| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Thiffault, N Aumont, R Quirion, J Poirie. Effect of MPTP and L-deprenyl on antioxidant enzymes and lipid peroxidation levels in mouse brain. Journal of neurochemistry. vol 65. issue 6. 1995-12-15. PMID:7595571. |
at the level of the substantia nigra (sn), even though increases in cat activity and reduction in sod and gsh-px activities were detected, lipid peroxidation was not altered. |
1995-12-15 |
2023-08-12 |
mouse |
| A Jaffer, G D van der Spuy, V A Russell, M Mintz, J J Taljaar. Activation of the subthalamic nucleus and pedunculopontine tegmentum: does it affect dopamine levels in the substantia nigra, nucleus accumbens and striatum? Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 4. issue 2. 1995-11-28. PMID:7583677. |
this study investigated whether death of substantia nigra (sn) dopaminergic neurons could be caused by the hyperactivity of afferent pathways resulting in the release of a toxic dose of excitatory amino acids in the sn. |
1995-11-28 |
2023-08-12 |
rat |
| M C Doretto, N Garcia-Cairasc. Differential audiogenic seizure sensitization by selective unilateral substantia nigra lesions in resistant Wistar rats. Physiology & behavior. vol 58. issue 2. 1995-11-03. PMID:7568430. |
evaluation of the participation of different substantia nigra sites in the sensitization of resistant (r) animals to audiogenic seizures (as), was performed after series of small (5 mc; n = 28), medium (10 mc; n = 57) and large (15 mc; 3 points of 5 mc each, n = 19) unilateral electrolytic lesions of the substantia nigra (sn) in r rats. |
1995-11-03 |
2023-08-12 |
rat |
| C A Kitt, B J Wilco. Preliminary evidence for neurodegenerative changes in the substantia nigra of Rett syndrome. Neuropediatrics. vol 26. issue 2. 1995-10-30. PMID:7566448. |
the results of our preliminary studies show abnormalities in neurons of the substantia nigra (sn), including decreased numbers of neurons, ubiquitin-stained neuronal inclusion bodies, decreased immunostaining for transmitter markers, and evidence of cell death using terminal deoxynucleotidyl transferase (tdt)-mediated dutp-biotin nick end labeling (tunel), which labels fragmented intranucleosomal dna. |
1995-10-30 |
2023-08-12 |
Not clear |
| H Ito, H Kusaka, S Matsumoto, T Ima. Topographic involvement of the striatal efferents in basal ganglia of patients with adult-onset motor neuron disease with basophilic inclusions. Acta neuropathologica. vol 89. issue 6. 1995-10-17. PMID:7545858. |
this report concerns the topographic immunohistochemical analysis of the putamen, globus pallidus (gp) and substantia nigra (sn) of two patients with adult-onset motor neuron disease with basophilic inclusions (mnd/bis), seven patients with sporadic classic amyotrophic lateral sclerosis (sporadic als) and five neurologically normal individuals. |
1995-10-17 |
2023-08-12 |
human |
| S A Oakman, P L Faris, P E Kerr, C Cozzari, B K Hartma. Distribution of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 9. 1995-10-12. PMID:7666171. |
stereotaxic microinjections of fluoro-gold- or rhodamine-labeled microspheres were made either to substantia nigra (sn) or ventral tegmental area (vta) in rat. |
1995-10-12 |
2023-08-12 |
rat |
| A M Kazee, C Cox, E K Richfiel. Substantia nigra lesions in Alzheimer disease and normal aging. Alzheimer disease and associated disorders. vol 9. issue 2. 1995-10-10. PMID:7662324. |
we retrospectively examined clinical and neuropathological features from 66 individuals participating in the rochester alzheimer disease center to determine the association of ad with substantia nigra (sn) pathology. |
1995-10-10 |
2023-08-12 |
Not clear |
| J Röper, F M Ashcrof. Metabolic inhibition and low internal ATP activate K-ATP channels in rat dopaminergic substantia nigra neurones. Pflugers Archiv : European journal of physiology. vol 430. issue 1. 1995-10-10. PMID:7667078. |
the patch-clamp technique was used to study whole-cell currents of acutely dissociated rat substantia nigra (sn) neurones. |
1995-10-10 |
2023-08-12 |
rat |
| K Korematsu, S Goto, S Nagahiro, N Inoue, T Oyama, K Yamada, Y Ushi. Change of phosphotyrosine immunoreactivity on microglia in the rat substantia nigra following striatal ischemic injury. Glia. vol 13. issue 2. 1995-09-28. PMID:7544325. |
using immunohistochemistry, we investigated changes in phosphotyrosine (p-tyr) immunoreactivity on the microglia of the rat substantia nigra (sn) following striatal ischemic injury produced by transient middle cerebral artery (mca) occlusion. |
1995-09-28 |
2023-08-12 |
rat |
| D G Davis, D L Spark. Dopaminergic and serotonergic neurotransmitters in bone marrow transplant patients. Journal of the neurological sciences. vol 130. issue 1. 1995-09-26. PMID:7544403. |
depigmentation of neurons in the substantia nigra (sn) is found in patients dying after bone marrow transplantation (bmt). |
1995-09-26 |
2023-08-12 |
human |
| T Himi, M Cao, N Mor. Reduced expression of the molecular markers of dopaminergic neuronal atrophy in the aging rat brain. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 50. issue 4. 1995-08-18. PMID:7614230. |
expression of mrnas encoding the dopamine transporter (dat) and tyrosine hydroxylase (th) in dopaminergic neurons of the substantia nigra (sn) was examined in young and aged fischer 344 rats by in situ hybridization. |
1995-08-18 |
2023-08-12 |
rat |
| S Fenu, A Carta, M Morell. Modulation of dopamine D1-mediated turning behavior and striatal c-fos expression by the substantia nigra. Synapse (New York, N.Y.). vol 19. issue 4. 1995-07-26. PMID:7792718. |
in order to study the possible contribution of the substantia nigra (sn) in the positive interaction between dopamine d1 receptor agonists and glutamate antagonists in unilaterally 6-hydroxydopamine (6-ohda) lesioned rats, the effect of the d1 agonist, skf 38393, was studied in combination with intranigral infusions of glutamate antagonists of the nmda (mk 801, cpp) or ampa (nbqx) type of receptor. |
1995-07-26 |
2023-08-12 |
rat |
| D L Rosin, K Melia, A M Knorr, E J Nestler, R H Roth, R S Duma. Chronic imipramine administration alters the activity and phosphorylation state of tyrosine hydroxylase in dopaminergic regions of rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 12. issue 2. 1995-07-20. PMID:7779239. |
chronic administration of imipramine (18 days) decreased levels of th enzyme activity in ventral tegmental area (vta) and substantia nigra (sn), dopaminergic cell body regions, as well as in caudate-putamen (cp), nucleus accumbens (acb), prefrontal cortex (pfc), and olfactory tubercle (ot), dopaminergic terminal fields. |
1995-07-20 |
2023-08-12 |
rat |
| J Abarca, K Gysling, R H Roth, G Busto. Changes in extracellular levels of glutamate and aspartate in rat substantia nigra induced by dopamine receptor ligands: in vivo microdialysis studies. Neurochemical research. vol 20. issue 2. 1995-07-20. PMID:7783840. |
the microdialysis technique was utilized to study the local effects of d1 and d2 family type dopamine (da) receptor (r) ligands on the in vivo release of endogenous glutamate (glu) and aspartate (asp) from rat substantia nigra (sn). |
1995-07-20 |
2023-08-12 |
rat |
| J M Gorell, R J Ordidge, G G Brown, J C Deniau, N M Buderer, J A Helper. Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease. Neurology. vol 45. issue 6. 1995-07-18. PMID:7783878. |
elevated iron levels in the substantia nigra (sn) of the brain in parkinson's disease (pd) may mediate lipid peroxidative reactions, promoting sn neuronal death. |
1995-07-18 |
2023-08-12 |
human |
| G Nikkhah, M G Cunningham, M A Cenci, R D McKay, A Björklun. Dopaminergic microtransplants into the substantia nigra of neonatal rats with bilateral 6-OHDA lesions. I. Evidence for anatomical reconstruction of the nigrostriatal pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 5 Pt 1. 1995-06-20. PMID:7538563. |
here we report on a novel approach by which fetal vm grafts are implanted unilaterally into the substantia nigra (sn) of 6-hydroxydopamine (6-ohda)-lesioned neonatal pups at postnatal day 3 (p3) using a microtransplantation technique. |
1995-06-20 |
2023-08-12 |
rat |
| T Wu, H L Wan. Protein kinase C mediates neurotensin inhibition of inwardly rectifying potassium currents in rat substantia nigra dopaminergic neurons. Neuroscience letters. vol 184. issue 2. 1995-05-23. PMID:7724045. |
whole-cell voltage-clamp recordings were used to investigate the molecular transduction mechanism by which neurotensin decreases the inwardly rectifying potassium conductance of dopaminergic (da) neurons acutely isolated from the rat substantia nigra (sn). |
1995-05-23 |
2023-08-12 |
rat |
| F Vaglini, F Fascetti, F Fornai, R Maggio, G U Corsin. (+)MK-801 prevents the DDC-induced enhancement of MPTP toxicity in mice. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704605. |
the number of th+ neurons in the substantia nigra (sn) of (+)mk-801-pretreated mice was not significantly different from that of control animals, indicating that this treatment specifically antagonized the extensive ddc-induced lesion of dopaminergic cell bodies in this brain area. |
1995-05-10 |
2023-08-12 |
mouse |
| G Bing, Y Zhang, Y Watanabe, B S McEwen, E A Ston. Locus coeruleus lesions potentiate neurotoxic effects of MPTP in dopaminergic neurons of the substantia nigra. Brain research. vol 668. issue 1-2. 1995-05-10. PMID:7704612. |
the observation that parkinson's disease (pd) is associated with locus coeruleus (lc) noradrenergic neuronal degeneration suggests that the lc noradrenergic system may be involved in the pathogenesis and natural progression of the destruction of the substantia nigra (sn) dopaminergic neurons in parkinson's disease. |
1995-05-10 |
2023-08-12 |
mouse |
| W D Le, J Engelhardt, W J Xie, L Schneider, R G Smith, S H Appe. Experimental autoimmune nigral damage in guinea pigs. Journal of neuroimmunology. vol 57. issue 1-2. 1995-05-09. PMID:7706439. |
in such animals, loss of 40% of the substantia nigra (sn) neurons and damage to an additional 10% of sn neurons was associated with a 37-43% decrease of tyrosine hydroxylase (th) activity and a 36% decrease of dopamine (da) content in the nigral-striatum. |
1995-05-09 |
2023-08-12 |
Not clear |