| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D G Cole, J H Growdon, M DiFigli. Levodopa induction of Fos immunoreactivity in rat brain following partial and complete lesions of the substantia nigra. Experimental neurology. vol 120. issue 2. 1993-06-17. PMID:8491280. |
partial lesions of the substantia nigra (sn) in rat provide a model of the early stages of pd. |
1993-06-17 |
2023-08-12 |
rat |
| F W Chang, S D Wang, K T Lu, E H Le. Differential interactive effects of gliotoxin and MPTP in the substantia nigra and the locus coeruleus in BALB/c mice. Brain research bulletin. vol 31. issue 3-4. 1993-06-11. PMID:7683960. |
we have previously demonstrated that chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) infusion to the substantia nigra (sn) and the locus coeruleus (lc) both produce a long-lasting neurotoxicity on dopamine (da) and norepinephrine (ne) neurons in these two areas, respectively. |
1993-06-11 |
2023-08-12 |
mouse |
| Y S Zhu, S B Jones, R E Burke, S O Franklin, C E Inturris. Quantitation of the levels of tyrosine hydroxylase and preproenkephalin mRNAs in nigrostriatal sites after 6-hydroxydopamine lesions. Life sciences. vol 52. issue 19. 1993-06-01. PMID:8097862. |
expression of the striatal proenkephalin gene is modulated by dopaminergic input from the substantia nigra (sn). |
1993-06-01 |
2023-08-12 |
rat |
| E G McGeer, E A Singh, P L McGee. Apparent anterograde transport of basic fibroblast growth factor in the rat nigrostriatal dopamine system. Neuroscience letters. vol 148. issue 1-2. 1993-05-26. PMID:1284444. |
five hours after the stereotaxic injection of approximately 1 ng of [125i]basic fibroblast growth factor (bfgf) into rat substantia nigra (sn), small but consistent amounts of radioactivity were found in the ipsilateral striatum (cp). |
1993-05-26 |
2023-08-11 |
rat |
| S Kapur, M C Austin, M D Underwood, V Arango, J J Man. Electroconvulsive shock increases tyrosine hydroxylase and neuropeptide Y gene expression in the locus coeruleus. Brain research. Molecular brain research. vol 18. issue 1-2. 1993-05-21. PMID:8097548. |
electroconvulsive seizures (ecs) increase tyrosine hydroxylase (th) activity in the locus coeruleus (lc) but not in the substantia nigra (sn). |
1993-05-21 |
2023-08-12 |
Not clear |
| S B Blunt, P Jenner, C D Marsde. Suppressive effect of L-dopa on dopamine cells remaining in the ventral tegmental area of rats previously exposed to the neurotoxin 6-hydroxydopamine. Movement disorders : official journal of the Movement Disorder Society. vol 8. issue 2. 1993-05-18. PMID:8097279. |
at the end of the treatment period, the number of dopamine cells remaining in each of the lesioned and intact substantia nigra (sn) and vta were assessed, using tyrosine hydroxylase immunohistochemistry. |
1993-05-18 |
2023-08-12 |
rat |
| C G Wasterlain, D G Fujikawa, L Penix, R Sanka. Pathophysiological mechanisms of brain damage from status epilepticus. Epilepsia. vol 34 Suppl 1. 1993-05-06. PMID:8385002. |
gaba metabolism in substantia nigra (sn) plays a key role in seizure arrest. |
1993-05-06 |
2023-08-12 |
human |
| T Ueda, T Ishikawa, K Kawata, K Setoyama, T Maekawa, T Sakabe, H Takeshit. [Nicergoline, an ergot alkaloid, improves ischemic brain damage by ameliorating the decreased cerebral blood flow and metabolism in spontaneously hypertensive rats]. No to shinkei = Brain and nerve. vol 44. issue 12. 1993-04-27. PMID:1296729. |
the decrease in lcbf in caudate-putamen (cp), parietal cortex (pc), thalamus (th), hypothalamus (ht), and substantia nigra (sn) were less in nic group than those in non-treated group. |
1993-04-27 |
2023-08-11 |
rat |
| V M Pickel, J Chan, S R Sesac. Cellular substrates for interactions between dynorphin terminals and dopamine dendrites in rat ventral tegmental area and substantia nigra. Brain research. vol 602. issue 2. 1993-04-13. PMID:8095430. |
dynorphin and other kappa opioid agonists are thought to elicit aversive actions and changes in motor activity through direct or indirect modulation of dopamine neurons in ventral tegmental area (vta) and substantia nigra (sn), respectively. |
1993-04-13 |
2023-08-12 |
mouse |
| A Elverfors, J Jonason, G Jonason, G Leonsson, H Nissbrand. Determination of release of endogenous dopamine from superfused substantia nigra slices. Journal of neuroscience methods. vol 45. issue 3. 1993-04-09. PMID:1363484. |
dopamine (da) is synthesized and released not only from the terminals of the nigrostriatal dopaminergic neuronal pathway but also from cell bodies and dendrites in the substantia nigra (sn). |
1993-04-09 |
2023-08-11 |
Not clear |
| J Peris, J D Scot. FG7142 causes opposite changes in [3H]GABA release from nigrocollicular regions. Pharmacology, biochemistry, and behavior. vol 44. issue 2. 1993-04-07. PMID:8383339. |
the activity of gabaergic neurons projecting from the striatum to the substantia nigra (sn) and from the sn to the superior colliculus (sc) may be involved in regulating seizure sensitivity such that striatonigral transmission is decreased and nigrocollicular transmission is increased in proconvulsant states. |
1993-04-07 |
2023-08-12 |
rat |
| A R Granat. Ascending and descending convergent inputs to neurons in the nucleus parabrachialis of the rat: an intracellular study. Brain research. vol 600. issue 2. 1993-03-23. PMID:8435754. |
responses of the nucleus parabrachialis neurons (pbn) to electrical stimulation of the lateral hypothalamus (hl), central nucleus of the amygdala (ac), dorsolateral funicullus in the spinal cord (sc), mediocaudal nucleus tractus solitarius (nts), and substantia nigra (sn) were investigated in anesthetized rats by intracellular recording technique. |
1993-03-23 |
2023-08-12 |
rat |
| I Tooyama, T Kawamata, D Walker, T Yamada, K Hanai, H Kimura, M Iwane, K Igarashi, E G McGeer, P L McGee. Loss of basic fibroblast growth factor in substantia nigra neurons in Parkinson's disease. Neurology. vol 43. issue 2. 1993-03-23. PMID:8437705. |
to explore whether an abnormality in bfgf expression occurs in parkinson's disease (pd), we examined the substantia nigra (sn) of six pd and eight control cases immunohistochemically using a monoclonal antibody to bfgf. |
1993-03-23 |
2023-08-12 |
Not clear |
| H Förstl, A Burns, P Luthert, N Cairns, P Lantos, R Lev. Clinical and neuropathological correlates of depression in Alzheimer's disease. Psychological medicine. vol 22. issue 4. 1993-02-25. PMID:1488485. |
we examined the neuropathological changes in the locus coeruleus (lc), substantia nigra (sn), basal nucleus of meynert and cortex of 52 patients (12 male, 40 female, mean age 83.2 +/- 6.4 years) with pathologically verified ad. |
1993-02-25 |
2023-08-11 |
Not clear |
| C Nitsch, G Wolfrum, F Schaefer, A L Scotti, J Unge. Opposite effects of intranigral ibotenic acid and 6-hydroxydopamine on motor behavior and on striatal neuropeptide Y neurons. Brain research bulletin. vol 30. issue 1-2. 1993-02-12. PMID:8420631. |
in the present investigation, the effects of an interruption of the striato-nigro-thalamic loop by ibotenic acid (ibo)-induced lesions of total substantia nigra (sn) on circling behavior and on striatal neuropeptide y (npy) neurons were compared with those after the selective destruction of the dopaminergic nigrostriatal projection with 6-hydroxydopamine (6-ohda). |
1993-02-12 |
2023-08-12 |
rat |
| M B Youdim, D Ben-Shachar, P Riedere. The possible role of iron in the etiopathology of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 8. issue 1. 1993-02-11. PMID:8419792. |
however, the recently described pathology of pd supports the view for a state of oxidative stress in the substantia nigra (sn), resulting as a consequence of the selective accumulation of iron in sn zona compacta and within the melanized dopamine neurons. |
1993-02-11 |
2023-08-12 |
rat |
| D J Calcagnetti, M D Schechte. Increases in the locomotor activity of rats after intracerebral administration of cathinone. Brain research bulletin. vol 29. issue 6. 1993-02-03. PMID:1473016. |
substantia nigra (sn) injections of cath were without effect. |
1993-02-03 |
2023-08-11 |
rat |
| V C Terra, N Garcia-Cairasc. Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections. Behavioural brain research. vol 52. issue 1. 1993-02-01. PMID:1335262. |
these audiogenic-like seizures were blocked by clobazam microinjection into the substantia nigra (sn) and partially modified by sn vehicle injection. |
1993-02-01 |
2023-08-11 |
rat |
| H Nissbrandt, S Hjort. Dopaminergic neurotransmission in somatodendritic and terminal areas of the rat brain: susceptibility to modulation by D1 and D2 receptors and to axotomy. Journal of neural transmission. General section. vol 90. issue 1. 1993-01-27. PMID:1361343. |
we have investigated the influence of d1 and d2 dopamine receptor active drugs on dopamine (da) release in substantia nigra (sn), striatum and limbic forebrain in intact and in hemisected rats in vivo. |
1993-01-27 |
2023-08-11 |
rat |
| D Ben-Shachar, M B Youdi. Iron, melanin and dopamine interaction: relevance to Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 17. issue 1. 1993-01-21. PMID:8416600. |
interaction between iron and melanin may provide a reasonable explanation for the vulnerability of the melanin containing dopaminergic neurons in the substantia nigra (sn) to neurodegeneration in parkinson's disease (pd). |
1993-01-21 |
2023-08-12 |
rat |