Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Belén Fernández, Isidro Ferrer, Fernando Gil, Sabine Hilfike. Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients. Toxicology reports. vol 4. 2020-09-30. PMID:28529891. |
iron levels in the healthy human brain are known to be high in certain areas such as the substantia nigra (sn), and increase further with age. |
2020-09-30 |
2023-08-13 |
mouse |
Chun Huang, Li Zhu, Huan Li, Fu-Guo Shi, Guo-Qing Wang, Yi-Zheng Wei, Jie Liu, Feng Zhan. Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:28533741. |
parkinson's disease (pd) is the second most neurodegenerative disorder with a regional decrease of dopamine (da) neurons in the substantia nigra (sn). |
2020-09-30 |
2023-08-13 |
rat |
Ashwin G Ramayya, Isaac Pedisich, Deborah Levy, Anastasia Lyalenko, Paul Wanda, Daniel Rizzuto, Gordon H Baltuch, Michael J Kahan. Proximity of Substantia Nigra Microstimulation to Putative GABAergic Neurons Predicts Modulation of Human Reinforcement Learning. Frontiers in human neuroscience. vol 11. 2020-09-30. PMID:28536513. |
neuronal firing in the substantia nigra (sn) immediately following reward is thought to play a crucial role in human reinforcement learning. |
2020-09-30 |
2023-08-13 |
human |
Juan M Viveros-Paredes, Rocio E González-Castañeda, Juerg Gertsch, Veronica Chaparro-Huerta, Rocio I López-Roa, Eduardo Vázquez-Valls, Carlos Beas-Zarate, Antoni Camins-Espuny, Mario E Flores-Sot. Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson's Disease Induced by MPTP. Pharmaceuticals (Basel, Switzerland). vol 10. issue 3. 2020-09-30. PMID:28684694. |
parkinson's disease (pd) is one of the most common neurodegenerative disorders and is characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2020-09-30 |
2023-08-13 |
Not clear |
Qingqing Wang, Nan Ren, Zhipeng Cai, Qingxia Lin, Zhangjing Wang, Qunwei Zhang, Siying Wu, Huangyuan L. Paraquat and MPTP induce neurodegeneration and alteration in the expression profile of microRNAs: the role of transcription factor Nrf2. NPJ Parkinson's disease. vol 3. 2020-09-30. PMID:29071302. |
exposure to 10 mg/kg pq or 30 mg/kg mptp caused damage to nerve cells in the substantia nigra (sn) in both nrf2 (+/+) and nrf2 (-/-) icr mice, which included cell morphological changes, detectable apoptosis and a significant reduction in the number of dopaminergic (da) neurons. |
2020-09-30 |
2023-08-13 |
mouse |
Eleonora Carboni, Jan-David Nicolas, Mareike Töpperwien, Christine Stadelmann-Nessler, Paul Lingor, Tim Saldit. Imaging of neuronal tissues by x-ray diffraction and x-ray fluorescence microscopy: evaluation of contrast and biomarkers for neurodegenerative diseases. Biomedical optics express. vol 8. issue 10. 2020-09-30. PMID:29082068. |
we have used scanning x-ray diffraction (xrd) and x-ray fluorescence (xrf) with micro-focused synchrotron radiation to study histological sections from human substantia nigra (sn). |
2020-09-30 |
2023-08-13 |
human |
Guo-Qing Wang, Dai-Di Li, Chun Huang, Di-Sheng Lu, Chao Zhang, Shao-Yu Zhou, Jie Liu, Feng Zhan. Icariin Reduces Dopaminergic Neuronal Loss and Microglia-Mediated Inflammation Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29375304. |
icariin reduces dopaminergic neuronal loss and microglia-mediated inflammation parkinson's disease (pd) is one of the most common neurodegenerative diseases characterized with a gradual loss of midbrain substantia nigra (sn) dopamine (da) neurons. |
2020-09-30 |
2023-08-13 |
rat |
Tatiana V Tarasova, Olga A Lytkina, Valeria V Goloborshcheva, Larisa N Skuratovskaya, Alexandr I Antohin, Ruslan K Ovchinnikov, Michail S Kukharsk. Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain. PeerJ. vol 6. 2020-09-30. PMID:29785351. |
previous studies of knockout mice have shown that inactivation of alpha-synuclein gene can lead to the reduction in number of da neurons in the substantia nigra (sn). |
2020-09-30 |
2023-08-13 |
mouse |
Tatiana V Tarasova, Olga A Lytkina, Valeria V Goloborshcheva, Larisa N Skuratovskaya, Alexandr I Antohin, Ruslan K Ovchinnikov, Michail S Kukharsk. Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain. PeerJ. vol 6. 2020-09-30. PMID:29785351. |
alpha-synuclein exerts a modulating effect on the formation of da neurons in the sn and has no effect on the formation of da neurons in vta, the structure that is much less susceptible to degeneration in a brain with pd, suggesting a potential role of alpha-synuclein in the development of the population of da neurons in substantia nigra. |
2020-09-30 |
2023-08-13 |
mouse |
Saumitra S Singh, Sachchida N Rai, Hareram Birla, Walia Zahra, Gaurav Kumar, Mallikarjuna R Gedda, Neeraj Tiwari, Ranjana Patnaik, Rakesh K Singh, Surya P Sing. Effect of Chlorogenic Acid Supplementation in MPTP-Intoxicated Mouse. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30127737. |
the activation of glial cells and oxidative stress levels were also estimated using inducible nitric oxide synthase (inos) and glial fibrillary acidic protein (gfap) immunoreactivity within substantia nigra (sn) and striatum of mptp-injected mice. |
2020-09-30 |
2023-08-13 |
mouse |
Margabandhu Gopi, Arambakkam Janardhanam Vanisre. Attenuated levels of phospholipids in the striatum of rats infused with rotenone causing hemiparkinsonism as detected by simple dye-lipid complex. IBRO reports. vol 3. 2020-09-30. PMID:30135937. |
parkinson's disease (pd), a progressive neurodegeneration, is characterized by loss of dopaminergic neurons in the substantia nigra (sn) and loss of motor co-ordination. |
2020-09-30 |
2023-08-13 |
rat |
Yuko Nakamura, Naohiro Okada, Akira Kunimatsu, Kiyoto Kasai, Shinsuke Koik. Anatomical Templates of the Midbrain Ventral Tegmental Area and Substantia Nigra for Asian Populations. Frontiers in psychiatry. vol 9. 2020-09-30. PMID:30210369. |
considering that the ventral tegmental area (vta) and substantia nigra (sn) in the midbrain are the primary dopamine producers, creating reliable anatomical templates of the vta and sn through neuroimaging studies would be useful for achieving a detailed understanding of this dopaminergic system. |
2020-09-30 |
2023-08-13 |
Not clear |
Xing-Zhi Guo, Chang Shan, Yan-Fang Hou, Geng Zhu, Bei Tao, Li-Hao Sun, Hong-Yan Zhao, Guang Ning, Sheng-Tian Li, Jian-Min Li. Osteocalcin Ameliorates Motor Dysfunction in a 6-Hydroxydopamine-Induced Parkinson's Disease Rat Model Through AKT/GSK3β Signaling. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:30319352. |
as dopaminergic neuronal injury in the substantia nigra (sn) is a pathological hallmark of parkinson's disease (pd), we investigated whether ocn could exert protective effects on 6-hydroxydopamine (6-ohda)-induced pd rat model. |
2020-09-30 |
2023-08-13 |
rat |
Biswarup Ghosh, Chen Zhang, Kristine S Ziemba, Anita M Fletcher, David M Yurek, George M Smit. Partial Reconstruction of the Nigrostriatal Circuit along a Preformed Molecular Guidance Pathway. Molecular therapy. Methods & clinical development. vol 14. 2020-09-30. PMID:31417940. |
the overall goal of our research is to establish a preformed molecular guidance pathway to direct the growth of dopaminergic axons from embryonic ventral mesencephalon (vm), tissue placed within the substantia nigra (sn), into the striatum to reconstruct the nigrostriatal pathway in a hemi-parkinson's disease rat model. |
2020-09-30 |
2023-08-13 |
rat |
Liangqin Shi, Chao Huang, Qihui Luo, Edmond Rogers, Yu Xia, Wentao Liu, Wenjing Ma, Wen Zeng, Li Gong, Jing Fang, Li Tang, Anchun Cheng, Riyi Shi, Zhengli Che. The Association of Iron and the Pathologies of Parkinson's Diseases in MPTP/MPP Frontiers in aging neuroscience. vol 11. 2020-09-30. PMID:31543809. |
the association of iron and the pathologies of parkinson's diseases in mptp/mpp despite much efforts in the last few decades, the mechanism of degeneration of dopamine (da) neurons in the substantia nigra (sn) in parkinson's disease (pd) remains unclear. |
2020-09-30 |
2023-08-13 |
monkey |
Hui Zhou, Lili Niu, Long Meng, Zhengrong Lin, Junjie Zou, Xiangxiang Xia, Xiaowei Huang, Wei Zhou, Tianyuan Bian, Hairong Zhen. Noninvasive Ultrasound Deep Brain Stimulation for the Treatment of Parkinson's Disease Model Mouse. Research (Washington, D.C.). vol 2019. 2020-09-30. PMID:31549045. |
moreover, our results reveal that stn-udbs or gp-udbs protects the dopamine (da) neurons from mptp neurotoxicity by downregulating bax (p < 0.001), upregulating bcl-2 (p < 0.01), blocking cytochrome c (cyt c) release from mitochondria (p < 0.05), and reducing cleaved-caspase 3 activity (p < 0.01) in the ipsilateral substantia nigra (sn). |
2020-09-30 |
2023-08-13 |
mouse |
Sora Ahn, Quan Feng Liu, Jae-Hwan Jang, Jeonghun Park, Ha Jin Jeong, Youngman Kim, Dong-Hee Kim, Guwon Jeong, Seung Tack Oh, Seong-Uk Park, Seung-Yeon Cho, Hi-Joon Park, Songhee Jeo. Gami-Chunggan Formula Prevents Motor Dysfunction in MPTP/p-Induced and A53T α-Synuclein Overexpressed Parkinson's Disease Mouse Model Though DJ-1 and BDNF Expression. Frontiers in aging neuroscience. vol 11. 2020-09-30. PMID:31555122. |
moreover, gcf inhibited the reduction of dopaminergic neurons in the substantia nigra (sn) and fibers in the striatum (st) against mptp/p challenge. |
2020-09-30 |
2023-08-13 |
mouse |
Asuncion Carmona, Stéphane Roudeau, Laura Perrin, Carole Carcenac, Delphine Vantelon, Marc Savasta, Richard Orteg. Mapping Chemical Elements and Iron Oxidation States in the Substantia Nigra of 6-Hydroxydopamine Lesioned Rats Using Correlative Immunohistochemistry With Proton and Synchrotron Micro-Analysis. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31680798. |
for example, iron concentration is increased in the substantia nigra (sn) of parkinson's disease patients and iron redox reactions might be involved in the pathogenesis. |
2020-09-30 |
2023-08-13 |
human |
Peng-Fei Qiao, Feng Shi, Ming-Fang Jiang, Yang Gao, Guang-Ming Ni. Application of high-field magnetic resonance imaging in Parkinson's disease. Experimental and therapeutic medicine. vol 13. issue 5. 2020-09-29. PMID:28565751. |
the corrected phase (cp) values of the substantia nigra (sn), red nucleus (rn), globus pallidus (gp) and putamen (put) were measured, and fractional anisotropy (fa) and apparent diffusion coefficient (adc) values were obtained. |
2020-09-29 |
2023-08-13 |
Not clear |
David Sulzer, Clifford Cassidy, Guillermo Horga, Un Jung Kang, Stanley Fahn, Luigi Casella, Gianni Pezzoli, Jason Langley, Xiaoping P Hu, Fabio A Zucca, Ioannis U Isaias, Luigi Zecc. Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson's disease. NPJ Parkinson's disease. vol 4. 2020-09-29. PMID:29644335. |
the diagnosis of parkinson's disease (pd) occurs after pathogenesis is advanced and many substantia nigra (sn) dopamine neurons have already died. |
2020-09-29 |
2023-08-13 |
human |