| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hemraj B Dodiya, Christopher B Forsyth, Robin M Voigt, Phillip A Engen, Jinal Patel, Maliha Shaikh, Stefan J Green, Ankur Naqib, Avik Roy, Jeffrey H Kordower, Kalipada Pahan, Kathleen M Shannon, Ali Keshavarzia. Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease. Neurobiology of disease. vol 135. 2021-01-15. PMID:30579705. |
in addition, rs promoted a number of rotenone-induced effects in the brain including: 1) reduced number of resting microglia and a higher number of dystrophic/phagocytic microglia as well as (fj-c+) dying cells in the substantia nigra (sn), 2) increased lipopolysaccharide (lps) reactivity in the sn, and 3) reduced dopamine (da) and da metabolites (dopac, hva) in the striatum compared to control mice. |
2021-01-15 |
2023-08-13 |
mouse |
| Oeystein Roed Brekk, Jonathan R Honey, Seungil Lee, Penelope J Hallett, Ole Isacso. Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 44. 2021-01-07. PMID:33060302. |
little is known of the cellular distribution of neutral lipids in the substantia nigra (sn) of parkinson's disease (pd) patients and its relationship to inflammatory signaling. |
2021-01-07 |
2023-08-13 |
mouse |
| Qi-Wen Han, Yu-He Yuan, Nai-Hong Che. The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31442553. |
parkinson's disease (pd) is a neurodegenerative disease and its characteristic is the progressive degeneration of dopaminergic neurons within the substantia nigra (sn) of the midbrain. |
2021-01-04 |
2023-08-13 |
Not clear |
| Ru Zeng, Qian Zhou, Wei Zhang, Xiaolong Fu, Qin Wu, Yuanfu Lu, Jingshan Shi, Shaoyu Zho. Icariin-mediated activation of autophagy confers protective effect on rotenone induced neurotoxicity in vivo and in vitro. Toxicology reports. vol 6. 2021-01-01. PMID:31334034. |
immunohistochemical analysis showed a significant loss in da neurons in the substantia nigra (sn) of rats treated with rot, accompanied by an increase in the accumulation of α-synuclein and a compromised mitochondrial respiration. |
2021-01-01 |
2023-08-13 |
rat |
| Xiao-Wen Wang, Liang-Jie Yuan, Ye Yang, Mei Zhang, Wen-Fang Che. IGF-1 inhibits MPTP/MPP American journal of physiology. Endocrinology and metabolism. vol 319. issue 4. 2020-12-31. PMID:32865008. |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) treatment significantly induced mouse movement disorder and decreased the protein level of tyrosine hydroxylase (th) in the substantia nigra (sn) and dopamine (da) content in striatum. |
2020-12-31 |
2023-08-13 |
mouse |
| Mariana Grigoruţă, Alejandro Martínez-Martínez, Raul Y Dagda, Ruben K Dagd. Psychological Stress Phenocopies Brain Mitochondrial Dysfunction and Motor Deficits as Observed in a Parkinsonian Rat Model. Molecular neurobiology. vol 57. issue 4. 2020-12-29. PMID:31836946. |
in pd, a substantial loss of substantia nigra (sn) neurons leads to rigid tremors, bradykinesia, and chronic fatigue. |
2020-12-29 |
2023-08-13 |
human |
| Minju Jo, Se-Hong O. A preliminary attempt to visualize nigrosome 1 in the substantia nigra for Parkinson's disease at 3T: An efficient susceptibility map-weighted imaging (SMWI) with quantitative susceptibility mapping using deep neural network (QSMnet). Medical physics. vol 47. issue 3. 2020-12-29. PMID:31883389. |
visibility of nigrosome 1 in the substantia nigra (sn) is used as an mr imaging biomarker for parkinson's disease. |
2020-12-29 |
2023-08-13 |
Not clear |
| Chen-Hong Guo, Ting Cao, Long-Tai Zheng, John L Waddington, Xue-Chu Zhe. Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson's disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin. Acta pharmacologica Sinica. vol 41. issue 4. 2020-12-21. PMID:32112040. |
the results showed that dicer cko mice exhibited progressive loss of da neurons in the substantia nigra (sn) following tamoxifen administration. |
2020-12-21 |
2023-08-13 |
mouse |
| Jiangnan Ma, Jinzhao Gao, Mengyue Niu, Xiaona Zhang, Jing Wang, Anmu Xi. P2X4R Overexpression Upregulates Interleukin-6 and Exacerbates 6-OHDA-Induced Dopaminergic Degeneration in a Rat Model of PD. Frontiers in aging neuroscience. vol 12. 2020-12-18. PMID:33328961. |
to study the possible effect of the atp-p2x4r signal axis on il-6 in pd, lentivirus carrying the p2x4r-overexpression gene or empty vector was injected into the substantia nigra (sn) of rats, followed by treatment of 6-hydroxydopamine (6-ohda) or saline 1 week later. |
2020-12-18 |
2023-08-13 |
rat |
| Jannik Prasuhn, Marcus Heldmann, Thomas F Münte, Norbert Brüggeman. A machine learning-based classification approach on Parkinson's disease diffusion tensor imaging datasets. Neurological research and practice. vol 2. 2020-12-17. PMID:33324945. |
the objective of our study is to investigate whether diffusion tensor imaging (dti) of the substantia nigra (sn) analyzed by machine learning algorithms (ml) can be used to identify pd patients. |
2020-12-17 |
2023-08-13 |
Not clear |
| Philipp Mahlknecht, Heike Stockner, Kathrin Marini, Arno Gasperi, Atbin Djamshidian, Peter Willeit, Stefan Kiechl, Johann Willeit, Gregorio Rungger, Werner Poewe, Klaus Sepp. Midbrain hyperechogenicity, hyposmia, mild parkinsonian signs and risk for incident Parkinson's disease over 10 years: A prospective population-based study. Parkinsonism & related disorders. vol 70. 2020-12-17. PMID:31864071. |
associations of substantia nigra (sn) hyperechogenicity on transcranial sonography, olfactory dysfunction, and mild parkinsonian signs (mps) with incident parkinson's disease (pd) have only been studied over limited periods of follow-up and their long-term predictive properties are unclear. |
2020-12-17 |
2023-08-13 |
Not clear |
| Kai Li, Yi-Lun Ge, Chen-Chen Gu, Jin-Ru Zhang, Hong Jin, Jiao Li, Xiao-Yu Cheng, Ya-Ping Yang, Fen Wang, Ying-Chun Zhang, Jing Chen, Cheng-Jie Mao, Chun-Feng Li. Substantia nigra echogenicity is associated with serum ferritin, gender and iron-related genes in Parkinson's disease. Scientific reports. vol 10. issue 1. 2020-12-11. PMID:32457446. |
substantia nigra (sn) hyperechogenicity is present in most parkinson's disease (pd) cases but is occasionally absent in some. |
2020-12-11 |
2023-08-13 |
human |
| E V Novosadova, V V Nenasheva, I V Makarova, O V Dolotov, L S Inozemtseva, E L Arsenyeva, S V Chernyshenko, R I Sultanov, S N Illarioshkin, I A Grivennikov, V Z Tarantu. Parkinson's Disease-Associated Changes in the Expression of Neurotrophic Factors and their Receptors upon Neuronal Differentiation of Human Induced Pluripotent Stem Cells. Journal of molecular neuroscience : MN. vol 70. issue 4. 2020-12-04. PMID:31820346. |
parkinson's disease (pd) is a neurodegenerative pathology resulting from the degeneration of dopaminergic (da) neurons in the substantia nigra (sn). |
2020-12-04 |
2023-08-13 |
human |
| Ting Li, Jing Shi, Bin Qin, Dongsheng Fan, Na Liu, Jingnian Ni, Tianqing Zhang, Hufang Zhou, Xiaoqing Xu, Mingqing Wei, Xuekai Zhang, Xiangzhu Wang, Jianping Liu, Yongyan Wang, Jinzhou Tia. Increased substantia nigra echogenicity correlated with visual hallucinations in Parkinson's disease: a Chinese population-based study. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 41. issue 3. 2020-11-30. PMID:31754876. |
as a noninvasive technique, transcranial sonography (tcs) of substantia nigra (sn) has gradually showed its effectiveness not only in diagnosis but also in understanding clinical features of parkinson's disease (pd). |
2020-11-30 |
2023-08-13 |
human |
| Carmen Diaz-Ruiz, Begoña Villar-Cheda, Antonio Dominguez-Meijide, Pablo Garrido-Gil, Maria J Guerra, Jose L Labandeira-Garci. Aging-Related Overactivity of the Angiotensin/AT1 Axis Decreases Sirtuin 3 Levels in the Substantia Nigra, Which Induces Vulnerability to Oxidative Stress and Neurodegeneration. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 75. issue 3. 2020-11-20. PMID:30412227. |
treatment with the specific sirt3 inhibitor agk7 induced overexpression of at1 and at2 in substantia nigra (sn) of rats, and in dopaminergic neuronal mes23.5 and microglial n9 cell lines. |
2020-11-20 |
2023-08-13 |
mouse |
| b' Ba\\xc5\\x9fak \\xc5\\x9eenel, Erguvan T \\xc3\\x96zel-K\\xc4\\xb1z\\xc4\\xb1l, Mine H Sorgun, Sabiha Tezcan-Aydemir, Sevin\\xc3\\xa7 K\\xc4\\xb1r\\xc4\\xb1c\\xc4\\xb. Transcranial sonography imaging of brainstem raphe, substantia nigra and cerebral ventricles in patients with geriatric depression. International journal of geriatric psychiatry. vol 35. issue 7. 2020-11-20. PMID:32100326.' |
the present study aimed to evaluate the changes in the echogenicity of brainstem raphe (br), substantia nigra (sn) and ventricular diameters by tcs in association with cognitive dysfunctions in patients with geriatric depression. |
2020-11-20 |
2023-08-13 |
Not clear |
| Yu-Ling Liu, Chia-Chi Hsu, Hui-Ju Huang, Chih-Jung Chang, Shu-Hui Sun, Anya Maan-Yuh Li. Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis. Molecular neurobiology. vol 57. issue 1. 2020-11-19. PMID:31832973. |
compared with the vehicle-treated rats, systemic administration of ga (100 mg/kg) significantly attenuated lps-induced increases in glial fibrillary acidic protein (a biomarker of activated astrocytes) and ed-1 (a biomarker of activated microglia), as well as inducible nitric oxide synthase (inos, a proinflammatory enzyme) and interleukin-1β (a proinflammatory cytokine), in the lps-infused substantia nigra (sn) of rat brain. |
2020-11-19 |
2023-08-13 |
rat |
| b' Slobodan Kapor, Milan Aksi\\xc4\\x87, Laslo Pu\\xc5\\xa1ka\\xc5\\xa1, Marin Juki\\xc4\\x87, Joko Poleksi\\xc4\\x87, Filip Milosavljevi\\xc4\\x87, Suncica Bjelica, Branislav Filipovi\\xc4\\x8. Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats. Frontiers in neuroanatomy. vol 14. 2020-11-17. PMID:33192342.' |
the volume of dopaminergic nuclei and the number of dopaminergic neurons in the substantia nigra (sn) and ventral tegmental area (vta) were analyzed in three representative coordinates. |
2020-11-17 |
2023-08-13 |
rat |
| Benedetta Conio, Matteo Martino, Paola Magioncalda, Andrea Escelsior, Matilde Inglese, Mario Amore, Georg Northof. Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders. Molecular psychiatry. vol 25. issue 1. 2020-11-17. PMID:30953003. |
in particular, the dopaminergic substantia nigra (snc)-related nigrostriatal pathway is structurally and functionally connected with core regions of the smn, whereas the ventral tegmental area (vta)-related mesocorticolimbic pathway with core regions of the sn. |
2020-11-17 |
2023-08-13 |
Not clear |
| Tadashi Takada, Naoki Yoneda, Tetsushi Hirano, Kanoko Onaru, Youhei Mantani, Toshifumi Yokoyama, Hiroshi Kitagawa, Yoshiaki Tabuchi, Collins Nimako, Mayumi Ishizuka, Yoshinori Ikenaka, Nobuhiko Hosh. Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice. The Journal of veterinary medical science. vol 82. issue 3. 2020-11-16. PMID:31983702. |
in addition, serotonin (5-ht) and tryptophan hydroxylase 2 (tph2) of the dorsal raphe nuclei (drn) and median raphe nuclei (mrn) and tyrosine hydroxylase (th) of the ventral tegmental area and substantia nigra (sn) were evaluated immunohistochemically. |
2020-11-16 |
2023-08-13 |
mouse |