| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoshimasa Nakamura, Makiko Kawakami, Akira Yoshihiro, Noriyuki Miyoshi, Hajime Ohigashi, Kiyoshi Kawai, Toshihiko Osawa, Koji Uchid. Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis. The Journal of biological chemistry. vol 277. issue 10. 2002-04-15. PMID:11751909. |
the mitochondrial death pathway was suggested to be involved in bitc-induced apoptosis because the treatment of cells with bitc-induced caspase-9-dependent apoptosis and mitochondrial transmembrane potential (delta psi m) alteration. |
2002-04-15 |
2023-08-12 |
rat |
| Junko Sonoyama, Itaru Matsumura, Sachiko Ezoe, Yusuke Satoh, Xian Zhang, Yoshihisa Kataoka, Emi Takai, Masao Mizuki, Takashi Machii, Hiroshi Wakao, Yuzuru Kanakur. Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells. The Journal of biological chemistry. vol 277. issue 10. 2002-04-15. PMID:11779872. |
in addition, n17 induced apoptosis in a small proportion of k562, whereas 694f and delta p85 were hardly effective. |
2002-04-15 |
2023-08-12 |
Not clear |
| Junko Sonoyama, Itaru Matsumura, Sachiko Ezoe, Yusuke Satoh, Xian Zhang, Yoshihisa Kataoka, Emi Takai, Masao Mizuki, Takashi Machii, Hiroshi Wakao, Yuzuru Kanakur. Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells. The Journal of biological chemistry. vol 277. issue 10. 2002-04-15. PMID:11779872. |
furthermore, although k562 was resistant to interferon-alpha- and dexamethasone-induced apoptosis, disruption of one pathway by n17, 694f, or delta p85 sensitized k562 to these reagents. |
2002-04-15 |
2023-08-12 |
Not clear |
| M F Denning, Y Wang, S Tibudan, S Alkan, B J Nickoloff, J-Z Qi. Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C. Cell death and differentiation. vol 9. issue 1. 2002-04-09. PMID:11803373. |
caspase activation and disruption of mitochondrial membrane potential during uv radiation-induced apoptosis of human keratinocytes requires activation of protein kinase c. the induction of apoptosis in human keratinocytes by uv radiation involves caspase-mediated cleavage and activation of protein kinase c delta (pkcdelta). |
2002-04-09 |
2023-08-12 |
human |
| Lee Carpenter, Damien Cordery, Trevor J Bide. Inhibition of protein kinase C delta protects rat INS-1 cells against interleukin-1beta and streptozotocin-induced apoptosis. Diabetes. vol 51. issue 2. 2002-03-15. PMID:11812738. |
inhibition of protein kinase c delta protects rat ins-1 cells against interleukin-1beta and streptozotocin-induced apoptosis. |
2002-03-15 |
2023-08-12 |
rat |
| K E Ben Jilani, K Akarid, D Arnoult, F Petit, E Baert, J P Gaillard, J C Ameisen, J Estaquie. Gamma-interferon induces apoptosis of the B lymphoma WEHI-279 cell line through a CD95/CD95L-independent mechanism. European cytokine network. vol 12. issue 4. 2002-03-08. PMID:11781185. |
we report that the inhibition of the b lymphoma cell wehi-279-proliferation induced by ifn-gamma, involves the induction of typical features of apoptosis (nuclear chromatin condensation and fragmentation, cell shrinkage, phosphatidyl-serine (ps) exposure and mitochondrial membrane potential (delta psim) loss). |
2002-03-08 |
2023-08-12 |
Not clear |
| Y Sakurai, Y Onishi, Y Tanimoto, H Kizak. Novel protein kinase C delta isoform insensitive to caspase-3. Biological & pharmaceutical bulletin. vol 24. issue 9. 2002-02-14. PMID:11558579. |
protein kinase c delta (pkc delta) plays a key regulatory role in a variety of cellular functions, including apoptosis, as well as cell growth and differentiation. |
2002-02-14 |
2023-08-12 |
mouse |
| H Liu, H Y Zhang, B C McPherson, T Baman, S Roth, Z Shao, X Zhu, Z Ya. Role of opioid delta1 receptors, mitochondrial K(ATP) channels, and protein kinase C during cardiocyte apoptosis. Journal of molecular and cellular cardiology. vol 33. issue 11. 2002-02-14. PMID:11708844. |
the selective opioid delta receptor agonist bw373u86 (20 pmol/l) also attenuated apoptosis (39+/-3%, n=6* v control). |
2002-02-14 |
2023-08-12 |
chicken |
| M Fukunaga, M Oka, M Ichihashi, T Yamamoto, H Matsuzaki, U Kikkaw. UV-induced tyrosine phosphorylation of PKC delta and promotion of apoptosis in the HaCaT cell line. Biochemical and biophysical research communications. vol 289. issue 2. 2002-01-24. PMID:11716513. |
uv-induced tyrosine phosphorylation of pkc delta and promotion of apoptosis in the hacat cell line. |
2002-01-24 |
2023-08-12 |
human |
| M Fukunaga, M Oka, M Ichihashi, T Yamamoto, H Matsuzaki, U Kikkaw. UV-induced tyrosine phosphorylation of PKC delta and promotion of apoptosis in the HaCaT cell line. Biochemical and biophysical research communications. vol 289. issue 2. 2002-01-24. PMID:11716513. |
protein kinase c delta (pkc delta) is activated through tyrosine phosphorylation and is involved in apoptosis induction in the h(2)o(2)-treated fibroblasts. |
2002-01-24 |
2023-08-12 |
human |
| M Fukunaga, M Oka, M Ichihashi, T Yamamoto, H Matsuzaki, U Kikkaw. UV-induced tyrosine phosphorylation of PKC delta and promotion of apoptosis in the HaCaT cell line. Biochemical and biophysical research communications. vol 289. issue 2. 2002-01-24. PMID:11716513. |
in the human keratinocyte hacat cell line, ultraviolet radiation, which induces apoptosis, promoted tyrosine phosphorylation and activation of pkc delta, but neither enhanced threonine phosphorylation in the activation loop nor generated the catalytic fragment of the pkc isoform. |
2002-01-24 |
2023-08-12 |
human |
| A M Sinclair, J A Lee, A Goldstein, D Xing, S Liu, R Ju, P W Tucker, E J Neufeld, R H Scheuerman. Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice. Blood. vol 98. issue 13. 2002-01-11. PMID:11739170. |
analysis of t lymphopoiesis demonstrated that cux/cdp(delta hd/delta hd) mice had dramatically reduced thymic cellularity due to enhanced apoptosis, with a preferential loss of cd4(+)cd8(+) thymocytes. |
2002-01-11 |
2023-08-12 |
mouse |
| T Hatae, M Wada, C Yokoyama, M Shimonishi, T Tanab. Prostacyclin-dependent apoptosis mediated by PPAR delta. The Journal of biological chemistry. vol 276. issue 49. 2002-01-10. PMID:11551955. |
prostacyclin-dependent apoptosis mediated by ppar delta. |
2002-01-10 |
2023-08-12 |
human |
| T Hatae, M Wada, C Yokoyama, M Shimonishi, T Tanab. Prostacyclin-dependent apoptosis mediated by PPAR delta. The Journal of biological chemistry. vol 276. issue 49. 2002-01-10. PMID:11551955. |
here, we report that intracellular prostacyclin formed by expressing prostacyclin synthase in human embryonic kidney 293 cells promotes apoptosis by activating endogenous peroxisome proliferator-activated receptor delta (ppar delta). |
2002-01-10 |
2023-08-12 |
human |
| T Hatae, M Wada, C Yokoyama, M Shimonishi, T Tanab. Prostacyclin-dependent apoptosis mediated by PPAR delta. The Journal of biological chemistry. vol 276. issue 49. 2002-01-10. PMID:11551955. |
the expression of an l431a/g434a mutant of ppar delta completely blocked prostacyclin-mediated ppar delta activation and apoptosis. |
2002-01-10 |
2023-08-12 |
human |
| I Falk, G Nerz, I Haidl, A Krotkova, K Eichman. Immature thymocytes that fail to express TCRbeta and/or TCRgamma delta proteins die by apoptotic cell death in the CD44(-)CD25(-) (DN4) subset. European journal of immunology. vol 31. issue 11. 2002-01-03. PMID:11745348. |
the results suggest that thymocytes unsuccessful in alpha beta or in gamma delta lineage development die by apoptosis in the dn4 subset. |
2002-01-03 |
2023-08-12 |
mouse |
| Y Shizukuda, P M Buttric. Protein kinase C(epsilon) modulates apoptosis induced by beta -adrenergic stimulation in adult rat ventricular myocytes via extracellular signal-regulated kinase (ERK) activity. Journal of molecular and cellular cardiology. vol 33. issue 10. 2001-12-31. PMID:11603922. |
the inhibition of pkc(epsilon) attenuated iso-induced apoptosis as measured by terminal deoxynucleotidyltransferase nick-end labeling (tunel) assay (18.2+/-3.8%v 49.0+/-2.4%p<0.05), while a pkc delta-specific peptide translocation inhibitor (delta v1-1) failed to do so (39.8+/-7.8%). |
2001-12-31 |
2023-08-12 |
rat |
| I Marzo, P Pérez-Galán, P Giraldo, D Rubio-Félix, A Anel, J Nava. Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria. The Biochemical journal. vol 359. issue Pt 3. 2001-12-13. PMID:11672427. |
in any case, delta psi(m) loss marked the point of no return in apoptosis and may be caused by two different pathways, one caspase-dependent and the other caspase-independent. |
2001-12-13 |
2023-08-12 |
human |
| I Marzo, P Pérez-Galán, P Giraldo, D Rubio-Félix, A Anel, J Nava. Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria. The Biochemical journal. vol 359. issue Pt 3. 2001-12-13. PMID:11672427. |
execution of apoptosis was always performed after delta psi(m) loss by a caspase-9-triggered caspase cascade and the action of aif. |
2001-12-13 |
2023-08-12 |
human |
| A C Rego, S Vesce, D G Nicholl. The mechanism of mitochondrial membrane potential retention following release of cytochrome c in apoptotic GT1-7 neural cells. Cell death and differentiation. vol 8. issue 10. 2001-12-11. PMID:11598797. |
the relationship is investigated between mitochondrial membrane potential (delta psi(m)), respiration and cytochrome c (cyt c) release in single neural bcl-2 transfected cells (gt1-7bcl-2) or gt1-7puro cells during apoptosis induced by staurosporine (sts). |
2001-12-11 |
2023-08-12 |
Not clear |