| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Kou, Yuemei Duan, Pengcheng Wang, Yaru Fu, Nerek Darabedian, Yonghui He, Dianlu Jiang, Dinglong Chen, Juan Xiang, Guokun Liu, Feimeng Zho. Norepinephrine-Fe(III)-ATP Ternary Complex and Its Relevance to Parkinson's Disease. ACS chemical neuroscience. vol 10. issue 6. 2020-07-07. PMID:31059226. |
the ternary complex can be detected in the substantia nigra (sn), locus coeruleus (lc), and striatum regions of c57bl/6 wild-type mice. |
2020-07-07 |
2023-08-13 |
mouse |
| Wenfeng Zhang, Changcheng Sun, Yufeng Shao, Zheng Zhou, Yiping Hou, Anan L. Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb. Scientific reports. vol 9. issue 1. 2020-07-06. PMID:30670747. |
olfactory dysfunction is a major non-motor symptom that appears during the early stages of parkinson's disease (pd), a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra (sn). |
2020-07-06 |
2023-08-13 |
mouse |
| Katrina Albert, Merja H Voutilainen, Andrii Domanskyi, T Petteri Piepponen, Sari Ahola, Raimo K Tuominen, Christopher Richie, Brandon K Harvey, Mikko Airavaar. Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease. Journal of neuroscience research. vol 97. issue 3. 2020-07-01. PMID:30548446. |
adeno-associated virus (aav) vector-mediated delivery of human α-synuclein (α-syn) gene in rat substantia nigra (sn) results in increased expression of α-syn protein in the sn and striatum which can progressively degenerate dopaminergic neurons. |
2020-07-01 |
2023-08-13 |
human |
| Huiying Liu, Hao Wu, Ning Zhu, Zijie Xu, Yue Wang, Yan Qu, Jun Wan. Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease in mice. Journal of neurochemistry. vol 152. issue 3. 2020-06-30. PMID:31442326. |
its pathological features are dopaminergic neuronal death in the substantia nigra (sn), and significant reduction in dopamine (da) content in the striatum. |
2020-06-30 |
2023-08-13 |
mouse |
| Germain Arribarat, Ofer Pasternak, Amaury De Barros, Monique Galitzky, Oliver Rascol, Patrice Péra. Substantia nigra locations of iron-content, free-water and mean diffusivity abnormalities in moderate stage Parkinson's disease. Parkinsonism & related disorders. vol 65. 2020-06-29. PMID:31182373. |
prior work demonstrated that free water in the posterior substantia nigra (sn) was elevated in parkinson's disease (pd) compared to healthy controls (hc) across single- and multi-site cohorts, and increased over 1 year in parkinson's disease but not in relation with the iron deposition in sn with the relaxometry t2*. |
2020-06-29 |
2023-08-13 |
Not clear |
| Michaela E Johnson, Xin-Fu Zhou, Larisa Bobrovskay. The effects of rotenone on TH, BDNF and BDNF-related proteins in the brain and periphery: Relevance to early Parkinson's disease. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30690135. |
loss of dopaminergic neurons in the substantia nigra (sn) is one of the pathological hallmarks in parkinson's disease (pd). |
2020-06-26 |
2023-08-13 |
rat |
| Anyu Tao, Guangzhi Chen, Zhijuan Mao, Hongling Gao, Youbin Deng, Renfan X. Essential tremor vs idiopathic Parkinson disease: Utility of transcranial sonography. Medicine. vol 99. issue 20. 2020-06-15. PMID:32443307. |
substantia nigra (sn) hyperechogenicity measured by transcranial sonography (tcs) is a promising biomarker for parkinson disease (pd). |
2020-06-15 |
2023-08-13 |
human |
| Ru Zeng, Xueting Wang, Qian Zhou, Xiaolong Fu, Qin Wu, Yuanfu Lu, Jingshan Shi, James E Klaunig, Shaoyu Zho. Icariin protects rotenone-induced neurotoxicity through induction of SIRT3. Toxicology and applied pharmacology. vol 379. 2020-06-01. PMID:31251943. |
rats treated with rot exhibited a marked loss of dopamine (da) neurons and a decline in motor function, along with a decrease in protein expressions of sirt3 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (pgc-1α) in the substantia nigra (sn). |
2020-06-01 |
2023-08-13 |
rat |
| Yuanyuan Li, Mengyue Niu, Aonan Zhao, Wenyan Kang, Zhichun Chen, Ningdi Luo, Liche Zhou, Xiongwei Zhu, Liming Lu, Jun Li. CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson's disease. Journal of neuroinflammation. vol 16. issue 1. 2020-05-27. PMID:31831012. |
migration of microglia to the substantia nigra (sn) could precede neurodegeneration in a53t mice. |
2020-05-27 |
2023-08-13 |
mouse |
| Alon Simchovitz, Mor Hanan, Naomi Niederhoffer, Nimrod Madrer, Nadav Yayon, Estelle R Bennett, David S Greenberg, Sebastian Kadener, Hermona Sore. NEAT1 is overexpressed in Parkinson's disease substantia nigra and confers drug-inducible neuroprotection from oxidative stress. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 10. 2020-05-25. PMID:31311324. |
to address this issue, we assessed neat1 expression levels and cell type patterns in the substantia nigra (sn) from 53 donors with and without pd, as well as in interference tissue culture tests followed by multiple in-house and web-available models of pd. |
2020-05-25 |
2023-08-13 |
Not clear |
| Cristina Cocco, Giulia Corda, Carlo Lisci, Barbara Noli, Manolo Carta, Carla Brancia, Elias Manca, Carla Masala, Francesco Marrosu, Paolo Solla, Barbara Manconi, Paolo Bongioanni, Gian-Luca Ferr. VGF peptides as novel biomarkers in Parkinson's disease. Cell and tissue research. vol 379. issue 1. 2020-05-21. PMID:31713727. |
parkinson's disease (pd) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2020-05-21 |
2023-08-13 |
human |
| Liping Zhang, LingYu Zhang, Lin Li, Christian Hölsche. Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in the Chronic MPTP Mouse Model of Parkinson's Disease. Journal of Parkinson's disease. vol 9. issue 1. 2020-05-20. PMID:30741689. |
in addition, both drugs rescued the decrease of tyrosine hydroxylase (th) levels, reduced the accumulation of α-syn, alleviated the chronic inflammation response in the brain, reduced lipid peroxidation, and inhibited the mitochondrial mitophagy signaling pathway, and furthermore increased expression of the key growth factor gdnf that protects dopaminergic neurons in the substantia nigra (sn) and striatum. |
2020-05-20 |
2023-08-13 |
mouse |
| Hye Ryeong Lim, Mai-Tram Vo, Dong Jun Kim, Unn Hwa Lee, Jong Hyuk Yoon, Hyung-Jun Kim, Jeongah Kim, Sang Ryong Kim, Jun Yeon Lee, Chae Ha Yang, Hee Young Kim, June-Seek Choi, Kijeong Kim, Esther Yang, Hyun Kim, Seongsoo Lee, Byung Ju Lee, Kyungjin Kim, Jeong Woo Park, Chang Man H. DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release. International journal of molecular sciences. vol 21. issue 1. 2020-05-15. PMID:31861806. |
drg2 was strongly expressed in the neurons of the dopaminergic system such as those in the striatum (str), ventral tegmental area (vta), and substantia nigra (sn), and on neuronal cell bodies in high-density regions such as the hippocampus (hip), cerebellum, and cerebral cortex in the mouse brain. |
2020-05-15 |
2023-08-13 |
mouse |
| Liyue Qin, Ziyu Chen, Liu Yang, Hailian Shi, Hui Wu, Beibei Zhang, Weiqi Zhang, Qi Xu, Fei Huang, Xiaojun W. Luteolin-7-O-glucoside protects dopaminergic neurons by activating estrogen-receptor-mediated signaling pathway in MPTP-induced mice. Toxicology. vol 426. 2020-05-14. PMID:31381935. |
parkinson's disease (pd) is a neurodegenerative disorder that is characterized by the degeneration of dopaminergic neurons in substantia nigra (sn). |
2020-05-14 |
2023-08-13 |
mouse |
| Rachael H Earls, Kelly B Menees, Jaegwon Chung, James Barber, Claire-Anne Gutekunst, Manuel G Hazim, Jae-Kyung Le. Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice. Journal of neuroinflammation. vol 16. issue 1. 2020-05-14. PMID:31796095. |
), preceding the degeneration of dopaminergic neurons in substantia nigra (sn). |
2020-05-14 |
2023-08-13 |
mouse |
| Yu-Chia Kao, Wei-Yen Wei, Kuen-Jer Tsai, Liang-Chao Wan. High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra. International journal of molecular sciences. vol 21. issue 1. 2020-05-14. PMID:31892244. |
tyrosine hydroxylase staining showed that the hfd resulted in fewer dopaminergic neurons in the substantia nigra (sn), but not the striatum. |
2020-05-14 |
2023-08-13 |
mouse |
| Clara Rodriguez-Sabate, Ingrid Morales, Fernando Monton, Manuel Rodrigue. The influence of Parkinson's disease on the functional connectivity of the motor loop of human basal ganglia. Parkinsonism & related disorders. vol 63. 2020-05-08. PMID:30833228. |
this functional connectivity was different in pd-patients who showed: 1. an increased synchrony between the primary motor cortex(m1)-external pallidum(gpe), putamen(put)-gpe, put-subthalamic nucleus (stn), stn-internal pallidum (gpi), stn-motor thalamus (tal), stn-gpi substantia nigra (sn) and sn-tal, 2. a decreased synchrony between put-gpi, gpe-stn, gpe-sn, stn-sn and gpi-sn, and 3. an increased anti-synchrony between gpe-sn and gpi-tal. |
2020-05-08 |
2023-08-13 |
human |
| Guohua Zhang, Chengguo Zhang, Yukai Wang, Lijuan Wang, Yuhu Zhang, Haiqun Xie, Jiancong Lu, Kun Ni. Is hyperhomocysteinemia associated with the structural changes of the substantia nigra in Parkinson's disease? A two-year follow-up study. Parkinsonism & related disorders. vol 60. 2020-05-04. PMID:30316729. |
it was recently found that structural changes in the substantia nigra (sn) and motor symptoms become more prominent in parkinson's disease (pd) patients with striatal silent lacunar infarction (ssli) than in those without ssli. |
2020-05-04 |
2023-08-13 |
Not clear |
| Nicola Tambasco, Federico Paolini Paoletti, Andrea Chiappiniello, Viviana Lisetti, Pasquale Nigro, Paolo Eusebi, Pietro Chiarini, Michele Romoli, Elona Brahimi, Simone Simoni, Marta Filidei, Piero Floridi, Roberto Tarducci, Lucilla Parnetti, Paolo Calabres. T2*-weighted MRI values correlate with motor and cognitive dysfunction in Parkinson's disease. Neurobiology of aging. vol 80. 2020-04-30. PMID:31103636. |
previous studies indicated that iron in the substantia nigra (sn) is related to disease duration and motor impairment. |
2020-04-30 |
2023-08-13 |
human |
| Katarzyna Z Kuter, Łukasz Olech, Norbert A Denche. Increased energetic demand supported by mitochondrial electron transfer chain and astrocyte assistance is essential to maintain the compensatory ability of the dopaminergic neurons in an animal model of early Parkinson's disease. Mitochondrion. vol 47. 2020-04-27. PMID:30578987. |
partial degeneration of dopaminergic neurons in the substantia nigra (sn), induces locomotor disability in animals but with time it is spontaneously compensated for by neurons surviving in the tissue by increasing their functional efficiency. |
2020-04-27 |
2023-08-13 |
rat |