 3. 2010-04-30. PMID:19890711. |
in this study, we reported that brain-derived growth factor (bdnf) protected neurons from phenylalanine-induced apoptosis and inhibition of trk receptor by k252a or downregulation of trkb abrogated the effect of bdnf. |
2010-04-30 |
2023-08-12 |
Not clear |
| Yongjun Zhang, Jing Zhao, Jing Wang, Xianting Jia. Brain-derived neurotrophic factor inhibits phenylalanine-induced neuronal apoptosis by preventing RhoA pathway activation. Neurochemical research. vol 35. issue 3. 2010-04-30. PMID:19890711. |
we further demonstrated that phenylalanine-induced rhoa activation and myosin light chain phosphorylation were inhibited by pretreatment with bdnf, while phenylalanine activates the mitochondria-mediated apoptosis through the rhoa/rho-associated kinase pathway. |
2010-04-30 |
2023-08-12 |
Not clear |
| Yongjun Zhang, Jing Zhao, Jing Wang, Xianting Jia. Brain-derived neurotrophic factor inhibits phenylalanine-induced neuronal apoptosis by preventing RhoA pathway activation. Neurochemical research. vol 35. issue 3. 2010-04-30. PMID:19890711. |
thus our studies indicate that the protective effect of bdnf against phenylalanine-induced neuronal apoptosis is probably mediated by suppression of rhoa signaling pathway via trkb receptor. |
2010-04-30 |
2023-08-12 |
Not clear |
| Yan Xia, Cheng Z Wang, Jie Liu, Noelle C Anastasio, Kenneth M Johnso. Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19887077. |
this study examined the role of the phosphatidylinositol-3 kinase (pi3k)/akt and extracellular signal-regulated kinase (erk) pathways in bdnf protection of pcp-induced apoptosis in corticostriatal organotypic cultures. |
2010-04-13 |
2023-08-12 |
rat |
| Yan Xia, Cheng Z Wang, Jie Liu, Noelle C Anastasio, Kenneth M Johnso. Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19887077. |
it was observed that bdnf inhibited pcp-induced apoptosis in a concentration-dependent fashion. |
2010-04-13 |
2023-08-12 |
rat |
| Yan Xia, Cheng Z Wang, Jie Liu, Noelle C Anastasio, Kenneth M Johnso. Brain-derived neurotrophic factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19887077. |
these data demonstrate that the protective effect of bdnf against pcp-induced apoptosis is mediated by parallel activation of the pi-3k/akt and erk pathways, most likely involves inhibition of gsk-3beta and activation of creb. |
2010-04-13 |
2023-08-12 |
rat |
| Bruno Manadas, Ana Rita Santos, Krisztina Szabadfi, João R Gomes, Spiros D Garbis, Michael Fountoulakis, Carlos B Duart. BDNF-induced changes in the expression of the translation machinery in hippocampal neurons: protein levels and dendritic mRNA. Journal of proteome research. vol 8. issue 10. 2010-02-01. PMID:19702335. |
bdnf changed the abundance of proteins involved in (i) nucleobase, nucleoside, nucleotide and nucleic acid metabolism, (ii) protein metabolism, (iii) carbohydrate metabolism, (iv) regulators of apoptosis, and (v) regulators of cell proliferation. |
2010-02-01 |
2023-08-12 |
Not clear |
| Ling Liu, Renliang Zhang, Kui Liu, Houguang Zhou, Yuping Tang, Jinjin Su, Xiaoyan Yu, Xuelian Yang, Min Tang, Qiang Don. Tissue kallikrein alleviates glutamate-induced neurotoxicity by activating ERK1. Journal of neuroscience research. vol 87. issue 16. 2010-01-05. PMID:19598250. |
collectively, these findings demonstrate that tk attenuates glutamate-induced apoptosis through an intracellular signaling pathway including activation of b2r, erk1/2, and nf-kappab and up-regulation of bdnf and bcl-2 expression. |
2010-01-05 |
2023-08-12 |
human |
| D Jantas, M Szymanska, B Budziszewska, W Laso. An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons. Apoptosis : an international journal on programmed cell death. vol 14. issue 7. 2009-09-14. PMID:19521778. |
the obtained data suggest an nmdar-independent action of memantine in attenuation of neuronal apoptosis and point to the engagement of bdnf and pi3-k/akt pathway in these processes. |
2009-09-14 |
2023-08-12 |
Not clear |