| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M B Youdim, L Lavi. Selective MAO-A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson's disease. Life sciences. vol 55. issue 25-26. 1995-01-18. PMID:7527888. |
in the absence of identification of either an endogenously or an exogenously derived dopaminergic neurotoxin, the most valid hypothesis currently envisaged for etiopathology of parkinson's disease (pd) is selective oxidative stress (os) in substantia nigra (sn). |
1995-01-18 |
2023-08-12 |
Not clear |
| H Nissbrandt, A Elverfors, G Engber. Pharmacologically induced cessation of burst activity in nigral dopamine neurons: significance for the terminal dopamine efflux. Synapse (New York, N.Y.). vol 17. issue 4. 1995-01-09. PMID:7992197. |
in the present combined electrophysiological and microdialysis study, the influence of the firing pattern on striatal da release was studied by using the previously observed ability of low doses of gamma-hydroxybutyrate (ghba) to profoundly regularize the firing pattern of rat da neurons in the substantia nigra (sn). |
1995-01-09 |
2023-08-12 |
rat |
| Y F Tsai, H W Tsai, M Y Ta. Comparison of brain dopamine depletion induced by low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in young and aged rats. Neuroscience research. vol 20. issue 1. 1995-01-05. PMID:7984338. |
effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) on dopamine levels in the striatum (st), substantia nigra (sn), olfactory tubercle (ot), ventral tegmental area (vta) and nucleus accumbens (na) were studied in young (1 month) and old (21 months) male long-evans rats. |
1995-01-05 |
2023-08-12 |
rat |
| T Wu, H L Wan. CCK-8-evoked cationic currents in substantia nigra dopaminergic neurons are mediated by InsP3-induced Ca2+ release. Neuroscience letters. vol 175. issue 1-2. 1994-12-29. PMID:7526297. |
our recent study demonstrated that by activating cck-a receptors, cck-8 excites substantia nigra (sn) dopaminergic (da) neurons via increasing a non-selective cationic conductance. |
1994-12-29 |
2023-08-12 |
Not clear |
| S A Bayer, L C Triarhou, J D Thomas, B Ghett. Correlated quantitative studies of the neostriatum, nucleus accumbens, substantia nigra, and ventral tegmental area in normal and weaver mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 11 Pt 2. 1994-12-02. PMID:7965086. |
normal mice (+/+) and homozygous weaver mutant mice (wv/wv) at 1 year of age were used for three-dimensional computer-aided reconstructions of the nucleus accumbens (na) and neostriatum (st) and for quantitative estimations of the total number of medium-sized neurons in the na and st, and for the total number of tyrosine hydroxylase (th)-containing neurons in the ventral tegmental area (vta) and substantia nigra (sn). |
1994-12-02 |
2023-08-12 |
mouse |
| N Kayadjanian, S Rétaux, A Menétrey, M J Besso. Stimulation by nicotine of the spontaneous release of [3H]gamma-aminobutyric acid in the substantia nigra and in the globus pallidus of the rat. Brain research. vol 649. issue 1-2. 1994-11-30. PMID:7953625. |
the effect of (-)-nicotine on the spontaneous release of [3h]gamma-aminobutyric acid ([3h]gaba) was studied in vitro in rat substantia nigra (sn) and globus pallidus (gp) slices. |
1994-11-30 |
2023-08-12 |
rat |
| J Thomas, J Wang, H Takubo, J Sheng, S de Jesus, K S Bankiewic. A 6-hydroxydopamine-induced selective parkinsonian rat model: further biochemical and behavioral characterization. Experimental neurology. vol 126. issue 2. 1994-11-17. PMID:7925817. |
the main focus of the present study was to define the rotational response of 6-hydroxydopamine-lesioned rats to dopaminergic agonists to separate the partially lesioned rats from those having complete substantia nigra (sn) and ventral tegmental area (vta) lesions. |
1994-11-17 |
2023-08-12 |
rat |
| U Muthane, K A Ramsay, H Jiang, V Jackson-Lewis, D Donaldson, S Fernando, M Ferreira, S Przedborsk. Differences in nigral neuron number and sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57/bl and CD-1 mice. Experimental neurology. vol 126. issue 2. 1994-11-17. PMID:7925820. |
to determine the possible reasons for this difference in mptp sensitivity between these two mouse strains, we have compared both the organization and the number of substantia nigra (sn) neurons, the primary target of mptp, in c57/bl and in cd-1 mice using immunostaining for tyrosine hydroxylase (th) and calbindin-d28k (calbindin). |
1994-11-17 |
2023-08-12 |
mouse |
| K R Isaacs, D M Jacobowit. Mapping of the colocalization of calretinin and tyrosine hydroxylase in the rat substantia nigra and ventral tegmental area. Experimental brain research. vol 99. issue 1. 1994-11-02. PMID:7925794. |
the distribution of calretinin (cr), a calcium binding protein, was compared with that of tyrosine hydroxylase (th), the rate-limiting enzyme in the synthesis of dopamine, throughout the rostrocaudal extent of the rat substantia nigra (sn) and ventral tegmental area (vta). |
1994-11-02 |
2023-08-12 |
rat |
| J Sian, D T Dexter, A J Lees, S Daniel, P Jenner, C D Marsde. Glutathione-related enzymes in brain in Parkinson's disease. Annals of neurology. vol 36. issue 3. 1994-10-04. PMID:8080243. |
the activity of the glutathione degradative enzyme, gamma-glutamyltranspeptidase, was selectively elevated in substantia nigra (sn) in pd. |
1994-10-04 |
2023-08-12 |
Not clear |
| E K O'Malley, B A Sieber, R S Morrison, I B Black, C F Dreyfu. Nigral type I astrocytes release a soluble factor that increases dopaminergic neuron survival through mechanisms distinct from basic fibroblast growth factor. Brain research. vol 647. issue 1. 1994-09-26. PMID:8069707. |
our studies have been directed to the identification of local, naturally-occurring molecules that support substantia nigra (sn) dopaminergic (da) neuron survival. |
1994-09-26 |
2023-08-12 |
Not clear |
| C Magariños-Ascone, E García-Austt, W Buñ. Polymodal sensory and motor convergence in substantia nigra neurons of the awake monkey. Brain research. vol 646. issue 2. 1994-09-23. PMID:8069677. |
responses of substantia nigra (sn) pars compacta (snc) and reticulata (snr) neurons to sensory stimulation and movement were investigated in awake macaca fascicularis. |
1994-09-23 |
2023-08-12 |
monkey |
| Q P Ma, Y Zhou, J S Ha. Electroacupuncture accelerated the expression of c-Fos protooncogene in dopaminergic neurons in the ventral tegmental area of the rat. The International journal of neuroscience. vol 70. issue 3-4. 1994-09-20. PMID:8063541. |
electroacupuncture stimulation significantly increased the number of fos-positive dopaminergic neurons in the ventral tegmental area (vta), whereas no significant c-fos expression in the dopaminergic neurons was observed in the substantia nigra (sn). |
1994-09-20 |
2023-08-12 |
rat |
| D M Bronstein, H Ye, K R Pennypacker, P M Hudson, J S Hon. Role of a 35 kDa fos-related antigen (FRA) in the long-term induction of striatal dynorphin expression in the 6-hydroxydopamine lesioned rat. Brain research. Molecular brain research. vol 23. issue 3. 1994-09-12. PMID:7914658. |
d1 dopamine (da) receptor agonists induce the expression of the opioid peptide dynorphin (dyn) in the striatum, an effect accentuated several fold by removing the dopaminergic innervation to the striatum (e.g., by lesioning the da cell bodies in the substantia nigra [sn]). |
1994-09-12 |
2023-08-12 |
rat |
| T Wu, H L Wan. CCK-8 excites substantia nigra dopaminergic neurons by increasing a cationic conductance. Neuroscience letters. vol 170. issue 2. 1994-09-12. PMID:8058194. |
using the whole-cell patch-clamp technique, we investigated electrophysiological effects of cholecystokinin on acutely isolated dopaminergic (da) neurons of rat substantia nigra (sn). |
1994-09-12 |
2023-08-12 |
rat |
| C Ambrogi Lorenzini, E Baldi, C Bucherelli, G Tasson. Passive avoidance response distribution by post-training substantia nigra functional tetrodotoxin inactivation in the rat. Archives italiennes de biologie. vol 132. issue 2. 1994-08-24. PMID:8042896. |
the tetrodotoxin (ttx) functional ablation technique was employed to assess the temporal coordinates of rat's substantia nigra (sn) in memory processing. |
1994-08-24 |
2023-08-12 |
rat |
| H Mochizuki, H Imai, K Endo, K Yokomizo, Y Murata, N Hattori, Y Mizun. Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys. Neuroscience letters. vol 168. issue 1-2. 1994-08-08. PMID:8028787. |
the mechanism of abnormal iron accumulation in the substantia nigra (sn) pars compacta of patients with parkinson's disease (pd) is unknown. |
1994-08-08 |
2023-08-12 |
monkey |
| A Charara, A Paren. Brainstem dopaminergic, cholinergic and serotoninergic afferents to the pallidum in the squirrel monkey. Brain research. vol 640. issue 1-2. 1994-07-21. PMID:7911724. |
large injections of ctb involving both pallidal segments produce numerous retrogradely labeled neurons in the substantia nigra (sn), the pedunculopontine tegmental nucleus (ppn) and the dorsal raphe nucleus (dr). |
1994-07-21 |
2023-08-12 |
squirrel_monkey |
| O Stork, T Hashimoto, K Obat. Increase of tyrosine hydroxylase and its mRNA in the rat substantia nigra pars reticulata by diazepam and picrotoxin. Neuroscience research. vol 19. issue 1. 1994-07-20. PMID:7911985. |
the number of th-positive cells was increased for both ish and imhc 8 h after a single administration of benzodiazepine diazepam, which facilitates gabaa-receptor-mediated transmission and reduces dopamine release in the substantia nigra (sn). |
1994-07-20 |
2023-08-12 |
rat |
| A Ayala, J Parrado, J Cano, A Machad. Reduction of 1-methyl 1,2,3,4-tetrahydroisoquinoline level in substantia nigra of the aged rat. Brain research. vol 638. issue 1-2. 1994-07-07. PMID:8199872. |
in this paper, we report the concentration of tiq and 1-metiq in two areas especially influenced by aging and parkinson's disease, the substantia nigra (sn) and striatum (st), of the rat at different ages. |
1994-07-07 |
2023-08-12 |
rat |