| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Devika Agarwal, Cynthia Sandor, Viola Volpato, Tara M Caffrey, Jimena Monzón-Sandoval, Rory Bowden, Javier Alegre-Abarrategui, Richard Wade-Martins, Caleb Webbe. A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders. Nature communications. vol 11. issue 1. 2020-09-14. PMID:32826893. |
we describe a human single-nuclei transcriptomic atlas for the substantia nigra (sn), generated by sequencing approximately 17,000 nuclei from matched cortical and sn samples. |
2020-09-14 |
2023-08-13 |
human |
| Marta Carmo, Francisco Q Gonçalves, Paula M Canas, Jean-Pierre Oses, Francisco D Fernandes, Filipe V Duarte, Carlos M Palmeira, Angelo R Tomé, Paula Agostinho, Geanne M Andrade, Rodrigo A Cunh. Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A British journal of pharmacology. vol 176. issue 18. 2020-09-14. PMID:31220343. |
enhanced atp release and cd73-mediated adenosine formation sustain adenosine a parkinson's disease (pd) involves an initial loss of striatal dopamine terminals evolving into degeneration of dopamine neurons in substantia nigra (sn), which can be modelled by 6-hydroxydopamine (6-ohda) administration. |
2020-09-14 |
2023-08-13 |
Not clear |
| Diego Perez-Rodriguez, Maria Kalyva, Melissa Leija-Salazar, Tammaryn Lashley, Maxime Tarabichi, Viorica Chelban, Steve Gentleman, Lucia Schottlaender, Hannah Franklin, George Vasmatzis, Henry Houlden, Anthony H V Schapira, Thomas T Warner, Janice L Holton, Zane Jaunmuktane, Christos Proukaki. Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing. Acta neuropathologica communications. vol 7. issue 1. 2020-09-11. PMID:31870437. |
in msa substantia nigra (sn), we noted snca gains in > 3% of dopaminergic (da) neurons (identified by neuromelanin) and neuromelanin-negative cells, including olig2-positive oligodendroglia. |
2020-09-11 |
2023-08-13 |
Not clear |
| Ella A Kasanga, Catherine L Owens, Mark A Cantu, Adam D Richard, Richard W Davis, Lisa M McDivitt, Blake Blancher, Brandon S Pruett, Christopher Tan, Austin Gajewski, Fredric P Manfredsson, Vicki A Nejtek, Michael F Salvator. GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal GDNF in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion. ACS chemical neuroscience. vol 10. issue 10. 2020-09-04. PMID:31538765. |
in pd and aging models, gdnf affects tyrosine hydroxylase (th) expression or phosphorylation in substantia nigra (sn), long after a single gdnf injection in striatum. |
2020-09-04 |
2023-08-13 |
rat |
| Deirdre B Hoban, Shelby Shrigley, Bengt Mattsson, Ludivine S Breger, Ulla Jarl, Tiago Cardoso, Jenny Nelander Wahlestedt, Kelvin C Luk, Anders Björklund, Malin Parma. Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 26. 2020-09-01. PMID:32541058. |
in this study, we establish a humanized transplantation model of pd that better recapitulates the main disease features, obtained by coinjection of preformed human α-synuclein (α-syn) fibrils and adeno-associated virus (aav) expressing human wild-type α-syn unilaterally into the rat substantia nigra (sn). |
2020-09-01 |
2023-08-13 |
human |
| b' Sacha Bohler, Xiaosong Liu, Julian Krauskopf, Florian Caiment, Jiri Aubrecht, Gerry A F Nicolaes, Jos C S Kleinjans, Jacco J Bried\\xc3\\xa. Acetaminophen Overdose as a Potential Risk Factor for Parkinson\'s Disease. Clinical and translational science. vol 12. issue 6. 2020-08-31. PMID:31305025.' |
thus, it is plausible that acetaminophen is taken up by the dopaminergic transport system into the substantia nigra (sn). |
2020-08-31 |
2023-08-13 |
human |
| Jiuyang Ding, Shanshan Hu, Yunle Meng, Chen Li, Jian Huang, Yitong He, Pingming Qi. Alpha-Synuclein deficiency ameliorates chronic methamphetamine induced neurodegeneration in mice. Toxicology. vol 438. 2020-08-31. PMID:32278788. |
meth increased α-syn level in the stratum oriens, pyramidal layer, stratum radiatum and stratum moleculare of hippocampal ca1, ca2 and ca3, polymorph layer of hippocampal dentate gyrus (dg), and substantia nigra (sn). |
2020-08-31 |
2023-08-13 |
mouse |
| Esraa A Kandil, Rabab H Sayed, Lamiaa A Ahmed, Mai A Abd El Fattah, Bahia M El-Saye. Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease. Clinical and experimental pharmacology & physiology. vol 46. issue 12. 2020-08-28. PMID:31408200. |
treatment of rats with abz markedly mitigated rotenone-induced histological alterations in substantia nigra (sn), restored striatal dopamine (da) level and motor functions and decreased the expression of α-synuclein (a disease marker protein). |
2020-08-28 |
2023-08-13 |
rat |
| Yu Zhang, Qimei Wu, Lei Zhang, Qing Wang, Zexian Yang, Jia Liu, Linyin Fen. Caffeic acid reduces A53T α-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease. Pharmacological research. vol 150. 2020-08-24. PMID:31707034. |
tyrosine hydroxylase and α-synuclein were assessed by immunohistochemistry or western blot in the substantia nigra (sn). |
2020-08-24 |
2023-08-13 |
mouse |
| Zhan Liu, Ao-Wang Qiu, Yan Huang, Ya Yang, Jin-Na Chen, Ting-Ting Gu, Bei-Bei Cao, Yi-Hua Qiu, Yu-Ping Pen. IL-17A exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of Parkinson's disease. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31351185. |
neuroinflammation has been involved in pathogenesis of parkinson's disease (pd), a chronic neurodegenerative disease characterized neuropathologically by progressive dopaminergic neuronal loss in the substantia nigra (sn). |
2020-08-14 |
2023-08-13 |
mouse |
| Eoin O'Neill, Rosa Chiara Goisis, Ruth Haverty, Andrew Harki. L-alpha-aminoadipic acid restricts dopaminergic neurodegeneration and motor deficits in an inflammatory model of Parkinson's disease in male rats. Journal of neuroscience research. vol 97. issue 7. 2020-08-13. PMID:30924171. |
neuroinflammation is a contributory factor underlying the progressive nature of dopaminergic neuronal loss within the substantia nigra (sn) of parkinson's disease (pd) patients, albeit the role of astrocytes in this process has been relatively unexplored to date. |
2020-08-13 |
2023-08-13 |
rat |
| Yunhu Bai, Shengming Wang, Feifei Wu, Xiangjun Xie, Yayun Wang, Yanling Yan. The Changes of Mitochondria in Substantia Nigra and Anterior Cerebral Cortex of Hepatic Encephalopathy Induced by Thioacetamide. Anatomical record (Hoboken, N.J. : 2007). vol 302. issue 7. 2020-08-06. PMID:30290401. |
in this study, molecular biology analysis was used to analyze the mitochondrial morphology in the substantia nigra (sn) and anterior cerebral cortex (acc) of the he mice. |
2020-08-06 |
2023-08-13 |
mouse |
| Debashis Dutta, Madhuchhanda Kundu, Susanta Mondal, Avik Roy, Samantha Ruehl, Deborah A Hall, Kalipada Paha. RANTES-induced invasion of Th17 cells into substantia nigra potentiates dopaminergic cell loss in MPTP mouse model of Parkinson's disease. Neurobiology of disease. vol 132. 2020-08-06. PMID:31445159. |
however, which particular t cell subsets are recruited to the substantia nigra (sn) by rantes is not known. |
2020-08-06 |
2023-08-13 |
mouse |
| Miquel Vila, Ariadna Laguna, Iria Carballo-Carbaja. Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology. Autophagy. vol 15. issue 11. 2020-08-06. PMID:31480882. |
in parkinson disease (pd), there is a preferential degeneration of neurons that contain the dark-brown cytoplasmic pigment neuromelanin, in particular dopaminergic neurons of the substantia nigra (sn), the loss of which leads to the typical motor symptoms of the disease and constitutes the cardinal pathological diagnostic criterion for pd. |
2020-08-06 |
2023-08-13 |
Not clear |
| Mohammad Raziya Banu, Muhammed Ibrahim, K Prabhu, Srinivasagam Rajasanka. Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats. Cells, tissues, organs. vol 208. issue 1-2. 2020-08-05. PMID:31982873. |
withaferin-a (wa) was evaluated for its neuroprotective efficacy on the dopamine (da) neurons of the substantia nigra (sn) and striatum (st) in aged rats. |
2020-08-05 |
2023-08-13 |
rat |
| Hui-Quan Li, Nicholas C Spitze. Exercise enhances motor skill learning by neurotransmitter switching in the adult midbrain. Nature communications. vol 11. issue 1. 2020-08-03. PMID:32366867. |
consistent with regulation of motor skills, we show that the switching neurons make projections to the substantia nigra (sn), ventral tegmental area (vta) and ventrolateral-ventromedial nuclei of the thalamus (vl-vm). |
2020-08-03 |
2023-08-13 |
mouse |
| Edward J Robinson, Sebastian Aguiar, Marten P Smidt, Lars P van der Heid. MCL1 as a Therapeutic Target in Parkinson's Disease? Trends in molecular medicine. vol 25. issue 12. 2020-07-21. PMID:31706839. |
dopamine neurons in the substantia nigra (sn) pars compacta are selectively lost during the progression of parkinson's disease (pd). |
2020-07-21 |
2023-08-13 |
Not clear |
| Basma Radwan, He Liu, Dipesh Chaudhur. The role of dopamine in mood disorders and the associated changes in circadian rhythms and sleep-wake cycle. Brain research. vol 1713. 2020-07-20. PMID:30481503. |
dopamine is primarily produced in the substantia nigra (sn) and the ventral tegmentum area (vta) in the brain. |
2020-07-20 |
2023-08-13 |
Not clear |
| Buket Ucar, Christian Humpe. Therapeutic efficacy of glial cell-derived neurotrophic factor loaded collagen scaffolds in ex vivo organotypic brain slice Parkinson's disease models. Brain research bulletin. vol 149. 2020-07-20. PMID:31004735. |
glial cell line-derived neurotrophic factor (gdnf) is a potent trophic factor that supports the survival of dopaminergic neurons of the substantia nigra (sn), which degenerate in parkinson's disease (pd). |
2020-07-20 |
2023-08-13 |
mouse |
| Marianna A Pagida, Anastasia E Konstantinidou, Margarita A Chrysanthou-Piterou, Efstratios S Patsouris, Maria T Panayotacopoulo. Apoptotic Markers in the Midbrain of the Human Neonate After Perinatal Hypoxic/Ischemic Injury. Journal of neuropathology and experimental neurology. vol 79. issue 1. 2020-07-20. PMID:31803912. |
our previous postmortem studies on neonates with neuropathological injury of perinatal hypoxia/ischemia (phi) showed a dramatic reduction of tyrosine hydroxylase expression (dopamine synthesis enzyme) in substantia nigra (sn) neurons, with reduction of their cellular size. |
2020-07-20 |
2023-08-13 |
human |