| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Panaretakis, I G Shabalina, D Grandér, M C Shoshan, J W DePierr. Reactive oxygen species and mitochondria mediate the induction of apoptosis in human hepatoma HepG2 cells by the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid. Toxicology and applied pharmacology. vol 173. issue 1. 2001-06-14. PMID:11350215. |
nac reduced delta psi(m) dissipation, caspase 9 activation, and apoptosis, indicating a role for pfoa-induced ros. |
2001-06-14 |
2023-08-12 |
human |
| T Panaretakis, I G Shabalina, D Grandér, M C Shoshan, J W DePierr. Reactive oxygen species and mitochondria mediate the induction of apoptosis in human hepatoma HepG2 cells by the rodent peroxisome proliferator and hepatocarcinogen, perfluorooctanoic acid. Toxicology and applied pharmacology. vol 173. issue 1. 2001-06-14. PMID:11350215. |
in addition, csa also reduced delta psi(m) dissipation, caspase 9 activation, and apoptosis, indicating a role for pfoa-induced opening of the mpt pore. |
2001-06-14 |
2023-08-12 |
human |
| S Harvey, R Decker, Y Dai, G Schaefer, L Tang, L Kramer, P Dent, S Gran. Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 7. issue 2. 2001-06-07. PMID:11234887. |
simultaneous or subsequent exposure of f-ara-a-treated cells (2 microm) to ucn-01 (100 nm) resulted in a marked potentiation of apoptosis, manifested by loss of mitochondrial membrane potential (delta psi(m)), cleavage/activation of procaspase-9 and procaspase-3, dna fragmentation, and degradation of poly-adp(ribosyl) polymerase. |
2001-06-07 |
2023-08-12 |
human |
| S Harvey, R Decker, Y Dai, G Schaefer, L Tang, L Kramer, P Dent, S Gran. Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 7. issue 2. 2001-06-07. PMID:11234887. |
cotreatment with ucn-01 also increased f-ara-a-mediated apoptosis and loss of delta psi(m) in u937 cells ectopically expressing bcl-2, although not to the same extent as that observed in empty-vector controls. |
2001-06-07 |
2023-08-12 |
human |
| M R Frey, O Leontieva, D J Watters, J D Blac. Stimulation of protein kinase C-dependent and -independent signaling pathways by bistratene A in intestinal epithelial cells. Biochemical pharmacology. vol 61. issue 9. 2001-05-03. PMID:11301042. |
notably, while depletion of pkc alpha, delta, and epsilon abrogated the cell cycle-specific effects of pma in iec-18 cells, the absence of these pkc isozymes failed to inhibit bisa-induced g(0)/g(1) and g(2)/m arrest or apoptosis. |
2001-05-03 |
2023-08-12 |
Not clear |
| T Hishita, S Tada-Oikawa, K Tohyama, Y Miura, T Nishihara, Y Tohyama, Y Yoshida, T Uchiyama, S Kawanish. Caspase-3 activation by lysosomal enzymes in cytochrome c-independent apoptosis in myelodysplastic syndrome-derived cell line P39. Cancer research. vol 61. issue 7. 2001-05-03. PMID:11306462. |
however, we found that etoposide induced apoptosis in p39 cells, a myelodysplastic syndrome-derived cell line, without the release of cytochrome c. furthermore, in etoposide-treated p39 cells, no changes in mitochondrial membrane potential (delta psi m) were detected by flow cytometry. |
2001-05-03 |
2023-08-12 |
Not clear |
| M E Reyland, K A Barzen, S M Anderson, D O Quissell, A A Matass. Activation of PKC is sufficient to induce an apoptotic program in salivary gland acinar cells. Cell death and differentiation. vol 7. issue 12. 2001-04-26. PMID:11175257. |
expression of constitutively activated pkc alpha or pkc delta, but not kinase negative mutants of these isoforms, or constitutively activated pkc epsilon, induces apoptosis in salivary acinar cells, suggesting a role for these isoforms in tpa-induced apoptosis. |
2001-04-26 |
2023-08-12 |
Not clear |
| K H Choi, H Hama-Inaba, B Wang, K Haginoya, T Odaka, T Yamada, I Hayata, H Ohyam. UVC-induced apoptosis in human epithelial tumor A431 cells: sequence of apoptotic changes and involvement of caspase (-8 and -3) cascade. Journal of radiation research. vol 41. issue 3. 2001-04-26. PMID:11210827. |
these results strongly suggest that the collapse of delta psi m is not a part of the central apoptotic machinery, and that caspase cascade(s), especially caspase-8 to -3, play an important role in uvc-induced apoptosis in a431. |
2001-04-26 |
2023-08-12 |
human |
| K Rober. Relocalization of cathepsin D and cytochrome c early in apoptosis revealed by immunoelectron microscopy. Laboratory investigation; a journal of technical methods and pathology. vol 81. issue 2. 2001-03-22. PMID:11232636. |
also, the former event probably occurs before the latter during apoptosis induced by oxidative stress because pretreatment with pepstatin a prevented release of cytochrome c and loss of delta psi(m) in cardiomyocytes exposed to naphthazarin. |
2001-03-22 |
2023-08-12 |
rat |
| A Takabayashi, Y Kawai, S Iwata, M Kanai, R Denno, K Kawada, K Obama, Y Tak. Nitric oxide induces a decrease in the mitochondrial membrane potential of peripheral blood lymphocytes, especially in natural killer cells. Antioxidants & redox signaling. vol 2. issue 4. 2001-03-08. PMID:11213472. |
noc18 induced a decrease in the delta psi m of the pbl in a dose-dependent fashion, induced an increase in the levels of reactive oxygen species (ros), and caused these cells to undergo apoptosis. |
2001-03-08 |
2023-08-12 |
human |
| Y S Kim, S H Jin, Y H Lee, J D Park, S I Ki. Differential expression of protein kinase C subtypes during ginsenoside Rh2-lnduced apoptosis in SK-N-BE(2) and C6Bu-1 cells. Archives of pharmacal research. vol 23. issue 5. 2001-02-15. PMID:11059834. |
during apoptosis induced by g-rh2 in sk-n-be(2) cells, pkc subtypes alpha, beta and gamma were progressively increased with prolonged treatment, whereas pkc delta increased transiently at 3 and 6 h and pkc epsilon was gradually down-regulated after 6 h following the treatment. |
2001-02-15 |
2023-08-12 |
human |
| Y S Kim, S H Jin, Y H Lee, J D Park, S I Ki. Differential expression of protein kinase C subtypes during ginsenoside Rh2-lnduced apoptosis in SK-N-BE(2) and C6Bu-1 cells. Archives of pharmacal research. vol 23. issue 5. 2001-02-15. PMID:11059834. |
in c6bu-1 cells, no significant changes in pkc subtypes alpha, gamma, delta, epsilon and zeta were observed during apoptosis induced by g-rh2. |
2001-02-15 |
2023-08-12 |
human |
| E J Kim, A Suliman, A Lam, R K Srivastav. Failure of Bcl-2 to block mitochondrial dysfunction during TRAIL-induced apoptosis. Tumor necrosis-related apoptosis-inducing ligand. International journal of oncology. vol 18. issue 1. 2001-02-15. PMID:11115558. |
trail initiates the activation of caspases, the loss of mitochondrial transmembrane potential (delta psi(m)), and the redistribution of mitochondrial cytochrome c. trail has no effect on delta psi(m) and apoptosis in jurkat cells deficient in either fadd or caspase-8, suggesting both fadd and caspase-8 are required for trail signaling. |
2001-02-15 |
2023-08-12 |
Not clear |
| E J Kim, A Suliman, A Lam, R K Srivastav. Failure of Bcl-2 to block mitochondrial dysfunction during TRAIL-induced apoptosis. Tumor necrosis-related apoptosis-inducing ligand. International journal of oncology. vol 18. issue 1. 2001-02-15. PMID:11115558. |
overexpression of bcl-2 delays, but does not inhibit, trail-induced delta psi(m), cytochrome c release from mitochondria and apoptosis, whereas etoposide-induced apoptosis is blocked by bcl-2. |
2001-02-15 |
2023-08-12 |
Not clear |
| E Katz, M R Deehan, S Seatter, C Lord, R D Sturrock, M M Harnet. B cell receptor-stimulated mitochondrial phospholipase A2 activation and resultant disruption of mitochondrial membrane potential correlate with the induction of apoptosis in WEHI-231 B cells. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 1. 2001-02-08. PMID:11123286. |
importantly, disruption of delta psi(m), atp depletion, and apoptosis can be prevented by rescue signals via cd40 or by delta psi(m) stabilizers such as antimycin or oligomycin. |
2001-02-08 |
2023-08-12 |
Not clear |
| E Katz, M R Deehan, S Seatter, C Lord, R D Sturrock, M M Harnet. B cell receptor-stimulated mitochondrial phospholipase A2 activation and resultant disruption of mitochondrial membrane potential correlate with the induction of apoptosis in WEHI-231 B cells. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 1. 2001-02-08. PMID:11123286. |
indeed, apoptotic signaling via the bcr in wehi-231 b cells does not stimulate the activation of caspase-3 and, consistent with this, bcr-mediated disruption of delta psi(m) and commitment to apoptosis take place in the presence of caspase inhibitors. |
2001-02-08 |
2023-08-12 |
Not clear |
| A Reichlin, Y Hu, E Meffre, H Nagaoka, S Gong, M Kraus, K Rajewsky, M C Nussenzwei. B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta. The Journal of experimental medicine. vol 193. issue 1. 2001-02-08. PMID:11136817. |
however, ig beta delta c b cells are arrested at the immature stage of b cell development in the bone marrow and die by apoptosis. |
2001-02-08 |
2023-08-12 |
mouse |
| M Cirinnà, R Trotta, P Salomoni, P Kossev, M Wasik, D Perrotti, B Calabrett. Bcl-2 expression restores the leukemogenic potential of a BCR/ABL mutant defective in transformation. Blood. vol 96. issue 12. 2001-02-01. PMID:11090078. |
compared to myeloid precursor 32dcl3 cells expressing wild type bcr/abl, cells expressing a bcr/abl mutant lacking amino acids 176-426 in the bcr domain (p185 delta bcr) are susceptible to apoptosis induced by interleukin-3 (il-3) deprivation. |
2001-02-01 |
2023-08-12 |
mouse |
| I Gautier, V Geeraert, J Coppey, M Coppey-Moisan, C Durieu. A moderate but not total decrease of mitochondrial membrane potential triggers apoptosis in neuron-like cells. Neuroreport. vol 11. issue 13. 2001-01-25. PMID:11006972. |
the effects of various degrees of perturbation of the mitochondrial membrane potential (mt delta psi) on apoptosis was investigated by intensified fluorescence digital-imaging microscopy on neuron-like cells, nd7. |
2001-01-25 |
2023-08-12 |
Not clear |
| I Gautier, V Geeraert, J Coppey, M Coppey-Moisan, C Durieu. A moderate but not total decrease of mitochondrial membrane potential triggers apoptosis in neuron-like cells. Neuroreport. vol 11. issue 13. 2001-01-25. PMID:11006972. |
these results suggest that a partial decrease of mt delta psi would allow mitochondrial functions required to trigger apoptosis to be sustained. |
2001-01-25 |
2023-08-12 |
Not clear |