| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noelia Morales-Prieto, Rebekah Bevans, Adam O'Mahony, Aaron Barron, Conor Giles Doran, Erin McCarthy, Ruth M Concannon, Susan R Goulding, Cathal M McCarthy, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. Human α-synuclein overexpression upregulates SKOR1 in a rat model of simulated nigrostriatal ageing. Aging cell. 2024-03-26. PMID:38529808. |
parkinson's disease (pd) is characterised by progressive loss of dopaminergic (da) neurons from the substantia nigra (sn) and α-synuclein (αsyn) accumulation. |
2024-03-26 |
2024-03-28 |
human |
| Jianing Shen, Junhua Xie, Liyuan Ye, Jian Mao, Shihao Sun, Weiwei Chen, Sijia Wei, Sisi Ruan, Linhai Wang, Hangcui Hu, Jingjing Wei, Yao Zheng, Zhouyan Xi, Ke Wang, Yan X. Neuroprotective effect of green tea extract (-)-epigallocatechin-3-gallate in a preformed fibril-induced mouse model of Parkinson's disease. Neuroreport. 2024-03-25. PMID:38526966. |
parkinson's disease (pd) is the second most common neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2024-03-25 |
2024-03-28 |
mouse |
| Lihong Deng, Wei Wei, Chunxia Qiao, Yubing Yin, Xiaojing Li, Hua Yu, Lingqi Jian, Xiaohong Ma, Liansheng Zhao, Qiang Wang, Wei Deng, Wanjun Guo, Tao L. Dynamic aberrances of substantia nigra-relevant coactivation patterns in first-episode treatment-naïve patients with schizophrenia. Psychological medicine. 2024-03-25. PMID:38523252. |
this study investigates the dynamic coactivation patterns (caps) associated with the substantia nigra (sn), a key dopaminergic nucleus, in first-episode treatment-naïve patients with schizophrenia (fes). |
2024-03-25 |
2024-03-27 |
Not clear |
| Nazlı Durmaz Çelik, Asli Yaman Kula, Uğur Toprak, Suzan Saylısoy, Aydan Topal, Serhat Özka. Evaluation of Substantia Nigra morphology in Parkinson's Disease. Medicine. vol 103. issue 12. 2024-03-22. PMID:38518035. |
in the elderly population, parkinson's disease (pd) is the second most common neurodegenerative disorder and is associated with morphological changes in the basal ganglia, especially the substantia nigra (sn). |
2024-03-22 |
2024-03-25 |
Not clear |
| A Amini, F Esmaeili, M Golpic. Possible role of lncRNAs in amelioration of Parkinson's disease symptoms by transplantation of dopaminergic cells. NPJ Parkinson's disease. vol 10. issue 1. 2024-03-13. PMID:38472261. |
behavioral and histopathological examinations revealed that cell transplantation partially compensated dopaminergic cell degeneration in st and substantia nigra (sn) of pd rats. |
2024-03-13 |
2024-03-15 |
rat |
| Yongyan Fan, Jianjun Ma, Dawei Yang, Xiaohuan Li, Keke Liang, Zonghan She, Xuelin Qi, Xiaoxue Shi, Qi Gu, Jinhua Zheng, Dongsheng L. Clinical findings of hyperechoic substantia nigra in patients with Parkinson's disease. The European journal of neuroscience. 2024-03-12. PMID:38469656. |
transcranial sonography (tcs) evaluations of the substantia nigra (sn) were performed in 40 healthy controls and 71 patients with pd, including patients with sn hyperechogenicity (sn+) and those with normal sn echogenicity (sn-). |
2024-03-12 |
2024-03-14 |
Not clear |
| Ziliang He, Yeye Hu, Ying Zhang, Jing Xie, Zhiqiang Niu, Guigui Yang, Ji Zhang, Zixuan Zhao, Shuai Wei, Haifeng Wu, Weicheng H. Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 127. 2024-03-12. PMID:38471370. |
parkinson's disease (pd), a neurodegenerative disorder, is characterized by motor symptoms due to the progressive loss of dopaminergic neurons in the substantia nigra (sn) and striatum (str), alongside neuroinflammation. |
2024-03-12 |
2024-03-15 |
Not clear |
| Yina Jia, Jing Li, Yutong Wang, Yiqing Ma, Lei Chen, Huaqi Zhang, Meilan Xue, Hui Lian. Folic Acid Rescues Dopaminergic Neurons in MPTP-Induced Mice by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment. Journal of agricultural and food chemistry. 2024-03-07. PMID:38453725. |
parkinson's disease (pd) is marked by the degeneration of dopaminergic neurons of the substantia nigra (sn), with neuroinflammation and mitochondrial dysfunction being key contributors. |
2024-03-07 |
2024-03-10 |
mouse |
| Marta Esteves, Ana Clara Cristóvão, Ana Vale, Marta Machado-Pereira, Raquel Ferreira, Liliana Bernardin. MicroRNA-124-3p Modulates Alpha-Synuclein Expression Levels in a Paraquat-Induced in vivo Model for Parkinson's Disease. Neurochemical research. 2024-03-07. PMID:38451434. |
our results showed that an intranigral administration of mir-124-3p reduced the expression and aggregation of α-synuclein in the substantia nigra (sn) of rats exposed to pq. |
2024-03-07 |
2024-03-09 |
rat |
| Sophie R Debs, Illya Conn, Brendan Navaneethan, Andriane G Penklis, Urs Meyer, Simon Killcross, Cynthia Shannon Weickert, Tertia D Purves-Tyso. Maternal immune activation and estrogen receptor modulation induce sex-specific dopamine-related behavioural and molecular alterations in adult rat offspring. Brain, behavior, and immunity. 2024-03-02. PMID:38431238. |
in the substantia nigra (sn), we found reduced drd2s mrna in raloxifene-treated female offspring with or without mia, and increased comt mrna in placebo-treated male mia offspring relative to placebo-treated controls. |
2024-03-02 |
2024-03-06 |
rat |
| Ying He, Ruicheng Li, Yuxi Yu, Chusheng Huang, Zhiran Xu, Tianbao Wang, Chen Ming, Hongri Huang, Zhongquan Q. Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models. Neurochemistry international. 2024-02-28. PMID:38417589. |
we first found that injecting nscs into the subarachnoid space relieved motor dysfunction in pd cynomolgus monkeys, as well as reduced dopaminergic neuron loss and neuronal damage in the substantia nigra (sn) and striatum. |
2024-02-28 |
2024-03-02 |
human |
| Yuxuan Dong, Yueyan Qi, Jinhu Chen, Siyuan Han, Wenjing Su, Xin Ma, Yang Yu, Yanqin Wan. Neuroprotective Effects of Bifidobacterium animalis subsp. lactis NJ241 in a Mouse Model of Parkinson's Disease: Implications for Gut Microbiota and PGC-1α. Molecular neurobiology. 2024-02-27. PMID:38409641. |
furthermore, it demonstrated protected against mptp-induced dopaminergic neuron death and inhibited the activation of glial cells in the substantia nigra (sn). |
2024-02-27 |
2024-03-02 |
mouse |
| Alex I Wiesman, Victoria Madge, Edward A Fon, Alain Dagher, D Louis Collins, Sylvain Baille. Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease. medRxiv : the preprint server for health sciences. 2024-02-26. PMID:38405952. |
parkinson's disease (pd) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (sn) and the locus coeruleus (lc), respectively, resulting in motor and cognitive impairments. |
2024-02-26 |
2024-02-28 |
Not clear |
| Yanpei Wang, Leilei Ma, Jiali Wang, Ningyu Liu, Weiwei Men, Shuping Tan, Jia-Hong Gao, Shaozheng Qin, Yong He, Qi Dong, Sha Ta. Association of emotional and behavioral problems with the development of the substantia nigra, subthalamic nucleus, and red nucleus volumes and asymmetries from childhood to adolescence: A longitudinal cohort study. Translational psychiatry. vol 14. issue 1. 2024-02-25. PMID:38403656. |
the substantia nigra (sn), subthalamic nucleus (stn), and red nucleus (rn) have been widely studied as important biomarkers of degenerative diseases. |
2024-02-25 |
2024-02-28 |
human |
| Cheng Liu, Yang Su, Xiaolong Ma, Yao Wei, Rui Qia. How close are we to a breakthrough? The hunt for blood biomarkers in Parkinson's disease diagnosis. The European journal of neuroscience. 2024-02-21. PMID:38379501. |
by the time clinical diagnosis becomes possible, more than 60% of dopamine neurons in the substantia nigra (sn) of patients have already degenerated. |
2024-02-21 |
2024-02-23 |
Not clear |
| Erind Alushaj, Nicholas Handfield-Jones, Alan Kuurstra, Anisa Morava, Ravi S Menon, Adrian M Owen, Manas Sharma, Ali R Khan, Penny A MacDonal. Increased iron in the substantia nigra pars compacta identifies patients with early Parkinson'sdisease: A 3T and 7T MRI study. NeuroImage. Clinical. vol 41. 2024-02-20. PMID:38377722. |
degeneration in the substantia nigra (sn) pars compacta (snc) underlies motor symptoms in parkinson's disease (pd). |
2024-02-20 |
2024-02-23 |
Not clear |
| G-L Liu, H-W Zhang, C-B Zha, T-W Fan, S-T Chen, T-T Shen, K H. Magnetic resonance imaging assessment of substantia nigral iron deposition in Parkinson's disease: a meta-analysis. European review for medical and pharmacological sciences. vol 28. issue 3. 2024-02-20. PMID:38375696. |
magnetic resonance imaging (mri) studies have shown that patients with parkinson's disease have an increased amount of iron in their substantia nigra (sn). |
2024-02-20 |
2024-02-22 |
Not clear |
| Qing He, Shuzhen Zhang, Jian Wang, Tengfei Ma, Ding Ma, Li Wu, Mengxi Zhou, Lei Zhao, Yajing Chen, Jianren Liu, Wei Che. The Synergistic Effect Study of Lipopolysaccharide (LPS) and A53T-α-Synuclein: Intranasal LPS Exposure on the A53T-α-Synuclein Transgenic Mouse Model of Parkinson's Disease. Molecular neurobiology. 2024-02-17. PMID:38367134. |
according to our results, after intranasal administration of lps, a53t-α-syn mice showed severe progressive anosmia, hypokinesia, selective dopaminergic (daergic) neuronal losses, decreased striatal dopamine (da) level, and enhanced α-synuclein accumulation within the substantia nigra (sn) in an age-dependent way. |
2024-02-17 |
2024-02-20 |
mouse |
| Areej Turkistani, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Athanasios Alexiou, Marios Papadakis, Mohamed M Elfiky, Hebatallah M Saad, Gaber El-Saber Batih. Therapeutic Potential Effect of Glycogen Synthase Kinase 3 Beta (GSK-3β) Inhibitors in Parkinson Disease: Exploring an Overlooked Avenue. Molecular neurobiology. 2024-02-17. PMID:38367137. |
parkinson's disease (pd) is a progressive neurodegenerative disease of the brain due to degeneration of dopaminergic neurons in the substantia nigra (sn). |
2024-02-17 |
2024-02-20 |
Not clear |
| Xiaomin Fu, Le Qu, Huamin Xu, Junxia Xi. Ndfip1 protected dopaminergic neurons via regulating mitochondrial function and ferroptosis in Parkinson's disease. Experimental neurology. 2024-02-16. PMID:38365133. |
here, our results showed that the expression of ndfip1 decreased in the substantia nigra (sn) of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-induced pd mouse model. |
2024-02-16 |
2024-02-19 |
mouse |