| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiro Sparks, Hannah Riskin-Jones, Collin Price, Jasmine DiCesare, Ausaf Bari, Nadia Hashoush, Nader Pouratia. Impulsivity Relates to Relative Preservation of Mesolimbic Connectivity in Patients with Parkinson Disease. NeuroImage. Clinical. vol 27. 2021-03-08. PMID:32361415. |
given the sensorimotor-lateral substantia nigra (sn) selective degeneration associated with pd, we posit that a relative sparing of the limbic-medial sn in the context of drt drives impulsive, reward-seeking behavior in pd patients with recent history of severe impulsivity. |
2021-03-08 |
2023-08-13 |
Not clear |
| Xiao-Rui Wang, Song-Xin Zhu, Xiao-Ming Wen, Jun-Xia Xie, Ning Son. [Altered dopamine metabolism and its role in pathogenesis of Parkinson's disease]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 1. 2021-03-08. PMID:33665664. |
parkinson's disease (pd), one of the most frequent neurodegenerative disorders, is characterized by the selective loss of dopaminergic neurons in the substantia nigra (sn). |
2021-03-08 |
2023-08-13 |
Not clear |
| Hayate Javed, Ramasamy Thangavel, Govindhasamy Pushpavathi Selvakumar, Iuliia Dubova, Noah Schwartz, Mohammad Ejaz Ahmed, Smita Zaheer, Duraisamy Kempuraj, Shankar Iyer, Asgar Zaheer, Mohammad Moshahid Kha. NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson's disease. International immunopharmacology. vol 83. 2021-03-08. PMID:32259702. |
in the present study, we have investigated the expression of nlrp3 inflammasome and caspase-1 in the substantia nigra (sn) of human pd and non-pd brains by immunohistochemistry. |
2021-03-08 |
2023-08-13 |
mouse |
| Hyongjun Jeon, Hee-Young Kim, Chang-Hwan Bae, Yukyoung Lee, Seungtae Ki. Korean Red Ginseng Regulates Intestinal Tight Junction and Inflammation in the Colon of a Parkinson's Disease Mouse Model. Journal of medicinal food. vol 23. issue 12. 2021-03-05. PMID:33121350. |
we investigated changes in the intestinal tight junctions and proinflammatory cytokines in the colon, and alpha-synuclein (asyn) in the colon and the substantia nigra (sn) of a pd mouse model. |
2021-03-05 |
2023-08-13 |
mouse |
| Emily Hill, Nicholas Dale, Mark J Wal. Moderate Changes in CO iScience. vol 23. issue 7. 2021-03-04. PMID:32683315. |
moderate changes in co the substantia nigra (sn) and ventral tegmental area (vta) are vital for the control of movement, goal-directed behavior, and encoding reward. |
2021-03-04 |
2023-08-13 |
Not clear |
| Xi Zhang, Zhihua Shao, Sutong Xu, Qiulu Liu, Chenming Liu, Yuping Luo, Lingjing Jin, Siguang L. Immune Profiling of Parkinson's Disease Revealed Its Association With a Subset of Infiltrating Cells and Signature Genes. Frontiers in aging neuroscience. vol 13. 2021-02-27. PMID:33633562. |
several transcriptomic datasets of substantia nigra (sn) from the gene expression omnibus (geo) database were separately collected as training cohort, testing cohort, and external validation cohort. |
2021-02-27 |
2023-08-13 |
human |
| Chiung Mei Chen, Chih-Hsin Lin, Yih-Ru Wu, Chien-Yu Yen, Yu-Ting Huang, Jia-Lan Lin, Chung-Yin Lin, Wan-Ling Chen, Chih-Ying Chao, Guey-Jen Lee-Chen, Ming-Tsan Su, Kuo-Hsuan Chan. Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability. Cells. vol 9. issue 5. 2021-02-24. PMID:32429337. |
parkinson's disease (pd) is a neurodegenerative disease characterized by selective dopaminergic (daergic) neuronal degeneration in the substantia nigra (sn) and proteinaceous α-synuclein-positive lewy bodies and lewy neuritis. |
2021-02-24 |
2023-08-13 |
mouse |
| Md Ezazul Haque, Mahbuba Akther, Shofiul Azam, Dong-Kug Choi, In-Su Ki. GPR4 Knockout Improves the Neurotoxin-Induced, Caspase-Dependent Mitochondrial Apoptosis of the Dopaminergic Neuronal Cell. International journal of molecular sciences. vol 21. issue 20. 2021-02-24. PMID:33053856. |
in parkinson's disease, mitochondrial oxidative stress-mediated apoptosis is a major cause of dopaminergic neuronal loss in the substantia nigra (sn). |
2021-02-24 |
2023-08-13 |
Not clear |
| Rahul Bharatiya, Abdeslam Chagraoui, Salomé De Deurwaerdere, Antonio Argiolas, Maria Rosaria Melis, Fabrizio Sanna, Philippe De Deurwaerder. Chronic Administration of Fipronil Heterogeneously Alters the Neurochemistry of Monoaminergic Systems in the Rat Brain. International journal of molecular sciences. vol 21. issue 16. 2021-02-22. PMID:32784929. |
fpn significantly decreased da and its metabolite levels in most striatal territories, including the nucleus accumbens and the substantia nigra (sn). |
2021-02-22 |
2023-08-13 |
rat |
| Yu Liu, Junchen Li, Naying He, Yongsheng Chen, Zhijia Jin, Fuhua Yan, E Mark Haack. Optimizing neuromelanin contrast in the substantia nigra and locus coeruleus using a magnetization transfer contrast prepared 3D gradient recalled echo sequence. NeuroImage. vol 218. 2021-02-19. PMID:32413460. |
neuromelanin (nm) loss in the substantia nigra (sn) and locus coeruleus (lc) is being investigated as an imaging biomarker for parkinson's disease (pd) using magnetization transfer contrast (mtc) magnetic resonance imaging. |
2021-02-19 |
2023-08-13 |
human |
| Kenneth Wengler, Xiang He, Anissa Abi-Dargham, Guillermo Horg. Reproducibility assessment of neuromelanin-sensitive magnetic resonance imaging protocols for region-of-interest and voxelwise analyses. NeuroImage. vol 208. 2021-02-17. PMID:31841683. |
neuromelanin-sensitive mri (nm-mri) provides a noninvasive measure of the content of neuromelanin (nm), a product of dopamine metabolism that accumulates with age in dopamine neurons of the substantia nigra (sn). |
2021-02-17 |
2023-08-13 |
Not clear |
| Simone Mesman, Marten P Smid. Acquisition of the Midbrain Dopaminergic Neuronal Identity. International journal of molecular sciences. vol 21. issue 13. 2021-02-16. PMID:32629812. |
the mesodiencephalic dopaminergic (mdda) group of neurons comprises molecularly distinct subgroups, of which the substantia nigra (sn) and ventral tegmental area (vta) are the best known, due to the selective degeneration of the sn during parkinson's disease. |
2021-02-16 |
2023-08-13 |
Not clear |
| Yasuhiro Fujiwara, Tetsuyoshi Hirai, Tomohiro Ueda, Hiroyuki Kumazoe, Shigeki It. Quantitative Acta radiologica (Stockholm, Sweden : 1987). vol 62. issue 2. 2021-02-15. PMID:32380909. |
quantitative quantitative evaluation of degeneration of the substantia nigra (sn) is important for early, pre-symptomatic diagnosis of parkinson's disease (pd). |
2021-02-15 |
2023-08-13 |
Not clear |
| K D Chaprov, E V Teterina, A Yu Roman, T A Ivanova, V V Goloborshcheva, V G Kucheryanu, S G Morozov, E A Lysikova, O A Lytkina, I V Koroleva, N Ia Popova, A I Antohin, R K Ovchinnikov, M S Kukharsk. [Comparative Analysis of MPTP Neurotoxicity in Mice with a Constitutive Knockout of the α-Synuclein Gene]. Molekuliarnaia biologiia. vol 55. issue 1. 2021-02-12. PMID:33566034. |
aggregated forms of α-synuclein are core components of pathohistological inclusions known as lewy bodies in substantia nigra (sn) neurons of patients with parkinson's disease (pd). |
2021-02-12 |
2023-08-13 |
mouse |
| Fábio G Teixeira, Helena Vilaça-Faria, Ana V Domingues, Jonas Campos, António J Salgad. Preclinical Comparison of Stem Cells Secretome and Levodopa Application in a 6-Hydroxydopamine Rat Model of Parkinson's Disease. Cells. vol 9. issue 2. 2021-02-12. PMID:32012897. |
in the present study, we aimed to access the impact of human bone marrow mscs (hbm-mscs) secretome in 6-hydroxydopamine (6-ohda) pd model when compared to levodopa administration, by addressing animals' motor performance, and substantia nigra (sn), and striatum (str) histological parameters by tyrosine hydroxylase (th) expression. |
2021-02-12 |
2023-08-13 |
human |
| Mahesh Ramalingam, Sujeong Jang, Han-Seong Jeon. Therapeutic Effects of Conditioned Medium of Neural Differentiated Human Bone Marrow-Derived Stem Cells on Rotenone-Induced Alpha-Synuclein Aggregation and Apoptosis. Stem cells international. vol 2021. 2021-02-10. PMID:33552161. |
pd is a chronic age-related neurodegenerative disease (ndd) characterized by loss of dopaminergic neurons in the substantia nigra (sn) and abnormal accumulation of |
2021-02-10 |
2023-08-13 |
human |
| Matteo Martino, Paola Magioncalda, Benedetta Conio, Laura Capobianco, Daniel Russo, Giulia Adavastro, Shankar Tumati, Zhonglin Tan, Hsin-Chien Lee, Timothy J Lane, Mario Amore, Matilde Inglese, Georg Northof. Abnormal Functional Relationship of Sensorimotor Network With Neurotransmitter-Related Nuclei via Subcortical-Cortical Loops in Manic and Depressive Phases of Bipolar Disorder. Schizophrenia bulletin. vol 46. issue 1. 2021-02-08. PMID:31150559. |
the study aimed to investigate the functional relationships of smn with substantia nigra (sn) and raphe nuclei (rn) via subcortical-cortical loops, and their alteration in bipolar mania and depression, as characterized by psychomotor excitation and inhibition. |
2021-02-08 |
2023-08-13 |
Not clear |
| Debopam Samanta, Raghu Ramakrishnaia. Early-Onset Parkinsonism and Halo Sign: Beta-propeller Proteinassociated Neurodegeneration. Journal of pediatric neurosciences. vol 15. issue 3. 2021-02-06. PMID:33531960. |
repeat brain mri showed iron deposition on the substantia nigra (sn) and basal ganglia, with hyperintense halo sign around a central linear hypointensity within the sn on the t1 imaging sequence. |
2021-02-06 |
2023-08-13 |
Not clear |
| Azizul Haque, Supriti Samantaray, Varduhi H Knaryan, Mollie Capone, Azim Hossain, Denise Matzelle, Raghavendar Chandran, Donald C Shields, Ariana Q Farrand, Heather A Boger, Naren L Bani. Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson's disease. Experimental neurology. vol 330. 2021-02-01. PMID:32302678. |
parkinson's disease (pd), a debilitating progressive degenerative movement disorder associated with loss of dopaminergic (da) neurons in the substantia nigra (sn), afflicts approximately one million people in the u.s., including a significant number of veterans. |
2021-02-01 |
2023-08-13 |
mouse |
| Kecheng Lei, Yijue Shen, Yijing He, Liwen Zhang, Jingxing Zhang, Weifang Tong, Yichun Xu, Lingjing Ji. Baicalin Represses C/EBP Oxidative medicine and cellular longevity. vol 2020. 2021-01-27. PMID:32566108. |
baicalin represses c/ebp parkinson's disease (pd) is a neurodegenerative disease characterized by the gradual loss of dopaminergic (da) neurons in the substantia nigra (sn) and the formation of intracellular lewy bodies (lb) in the brain, which aggregates |
2021-01-27 |
2023-08-13 |
Not clear |