| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C G Charlton, B Crowel. Striatal dopamine depletion, tremors, and hypokinesia following the intracranial injection of S-adenosylmethionine: a possible role of hypermethylation in parkinsonism. Molecular and chemical neuropathology. vol 26. issue 3. 1996-10-22. PMID:8748929. |
the major symptoms of parkinson disease (pd) are tremors, hypokinesia, rigidity, and abnormal posture, caused by the degeneration of dopamine (da) neurons in the substantia nigra (sn) and deficiency of da in the neostriatal da terminals. |
1996-10-22 |
2023-08-12 |
rat |
| M Fortin, A Paren. Calretinin as a marker of specific neuronal subsets in primate substantia nigra and subthalamic nucleus. Brain research. vol 708. issue 1-2. 1996-10-11. PMID:8720880. |
neurons immunoreactive for the calcium-binding protein calretinin (cr) were visualized in the substantia nigra (sn) pars compacta (snc), reticulata (snr) and lateralis (snl), the ventral tegmental area (vta) and the subthalamic nucleus (stn) of squirrel monkeys. |
1996-10-11 |
2023-08-12 |
monkey |
| R Haaxma, A van Boxtel, W H Brouwer, L N Goeken, J J Denier van der Gon, J G Colebatch, A Martin, D J Brooks, J Noth, C D Marsde. Motor function in a patient with bilateral lesions of the globus pallidus. Movement disorders : official journal of the Movement Disorder Society. vol 10. issue 6. 1996-09-27. PMID:8749996. |
this study describes the long-term deficits of a patient who, after a toxic encephalopathy, sustained extensive bilateral damage to both segments of the globus pallidus (gp) and the right substantia nigra (sn). |
1996-09-27 |
2023-08-12 |
Not clear |
| J Gałazka-Friedman, E R Bauminger, A Friedman, M Barcikowska, D Hechel, I Nowi. Iron in parkinsonian and control substantia nigra--a Mössbauer spectroscopy study. Movement disorders : official journal of the Movement Disorder Society. vol 11. issue 1. 1996-09-26. PMID:8771061. |
we used mössbauer spectroscopy to study the iron content, the redox state, and the binding site of iron in substantia nigra (sn) from parkinsonian (pd) and control brains. |
1996-09-26 |
2023-08-12 |
Not clear |
| W R Galpern, D M Frim, S B Tatter, C A Altar, M F Beal, O Isacso. Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration. Cell transplantation. vol 5. issue 2. 1996-08-27. PMID:8689033. |
using this mpp+ rat model of nigral degeneration, we evaluated the neurochemical effects of supranigral, cell-mediated delivery of bdnf on substantia nigra (sn) dopamine (da) content and turnover. |
1996-08-27 |
2023-08-12 |
rat |
| H Pakkenberg, B B Andersen, R S Burns, B Pakkenber. A stereological study of substantia nigra in young and old rhesus monkeys. Brain research. vol 693. issue 1-2. 1996-07-31. PMID:8653409. |
the number of pigmented and non-pigmented neurons in the substantia nigra (sn) of 10 old and six young female macaca mulatta monkeys and in three old alpha male monkeys were estimated using new stereological cell counting methods. |
1996-07-31 |
2023-08-12 |
monkey |
| A Fukuda, M Kumazaki, K Onizuka, I Fujimoto, H Hida, Y Shimano, K Muramatsu, K Nakajima, H Nishin. Labeling and identification of living donor cells in brain slices of recipient hemiparkinsonian model rats for physiological recordings: methods for physiological assessments of neural transplantation. Experimental neurology. vol 137. issue 2. 1996-07-11. PMID:8635546. |
cell suspensions were prepared from the substantia nigra (sn) of embryonic days 15 or 16 rats with enzymatic and mechanical trituration. |
1996-07-11 |
2023-08-12 |
rat |
| R Pallini, E Fernandez, L Lauretti, E Dell'Anna, F La Marca, C Gangitano, A DelFà, C Olivieri-Sangiacomo, A Sbriccoli, G F Ross. Superior cervical ganglion regenerating axons through peripheral nerve grafts and reversal of behavioral deficits in hemiparkinsonian rats. Journal of neurosurgery. vol 84. issue 3. 1996-05-24. PMID:8609563. |
in adult rats, 6-hydroxydopamine (6-ohda) was stereotactically injected into the right substantia nigra (sn). |
1996-05-24 |
2023-08-12 |
rat |
| X L Chen, F J Roisen, M Gupt. The effect of prior in vitro exposure of donor cells to trophic factors in neurotransplantation. Experimental neurology. vol 138. issue 1. 1996-04-11. PMID:8593897. |
transplantation of ngf-naive pc12 cells leads to a significant increase in the number of dopaminergic neurons in the host substantia nigra (sn) compared to mptp-treated animals. |
1996-04-11 |
2023-08-12 |
mouse |
| A Parent, A Charara, D Pinaul. Single striatofugal axons arborizing in both pallidal segments and in the substantia nigra in primates. Brain research. vol 698. issue 1-2. 1996-03-20. PMID:8581498. |
the striatofugal fiber system in primates is believed to be composed of separate subsystems terminating in either the external (gpe) or internal (gpi) segment of the globus pallidus, or in the substantia nigra (sn). |
1996-03-20 |
2023-08-12 |
monkey |
| S F Ali, K J Kordsmeier, B Goug. Drug-induced circling preference in rats. Correlation with monoamine levels. Molecular neurobiology. vol 11. issue 1-3. 1996-03-07. PMID:8561958. |
dopamine (da) and its metabolites 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) concentrations significantly decreased ipsilaterally in lesioned caudate nucleus (cn) and substantia nigra (sn). |
1996-03-07 |
2023-08-12 |
human |
| Y S Fu, G F Tseng, H S Yi. Extrinsic inhibitory innervation to rubral neurons in rat brain-stem slices. Experimental neurology. vol 137. issue 1. 1996-03-01. PMID:8566205. |
ipsilateral stimuli to areas in the dorsolateral mesencephalic reticular formation (dlmrf) or substantia nigra (sn) elicited monosynaptic hyperpolarizing postsynaptic potentials (psps) in about 95% of rn neurons recorded. |
1996-03-01 |
2023-08-12 |
rat |
| M J Nirenberg, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 2. 1996-02-22. PMID:8551328. |
these functions are initiated through the release of dopamine from axon terminals in the striatum or from dendrites in the substantia nigra (sn) and are terminated by the reuptake of dopamine by the sodium- and chloride-dependent dopamine transporter (dat). |
1996-02-22 |
2023-08-12 |
rat |
| G Ellison, U Liminga, A Key. Oral movement patterns induced in rats by local infusions into striatum depend upon the regimen of prior neuroleptic exposure. Psychopharmacology. vol 121. issue 2. 1996-02-14. PMID:8545532. |
the rats were then withdrawn from chronic hal and bilateral cannulae were implanted in the ventrolateral striatum (vls) and substantia nigra (sn). |
1996-02-14 |
2023-08-12 |
rat |
| I S Lolova, S R Lolo. Age-related changes in basic fibroblast growth factor-immunoreactive cells of rat substantia nigra. Mechanisms of ageing and development. vol 82. issue 2-3. 1996-02-08. PMID:8538246. |
immunohistochemistry and computer-assisted image analysis were used to examine the age-related changes in bfgf-immunoreactivity in rat substantia nigra (sn). |
1996-02-08 |
2023-08-12 |
rat |
| B Ziolkowska, G Horn, A Kupsch, V Höll. The expression of proenkephalin and prodynorphin genes and the induction of c-fos gene by dopaminergic drugs are not altered in the straitum of MPTP-treated mice. Journal of neural transmission. Parkinson's disease and dementia section. vol 9. issue 2-3. 1996-02-01. PMID:8527000. |
two weeks after systemic administration of mptp (2 x 40 mg/kg, s.c. 18h apart), the lesion of the substantia nigra (sn) could be visualised by loss of the nigral tyrosine hydroxylase (th) mrna hybridization signal and by a 91% decrease in striatal dopamine levels. |
1996-02-01 |
2023-08-12 |
mouse |
| J F O'Callaghan, S A Greenfiel. Inhibition of the ATP-sensitive potassium channel in the guinea pig substantia nigra by BMS 181100 is not mediated by a sigma-binding site. Journal of neuroscience research. vol 42. issue 1. 1996-01-30. PMID:8531229. |
quantitative autoradiography of brain tissue has revealed a high density of binding sites for the k-atp channel antagonists, the sulphonylureas, and for sigma-ligands in the substantia nigra (sn). |
1996-01-30 |
2023-08-12 |
Not clear |
| H Okamura, C Yokoyama, Y Ibat. Lateromedial gradient of the susceptibility of midbrain dopaminergic neurons to neonatal 6-hydroxydopamine toxicity. Experimental neurology. vol 136. issue 2. 1996-01-17. PMID:7498403. |
in all cases of intracisternal 6-ohda treatment, a9 dopaminergic neurons in the substantia nigra (sn) were much more vulnerable to death than more medially located a10 dopaminergic neurons. |
1996-01-17 |
2023-08-12 |
Not clear |
| O K Ronnekleiv, B R Naylo. Chronic cocaine exposure in the fetal rhesus monkey: consequences for early development of dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 11. 1995-12-26. PMID:7472487. |
also in the day 60 fetuses, the th-ir neurons were distributed similarly in both groups (n = 5 each), but the th mrna content, measured by quantitative in situ hybridization, was reduced in the substantia nigra (sn) and ventral tegmental area (vta) after cocaine treatment. |
1995-12-26 |
2023-08-12 |
monkey |
| T Yamad. Further observations on MxA-positive Lewy bodies in Parkinson's disease brain tissues. Neuroscience letters. vol 195. issue 1. 1995-12-18. PMID:7478250. |
we recently reported that in cases of parkinson's disease (pd), lewy bodies (lbs) in the substantia nigra (sn) were positive for mxa. |
1995-12-18 |
2023-08-12 |
mouse |