| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Gorell, R J Ordidge, G G Brown, J C Deniau, N M Buderer, J A Helper. Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease. Neurology. vol 45. issue 6. 1995-07-18. PMID:7783878. |
elevated iron levels in the substantia nigra (sn) of the brain in parkinson's disease (pd) may mediate lipid peroxidative reactions, promoting sn neuronal death. |
1995-07-18 |
2023-08-12 |
human |
| G Nikkhah, M G Cunningham, M A Cenci, R D McKay, A Björklun. Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. I. Evidence for anatomical reconstruction of the nigrostriatal pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 5 Pt 1. 1995-06-20. PMID:7538563. |
here we report on a novel approach by which fetal vm grafts are implanted unilaterally into the substantia nigra (sn) of 6-hydroxydopamine (6-ohda)-lesioned neonatal pups at postnatal day 3 (p3) using a microtransplantation technique. |
1995-06-20 |
2023-08-12 |
rat |
| T Wu, H L Wan. Protein kinase C mediates neurotensin inhibition of inwardly rectifying potassium currents in rat substantia nigra dopaminergic neurons. Neuroscience letters. vol 184. issue 2. 1995-05-23. PMID:7724045. |
whole-cell voltage-clamp recordings were used to investigate the molecular transduction mechanism by which neurotensin decreases the inwardly rectifying potassium conductance of dopaminergic (da) neurons acutely isolated from the rat substantia nigra (sn). |
1995-05-23 |
2023-08-12 |
rat |
| F Vaglini, F Fascetti, F Fornai, R Maggio, G U Corsin. (+)MK-801 prevents the DDC-induced enhancement of MPTP toxicity in mice. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704605. |
the number of th+ neurons in the substantia nigra (sn) of (+)mk-801-pretreated mice was not significantly different from that of control animals, indicating that this treatment specifically antagonized the extensive ddc-induced lesion of dopaminergic cell bodies in this brain area. |
1995-05-10 |
2023-08-12 |
mouse |
| G Bing, Y Zhang, Y Watanabe, B S McEwen, E A Ston. Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704612. |
the observation that parkinson's disease (pd) is associated with locus coeruleus (lc) noradrenergic neuronal degeneration suggests that the lc noradrenergic system may be involved in the pathogenesis and natural progression of the destruction of the substantia nigra (sn) dopaminergic neurons in parkinson's disease. |
1995-05-10 |
2023-08-12 |
mouse |
| W D Le, J Engelhardt, W J Xie, L Schneider, R G Smith, S H Appe. Experimental autoimmune nigral damage in guinea pigs. Journal of neuroimmunology. vol 57. issue 1-2. 1995-05-09. PMID:7706439. |
in such animals, loss of 40% of the substantia nigra (sn) neurons and damage to an additional 10% of sn neurons was associated with a 37-43% decrease of tyrosine hydroxylase (th) activity and a 36% decrease of dopamine (da) content in the nigral-striatum. |
1995-05-09 |
2023-08-12 |
Not clear |
| C G Charlton, J Mac. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Molecular neurobiology. vol 9. issue 1-3. 1995-04-18. PMID:7888091. |
the major symptoms of parkinson's disease (pd) are tremors, hypokinesia, rigidity, and abnormal posture, caused by degeneration of dopamine (da) neurons in the substantia nigra (sn) and deficiency of da in the neostriatal dopaminergic terminals. |
1995-04-18 |
2023-08-12 |
rat |
| B J Hoffer, A Hoffman, K Bowenkamp, P Huettl, J Hudson, D Martin, L F Lin, G A Gerhard. Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Neuroscience letters. vol 182. issue 1. 1995-04-18. PMID:7891873. |
this dose also produced levels of da in the ipsilateral substantia nigra (sn) which were not statistically different from the contralateral side. |
1995-04-18 |
2023-08-12 |
rat |
| L Angyá. Medullary-induced alterations in intracranial self-stimulation from the substantia nigra. Neurobiology (Budapest, Hungary). vol 2. issue 3. 1995-04-13. PMID:7881399. |
the intracranial electrical self-stimulation (icss) from the substantia nigra (sn) was reduced by simultaneous stimulation of the nucleus of the solitary tract (nts) in cats. |
1995-04-13 |
2023-08-12 |
Not clear |
| S L Moshé, L L Brown, H Kubová, J Velísková, R S Zukin, E F Sperbe. Maturation and segregation of brain networks that modify seizures. Brain research. vol 665. issue 1. 1995-04-12. PMID:7882007. |
we demonstrate that in the mature substantia nigra (sn) there are two topographically discrete gabaa-sensitive regions which differ in the amount of mrna expression of the gabaa receptor alpha 1 subunit. |
1995-04-12 |
2023-08-12 |
Not clear |
| D S Horoupian, P L Ch. Unusual case of corticobasal degeneration with tau/Gallyas-positive neuronal and glial tangles. Acta neuropathologica. vol 88. issue 6. 1995-03-31. PMID:7879609. |
at autopsy, frontal lobe atrophy, discoloration of putamen (pt) and pallor of substantia nigra (sn) were observed. |
1995-03-31 |
2023-08-12 |
Not clear |
| Y Ichitani, H Okamura, D Nakahara, I Nagatsu, Y Ibat. Biochemical and immunocytochemical changes induced by intrastriatal 6-hydroxydopamine injection in the rat nigrostriatal dopamine neuron system: evidence for cell death in the substantia nigra. Experimental neurology. vol 130. issue 2. 1995-03-27. PMID:7867756. |
four weeks after 6-ohda injection into the striatum, concentrations of da and its metabolites were specifically decreased in the substantia nigra (sn), as well as in the striatum, ipsilateral to the injection. |
1995-03-27 |
2023-08-12 |
rat |
| M F Hawkins, R D Fuller, A A Baumeister, M D McCallu. Effects in the rat of intranigral morphine and DAGO on eating and gnawing induced by stress. Pharmacology, biochemistry, and behavior. vol 49. issue 3. 1995-03-22. PMID:7862730. |
we have reported previously that a nonspecific opioid antagonist and a mu-selective antagonist decrease this stress-induced eating (sie) when they are microinjected into the substantia nigra (sn). |
1995-03-22 |
2023-08-12 |
rat |
| J S Morley, A A Bazzaz, D M Ensor, J B Mile. Reversal of mitochondrial damage in a rat model of Parkinson's disease by a neurotrophic peptide (MPF analogue). Neuroreport. vol 5. issue 15. 1995-03-06. PMID:7841367. |
transmission electron microscopy (tem) has now revealed that this effect is related to reversal of the mitochondrial damage to substantia nigra (sn) neurones induced by the lesion. |
1995-03-06 |
2023-08-12 |
human |
| E Oestreicher, G J Sengstock, P Riederer, C W Olanow, A J Dunn, G W Arendas. Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study. Brain research. vol 660. issue 1. 1995-02-21. PMID:7828004. |
a significant increase was observed in both iron concentration (+35%) and iron content (+33) within the substantia nigra (sn) ipsilateral to comprehensive 6-ohda lesions. |
1995-02-21 |
2023-08-12 |
rat |
| G J Sengstock, C W Olanow, A J Dunn, S Barone, G W Arendas. Progressive changes in striatal dopaminergic markers, nigral volume, and rotational behavior following iron infusion into the rat substantia nigra. Experimental neurology. vol 130. issue 1. 1995-02-14. PMID:7529713. |
we recently reported that intranigral fe infusion into the rat substantia nigra (sn) induces dose-dependent sn neurodegeneration and associated reductions in striatal dopaminergic (da) markers. |
1995-02-14 |
2023-08-12 |
rat |
| E D Levin, S J Briggs, N C Christopher, J T Auma. Working memory performance and cholinergic effects in the ventral tegmental area and substantia nigra. Brain research. vol 657. issue 1-2. 1995-02-14. PMID:7820615. |
the midbrain da nuclei, the substantia nigra (sn) and the ventral tegmental area (vta) have relatively dense concentrations of nicotinic receptors which may be critical sites of action for mecamylamine and nicotine. |
1995-02-14 |
2023-08-12 |
rat |
| M E Rice, C D Richards, S Nedergaard, J Hounsgaard, C Nicholson, S A Greenfiel. Direct monitoring of dopamine and 5-HT release in substantia nigra and ventral tegmental area in vitro. Experimental brain research. vol 100. issue 3. 1995-02-08. PMID:7813678. |
fast-scan cyclic voltammetry with carbon fibre microelectrodes was used to detect endogenous dopamine (da) and 5-hydroxytryptamine (5-ht) release from three distinct regions of guinea-pig mid-brain in vitro: rostral and caudal substantia nigra (sn) and the ventral tegmental area (vta). |
1995-02-08 |
2023-08-12 |
Not clear |
| M Kambouris, L Sangameswaran, L C Triarhou, C A Kozak, S R Dlouhy, B Ghetti, M E Hode. Molecular characterization of a novel cDNA from murine cerebellum, developmental expression, and distribution in brain. Brain research. Molecular brain research. vol 25. issue 3-4. 1995-02-02. PMID:7808217. |
in the adult mouse brain, strong hybridization was detected in cerebellum, hippocampus, substantia nigra (sn), and cerebral cortex. |
1995-02-02 |
2023-08-12 |
mouse |
| J K Andersen, D M Frim, O Isacson, M F Beal, X O Breakefiel. Elevation of neuronal MAO-B activity in a transgenic mouse model does not increase sensitivity to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Brain research. vol 656. issue 1. 1995-01-31. PMID:7804823. |
levels of striatal dopamine (da) and its metabolite 3,4-dihydroxyphenylacetic acid (dopac), as well as tyrosine hydroxylase (th)-immunopositive cell numbers in the substantia nigra (sn) were compared 1 week later between transgenics and controls. |
1995-01-31 |
2023-08-12 |
mouse |