| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W J Kelly, R E Burk. Apoptotic neuron death in rat substantia nigra induced by striatal excitotoxic injury is developmentally dependent. Neuroscience letters. vol 220. issue 2. 1997-03-20. PMID:8981479. |
we have previously observed that an axon-sparing lesion of the striatum during development is associated with an induction of apoptotic cell death in the substantia nigra (sn). |
1997-03-20 |
2023-08-12 |
rat |
| M Poltorak, J R Williams, K D Moore, W J Free. Changes in L1 antigen expression in the rat striatum after substantia nigra lesions. Journal of neural transplantation & plasticity. vol 6. issue 1. 1997-03-19. PMID:8959552. |
in the medial-periventricular part of the striatum, both complete and partial substantia nigra (sn) lesions decreased l1 expression. |
1997-03-19 |
2023-08-12 |
rat |
| S S Shim, B S Bunney, W X Sh. Effects of lesions in the medial prefrontal cortex on the activity of midbrain dopamine neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 5. 1997-03-14. PMID:8914116. |
in the substantia nigra (sn), the same lesions increased the firing rate and had no effect on either the bursting activity of the number of active da cells. |
1997-03-14 |
2023-08-12 |
rat |
| A Roll, M M Wierzbicka, W Wol. The "gap paradigm" leads to express-like saccadic reaction times in Parkinson's disease. Experimental brain research. vol 111. issue 1. 1997-03-11. PMID:8891643. |
it was suggested that the substantia nigra (sn) could take part in the control of these saccades. |
1997-03-11 |
2023-08-12 |
human |
| J Nabekura, T Omura, N Akaik. Alpha 2 adrenoceptor potentiates glycine receptor-mediated taurine response through protein kinase A in rat substantia nigra neurons. Journal of neurophysiology. vol 76. issue 4. 1997-03-11. PMID:8899617. |
the modulatory effect of alpha 2 adrenoceptor on the taurine response was investigated in substantia nigra (sn) neurons acutely dissociated from the rat using a nystatin perforated-patch recording mode under voltage-clamp conditions. |
1997-03-11 |
2023-08-12 |
rat |
| J Nabekura, T Omura, N Horimoto, T Ogawa, N Akaik. Alpha 1 adrenoceptor activation potentiates taurine response mediated by protein kinase C in substantia nigra neurons. Journal of neurophysiology. vol 76. issue 4. 1997-03-11. PMID:8899618. |
the potentiation of glycine receptor-mediated taurine response (itau) by alpha 1 adrenoceptor activation was investigated in neurons freshly dissociated from the rat substantia nigra (sn) using a nystatin perforated-patch recording. |
1997-03-11 |
2023-08-12 |
rat |
| M E Andrés, K Gysling, S Araneda, A Venegas, G Busto. NMDA-NR1 receptor subunit mRNA expression in rat brain after 6-OH-dopamine induced lesions: a non-isotopic in situ hybridization study. Journal of neuroscience research. vol 46. issue 3. 1997-03-11. PMID:8933377. |
in contrast, both zona compacta and reticulata of substantia nigra (sn) showed a reduced number of cells with nevertheless intense nr1 mrna his signals. |
1997-03-11 |
2023-08-12 |
rat |
| B K Jin, M Belloni, B Conti, H J Federoff, R Starr, J H Son, H Baker, T H Jo. Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector. Human gene therapy. vol 7. issue 16. 1997-02-21. PMID:8930662. |
two days and 10 weeks after thlac injection into rat caudate nucleus (cn), x-gal-stained cells were observed in the substantia nigra (sn) and locus ceruleus (lc) ipsilateral to the injection site. |
1997-02-21 |
2023-08-12 |
mouse |
| H C Hung, E H Le. The mesolimbic dopaminergic pathway is more resistant than the nigrostriatal dopaminergic pathway to MPTP and MPP+ toxicity: role of BDNF gene expression. Brain research. Molecular brain research. vol 41. issue 1-2. 1997-02-20. PMID:8883930. |
results revealed that chronic mptp treatment produced a significant and irreversible da depletion in the striatum (st) as well as a marked decrease in tyrosine-hydroxylase (th) mrna level in the substantia nigra (sn). |
1997-02-20 |
2023-08-12 |
mouse |
| X M Shen, B Xia, M Z Wrona, G Dryhurs. Synthesis, redox properties, in vivo formation, and neurobehavioral effects of N-acetylcysteinyl conjugates of dopamine: possible metabolites of relevance to Parkinson's disease. Chemical research in toxicology. vol 9. issue 7. 1997-02-20. PMID:8902266. |
a very early event in the pathogenesis of idiopathic parkinson's disease (pd) has been proposed to be an elevated translocation of l-cysteine (cysh) and/or glutathione (gsh) into pigmented dopaminergic cell bodies in the substantia nigra (sn) in which cytoplasmic dopamine (da) is normally autoxidized to da-o-quinone as the first step in a reaction leading to black neuromelanin polymer. |
1997-02-20 |
2023-08-12 |
mouse |
| Y He, P S Thong, T Lee, S K Leong, C Y Shi, P T Wong, S Y Yuan, F Wat. Increased iron in the substantia nigra of 6-OHDA induced parkinsonian rats: a nuclear microscopy study. Brain research. vol 735. issue 1. 1997-02-11. PMID:8905180. |
the trace elemental concentrations, including iron, in the substantia nigra (sn) of a 6-ohda induced rat model of parkinson's disease were measured using nuclear microscopy. |
1997-02-11 |
2023-08-12 |
rat |
| D J Martens, I Q Whishaw, E I Miklyaeva, S M Pelli. Spatio-temporal impairments in limb and body movements during righting in an hemiparkinsonian rat analogue: relevance to axial apraxia in humans. Brain research. vol 733. issue 2. 1997-02-06. PMID:8891308. |
this hypothesis was tested by comparing the righting of rats with unilateral 6-hydroxydopamine (6-ohda) lesions of the substantia nigra (sn) with that of intact rats. |
1997-02-06 |
2023-08-12 |
rat |
| J L Tseng, E E Baetge, A D Zurn, P Aebische. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 1. 1997-02-04. PMID:8987758. |
parkinson's disease (pd) is characterized by the progressive loss of the substantia nigra (sn) dopaminergic neurons projecting to the striatum. |
1997-02-04 |
2023-08-12 |
rat |
| S A Jones-Humble, M J Durcan, D Lyerly, R M Norton, F L Tang, A V Russell, M J Watson, P J Gengo, P F Morgan, C M Wang, B R Cooper, R F Co. Preclinical neurochemical and electrophysiological profile of 1192U90, a potential antipsychotic. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 3. 1997-01-15. PMID:8873105. |
subcutaneous injection of 1192u90 (0.8 mg/kg/day) and clozapine (20 mg/kg/day) for 28 days preferentially decreased the number of spontaneously active dopamine cells in the ventral tegmental area (vta) but not the substantia nigra (sn) of rats, as measured by population sampling. |
1997-01-15 |
2023-08-12 |
rat |
| H Boecker, A Weindl, K Leenders, A Antonini, T Kuwert, F Kruggel, H Grafin von Einsiedel, B Conra. Secondary parkinsonism due to focal substantia nigra lesions: a PET study with [18F]FDG and [18F]fluorodopa. Acta neurologica Scandinavica. vol 93. issue 6. 1997-01-08. PMID:8836298. |
magnetic resonance imaging (mri) depicted lesions affecting the substantia nigra (sn) bilaterally, but more pronounced on the left side. |
1997-01-08 |
2023-08-12 |
Not clear |
| S Y Ma, J O Rinne, Y Collan, M Röyttä, U K Rinn. A quantitative morphometrical study of neuron degeneration in the substantia nigra in Parkinson's disease. Journal of the neurological sciences. vol 140. issue 1-2. 1997-01-03. PMID:8866425. |
we studied the pigmented neurons of the substantia nigra (sn) from 8 controls and 20 patients with parkinson's disease (pd) using a computerized morphometric methodology. |
1997-01-03 |
2023-08-12 |
Not clear |
| W H Church, Y T Fon. Changes in uric acid during acute infusion of MPP+, 6-OHDA, and FeCl3. A microdialysis study in the substantia nigra of the guinea pig. Molecular and chemical neuropathology. vol 27. issue 2. 1996-12-17. PMID:8962598. |
striatal and substantia nigra (sn) tissues were analyzed for uric acid (ua) and dopamine (da) 3 h postinfusion. |
1996-12-17 |
2023-08-12 |
Not clear |
| M J Nirenberg, J Chan, Y Liu, R H Edwards, V M Picke. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 13. 1996-12-13. PMID:8753875. |
midbrain dopaminergic neurons are known to release dopamine from somata and/or dendrites located in the substantia nigra (sn) and the ventral tegmental area (vta). |
1996-12-13 |
2023-08-12 |
rat |
| X X Zhang, G Z Ji. (-)-stepholidine vs 12-chloroscoulerine enantiomers on firing activity of substantia nigral dopamine neurons. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 17. issue 1. 1996-12-05. PMID:8737445. |
to compare the potencies between (-)-stepholidine ((-)-spd) and 12-chloroscoulerine (csl) enantiomers on firing of substantia nigra (sn) dopamine (da) neurons. |
1996-12-05 |
2023-08-12 |
Not clear |
| H Hamano, J Nabekura, M Nishikawa, T Ogaw. Docosahexaenoic acid reduces GABA response in substantia nigra neuron of rat. Journal of neurophysiology. vol 75. issue 3. 1996-12-03. PMID:8867135. |
the effects of docosahexaenoic acid (dha) on gamma-aminobutyric acid (gaba) response (igaba) were investigated on the neuron acutely dissociated from rat substantia nigra (sn), with the use of patch recordings in a whole cell mode. |
1996-12-03 |
2023-08-12 |
rat |