| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philip Long, Parwez Samnakay, Peter Jenner, Sarah Ros. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. The European journal of neuroscience. vol 36. issue 6. 2013-01-09. PMID:22779921. |
osteopontin (opn) expression is reduced in surviving dopaminergic neurones in the substantia nigra (sn) in parkinson's disease (pd), and protects against mpp(+) -induced cell death in primary mesencephalic cultures and 6-ohda-induced cell loss in the rat, while inactivation of opn aggravates cell death. |
2013-01-09 |
2023-08-12 |
human |
| Q David Walker, Misha L Johnson, Amanda E D Van Swearingen, Andrew E Arrant, Joseph M Caster, Cynthia M Kuh. Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22342988. |
dopamine neuron number and density in substantia nigra (sn) and ventral tegmental area (vta) were determined in the same animals using tyrosine-hydroxylase immunohistochemistry and unbiased stereology. |
2012-12-20 |
2023-08-12 |
rat |
| John Man Tak Chu, Ying Shing Chan, Liang Wei Chen, Ken Kin Lam Yun. Neurokinin receptor 3 peptide exacerbates 6-hydroxydopamine-induced dopaminergic degeneration in rats through JNK pathway. Journal of neurochemistry. vol 123. issue 3. 2012-12-19. PMID:22762252. |
neurokinin 3 (nk3) receptor is predominantly expressed in striatum and substantia nigra (sn). |
2012-12-19 |
2023-08-12 |
rat |
| P Riederer, J Sian-Hülsman. The significance of neuronal lateralisation in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 8. 2012-11-29. PMID:22367437. |
the destruction of the dopaminergic neurons in the substantia nigra (sn) and consequent depletion of striatal dopamine elicits the main movement deficits related to parkinson's disease (pd). |
2012-11-29 |
2023-08-12 |
Not clear |
| b' I Peltonen, T T My\\xc3\\xb6h\\xc3\\xa4nen, P T M\\xc3\\xa4nnist\\xc3\\xb. Different interactions of prolyl oligopeptidase and neurotensin in dopaminergic function of the rat nigrostriatal and mesolimbic pathways. Neurochemical research. vol 37. issue 9. 2012-11-20. PMID:22729983.' |
a colocalization of prep with neurotensin and neurotensin receptor 1 (nts1) in the rat striatum, nucleus accumbens (nacc), substantia nigra (sn) and ventral tegmental area (vta) was studied with immunofluorescence. |
2012-11-20 |
2023-08-12 |
rat |
| J Deignan, R Luján, C Bond, A Riegel, M Watanabe, J T Williams, J Maylie, J P Adelma. SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons. Neuroscience. vol 217. 2012-11-19. PMID:22554781. |
the firing properties of dopamine (da) neurons in the substantia nigra (sn) pars compacta are strongly influenced by the activity of apamin-sensitive small conductance ca(2+)-activated k(+) (sk) channels. |
2012-11-19 |
2023-08-12 |
mouse |
| Erik K Kastman, Auriel A Willette, Christopher L Coe, Barbara B Bendlin, Kris J Kosmatka, Donald G McLaren, Guofan Xu, Elisa Canu, Aaron S Field, Andrew L Alexander, Mary Lou Voytko, T Mark Beasley, Ricki J Colman, Richard H Weindruch, Sterling C Johnso. A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 34. 2012-11-19. PMID:23082321. |
both the cr and control monkeys showed age-related increases in iron concentrations in globus pallidus (gp) and substantia nigra (sn), although the cr group had significantly less iron deposition in the gp, sn, red nucleus, and temporal cortex. |
2012-11-19 |
2023-08-12 |
monkey |
| Sheila V Kusnoor, Michael Bubser, Ariel Y Deutc. The effects of nigrostriatal dopamine depletion on the thalamic parafascicular nucleus. Brain research. vol 1446. 2012-11-13. PMID:22353754. |
neuronal loss in parkinson's disease (pd) is seen in a number of brain regions in addition to the substantia nigra (sn). |
2012-11-13 |
2023-08-12 |
rat |
| Katarzyna Kuter, Wacław Kolasiewicz, Krystyna Gołembiowska, Anna Dziubina, Gert Schulze, Klemencja Berghauzen, Jadwiga Wardas, Krystyna Ossowsk. Partial lesion of the dopaminergic innervation of the ventral striatum induces "depressive-like" behavior of rats. Pharmacological reports : PR. vol 63. issue 6. 2012-11-07. PMID:22358086. |
levels of dopamine, dopac and hva were decreased in the nucleus accumbens (nac) 2 weeks after 6-ohda but were not changed in the cp, frontal cortex (fcx) and substantia nigra (sn). |
2012-11-07 |
2023-08-12 |
rat |
| Patricia Szot, Allyn Franklin, Carl Sikkema, Charles W Wilkinson, Murray A Raskin. Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results in a Correlation of Dopaminergic Neuronal Number to Striatal Dopamine Concentration. Frontiers in pharmacology. vol 3. 2012-11-07. PMID:23129999. |
the number of dopaminergic neurons in the substantia nigra (sn) and ventral tegmental area (vta), and noradrenergic neurons in the lc were determined. |
2012-11-07 |
2023-08-12 |
mouse |
| Julia Schiemann, Falk Schlaudraff, Verena Klose, Markus Bingmer, Susumu Seino, Peter J Magill, Kareem A Zaghloul, Gaby Schneider, Birgit Liss, Jochen Roepe. K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration. Nature neuroscience. vol 15. issue 9. 2012-11-05. PMID:22902720. |
we found that, in medial da neurons of the substantia nigra (sn), activity of atp-sensitive potassium (k-atp) channels enabled nmda-mediated bursting in vitro as well as spontaneous in vivo burst firing in anesthetized mice. |
2012-11-05 |
2023-08-12 |
mouse |
| Pichest Metarugcheep, Suchat Hanchaiphiboolkul, Akravudh Viriyavejakul, Somsak Chanyawattiwong. The usage of proton magnetic resonance spectroscopy in Parkinson's disease. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. vol 95. issue 7. 2012-11-01. PMID:22919991. |
however this technique has never been used to evaluate the substantia nigra (sn) in pd patients. |
2012-11-01 |
2023-08-12 |
Not clear |
| Shanshan Wang, Michael S Okun, Oleg Suslov, Tong Zheng, Nikolaus R McFarland, Vinata Vedam-Mai, Kelly D Foote, Steven N Roper, Anthony T Yachnis, Florian A Siebzehnrubl, Dennis A Steindle. Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains. Brain research. vol 1464. 2012-10-23. PMID:22652067. |
substantia nigra, "sn") and are able to differentiate into both glia and neurons, but only under particular growth conditions including co-culturing with embryonic stem cell-derived neural precursors ("esnps"); this suggests that pd multipotent neural stem/progenitor cells do reside within the sn and other areas, but by themselves appear to lack key factors required for neuronal differentiation. |
2012-10-23 |
2023-08-12 |
human |
| b' Vladimir S Kosti\\xc4\\x87, Marina Svetel, Milija Mijajlovi\\xc4\\x87, Aleksandra Pavlovi\\xc4\\x87, Milica Je\\xc4\\x8dmenica-Luki\\xc4\\x87, Du\\xc5\\xa1ko Kozi\\xc4\\x87, Du\\xc5\\xa1an Kozi\\xc4\\x8. Transcranial sonography in pantothenate kinase-associated neurodegeneration. Journal of neurology. vol 259. issue 5. 2012-10-17. PMID:22057405.' |
after it was reported that increased tissue iron concentrations were associated with increased echogenicity of the substantia nigra (sn) obtained with transcranial sonography (tcs) in animal and postmortem studies, our goal was to use this method in a disorder characterized with iron accumulation in human brain tissue. |
2012-10-17 |
2023-08-12 |
human |
| Keiji Mori, Yoko S Kaneko, Akira Nakashima, Hiroshi Nagasaki, Toshiharu Nagatsu, Ikuko Nagatsu, Akira Ot. Subventricular zone under the neuroinflammatory stress and Parkinson's disease. Cellular and molecular neurobiology. vol 32. issue 5. 2012-10-17. PMID:22189676. |
this review summarizes the effects of neuroinflammatory stress on the subventricular zone (svz), where new neurons are constitutively produced in the adult brain, especially focusing on the relation with parkinson's disease (pd), because the svz is under the control of dopaminergic afferents from the substantia nigra (sn). |
2012-10-17 |
2023-08-12 |
Not clear |
| P Szot, L Knight, A Franklin, C Sikkema, S Foster, C W Wilkinson, S S White, M A Raskin. Lesioning noradrenergic neurons of the locus coeruleus in C57Bl/6 mice with unilateral 6-hydroxydopamine injection, to assess molecular, electrophysiological and biochemical changes in noradrenergic signaling. Neuroscience. vol 216. 2012-10-17. PMID:22542679. |
direct administration of 6ohda into the lc results in the specific reduction of noradrenergic neurons in the lc (as measured by electrophysiology, immunoreactivity and in situ hybridization), the lateral tegmental neurons and dopaminergic neurons in the substantia nigra (sn) and ventral tegmental region were unaffected. |
2012-10-17 |
2023-08-12 |
mouse |
| Patricia Muñoz, Sandro Huenchuguala, Irmgard Paris, Carlos Cuevas, Monica Villa, Pablo Caviedes, Juan Segura-Aguilar, Yousef Tizab. Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson's disease. Neurotoxicity research. vol 22. issue 2. 2012-10-10. PMID:22528249. |
parkinson's disease is a debilitating progressive neurodegenerative disorder that results from the loss of or damage to dopaminergic cells containing neuromelanin in the substantia nigra (sn). |
2012-10-10 |
2023-08-12 |
Not clear |
| Dimitra Giannakopoulou, Véronique Daguin-Nerrière, Adamantia Mitsacos, Elias D Kouvelas, Isabelle Neveu, Panagiotis Giompres, Philippe Brache. Ectopic expression of TrKA in the adult rat basal ganglia induces both nerve growth factor-dependent and -independent neuronal responses. Journal of neuroscience research. vol 90. issue 8. 2012-10-05. PMID:22419059. |
to address this question, adeno-associated virus (aav) vectors were used to express trka in the substantia nigra (sn) and striatum of adult rats. |
2012-10-05 |
2023-08-12 |
rat |
| Zuoli Sun, Jun Jia, Xiaoli Gong, Yanjun Jia, Jiahui Deng, Xuan Wang, Xiaomin Wan. Inhibition of glutamate and acetylcholine release in behavioral improvement induced by electroacupuncture in parkinsonian rats. Neuroscience letters. vol 520. issue 1. 2012-10-04. PMID:22583765. |
high-frequency ea stimulation at dazhui (gv14) and baihui (gv20) acupoints decreased rotational behavior induced by apomorphine (apo) and improved motor coordination, protected axotomized dopaminergic neurons from degeneration in the substantia nigra (sn), it did not increase striatal dopamine (da) levels. |
2012-10-04 |
2023-08-12 |
rat |
| Hong Yuan, Li-Wu Liang, Zheng-Jing Chen, Hui-Ru Ji, Mei-Kang Wang, Hai-Ying Zhang, Cao Li, Jian-Yang X. R-apomorphine protects against 6-hydroxydopamine-induced nigrostriatal damage in rat. Neuroscience bulletin. vol 22. issue 6. 2012-10-02. PMID:17690718. |
objective the aim of the present study was not only to assess the retrograde degenerative changes in the dopaminergic neurons of the substantia nigra (sn) and ventral tegmental area (vta) after injection of 6-hydroxydopamine (6-ohda) into the striatum, but also to use this 6-ohda model of parkinson's disease to explore the possible neuroprotective effect of r-apomorphine (r-apo). |
2012-10-02 |
2023-08-12 |
rat |