| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danlei Wang, Hongling Gao, Qixiong Qin, Jingyi Li, Jingwei Zhao, Yi Qu, Jiangting Li, Yongjie Xiong, Zhe Min, Zhijuan Mao, Zheng Xu. MicroRNA-218-5p-Ddx41 axis restrains microglia-mediated neuroinflammation through downregulating type I interferon response in a mouse model of Parkinson's disease. Journal of translational medicine. vol 22. issue 1. 2024-01-16. PMID:38229084. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2024-01-16 |
2024-01-19 |
mouse |
| Qian Wang, Minghui Wang, Insup Choi, Lily Sarrafha, Marianna Liang, Lap Ho, Kurt Farrell, Kristin G Beaumont, Robert Sebra, Claudia De Sanctis, John F Crary, Tim Ahfeldt, Joel Blanchard, Drew Neavin, Joseph Powell, David A Davis, Xiaoyan Sun, Bin Zhang, Zhenyu Yu. Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson's disease. Science advances. vol 10. issue 2. 2024-01-10. PMID:38198537. |
parkinson's disease (pd) is characterized pathologically by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2024-01-10 |
2024-01-13 |
human |
| Xin Geng, Yanghong Zou, Tao Huang, Shipeng Li, Ailan Pang, Hualin Y. Electroacupuncture Improves Neuronal Damage and Mitochondrial Dysfunction Through the TRPC1 and SIRT1/AMPK Signaling Pathways to Alleviate Parkinson's Disease in Mice. Journal of molecular neuroscience : MN. vol 74. issue 1. 2024-01-08. PMID:38189854. |
western blotting was used to detect the expression of related proteins in mouse pathological samples; tunel measured neuronal apoptosis levels; nissl staining observed neuronal damage; immunofluorescence and immunohistochemistry were used to detect the expression of iba-1, th, and α-syn in substantia nigra denser (sn). |
2024-01-08 |
2024-01-10 |
mouse |
| Asuncion Carmona, Eleonora Carboni, Lucas Caldi Gomes, Stéphane Roudeau, Fabian Maass, Christof Lenz, Richard Ortega, Paul Lingo. Metal dyshomeostasis in the substantia nigra of patients with Parkinson's disease or multiple sclerosis. Journal of neurochemistry. 2024-01-05. PMID:38178798. |
this study aimed to compare the intra- and extra-neuronal metal content and the expression of proteins related to metal homeostasis in the substantia nigra (sn) from patients with parkinson's disease (pd), multiple sclerosis (ms), and control subjects. |
2024-01-05 |
2024-01-07 |
human |
| Pascal Salin, Christophe Melon, Carine Chassain, Paolo Gubellini, Guilhem Pages, Bruno Pereira, Yann Le Fur, Franck Durif, Lydia Kerkerian-Le Gof. Interhemispheric reactivity of the subthalamic nucleus sustains progressive dopamine neuron loss in asymmetrical parkinsonism. Neurobiology of disease. 2024-01-05. PMID:38182075. |
we previously developed a rat pd model that mimics these typical features, based on unilateral injection of a substrate inhibitor of excitatory amino acid transporters, l-trans-pyrrolidine-2,4-dicarboxylate (pdc) in the substantia nigra (sn). |
2024-01-05 |
2024-01-08 |
rat |
| Hua Rong, Xiaoming Li, Chunlei Yu, Wenbao Wang, Libo Li, Tianjiao Xu, Yisong Ding, Yingshi Su, Xiaoli Wan. Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson's disease mice model. Folia neuropathologica. 2024-01-04. PMID:38174686. |
using open field, rotarod, and pole climbing tests, we have found that b-ecd alleviates motor disorder in mptp/pro-induced mice and ultimately reduces the impairment of tyrosine hydroxylase (th)-positive dopaminergic neurons in the substantia nigra (sn). |
2024-01-04 |
2024-01-06 |
mouse |
| Dmitry Troshev, Anna Kolacheva, Ekaterina Pavlova, Victor Blokhin, Michael Ugrumo. Application of OpenArray Technology to Assess Changes in the Expression of Functionally Significant Genes in the Substantia Nigra of Mice in a Model of Parkinson's Disease. Genes. vol 14. issue 12. 2023-12-23. PMID:38137024. |
we used openarray technology to assess gene expression in the substantia nigra (sn) cells of mice in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) model of pd and in controls. |
2023-12-23 |
2023-12-25 |
mouse |
| Sora Kang, Youngjin Noh, Seung Jun Oh, Hye Ji Yoon, Suyeol Im, Hung Taeck Kwon, Youngmi Kim Pa. Neuroprotective Effects of Aldehyde-Reducing Composition in an LPS-Induced Neuroinflammation Model of Parkinson's Disease. Molecules (Basel, Switzerland). vol 28. issue 24. 2023-12-23. PMID:38138478. |
oral administration of arc at 10 or 20 units/kg/day for 3 days prior to intraperitoneal injection of lps (10 mg/kg) effectively preserved dopaminergic neurons in the substantia nigra (sn) and striatum by preventing lps-induced cell death. |
2023-12-23 |
2023-12-25 |
Not clear |
| Vincent Coulombe, Laurent Goetz, Manik Bhattacharjee, Peter V Gould, Stephan Saikali, Mohamad Ali Takech, Éric Philippe, André Parent, Martin Paren. Cholinergic and Nadph-δ neurons in the pedunculopontine and laterodorsal tegmental nuclei of human and nonhuman primates. The Journal of comparative neurology. 2023-12-18. PMID:38108576. |
three-dimensional reconstructions reveal that chat+ neurons in the ppn and ldtg form a continuum with some overlaps with pigmented neurons of the locus coeruleus, dorsally, and of the substantia nigra (sn) complex, ventrally. |
2023-12-18 |
2023-12-21 |
human |
| Joana Carvalheiro, Marios G Philiastide. Distinct spatiotemporal brainstem pathways of outcome valence during reward- and punishment-based learning. Cell reports. vol 42. issue 12. 2023-12-15. PMID:38100353. |
here, using simultaneously acquired electroencephalography and functional magnetic resonance imaging data, we show that during reward learning the substantia nigra (sn)/ventral tegmental area (vta) and locus coeruleus are initially activated following negative outcomes, while the vta subsequently re-engages exhibiting greater responses for positive than negative outcomes, consistent with an early arousal/avoidance response and a later value-updating process, respectively. |
2023-12-15 |
2023-12-18 |
human |
| Bianca Guglietti, Sanam Mustafa, Frances Corrigan, Lyndsey E Collins-Prain. Anatomical distribution of Fyn kinase in the human brain in Parkinson's disease. Parkinsonism & related disorders. vol 118. 2023-12-15. PMID:38101025. |
chronic neuroinflammation has been observed not just in the substantia nigra (sn), but also in several key regions of the brain, with disruption associated with symptoms presentation in pd. |
2023-12-15 |
2023-12-18 |
human |
| Septian Hartono, Robert Chun Chen, Thomas Welton, An Sen Tan, Weiling Lee, Peik Yen Teh, Celeste Chen, Wenlu Hou, Wei Ping Tham, Ee Wei Lim, Kumar M Prakash, Yao-Chia Shih, Kuan Jin Lee, Louis C S Tan, Eng King Tan, Ling Ling Cha. Quantitative iron-neuromelanin MRI associates with motor severity in Parkinson's disease and matches radiological disease classification. Frontiers in aging neuroscience. vol 15. 2023-12-13. PMID:38090717. |
in a large case-control pd cohort, we evaluated the diagnostic accuracy of quantitative iron-neuromelanin mri parameters from the substantia nigra (sn), their radiological utility, and clinical association. |
2023-12-13 |
2023-12-17 |
Not clear |
| Mohammad Dehestani, Velina Kozareva, Cornelis Blauwendraat, Ernest Fraenkel, Thomas Gasser, Vikas Bansa. Transcriptomic changes in oligodendrocytes and precursor cells predicts clinical outcomes of Parkinson's disease. bioRxiv : the preprint server for biology. 2023-12-12. PMID:37502982. |
in the second dataset obtained from the substantia nigra (sn), opcs displayed notable predictive ability for updrs-iii. |
2023-12-12 |
2023-12-17 |
Not clear |
| Deepika Shukla, Anshika Goel, Pravat K Mandal, Shallu Joon, Khushboo Punjabi, Yashika Arora, Rajnish Kumar, Veer Singh Mehta, Padam Singh, Joseph C Maroon, Rishu Bansal, Kanika Sandal, Rimil Guha Roy, Avantika Samkaria, Shallu Sharma, Sandhya Sandhilya, Shradha Gaur, S Parvathi, Mallika Josh. Glutathione Depletion and Concomitant Elevation of Susceptibility in Patients with Parkinson's Disease: State-of-the-Art MR Spectroscopy and Neuropsychological Study. ACS chemical neuroscience. 2023-12-05. PMID:38050970. |
in the current study, we have investigated the impact of os in pd by measuring the antioxidant glutathione (gsh) levels from the substantia nigra (sn), left hippocampus (lh) and neurotransmitter γ-amino butyric acid (gaba) levels from sn region. |
2023-12-05 |
2023-12-10 |
Not clear |
| Lu Geng, Wenqing Gao, Hexige Saiyin, Yuanyuan Li, Yu Zeng, Zhifei Zhang, Xue Li, Zuolong Liu, Qiang Gao, Ping An, Ning Jiang, Xiaofei Yu, Xiangjun Chen, Suhua Li, Lei Chen, Boxun Lu, Aiqun Li, Guoyuan Chen, Yidong Shen, Haibing Zhang, Mei Tian, Zhuohua Zhang, Jixi L. MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson's disease. Molecular neurodegeneration. vol 18. issue 1. 2023-12-02. PMID:38041169. |
parkinson's disease (pd), one of the most devastating neurodegenerative brain disorders, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) and deposits of α-synuclein aggregates. |
2023-12-02 |
2023-12-10 |
mouse |
| Rupert D Smit, Biswarup Ghosh, Thomas J Campion, Rachel Stingel, Emily Lavell, Robert Hooper, Xiaoxuan Fan, Jonathan Soboloff, George M Smit. STAT3 protects dopaminergic neurons against degeneration in animal model of Parkinson's disease. Brain research. vol 1824. 2023-12-01. PMID:38030102. |
parkinson's disease (pd) is the most prevalent disorder of the basal ganglia, propagated by the degeneration of axon terminals within the striatum and subsequent loss of dopaminergic neurons in the substantia nigra (sn). |
2023-12-01 |
2023-12-10 |
Not clear |
| Zhixin Xiao, Xiaoya Wang, Xuening Pan, Junxia Xie, Huamin X. Mitochondrial iron dyshomeostasis and its potential as a therapeutic target for Parkinson's disease. Experimental neurology. 2023-11-25. PMID:38007207. |
understanding how iron damages dopaminergic neurons in the substantia nigra (sn) of pd is particularly important for developing targeted neurotherapeutic strategies for the disease. |
2023-11-25 |
2023-11-28 |
Not clear |
| John Woulfe, David G Munoz, Douglas A Gray, Hyder A Jinnah, Alyona Ivanov. Inosine monophosphate dehydrogenase intranuclear inclusions are markers of aging and neuronal stress in the human substantia nigra. Neurobiology of aging. vol 134. 2023-11-22. PMID:37992544. |
we explored mechanisms involved in the age-dependent degeneration of human substantia nigra (sn) dopamine (da) neurons. |
2023-11-22 |
2023-11-29 |
human |
| De-Wen Kong, Li-da Du, Run-Zhe Liu, Tian-Yi Yuan, Shou-Bao Wang, Yue-Hua Wang, Yang Lu, Lian-Hua Fang, Guan-Hua D. Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels. Acta pharmacologica Sinica. 2023-11-22. PMID:37993535. |
dopaminergic neurons in the substantia nigra (sn) expressing sur1/kir6.2 type atp-sensitive potassium channels (k-atp) are more vulnerable to rotenone or metabolic stress, which may be an important reason for the selective degeneration of neurons in parkinson's disease (pd). |
2023-11-22 |
2023-11-29 |
Not clear |
| Ping-Chen Ho, Fu-Yun Hsiao, Shi-Hong Chiu, Syun-Ruei Lee, Hau-Jie Ya. A nigroincertal projection mediates aversion and enhances coping responses to potential threat. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 12. 2023-11-20. PMID:37983662. |
recent studies have shown that the non-da neurons in the ventral tegmental area (vta) and substantia nigra (sn) not only modulate motivational behaviors but also regulate defensive behaviors. |
2023-11-20 |
2023-11-29 |
Not clear |