| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xialin Zuo, Qinghua Hou, Jizi Jin, Xiaohui Chen, Lixuan Zhan, Yanyan Tang, Zhe Shi, Weiwen Sun, En X. Inhibition of Cathepsins B Induces Neuroprotection Against Secondary Degeneration in Ipsilateral Substantia Nigra After Focal Cortical Infarction in Adult Male Rats. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:29867438. |
here, we investigate the role of cathb in the secondary degeneration of ipsilateral substantia nigra (sn) after focal cortical infarction. |
2020-10-01 |
2023-08-13 |
rat |
| Eugene Bok, Eun Ju Cho, Eun Sook Chung, Won-Ho Shin, Byung Kwan Ji. Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra Experimental neurobiology. vol 27. issue 4. 2020-10-01. PMID:30181693. |
interleukin-4 contributes to degeneration of dopamine neurons in the lipopolysaccharide-treated substantia nigra the present study investigated the effects of interleukin (il)-4 on dopamine (da) neurons in the substantia nigra (sn) |
2020-10-01 |
2023-08-13 |
Not clear |
| Sun Ryu, Hyongjun Jeon, Sungtae Koo, Seungtae Ki. Korean Red Ginseng Enhances Neurogenesis in the Subventricular Zone of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30459594. |
after the last pole test, dopaminergic neuronal survival in the striatum and the substantia nigra (sn), cell proliferation in the svz and mrna expression of neurotrophic factors and dopamine receptors in the striatum were evaluated. |
2020-10-01 |
2023-08-13 |
mouse |
| Khadija Tayara, Ana M Espinosa-Oliva, Irene García-Domínguez, Afrah Abdul Ismaiel, Antonio Boza-Serrano, Tomas Deierborg, Alberto Machado, Antonio J Herrera, José L Venero, Rocío M de Pablo. Divergent Effects of Metformin on an Inflammatory Model of Parkinson's Disease. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30519161. |
however, the effect of metformin on the substantia nigra (sn), the main structure affected in parkinson's disease (pd), has not yet been studied in depth. |
2020-10-01 |
2023-08-13 |
rat |
| Soledad Marton, Bruno González, Sebastián Rodríguez-Bottero, Ernesto Miquel, Laura Martínez-Palma, Mariana Pazos, José Pedro Prieto, Paola Rodríguez, Dalibor Sames, Gustavo Seoane, Cecilia Scorza, Patricia Cassina, Ignacio Carrer. Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30890941. |
in this work, we examined the effect of ibogaine acute administration on the expression of these nfs in the vta, prefrontal cortex (pfc), nucleus accumbens (nacc) and the substantia nigra (sn). |
2020-10-01 |
2023-08-13 |
human |
| Yan-Li Yang, Xue-Rui Ran, Yong Li, Li Zhou, Li-Fei Zheng, Yu Han, Qing-Qing Cai, Zhi-Yong Wang, Jin-Xia Zh. Expression of Dopamine Receptors in the Lateral Hypothalamic Nucleus and Their Potential Regulation of Gastric Motility in Rats With Lesions of Bilateral Substantia Nigra. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30923496. |
we have previously demonstrated that the neurons in the substantia nigra (sn) project to the lateral hypothalamic nucleus (lh) and the dorsal motor nucleus of vagus (dmv) receives the neural projection from lh by the means of anterograde and retrograde neural tracing technology. |
2020-10-01 |
2023-08-13 |
rat |
| Shuke Nie, Kai Ma, Mingkuan Sun, Matthew Lee, Yang Tan, Guiqin Chen, Zhentao Zhang, Zhaohui Zhang, Xuebing Ca. 7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents. Parkinson's disease. vol 2019. 2020-10-01. PMID:30944722. |
th immunostaining was performed to evaluate rotenone-induced neurotoxicity on substantia nigra (sn) dopaminergic neurons and the da terminals in the striatum. |
2020-10-01 |
2023-08-13 |
rat |
| Kyung Hwa Kim, Seung Young Lee, Jaekwon Shin, Jae-Taeg Hwang, Hat Nim Jeon, Hyunsu Ba. Dose-Dependent Neuroprotective Effect of Standardized Bee Venom Phospholipase A Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:31024294. |
dose-dependent neuroprotective effect of standardized bee venom phospholipase a parkinson's disease (pd) is a chronic progressive neurodegenerative movement disorder characterized by the selective loss of dopaminergic neurons within the substantia nigra (sn). |
2020-10-01 |
2023-08-13 |
bee |
| Katrina Albert, Juho-Matti Renko, Kert Mätlik, Mikko Airavaara, Merja H Voutilaine. Cerebral Dopamine Neurotrophic Factor Diffuses Around the Brainstem and Does Not Undergo Anterograde Transport After Injection to the Substantia Nigra. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31244598. |
we injected recombinant human cdnf to the substantia nigra (sn) of naïve male wistar rats and analyzed the brains 2, 6, and 24 h after injections. |
2020-10-01 |
2023-08-13 |
human |
| Hendrik Schöneborn, Fabian Raudzus, Emilie Secret, Nils Otten, Aude Michel, Jérome Fresnais, Christine Ménager, Jean-Michel Siaugue, Holm Zaehres, Irmgard D Dietzel, Rolf Heuman. Novel Tools towards Magnetic Guidance of Neurite Growth: (I) Guidance of Magnetic Nanoparticles into Neurite Extensions of Induced Human Neurons and In Vitro Functionalization with RAS Regulating Proteins. Journal of functional biomaterials. vol 10. issue 3. 2020-10-01. PMID:31315182. |
parkinson's disease (pd) is a neurodegenerative disease associated with loss or dysfunction of dopaminergic neurons located in the substantia nigra (sn), and there is no cure available. |
2020-10-01 |
2023-08-13 |
human |
| Batoul Darwish, Farah Chamaa, Elie D Al-Chaer, Nayef E Saadé, Wassim Abou-Khei. Intranigral Injection of Endotoxin Suppresses Proliferation of Hippocampal Progenitor Cells. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31333405. |
in this study, we investigate the effect of mild inflammation, induced by unilateral injection of endotoxin (et) in the substantia nigra (sn)/ventral tegmental area, on the proliferation and survival of stem/progenitor cells in the dentate gyrus (dg) of the hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Li Zhou, Xue-Rui Ran, Feng Hong, Guang-Wen Li, Jin-Xia Zh. Downregulated Dopamine Receptor 2 and Upregulated Corticotrophin Releasing Hormone in the Paraventricular Nucleus Are Correlated With Decreased Glucose Tolerance in Rats With Bilateral Substantia Nigra Lesions. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31396037. |
our previous studies have reported that pvn neurons express numerous dopamine receptors (drs) and accept direct projections from the substantia nigra (sn). |
2020-10-01 |
2023-08-13 |
mouse |
| Jizi Jin, Yanyan Tang, Kongping Li, Xialin Zuo, Lixuan Zhan, Weiwen Sun, En X. Bone Marrow Stromal Cells Alleviate Secondary Damage in the Substantia Nigra After Focal Cerebral Infarction in Rats. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31396057. |
previously, we had reported that the secondary degeneration occurred in the ipsilateral substantia nigra (sn) after permanent distal branch of middle cerebral artery occlusion (dmcao) in sprague-dawley rats. |
2020-10-01 |
2023-08-13 |
rat |
| Juan Lu, Xuelei Liu, Ye Tian, Hang Li, Zhenxing Ren, Shuang Liang, Guiyu Zhang, Caiping Zhao, Xinrong Li, Tingting Wang, Dongfeng Chen, Weihong Kuang, Meiling Zh. Moxibustion Exerts a Neuroprotective Effect through Antiferroptosis in Parkinson's Disease. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-10-01. PMID:31467572. |
a parkinson's disease model was established in rats using a two-point stereotactic 6-hydroxydopamine injection in the right substantia nigra (sn) and ventral tegmental area. |
2020-10-01 |
2023-08-13 |
rat |
| Takuya Fujiwara, Yoshiyuki Watanabe, Hisashi Tanaka, Hiroto Takahashi, Shin Nabatame, Wang Yi, Noriyuki Tomiyam. Quantitative susceptibility mapping (QSM) evaluation of infantile neuroaxonal dystrophy. BJR case reports. vol 5. issue 2. 2020-10-01. PMID:31501698. |
brain mri showed low intensity areas in globus pallidus (gp) and substantia nigra (sn) on |
2020-10-01 |
2023-08-13 |
Not clear |
| Ching-Chi Chiu, Tu-Hsueh Yeh, Rou-Shayn Chen, Hua-Chien Chen, Ying-Zu Huang, Yi-Hsin Weng, Yi-Chuan Cheng, Yu-Chuan Liu, Ann-Joy Cheng, Ya-Ching Lu, Yu-Jie Chen, Yan-Wei Lin, Chia-Chen Hsu, Ying-Ling Chen, Chin-Song Lu, Hung-Li Wan. Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:31572127. |
an upregulated level of mir-204-5p was also observed in the serum and substantia nigra (sn) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse model of pd. |
2020-10-01 |
2023-08-13 |
mouse |
| Chao Huang, Wenjing Ma, Qihui Luo, Liangqin Shi, Yu Xia, Chengjie Lao, Wentao Liu, Yuanfeng Zou, Anchun Cheng, Riyi Shi, Zhengli Che. Iron overload resulting from the chronic oral administration of ferric citrate induces parkinsonism phenotypes in middle-aged mice. Aging. vol 11. issue 21. 2020-10-01. PMID:31699955. |
in this study, we found that the chronic oral administration of ferric citrate (2.5 mg/day and 10 mg/day) for 16 weeks selectively induced iron accumulation in the corpus striatum (cpu), substantia nigra (sn) and hippocampus, which typically caused parkinsonism phenotypes in middle-aged mice. |
2020-10-01 |
2023-08-13 |
mouse |
| Shiqing Zhang, Peng Sun, Kaili Lin, Florence Hiu Ling Chan, Qi Gao, Wai Fung Lau, Vellaisamy A L Roy, Hongqi Zhang, King Wai Chiu Lai, Zhifeng Huang, Ken Kin Lam Yun. Extracellular Nanomatrix-Induced Self-Organization of Neural Stem Cells into Miniature Substantia Nigra-Like Structures with Therapeutic Effects on Parkinsonian Rats. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 24. 2020-10-01. PMID:31871862. |
substantia nigra (sn) is a complex and critical region of the brain wherein parkinson's disease (pd) arises from the degeneration of dopaminergic neurons. |
2020-10-01 |
2023-08-13 |
rat |
| Renrong Wei, Cuiping Rong, Qingfeng Xie, Shouhai Wu, Yuchao Feng, Ruihua Wang, Zhenhui Dai, Tongxiang Li. Neuroprotective Effect of Optimized Yinxieling Formula in 6-OHDA-Induced Chronic Model of Parkinson's Disease through the Inflammation Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2019. 2020-10-01. PMID:31929812. |
parkinson's disease (pd) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (sn)-striatum circuit, which is associated with glial activation and consequent chronic neuroinflammation. |
2020-10-01 |
2023-08-13 |
mouse |
| Tineke K Steiger, Nico Bunzec. Reward Dependent Invigoration Relates to Theta Oscillations and Is Predicted by Dopaminergic Midbrain Integrity in Healthy Elderly. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28174533. |
importantly, analyses of structural mri data revealed that individual reward-related differences in the elderlies' response time could be predicted by the structural integrity of the dopaminergic substantia nigra (sn; as measured by magnetization transfer (mt)). |
2020-09-30 |
2023-08-13 |
human |