| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenlong Zhang, Junwei Gong, Liuyan Ding, Zhiling Zhang, Xiaowen Pan, Xiang Chen, Wenyuan Guo, Xiaokang Zhang, Xinling Yang, Guoyou Peng, Yuwan Lin, Feng Gao, Yuanquan Li, Xiaoqin Zhu, Aiguo Xuan, Shu Wang, Xiangdong Sun, Yunlong Zhang, Pingyi X. Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease. Cell death & disease. vol 11. issue 10. 2021-04-09. PMID:33093440. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by lewy body formation and progressive dopaminergic neuron death in the substantia nigra (sn). |
2021-04-09 |
2023-08-13 |
mouse |
| Tianbin Song, Jiping Li, Shanshan Mei, Xiaofei Jia, Hongwei Yang, Yongquan Ye, Jianmin Yuan, Yuqing Zhang, Jie L. Nigral Iron Deposition Is Associated With Levodopa-Induced Dyskinesia in Parkinson's Disease. Frontiers in neuroscience. vol 15. 2021-04-09. PMID:33828454. |
to investigate iron deposition in the substantia nigra (sn) of parkinson's disease (pd) patients associated with levodopa-induced dyskinesia (lid). |
2021-04-09 |
2023-08-13 |
Not clear |
| Sergio Ortiz-Padilla, Elier Soto-Orduño, Marisa Escobar Barrios, Abril Armenta Manjarrez, Yadira Bastián, J Alfredo Mende. Blockade of the dopaminergic neurotransmission with AMPT and reserpine induces a differential expression of genes of the dopaminergic phenotype in substantia nigra. Neuropharmacology. vol 166. 2021-04-02. PMID:31870855. |
here, our results suggest that the somatodendritic release of dopamine in the substantia nigra (sn) may stimulate gabaergic neurons that project their axons into the hippocampus. |
2021-04-02 |
2023-08-13 |
Not clear |
| Melanie M Pina, Dipanwita Pati, Lara S Hwa, Sarah Y Wu, Alexandra A Mahoney, Chiazam G Omenyi, Montserrat Navarro, Thomas L Kas. The kappa opioid receptor modulates GABA neuron excitability and synaptic transmission in midbrainprojections from the insular cortex. Neuropharmacology. vol 165. 2021-03-30. PMID:31870854. |
within this microcircuit, dyn is robustly expressed in layer 2/3, while kor is localized to deep layer 5, which sends a long-range projection to the substantia nigra (sn). |
2021-03-30 |
2023-08-13 |
Not clear |
| Abbas Mohammadipour, Hossein Haghir, Alireza Ebrahimzadeh Bideska. A link between nanoparticles and Parkinson's disease. Which nanoparticles are most harmful? Reviews on environmental health. vol 35. issue 4. 2021-03-30. PMID:32681785. |
they can damage neurons, in particular dopaminergic neurons in the substantia nigra (sn) and striatal neurons which their lesion is associated with parkinson's disease (pd). |
2021-03-30 |
2023-08-13 |
Not clear |
| Lu-Lu Bu, Ying-Yu Xie, Dan-Yu Lin, Ying Chen, Xiu-Na Jing, Yan-Ran Liang, Su-Dan Peng, Kai-Xun Huang, En-Xiang Ta. LncRNA-T199678 Mitigates α-Synuclein-Induced Dopaminergic Neuron Injury via miR-101-3p. Frontiers in aging neuroscience. vol 12. 2021-03-29. PMID:33328976. |
parkinson's disease (pd) is the second most common neurodegenerative disorder characterized by dopaminergic neuron death and the abnormal accumulation and aggregation of α-synuclein (α-syn) in the substantia nigra (sn). |
2021-03-29 |
2023-08-13 |
Not clear |
| Ekaterina Lazdon, Nofar Stolero, Dan Frenke. Microglia and Parkinson's disease: footprints to pathology. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 2. 2021-03-26. PMID:32016606. |
markers of inflammation can be found around the regions of risk and adjacent to the appearance of lewy bodies within the basal ganglia and the substantia nigra (sn) that are associated with pd pathology. |
2021-03-26 |
2023-08-13 |
Not clear |
| Seyed-Ahmad Ahmadi, Kai Bötzel, Johannes Levin, Juliana Maiostre, Tassilo Klein, Wolfgang Wein, Verena Rozanski, Olaf Dietrich, Birgit Ertl-Wagner, Nassir Navab, Annika Plat. Analyzing the co-localization of substantia nigra hyper-echogenicities and iron accumulation in Parkinson's disease: A multi-modal atlas study with transcranial ultrasound and MRI. NeuroImage. Clinical. vol 26. 2021-03-26. PMID:32050136. |
transcranial b-mode sonography (tcs) can detect hyperechogenic speckles in the area of the substantia nigra (sn) in parkinson's disease (pd). |
2021-03-26 |
2023-08-13 |
Not clear |
| Yong Wang, Qian Wang, Ruobing Yu, Qi Zhang, Zhonghai Zhang, Haiying Li, Chao Ren, Rongli Yang, Haichen Ni. Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression. Aging. vol 12. issue 14. 2021-03-24. PMID:32706757. |
the mαsyn expression leads to the loss of dopaminergic neurons in the substantia nigra (sn) and consequent motor dysfunctions. |
2021-03-24 |
2023-08-13 |
human |
| Nadja Mannal, Katharina Kleiner, Michael Fauler, Antonios Dougalis, Christina Poetschke, Birgit Lis. Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices. Frontiers in synaptic neuroscience. vol 13. 2021-03-16. PMID:33716704. |
dopaminergic (da) midbrain neurons within the substantia nigra (sn) display an autonomous pacemaker activity that is crucial for dopamine release and voluntary movement control. |
2021-03-16 |
2023-08-13 |
mouse |
| Dong-Xin Wang, An-Di Chen, Qing-Jun Wang, Yue-Yang Xin, Jie Yin, Yu-Hong Jin. Protective effect of metformin against rotenone-induced parkinsonism in mice. Toxicology mechanisms and methods. vol 30. issue 5. 2021-03-12. PMID:32189544. |
pd animal model was established by unilateral rotenone injection into the right substantia nigra (sn) of c57bl/6 mice. |
2021-03-12 |
2023-08-13 |
mouse |
| Clara Domínguez Vivero, Yago Leira, Marta Saavedra Piñeiro, Xiana Rodríguez-Osorio, Pedro Ramos-Cabrer, Carmen Villalba Martín, Tomás Sobrino, Francisco Campos, José Castillo, Rogelio Leir. Iron Deposits in Periaqueductal Gray Matter Are Associated with Poor Response to OnabotulinumtoxinA in Chronic Migraine. Toxins. vol 12. issue 8. 2021-03-12. PMID:32731573. |
selected biomarkers in plasma during interictal periods (calcitonin gene-related peptide (cgrp) and pentraxin-3 (ptx3)) and neuroimaging changes (iron deposits in the red nucleus (rn), substantia nigra (sn), globus pallidus (gp), and periaqueductal gray matter (pag), and white matter lesions (wml)) were determined. |
2021-03-12 |
2023-08-13 |
human |
| Violina Kakoty, Sarathlal K C, Ruei-Dun Tang, Chih Hao Yang, Sunil Kumar Dubey, Rajeev Taliya. Fibroblast growth factor 21 and autophagy: A complex interplay in Parkinson disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 127. 2021-03-11. PMID:32361164. |
the predominant pathological hallmark is progressive loss of dopaminergic (da) neurones in the substantia nigra (sn) complicated by aggregation of misfolded forms of alpha-synuclein (α-syn). |
2021-03-11 |
2023-08-13 |
Not clear |
| Xinrong Li, Wenwen Si, Zhan Li, Ye Tian, Xuelei Liu, Shanyu Ye, Zifeng Huang, Yichun Ji, Caiping Zhao, Xiaoqian Hao, Dongfeng Chen, Meiling Zh. miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in International journal of molecular medicine. vol 47. issue 4. 2021-03-10. PMID:33649797. |
mir‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in parkinson's disease (pd) is a neurodegenerative disease characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2021-03-10 |
2023-08-13 |
Not clear |
| Hayate Javed, Ramasamy Thangavel, Govindhasamy Pushpavathi Selvakumar, Iuliia Dubova, Noah Schwartz, Mohammad Ejaz Ahmed, Smita Zaheer, Duraisamy Kempuraj, Shankar Iyer, Asgar Zaheer, Mohammad Moshahid Kha. NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson's disease. International immunopharmacology. vol 83. 2021-03-08. PMID:32259702. |
in the present study, we have investigated the expression of nlrp3 inflammasome and caspase-1 in the substantia nigra (sn) of human pd and non-pd brains by immunohistochemistry. |
2021-03-08 |
2023-08-13 |
mouse |
| Hiro Sparks, Hannah Riskin-Jones, Collin Price, Jasmine DiCesare, Ausaf Bari, Nadia Hashoush, Nader Pouratia. Impulsivity Relates to Relative Preservation of Mesolimbic Connectivity in Patients with Parkinson Disease. NeuroImage. Clinical. vol 27. 2021-03-08. PMID:32361415. |
given the sensorimotor-lateral substantia nigra (sn) selective degeneration associated with pd, we posit that a relative sparing of the limbic-medial sn in the context of drt drives impulsive, reward-seeking behavior in pd patients with recent history of severe impulsivity. |
2021-03-08 |
2023-08-13 |
Not clear |
| Xiao-Rui Wang, Song-Xin Zhu, Xiao-Ming Wen, Jun-Xia Xie, Ning Son. [Altered dopamine metabolism and its role in pathogenesis of Parkinson's disease]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665664. |
parkinson's disease (pd), one of the most frequent neurodegenerative disorders, is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2021-03-08 |
2023-08-13 |
Not clear |
| Hyongjun Jeon, Hee-Young Kim, Chang-Hwan Bae, Yukyoung Lee, Seungtae Ki. Korean Red Ginseng Regulates Intestinal Tight Junction and Inflammation in the Colon of a Parkinson's Disease Mouse Model. Journal of medicinal food. vol 23. issue 12. 2021-03-05. PMID:33121350. |
we investigated changes in the intestinal tight junctions and proinflammatory cytokines in the colon, and alpha-synuclein (asyn) in the colon and the substantia nigra (sn) of a pd mouse model. |
2021-03-05 |
2023-08-13 |
mouse |
| Emily Hill, Nicholas Dale, Mark J Wal. Moderate Changes in CO iScience. vol 23. issue 7. 2021-03-04. PMID:32683315. |
moderate changes in co the substantia nigra (sn) and ventral tegmental area (vta) are vital for the control of movement, goal-directed behavior, and encoding reward. |
2021-03-04 |
2023-08-13 |
Not clear |
| Xi Zhang, Zhihua Shao, Sutong Xu, Qiulu Liu, Chenming Liu, Yuping Luo, Lingjing Jin, Siguang L. Immune Profiling of Parkinson's Disease Revealed Its Association With a Subset of Infiltrating Cells and Signature Genes. Frontiers in aging neuroscience. vol 13. 2021-02-27. PMID:33633562. |
several transcriptomic datasets of substantia nigra (sn) from the gene expression omnibus (geo) database were separately collected as training cohort, testing cohort, and external validation cohort. |
2021-02-27 |
2023-08-13 |
human |