| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Anjum, P Joshi, A Kha. Induction of apoptosis in AK-5 tumor cells by a serum factor from tumor rejecting animals: cytochrome c release independent of Bcl-2 and caspases. Cell death and differentiation. vol 8. issue 10. 2001-12-11. PMID:11598802. |
the anti-apoptotic protein bcl-2 and the pancaspase inhibitor zvad-fmk did not prevent cytochrome c release, but completely blocked the reduction in delta psi(m), dna fragmentation and apoptosis. |
2001-12-11 |
2023-08-12 |
rat |
| H Z Le. Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell. British journal of pharmacology. vol 134. issue 5. 2001-12-07. PMID:11682458. |
the decrease in the expression of pkc delta and epsilon may play a critical role in aloe-emodin- and emodin-induced apoptosis in ch27 and h460 cells. |
2001-12-07 |
2023-08-12 |
human |
| H Stridh, I Cotgreave, M Müller, S Orrenius, D Gigliott. Organotin-induced caspase activation and apoptosis in human peripheral blood lymphocytes. Chemical research in toxicology. vol 14. issue 7. 2001-12-04. PMID:11453724. |
tbt also caused an early loss of mitochondrial membrane potential (delta(psi)(m)) and release of cytochrome c, suggesting that apoptosis was triggered by the mitochondrial pathway. |
2001-12-04 |
2023-08-12 |
human |
| M C Heidkamp, A L Bayer, J L Martin, A M Samare. Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C epsilon and delta in neonatal rat ventricular myocytes. Circulation research. vol 89. issue 10. 2001-12-04. PMID:11701615. |
differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase c epsilon and delta in neonatal rat ventricular myocytes. |
2001-12-04 |
2023-08-12 |
rat |
| H W Chen, M J Hsu, C T Chien, H C Huan. Effect of alisol B acetate, a plant triterpene, on apoptosis in vascular smooth muscle cells and lymphocytes. European journal of pharmacology. vol 419. issue 2-3. 2001-11-01. PMID:11426834. |
apoptosis was induced after the cells were exposed to 10(-5)-10(-4) m alisol b or 10(-6) m dexamethasone for 48 h. the mitochondrial membrane potential (delta psi(m)) was significantly reduced after the alisol b treatment, indicating that the mitochondria might play a role in the alisol b induced cell apoptosis. |
2001-11-01 |
2023-08-12 |
human |
| S Yoshii, M Tanaka, Y Otsuki, T Fujiyama, H Kataoka, H Arai, H Hanai, H Sugimur. Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene. Molecular and cellular biology. vol 21. issue 20. 2001-11-01. PMID:11564864. |
interestingly, overexpression of alphapix (delta ch) and a catalytically active mutant pak1 (t423e) accelerated b(a)p-induced apoptosis in hela cells, whereas alphapix (delta sh3), pak1 (k299r), and sek 1 (k220a, k224l) inhibited b(a)p-initiated apoptosis. |
2001-11-01 |
2023-08-12 |
Not clear |
| S Yoshii, M Tanaka, Y Otsuki, T Fujiyama, H Kataoka, H Arai, H Hanai, H Sugimur. Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene. Molecular and cellular biology. vol 21. issue 20. 2001-11-01. PMID:11564864. |
finally, a preferential caspase inhibitor, z-asp-ch2-dcb, strongly blocked the alphapix (delta ch)-enhanced apoptosis in cells treated with b(a)p but did not block pak1/jnk1 activation. |
2001-11-01 |
2023-08-12 |
Not clear |
| M W Bergmann, P Loser, R Dietz, R von Harsdor. Effect of NF-kappa B Inhibition on TNF-alpha-induced apoptosis and downstream pathways in cardiomyocytes. Journal of molecular and cellular cardiology. vol 33. issue 6. 2001-10-25. PMID:11444925. |
however, specific inhibition of nf-kappa b activation by ad5-i kappa b alpha delta n (moi=50) or mg132 (5 microm) increased apoptosis as measured by subg1-assay (h9c2 cells) and annexin v binding/propidium iodide (neonatal cardiomyocytes, facs-analysis: 7+/-2% to 26+/-5% annexin v positive/pi negative), respectively. |
2001-10-25 |
2023-08-12 |
mouse |
| T Yoshino, H Kishi, T Nagata, K Tsukada, S Saito, A Muraguch. Differential involvement of p38 MAP kinase pathway and Bax translocation in the mitochondria-mediated cell death in TCR- and dexamethasone-stimulated thymocytes. European journal of immunology. vol 31. issue 9. 2001-10-25. PMID:11536168. |
these results suggest that activated p38 kinase pathway by tcr stimulation induces translocation of bax to mitochondria, causing delta psi(m) disruption, and the release of cytochrome c, which finally induces caspase-3-mediated apoptosis in thymocytes. |
2001-10-25 |
2023-08-12 |
Not clear |
| C Adrie, M Bachelet, M Vayssier-Taussat, F Russo-Marie, I Bouchaert, M Adib-Conquy, J M Cavaillon, M R Pinsky, J F Dhainaut, B S Poll. Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsis. American journal of respiratory and critical care medicine. vol 164. issue 3. 2001-10-04. PMID:11500338. |
reduced mitochondrial membrane potential (delta(psi)m), which is considered as an initial and irreversible step towards apoptosis, as well as cell death regulating proteins, such as fas, hsp70, or bcl-2, may play an important role in sepsis. |
2001-10-04 |
2023-08-12 |
human |
| C Adrie, M Bachelet, M Vayssier-Taussat, F Russo-Marie, I Bouchaert, M Adib-Conquy, J M Cavaillon, M R Pinsky, J F Dhainaut, B S Poll. Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsis. American journal of respiratory and critical care medicine. vol 164. issue 3. 2001-10-04. PMID:11500338. |
we studied the relationship between sepsis severity and peripheral blood monocyte delta(psi)m, cell death (necrosis and apoptosis), soluble fas ligand, hsp70, and bcl-2 expression over time in 18 patients with sepsis, and compared these data with those of a group of 17 healthy control subjects. |
2001-10-04 |
2023-08-12 |
human |
| K Ohishi, B Varnum-Finney, R E Serda, C Anasetti, I D Bernstei. The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells. Blood. vol 98. issue 5. 2001-10-04. PMID:11520788. |
a previous report indicated that monocytes express relatively high amounts of notch-1 and notch-2 and that the immobilized extracellular domain of the notch ligand, delta-1 (delta(ext-myc)), induces apoptosis in peripheral blood monocytes cultured with macrophage colony-stimulating factor (m-csf), but not granulocyte-macrophage csf (gm-csf). |
2001-10-04 |
2023-08-12 |
Not clear |
| T A Sarafian, D P Tashkin, M D Rot. Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis. Toxicology and applied pharmacology. vol 174. issue 3. 2001-08-30. PMID:11485387. |
marijuana smoke and delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit fas-mediated apoptosis. |
2001-08-30 |
2023-08-12 |
Not clear |
| T A Sarafian, D P Tashkin, M D Rot. Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis. Toxicology and applied pharmacology. vol 174. issue 3. 2001-08-30. PMID:11485387. |
in the present study, our objective was to determine the effects of delta(9)-thc on the balance between fas-induced apoptosis and necrosis in a549 lung tumor cells. |
2001-08-30 |
2023-08-12 |
Not clear |
| T A Sarafian, D P Tashkin, M D Rot. Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosis. Toxicology and applied pharmacology. vol 174. issue 3. 2001-08-30. PMID:11485387. |
flow cytometry was used to measure the percentage of cells undergoing apoptosis (staining for annexin v) versus necrosis (staining for propidium iodide) and confirmed that both marijuana tar extract and synthetic delta(9)-thc inhibit fas-induced apoptosis while promoting necrosis. |
2001-08-30 |
2023-08-12 |
Not clear |
| A P Jansen, N E Dreckschmidt, E G Verwiebe, D L Wheeler, T D Oberley, A K Verm. Relation of the induction of epidermal ornithine decarboxylase and hyperplasia to the different skin tumor-promotion susceptibilities of protein kinase C alpha, -delta and -epsilon transgenic mice. International journal of cancer. vol 93. issue 5. 2001-08-16. PMID:11477572. |
tpa-induced odc activity and the resultant accumulation of polyamines may play different roles (e.g., induction of apoptosis vs. proliferation) in the pathways leading to the induction of cancer in pkc alpha, pkc delta and pkc epsilon transgenic mice. |
2001-08-16 |
2023-08-12 |
mouse |
| F Chang, J A McCubre. P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells. Oncogene. vol 20. issue 32. 2001-08-09. PMID:11466616. |
the cell clones with the highest delta raf activity, fd/delta b-raf:er, underwent apoptosis before cell proliferation. |
2001-08-09 |
2023-08-12 |
Not clear |
| J A Sánchez-Alcázar, J G Ault, A Khodjakov, E Schneide. Increased mitochondrial cytochrome c levels and mitochondrial hyperpolarization precede camptothecin-induced apoptosis in Jurkat cells. Cell death and differentiation. vol 7. issue 11. 2001-06-21. PMID:11139283. |
in the present study, we showed that, in jurkat human t cells, camptothecin-induced apoptosis is preceded by (i) an increase in cytochrome c and subunit iv of cytochrome c oxidase (cox iv) levels in mitochondria; and (ii) an elevation of the mitochondrial membrane potential (delta(psi)m). |
2001-06-21 |
2023-08-12 |
human |
| J A Sánchez-Alcázar, J G Ault, A Khodjakov, E Schneide. Increased mitochondrial cytochrome c levels and mitochondrial hyperpolarization precede camptothecin-induced apoptosis in Jurkat cells. Cell death and differentiation. vol 7. issue 11. 2001-06-21. PMID:11139283. |
together, these data suggest that mitochondrial cytochrome c and cox iv enrichment are early events preceding the onset of apoptosis and that cytochrome c release is upstream of caspase activation and loss of delta(psi)m. furthermore, prevention by z-vad of cytochrome c and cox iv depletion in mitochondria suggests the possibility that a caspase-like activity in mitochondria is involved in the proteolytic depletion of respiratory chain proteins. |
2001-06-21 |
2023-08-12 |
human |
| R Mandil, E Ashkenazi, M Blass, I Kronfeld, G Kazimirsky, G Rosenthal, F Umansky, P S Lorenzo, P M Blumberg, C Brodi. Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells. Cancer research. vol 61. issue 11. 2001-06-21. PMID:11389098. |
pkcalpha and delta have been implicated as potential signaling molecules in apoptosis. |
2001-06-21 |
2023-08-12 |
human |