| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Shen, Dong-Lin Li, Xiu-Xiu Tan, Wei-Wei Tao, Cheng-Juan Xie, Xue-Gong Shi, Yu Wan. A transcranial sonography study of brainstem and its association with depression in idiopathic generalized epilepsy with tonic-clonic seizures. Epilepsy & behavior : E&B. vol 102. 2020-10-19. PMID:31726317. |
echogenicity of the caudate nuclei (cn), lentiform nuclei (ln), substantia nigra (sn), and br and widths of the lateral ventricle (lv) frontal horns and the third ventricle (tv) were assessed via tcs. |
2020-10-19 |
2023-08-13 |
Not clear |
| Jay S Schneider, Radha Aras, Courtney K Williams, James B Koprich, Jonathan M Brotchie, Vikrant Sing. GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson's Disease. Scientific reports. vol 9. issue 1. 2020-10-14. PMID:31182727. |
we used targeted adeno-associated viral vector (aav) overexpression of human mutant α-synuclein (a53t) in the rat substantia nigra (sn) to produce degeneration of sn dopamine neurons, loss of striatal dopamine levels, and behavioral impairment. |
2020-10-14 |
2023-08-13 |
human |
| Jia-Xi Wang, Jin-Ying Zhuang, Lulu Fu, Qin Lei, Mingxia Fan, Weidong Zhan. How ovarian hormones influence the behavioral activation and inhibition system through the dopamine pathway. PloS one. vol 15. issue 8. 2020-10-07. PMID:32790683. |
prior reports point dopamine (da) pathways, mainly including ventral tegmental area (vta) and substantia nigra (sn), implicate in subserving reward-related functions associated with bas and inhibitory functions related with bis. |
2020-10-07 |
2023-08-13 |
Not clear |
| Govindhasamy Pushpavathi Selvakumar, Mohammad Ejaz Ahmed, Sudhanshu P Raikwar, Ramasamy Thangavel, Duraisamy Kempuraj, Iuliia Dubova, Daniyal Saeed, Haris Zahoor, Keerthivaas Premkumar, Smita Zaheer, Shankar Iyer, Asgar Zahee. CRISPR/Cas9 Editing of Glia Maturation Factor Regulates Mitochondrial Dynamics by Attenuation of the NRF2/HO-1 Dependent Ferritin Activation in Glial Cells. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 4. 2020-10-05. PMID:30810907. |
we have previously shown that gmf expression is significantly upregulated in the substantia nigra (sn) of pd brains. |
2020-10-05 |
2023-08-13 |
Not clear |
| Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Justyna Barut, Piotr Chmielarz, Marta Kot, Monika Bagińska, Rosanna Parlato, Władysława Anna Daniel, Irena Nalep. Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism. Scientific reports. vol 9. issue 1. 2020-10-05. PMID:30918302. |
postmortem studies of brains from pd patients have revealed the degeneration of noradrenergic neurons in the locus coeruleus (lc) to the same or even greater extent than that observed in the dopaminergic neurons of substantia nigra (sn) and ventral tegmental area (vta). |
2020-10-05 |
2023-08-13 |
mouse |
| Katherine A Fu, Romil Nathan, Ivo D Dinov, Junning Li, Arthur W Tog. T2-Imaging Changes in the Nigrosome-1 Relate to Clinical Measures of Parkinson's Disease. Frontiers in neurology. vol 7. 2020-10-01. PMID:27812347. |
the nigrosome-1 region of the substantia nigra (sn) undergoes the greatest and earliest dopaminergic neuron loss in parkinson's disease (pd). |
2020-10-01 |
2023-08-13 |
Not clear |
| Evgeny A Budygin, Erik B Oleson, Yun Beom Lee, Lawrence C Blume, Michael J Bruno, Allyn C Howlett, Alexis C Thompson, Caroline E Bas. Acute Depletion of D2 Receptors from the Rat Substantia Nigra Alters Dopamine Kinetics in the Dorsal Striatum and Drug Responsivity. Frontiers in behavioral neuroscience. vol 10. 2020-10-01. PMID:28154530. |
the present study takes a different approach using rna interference (rnai) to knockdown the expression of the d2 receptors (d2r) in the substantia nigra (sn), including dopaminergic neurons, which project primarily to the dorsal striatum (dstr) in adult rats. |
2020-10-01 |
2023-08-13 |
mouse |
| Yunseon Jang, Min Joung Lee, Jeongsu Han, Soo Jeong Kim, Ilhwan Ryu, Xianshu Ju, Min Jeong Ryu, Woosuk Chung, Eungseok Oh, Gi Ryang Kweon, Jun Young He. A High-fat Diet Induces a Loss of Midbrain Dopaminergic Neuronal Function That Underlies Motor Abnormalities. Experimental neurobiology. vol 26. issue 2. 2020-10-01. PMID:28442947. |
a dopaminergic neuronal pathway from the substantia nigra (sn) to the striatum is responsible for regulating grip strength and motor initiation through tyrosine hydroxylase (th) activity-dependent dopamine release. |
2020-10-01 |
2023-08-13 |
mouse |
| Shuifen Ye, Ho Kee Koon, Wen Fan, Yihui Xu, Wei Wei, Chuanshan Xu, Jing Ca. Effect of a Traditional Chinese Herbal Medicine Formulation on Cell Survival and Apoptosis of MPP Parkinson's disease. vol 2017. 2020-10-01. PMID:28607800. |
effect of a traditional chinese herbal medicine formulation on cell survival and apoptosis of mpp progressive degeneration of dopaminergic neurons in the substantia nigra (sn) is implicated in parkinson's disease (pd). |
2020-10-01 |
2023-08-13 |
Not clear |
| Rui Cui, Yunxiao Kang, Li Wang, Shuangcheng Li, Xiaoming Ji, Wensheng Yan, Guoliang Zhang, Huixian Cui, Geming Sh. Testosterone Propionate Exacerbates the Deficits of Nigrostriatal Dopaminergic System and Downregulates Nrf2 Expression in Reserpine-Treated Aged Male Rats. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28620296. |
the status of oxidative stress of experimental animals was evaluated by analyzing oxidative stress parameters and nuclear factor erythroid 2-related factor 2 (nrf2)-antioxidant response element (are) signaling pathway in substantia nigra (sn). |
2020-10-01 |
2023-08-13 |
rat |
| Yuan Fang, Yanchao Dong, Tao Zheng, Dan Du, Jiexia Wen, Dawei Gao, Lanxiang Li. Altered Tracer Distribution and Clearance in the Extracellular Space of the Substantia Nigra in a Rodent Model of Parkinson's Disease. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28790882. |
all rats received an injection of the extracellular tracer gadolinium-diethylene triaminepentacetic acid (gd-dtpa) directly into the substantia nigra (sn). |
2020-10-01 |
2023-08-13 |
rat |
| Moritz D Brandt, Diana Krüger-Gerlach, Andreas Hermann, Anne K Meyer, Kwang-Soo Kim, Alexander Storc. Early Postnatal but Not Late Adult Neurogenesis Is Impaired in the Pitx3-Mutant Animal Model of Parkinson's Disease. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28883785. |
as dopamine plays an important role in regulating precursor cell proliferation, the loss of dopaminergic neurons in the substantia nigra (sn) in pd may be related to the reduced neurogenesis observed in the neurogenic regions of the adult brain: subventricular zone (svz) and dentate gyrus (dg). |
2020-10-01 |
2023-08-13 |
mouse |
| Janin Lautenschläger, Eugene V Mosharov, Ellen Kanter, David Sulzer, Gabriele S Kaminski Schierl. An Easy-to-Implement Protocol for Preparing Postnatal Ventral Mesencephalic Cultures. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:29556177. |
here, we provide an easy-to-implement protocol for culturing postnatal ventral mesencephalic cells from the substantia nigra (sn) and the ventral tegmental area using commercially available media, dishes, and general lab equipment, avoiding extensive material and equipment purchases. |
2020-10-01 |
2023-08-13 |
Not clear |
| Danielle E Mor, Harry Ischiropoulo. The Convergence of Dopamine and α-Synuclein: Implications for Parkinson's Disease. Journal of experimental neuroscience. vol 12. 2020-10-01. PMID:29559809. |
in parkinson's disease (pd), the loss of dopamine-producing neurons in the substantia nigra (sn) leads to severe motor impairment, and pathological inclusions known as lewy bodies contain aggregated α-synuclein protein. |
2020-10-01 |
2023-08-13 |
mouse |
| Xialin Zuo, Qinghua Hou, Jizi Jin, Xiaohui Chen, Lixuan Zhan, Yanyan Tang, Zhe Shi, Weiwen Sun, En X. Inhibition of Cathepsins B Induces Neuroprotection Against Secondary Degeneration in Ipsilateral Substantia Nigra After Focal Cortical Infarction in Adult Male Rats. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:29867438. |
here, we investigate the role of cathb in the secondary degeneration of ipsilateral substantia nigra (sn) after focal cortical infarction. |
2020-10-01 |
2023-08-13 |
rat |
| Eugene Bok, Eun Ju Cho, Eun Sook Chung, Won-Ho Shin, Byung Kwan Ji. Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra Experimental neurobiology. vol 27. issue 4. 2020-10-01. PMID:30181693. |
interleukin-4 contributes to degeneration of dopamine neurons in the lipopolysaccharide-treated substantia nigra the present study investigated the effects of interleukin (il)-4 on dopamine (da) neurons in the substantia nigra (sn) |
2020-10-01 |
2023-08-13 |
Not clear |
| Sun Ryu, Hyongjun Jeon, Sungtae Koo, Seungtae Ki. Korean Red Ginseng Enhances Neurogenesis in the Subventricular Zone of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mice. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30459594. |
after the last pole test, dopaminergic neuronal survival in the striatum and the substantia nigra (sn), cell proliferation in the svz and mrna expression of neurotrophic factors and dopamine receptors in the striatum were evaluated. |
2020-10-01 |
2023-08-13 |
mouse |
| Khadija Tayara, Ana M Espinosa-Oliva, Irene García-Domínguez, Afrah Abdul Ismaiel, Antonio Boza-Serrano, Tomas Deierborg, Alberto Machado, Antonio J Herrera, José L Venero, Rocío M de Pablo. Divergent Effects of Metformin on an Inflammatory Model of Parkinson's Disease. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30519161. |
however, the effect of metformin on the substantia nigra (sn), the main structure affected in parkinson's disease (pd), has not yet been studied in depth. |
2020-10-01 |
2023-08-13 |
rat |
| Soledad Marton, Bruno González, Sebastián Rodríguez-Bottero, Ernesto Miquel, Laura Martínez-Palma, Mariana Pazos, José Pedro Prieto, Paola Rodríguez, Dalibor Sames, Gustavo Seoane, Cecilia Scorza, Patricia Cassina, Ignacio Carrer. Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30890941. |
in this work, we examined the effect of ibogaine acute administration on the expression of these nfs in the vta, prefrontal cortex (pfc), nucleus accumbens (nacc) and the substantia nigra (sn). |
2020-10-01 |
2023-08-13 |
human |
| Yan-Li Yang, Xue-Rui Ran, Yong Li, Li Zhou, Li-Fei Zheng, Yu Han, Qing-Qing Cai, Zhi-Yong Wang, Jin-Xia Zh. Expression of Dopamine Receptors in the Lateral Hypothalamic Nucleus and Their Potential Regulation of Gastric Motility in Rats With Lesions of Bilateral Substantia Nigra. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:30923496. |
we have previously demonstrated that the neurons in the substantia nigra (sn) project to the lateral hypothalamic nucleus (lh) and the dorsal motor nucleus of vagus (dmv) receives the neural projection from lh by the means of anterograde and retrograde neural tracing technology. |
2020-10-01 |
2023-08-13 |
rat |