| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao Sun, Ning Song, Anmu Xie, Junxia Xie, Hong Jian. High hepcidin level accounts for the nigral iron accumulation in acute peripheral iron intoxication rats. Toxicology letters. vol 212. issue 3. 2012-09-25. PMID:22659129. |
our previous publication revealed that acute iron intoxication induced iron deposit and dopaminergic neuron degeneration in the substantia nigra (sn) of a rat model. |
2012-09-25 |
2023-08-12 |
rat |
| Jie Li, Junfeng Yang, Peng Zhao, Shen Li, Renyun Zhang, Xiaobin Zhang, Dan Liu, Benshu Zhan. Neuromelanin enhances the toxicity of α-synuclein in SK-N-SH cells. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 6. 2012-09-20. PMID:22200858. |
the key pathological feature of parkinson's disease (pd) is selective degeneration of the neuromelanin (nm)-pigmented dopaminergic neurons in the substantia nigra (sn). |
2012-09-20 |
2023-08-12 |
human |
| G Webster Ross, Robert D Abbott, Helen Petrovitch, Caroline M Tanner, Lon R Whit. Pre-motor features of Parkinson's disease: the Honolulu-Asia Aging Study experience. Parkinsonism & related disorders. vol 18 Suppl 1. 2012-08-27. PMID:22166434. |
additionally, brain autopsies have been sought since 1991 allowing use of incidental lewy bodies and neuronal loss in the substantia nigra (sn) and locus coeruleus (lc) as additional endpoints for the pd process. |
2012-08-27 |
2023-08-12 |
Not clear |
| A Machado, A J Herrera, J L Venero, M Santiago, R M de Pablos, R F Villarán, A M Espinosa-Oliva, S Argüelles, M Sarmiento, M J Delgado-Cortés, R Mauriño, J Can. Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons. ISRN neurology. vol 2011. 2012-08-23. PMID:22389821. |
the implication of neuroinflammation on this disease was originally established in 1988, when the presence of activated microglia in the substantia nigra (sn) of parkinsonians was reported by mcgeer et al. |
2012-08-23 |
2023-08-12 |
Not clear |
| Melissa L Perreault, Theresa Fan, Mohammed Alijaniaram, Brian F O'Dowd, Susan R Georg. Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2. PloS one. vol 7. issue 3. 2012-08-20. PMID:22428025. |
activation of the d1r-d2r heteromer in these neurons resulted in the simultaneous, but differential regulation of proteins involved in gaba and glutamate production or vesicular uptake in the nucleus accumbens (nac), ventral tegmental area (vta), caudate putamen and substantia nigra (sn). |
2012-08-20 |
2023-08-12 |
Not clear |
| Jun Wang, Hong Jiang, Jun-Xia Xi. [Correlation between iron levels and degeneration of dopaminergic neurons in rat nigrostriatal system during the early 6-OHDA lesions in medial forebrain bundle]. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 4. 2012-08-16. PMID:12937822. |
the results showed that 1 d or 3 d after lesions in mfb, there was a 45% or 66% reduction, respectively, in the density of tyrosine hydroxylase (th) immunoreactive cells in the substantia nigra (sn) of the lesioned side accompanied by an increase in iron staining intensity and iron concentration; while there was no change in dopamine (da) release in the striatum (str) of the lesioned side compared with the unlesioned side and the normal rats. |
2012-08-16 |
2023-08-12 |
rat |
| Alin Ciobica, Manuela Padurariu, Lucian Hritc. The effects of short-term nicotine administration on behavioral and oxidative stress deficiencies induced in a rat model of Parkinson's disease. Psychiatria Danubina. vol 24. issue 2. 2012-08-14. PMID:22706419. |
we previously demonstrated that a 6-hydroxydopamine (6-ohda) induced lesion of substantia nigra (sn), which is a very well known animal model of parkinson's disease, resulted in memory deficits and increased brain oxidative stress. |
2012-08-14 |
2023-08-12 |
rat |
| C Venkateshappa, G Harish, Rajeswara Babu Mythri, Anita Mahadevan, M M Srinivas Bharath, S K Shanka. Increased oxidative damage and decreased antioxidant function in aging human substantia nigra compared to striatum: implications for Parkinson's disease. Neurochemical research. vol 37. issue 2. 2012-08-13. PMID:21971758. |
parkinson's disease (pd) is characterized by selective degeneration and loss of dopaminergic neurons in the substantia nigra (sn) of the ventral mid brain leading to dopamine depletion in the striatum. |
2012-08-13 |
2023-08-12 |
human |
| LinLin Tian, Morvarid Karimi, Susan K Loftin, Chris A Brown, HuChuan Xia, JinBin Xu, Robert H Mach, Joel S Perlmutte. No differential regulation of dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) binding in a primate model of Parkinson disease. PloS one. vol 7. issue 2. 2012-08-03. PMID:22359591. |
quantitative estimates of the number of tyrosine hydroxylase (th)-immunoreactive (ir) neurons in substantia nigra (sn) were determined with unbiased stereology, and quantitative autoradiography was used to measure dat and vmat2 striatal specific binding. |
2012-08-03 |
2023-08-12 |
monkey |
| John M T Chu, L W Chen, Y S Chan, Ken K L Yun. Neuroprotective effects of neurokinin receptor one in dopaminergic neurons are mediated through Akt/PKB cell signaling pathway. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21907219. |
in 6-ohda lesioned rats, protection of th immunoreactive neurons and terminals in substantia nigra (sn) and striatum was found after septide treatment. |
2012-08-01 |
2023-08-12 |
rat |
| Grit Taschenberger, Manuel Garrido, Yuliya Tereshchenko, Mathias Bähr, Markus Zweckstetter, Sebastian Kügle. Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons. Acta neuropathologica. vol 123. issue 5. 2012-08-01. PMID:22167382. |
to investigate the impact of αsynuclein aggregation on the progression of neurodegeneration, we expressed variants with different fibrillation propensities in the rat substantia nigra (sn) by means of recombinant adeno-associated viral (aav) vectors. |
2012-08-01 |
2023-08-12 |
human |
| Peternella S Verhave, Marjan J Jongsma, Roland M Van Den Berg, Raymond A P Vanwersch, August B Smit, Ingrid H C H M Philippen. Neuroprotective effects of riluzole in early phase Parkinson's disease on clinically relevant parameters in the marmoset MPTP model. Neuropharmacology. vol 62. issue 4. 2012-07-27. PMID:22178201. |
at three weeks following the last mptp challenge, brains were dissected and dopamine levels in the striatum and the tyrosine hydroxylase (th) expressing dopamine (da) neurons in the substantia nigra (sn) were compared. |
2012-07-27 |
2023-08-12 |
monkey |
| Peternella S Verhave, Marjan J Jongsma, Roland M Van Den Berg, Raymond A P Vanwersch, August B Smit, Ingrid H C H M Philippen. Neuroprotective effects of riluzole in early phase Parkinson's disease on clinically relevant parameters in the marmoset MPTP model. Neuropharmacology. vol 62. issue 4. 2012-07-27. PMID:22178201. |
mptp affected all behavioral parameters and sleep architecture and induced a relatively mild (50%) decline of da neurons in the substantia nigra (sn). |
2012-07-27 |
2023-08-12 |
monkey |
| Hany E S Marei, Asma Althani, Nahla Afifi, Fabrizio Michetti, Mario Pescatori, Roberto Pallini, Patricia Casalbore, Carlo Cenciarelli, Philip Schwartz, Abd-Elmaksoud Ahme. Gene expression profiling of embryonic human neural stem cells and dopaminergic neurons from adult human substantia nigra. PloS one. vol 6. issue 12. 2012-07-20. PMID:22163301. |
we used agilent's and illumina whole human genome oligonucleotide microarray to compare the genomic profiles of human embryonic nsc at a single time point in culture, and a multicellular tissue from postmortem adult substantia nigra (sn) which are rich in dopaminergic (da) neurons. |
2012-07-20 |
2023-08-12 |
human |
| Eman I Ahmed, Katharine V Northcutt, Joseph S Lonstei. L-amino acid decarboxylase- and tyrosine hydroxylase-immunoreactive cells in the extended olfactory amygdala and elsewhere in the adult prairie vole brain. Journal of chemical neuroanatomy. vol 43. issue 1. 2012-07-19. PMID:22074805. |
we also investigated the presence of th/aadc cells in the anteroventral periventricular nucleus (avpv), medial preoptic area (mpo), arcuate nucleus (arh), zona incerta (zi), substantia nigra (sn) and ventral tegmental area (vta). |
2012-07-19 |
2023-08-12 |
rat |
| Sang Ryong Kim, Tatyana Kareva, Olga Yarygina, Nikolai Kholodilov, Robert E Burk. AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth. Molecular therapy : the journal of the American Society of Gene Therapy. vol 20. issue 2. 2012-07-10. PMID:22008911. |
to this end we have investigated the ability of a constitutively active form of the gtpase rheb, an important activator of mammalian target of rapamycin (mtor) signaling, to mediate neurotrophic effects in dopamine neurons of the substantia nigra (sn), a population of neurons affected in pd. |
2012-07-10 |
2023-08-12 |
mouse |
| Rong Wang, Zegang Ma, Jun Wang, Junxia Xi. L-type Cav1.2 calcium channel is involved in 6-hydroxydopamine-induced neurotoxicity in rats. Neurotoxicity research. vol 21. issue 3. 2012-06-26. PMID:21901331. |
by the semi-quantitative reverse transcription polymerase chain reaction (rt-pcr) studies, we showed that the expression of l-type cav1.2 calcium channel α1 subunit mrna increased in the substantia nigra (sn) of 6-ohda-lesioned rats. |
2012-06-26 |
2023-08-12 |
rat |
| Alin Ciobica, Zenovia Olteanu, Manuela Padurariu, Lucian Hritc. The effects of pergolide on memory and oxidative stress in a rat model of Parkinson's disease. Journal of physiology and biochemistry. vol 68. issue 1. 2012-06-26. PMID:22006204. |
one of the most widely used animal models of parkinson's disease (pd) involves injecting 6-hydroxydopamine (6-ohda) directly into the substantia nigra (sn). |
2012-06-26 |
2023-08-12 |
rat |
| Ferry S P Sagala, Daniel Harnack, Evgeny Bobrov, Reinhard Sohr, Christoph Gertler, D James Surmeier, Andreas Kupsc. Neurochemical characterization of the striatum and the nucleus accumbens in L-type Ca(v)1.3 channels knockout mice. Neurochemistry international. vol 60. issue 3. 2012-06-25. PMID:22202668. |
l-type ca(v)1.3 channels control the autonomous pacemaking of the substantia nigra (sn) dopamine (da) neurons, which maintains the sustained release of da in the striatum, its target structure. |
2012-06-25 |
2023-08-12 |
mouse |
| Patricia Mathieu, Valeria Roca, Cecilia Gamba, Ana Del Pozo, Fernando Pitoss. Neuroprotective effects of human umbilical cord mesenchymal stromal cells in an immunocompetent animal model of Parkinson's disease. Journal of neuroimmunology. vol 246. issue 1-2. 2012-06-19. PMID:22458982. |
microglial activation in the substantia nigra (sn) is a ubiquitous feature in pd which could mediate toxic effects. |
2012-06-19 |
2023-08-12 |
human |