| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ye Lu, Chengyuan Zhang, Shilin Jiang, Feng Yua. Anti-Dlx5 Retards the Progression of Osteoarthritis through Inhibiting Chondrocyte Hypertrophy and Apoptosis. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-03-14. PMID:35280506. |
moreover, myc and caspase-3, the critical mediators for chondrocyte apoptosis, were both decreased after anti-dlx5 treatment. |
2022-03-14 |
2023-08-13 |
Not clear |
| Federico Costanzo, Marta Martínez Diez, Gema Santamaría Nuñez, Juan Ignacio Díaz-Hernandéz, Carlos Mario Genes Robles, Javier Díez Pérez, Emmanuel Compe, Romeo Ricci, Tsai-Kun Li, Frédéric Coin, Juan Fernando Martínez Leal, Eva Maria Garrido-Martin, Jean Marc Egl. Promoters of ASCL1- and NEUROD1-dependent genes are specific targets of lurbinectedin in SCLC cells. EMBO molecular medicine. 2022-03-09. PMID:35263037. |
this abrogates the expression of ascl1 and neurod1 and of their dependent genes, such as bcl2, insm1, myc, and aurka, which are responsible for relevant sclc tumorigenic properties such as inhibition of apoptosis and cell survival, as well as for a part of its neuroendocrine features. |
2022-03-09 |
2023-08-13 |
Not clear |
| Chunyan Fu, Qincui Shuang, Yonghui Liu, Li Zeng, Wen S. Baihe Extracts Reduce the Activation and Apoptosis of Microglia in the Hippocampus of Mice with Depression-like Behaviors by Downregulating MYC. ACS chemical neuroscience. 2022-02-09. PMID:35139304. |
baihe extracts reduce the activation and apoptosis of microglia in the hippocampus of mice with depression-like behaviors by downregulating myc. |
2022-02-09 |
2023-08-13 |
mouse |
| Tingyu Qin, Ying Cheng, Xiaozhong Wan. RNA-binding proteins as drivers of AML and novel therapeutic targets. Leukemia & lymphoma. 2022-01-25. PMID:35075986. |
in addition, targeting an rbp that is significantly related to aml can trigger the apoptosis of leukemic stem cells or promote the proliferation of stem and progenitor cells by modulating the expression of important pathway regulatory factors such as hoxa9, myc, and cdkn1a. |
2022-01-25 |
2023-08-13 |
Not clear |
| Natsuki Imayoshi, Makoto Yoshioka, Kuniaki Tanaka, Shyh-Ming Yang, Koshi Akahane, Yuki Toda, Shigekuni Hosogi, Takeshi Inukai, Seiji Okada, David J Maloney, Tatsutoshi Nakahata, Junko Takita, Itaru Kato, Eishi Ashihar. CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia. Biochemical and biophysical research communications. vol 590. 2021-12-31. PMID:34971957. |
cn470 suppressed mrna and protein expression of myc and induced apoptosis in mll-r all cells, following a cell cycle arrest in the g1 phase. |
2021-12-31 |
2023-08-13 |
Not clear |
| Yanqiu Gong, Yu Liu, Tian Wang, Zhigui Li, Li Gao, Haining Chen, Yang Shu, Yuan Li, Heng Xu, Zongguang Zhou, Lunzhi Da. Age-Associated Proteomic Signatures and Potential Clinically Actionable Targets of Colorectal Cancer. Molecular & cellular proteomics : MCP. vol 20. 2021-12-10. PMID:34129943. |
gene set enrichment analysis showed that distinct age-dependent clinical outcomes might mainly attribute to varied myc targets v1/v2, e2f targets and g2m checkpoint gene sets, which were associated with cancer cell proliferation, cell apoptosis, tumor growth, and tumor metastasis. |
2021-12-10 |
2023-08-13 |
Not clear |
| Amir Mahani, Gustav Arvidsson, Laia Sadeghi, Alf Grandien, Anthony P H Wrigh. Differential Transcriptional Reprogramming by Wild Type and Lymphoma-Associated Mutant MYC Proteins as B-Cells Convert to a Lymphoma Phenotype. Cancers. vol 13. issue 23. 2021-12-10. PMID:34885204. |
unlike many previous studies, the cell system exploits primary b-cells that are transduced to allow regulated myc expression under circumstances where apoptosis and senescence pathways are abrogated by the over-expression of the bcl-xl and bmi1 proteins. |
2021-12-10 |
2023-08-13 |
human |
| Chiara Pighi, Taek-Chin Cheong, Mara Compagno, Enrico Patrucco, Maddalena Arigoni, Martina Olivero, Qi Wang, Cristina López, Stephan H Bernhart, Bruno M Grande, Teresa Poggio, Fernanda Langellotto, Lisa Bonello, Riccardo Dall'Olio, Sandra Martínez-Martín, Luca Molinaro, Paola Francia di Celle, Jonathan R Whitfield, Laura Soucek, Claudia Voena, Raffaele A Calogero, Ryan D Morin, Louis M Staudt, Reiner Siebert, Alberto Zamò, Roberto Chiarl. Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma. Blood advances. vol 5. issue 23. 2021-12-09. PMID:34625792. |
inhibition of myc by the omomyc mini-protein blocked cell proliferation and increased apoptosis, effects further increased by combined bcl6 targeting. |
2021-12-09 |
2023-08-13 |
mouse |
| Yan Wang, Dongmei Guo, Banban Li, Yanyan Wang, Bo Wang, Zan Wang, Meng Wang, Qingliang Ten. MiR-665 suppresses the progression of diffuse large B cell lymphoma (DLBCL) through targeting LIM and SH3 protein 1 (LASP1). Leukemia research. vol 112. 2021-12-09. PMID:34875555. |
thus, we demonstrates that mir-665 suppresses dlbcl cell malignant behaviors by inhibiting cell proliferation and invasion and inducing apoptosis via targeting lasp1 and myc, suggesting the importance of mir-665 in dlbcl progression. |
2021-12-09 |
2023-08-13 |
mouse |
| Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W I Cox, Mattia Chiesa, Yuri D'Alessandra, Michela Garofalo, Caroline H Topham, Gianpiero Di Lev. Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686114. |
we found that dinaciclib-triggered apoptosis is triggered by cdk9 inhibition and the resultant reduction in rna pol ii phosphorylation, which leads to the downregulation of the oncogenic marker myc, and the anti-apoptotic protein mcl-1. |
2021-11-22 |
2023-08-13 |
Not clear |
| Chen Wang, Jiawei Zhang, Jie Yin, Yichao Gan, Senlin Xu, Ying Gu, Wendong Huan. Alternative approaches to target Myc for cancer treatment. Signal transduction and targeted therapy. vol 6. issue 1. 2021-11-15. PMID:33692331. |
myc protein orchestrates diverse physiological processes, including cell proliferation, differentiation, survival, and apoptosis. |
2021-11-15 |
2023-08-13 |
human |
| Yeon Bi Han, Jeong Mi Yang, Hyun Jung Kwon, Jeong-Ok Lee, Jong Seok Lee, Jin Ho Pai. Clinicopathologic and Prognostic Significance of Bruton's Tyrosine Kinase Expression in Diffuse Large B-Cell Lymphoma. Anticancer research. vol 41. issue 11. 2021-11-15. PMID:34732441. |
we investigated the clinicopathological significance of btk positivity in dlbcl according to known molecules related to resistance to btk inhibitors [bcl2 apoptosis regulator (bcl2)/myc proto-oncogene, bhlh transcription factor (myc)]. |
2021-11-15 |
2023-08-13 |
Not clear |
| Caili Bi, Xue Zhang, Yueyue Chen, Yushuo Dong, Yixin Shi, Yunshen Lei, Dan Lv, Xiaowei Cao, Wei Li, Hongcan Sh. MAGT1 is required for HeLa cell proliferation through regulating p21 expression, S-phase progress, and ERK/p38 MAPK MYC axis. Cell cycle (Georgetown, Tex.). vol 20. issue 21. 2021-11-12. PMID:34499581. |
we showed that cell proliferation was substantially restricted by s-phase arrest and apoptosis in the magt1-knocked down cells, which was further confirmed by the increased expression of p21, cyclin-a1, and cyclin-b1, as well as the decreased expression of myc, cyclin-d1, cyclin-e1, and cdk2. |
2021-11-12 |
2023-08-13 |
Not clear |
| Debora Traversa, Giorgia Simonetti, Doron Tolomeo, Grazia Visci, Gemma Macchia, Martina Ghetti, Giovanni Martinelli, Lasse S Kristensen, Clelia Tiziana Storlazz. Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease. British journal of cancer. 2021-11-10. PMID:34754096. |
the stimulation of cell proliferation, invasion and drug resistance, cell metabolism regulation, and apoptosis inhibition is controlled through multiple targets, including myc, p21, stat3, vimentin, cadherins, the pi3k/akt, hk2, bcl2, and casp3. |
2021-11-10 |
2023-08-13 |
human |
| Xiaobo Zheng, Li Feng, Yunfan Yin, Chune Yu, Xiujing He, Jiao Zhu, Ming Zhang, Jing Yu, Mingqing X. Comprehensive analysis of aberrant alternative splicing related to carcinogenesis and prognosis of papillary thyroid cancer. Aging. vol 13. issue 19. 2021-11-03. PMID:34628367. |
parent genes with cases remarkably enriched in the pathways were linked with carcinogenesis, such as p53, kras, il6-jak-stat3, apoptosis, and myc signaling. |
2021-11-03 |
2023-08-13 |
Not clear |
| Weicheng Lu, Hong Chen, Bo Liang, Chaopeng Ou, Mingwei Zhang, Qiuyuan Yue, Jingdun Xi. Integrative Analyses and Verification of the Expression and Prognostic Significance for RCN1 in Glioblastoma Multiforme. Frontiers in molecular biosciences. vol 8. 2021-11-02. PMID:34722631. |
pathways analyses indicated that rcn1 was involved in keas and myc pathways and apoptosis. |
2021-11-02 |
2023-08-13 |
Not clear |
| Seyed Esmaeil Ahmadi, Samira Rahimi, Bahman Zarandi, Rouzbeh Chegeni, Majid Saf. MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies. Journal of hematology & oncology. vol 14. issue 1. 2021-11-01. PMID:34372899. |
myc oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, dna damage response, and hematopoiesis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Xiaomei Ying, Liang Chen, Jiaheng Xie, Yiming Hu, Qingqing Wu, Liyu Cao, Hongzhu Y. ANXA1 (Annexin A1) regulated by MYC (MYC proto-oncogene) promotes the growth of papillary thyroid carcinoma. Bioengineered. 2021-11-01. PMID:34723715. |
finally, we identified the expression of anxa1 and myc and then evaluated their function associated with proliferation and apoptosis in ptc cell lines by cck8 proliferation and flow cytometry apoptosis experiment. |
2021-11-01 |
2023-08-13 |
Not clear |
| Dalal AlSultan, Emma Kavanagh, Shane O'Grady, Alex J Eustace, Alina Castell, Lars-Gunnar Larsson, John Crown, Stephen F Madden, Michael J Duff. The novel low molecular weight MYC antagonist MYCMI-6 inhibits proliferation and induces apoptosis in breast cancer cells. Investigational new drugs. vol 39. issue 2. 2021-10-27. PMID:33052557. |
the novel low molecular weight myc antagonist mycmi-6 inhibits proliferation and induces apoptosis in breast cancer cells. |
2021-10-27 |
2023-08-13 |
Not clear |
| Colleen T Harrington, Elena Sotillo, Chi V Dang, Andrei Thomas-Tikhonenk. Tilting MYC toward cancer cell death. Trends in cancer. vol 7. issue 11. 2021-10-26. PMID:34481764. |
here we introduce a counterintuitive idea that modestly and transiently elevating myc levels could aid chemotherapy-induced apoptosis and thus benefit the patients as much, if not more than myc inhibition. |
2021-10-26 |
2023-08-13 |
human |