| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefanie Reyes, Yuhong Fu, Kay Double, Lachlan Thompson, Deniz Kirik, George Paxinos, Glenda M Hallida. GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area. The Journal of comparative neurology. vol 520. issue 12. 2013-04-08. PMID:22252428. |
g-protein-regulated inward-rectifier potassium channel 2 (girk2) is reported to be expressed only within certain dopamine neurons of the substantia nigra (sn), although very limited data are available in humans. |
2013-04-08 |
2023-08-12 |
mouse |
| Suraj Pradhan, Katrin Andreasso. Commentary: Progressive inflammation as a contributing factor to early development of Parkinson's disease. Experimental neurology. vol 241. 2013-04-08. PMID:23261765. |
dysregulated immune activation in the substantia nigra (sn). |
2013-04-08 |
2023-08-12 |
mouse |
| Maria Sierra, Pascual Sánchez-Juan, María Isabel Martínez-Rodríguez, Isabel González-Aramburu, Inés García-Gorostiaga, María Remedios Quirce, Enrique Palacio, José Manuel Carril, José Berciano, Onofre Combarros, Jon Infant. Olfaction and imaging biomarkers in premotor LRRK2 G2019S-associated Parkinson disease. Neurology. vol 80. issue 7. 2013-04-08. PMID:23325906. |
to ascertain in a cross-sectional study whether substantia nigra (sn) echogenicity, olfaction, and dopamine transporter (dat)-spect are reliable premotor biomarkers in a cohort of asymptomatic carriers of the lrrk2 g2019s mutation (asg2019s+). |
2013-04-08 |
2023-08-12 |
Not clear |
| b' E Iu Sitnikova, T N Egorova, V V Raevski\\xc4\\xa. [Reduction of the number of neurons in substantia nigra (Pars compacta) positively correlates with a reduction of seizure activity in WAG/Rij rats]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 62. issue 5. 2013-04-05. PMID:23227734.' |
positive correlations were revealed between the incidence of epileptic discharges and the number of neurons in substantia nigra suggesting that animals with lower number of neurons in sn expressed fewer absence seizures, and vice versa. |
2013-04-05 |
2023-08-12 |
rat |
| Hyun-Jung Park, Jin Young Shin, Bo Ra Lee, Hyun Ok Kim, Phil Hyu Le. Mesenchymal stem cells augment neurogenesis in the subventricular zone and enhance differentiation of neural precursor cells into dopaminergic neurons in the substantia nigra of a parkinsonian model. Cell transplantation. vol 21. issue 8. 2013-04-01. PMID:22546197. |
the number of brdu-ir cells in the svz and the substantia nigra (sn) was significantly increased in the hmsc-treated pd group compared with the mptp-only-treated group. |
2013-04-01 |
2023-08-12 |
human |
| F L Campos, A C Cristovão, S M Rocha, C P Fonseca, G Baltaza. GDNF contributes to oestrogen-mediated protection of midbrain dopaminergic neurones. Journal of neuroendocrinology. vol 24. issue 11. 2013-03-28. PMID:22672424. |
parkinson's disease (pd) is characterised by the preferential loss of dopaminergic neurones from the substantia nigra (sn) that leads to the hallmark motor disturbances. |
2013-03-28 |
2023-08-12 |
human |
| Gulay Hacioglu, Yasemin Seval-Celik, Gamze Tanriover, Ozlem Ozsoy, Esen Saka-Topcuoglu, Sevin Balkan, Aysel Aga. Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. Folia histochemica et cytobiologica. vol 50. issue 2. 2013-03-26. PMID:22763967. |
the dopaminergic lesion was determined by immunohistochemical analysis for tyrosine hydroxylase (th)-immunopositive cells in substantia nigra (sn). |
2013-03-26 |
2023-08-12 |
rat |
| Hei Ming-Yan, Ya-Li Luo, Xiao-Chun Zhang, Hong Liu, Ru Gao, Jing-Jiang W. Hypoxic-ischemic injury decreases anxiety-like behavior in rats when associated with loss of tyrosine-hydroxylase immunoreactive neurons of the substantia nigra. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 1. 2013-03-14. PMID:22147192. |
neonatal sprague-dawley rats were randomly divided into normal control, mild hypoxia-ischemia (hi), and severe hi groups (n = 10 in each group at each time) on postnatal day 7 (p7) to study the effect of mild and severe hi on anxiety-like behavior and the expression of tyrosine hydroxylase (th) in the substantia nigra (sn). |
2013-03-14 |
2023-08-12 |
rat |
| Eun Sook Chung, Himchan Kim, Gihyun Lee, Soojin Park, Hyunseong Kim, Hyunsu Ba. Neuro-protective effects of bee venom by suppression of neuroinflammatory responses in a mouse model of Parkinson's disease: role of regulatory T cells. Brain, behavior, and immunity. vol 26. issue 8. 2013-03-12. PMID:22974722. |
treatment with bv prevented degeneration of da neurons in the substantia nigra (sn). |
2013-03-12 |
2023-08-12 |
mouse |
| Philipp Klaissle, Anne Lesemann, Petra Huehnchen, Andreas Hermann, Alexander Storch, Barbara Steine. Physical activity and environmental enrichment regulate the generation of neural precursors in the adult mouse substantia nigra in a dopamine-dependent manner. BMC neuroscience. vol 13. 2013-03-08. PMID:23110504. |
parkinson's disease is characterized by a continuous loss of neurons within the substantia nigra (sn) leading to a depletion of dopamine. |
2013-03-08 |
2023-08-12 |
mouse |
| Xiao Hong Wang, Gang Lu, Xiang Hu, Kam Sze Tsang, Wing Hang Kwong, Feng Xia Wu, Hai Wei Meng, Shu Jiang, Shu Wei Liu, Ho Keung Ng, Wai Sang Poo. Quantitative assessment of gait and neurochemical correlation in a classical murine model of Parkinson's disease. BMC neuroscience. vol 13. 2013-03-08. PMID:23151254. |
correlations of gait parameters with tyrosine hydroxylase (th) protein levels in the substantia nigra (sn) were also investigated. |
2013-03-08 |
2023-08-12 |
Not clear |
| Mi Jin Kim, Dae Won Kim, Hoon Jae Jeong, Eun Jeong Sohn, Min Jea Shin, Eun Hee Ahn, Soon Won Kwon, Young Nam Kim, Duk-Soo Kim, Jinseu Park, Won Sik Eum, Hyun Sook Hwang, Soo Young Cho. Tat-Frataxin protects dopaminergic neuronal cells against MPTP-induced toxicity in a mouse model of Parkinson's disease. Biochimie. vol 94. issue 11. 2013-03-05. PMID:22809528. |
parkinson's disease (pd) is caused by various factors such as reactive oxygen species (ros), dysfunction of mitochondria, and aggregation of misfolded proteins, thereby leading to loss of dopaminergic (da) neurons in the substantia nigra (sn) of the brain. |
2013-03-05 |
2023-08-12 |
mouse |
| Franz Marxreiter, Martin Regensburger, Jürgen Winkle. Adult neurogenesis in Parkinson's disease. Cellular and molecular life sciences : CMLS. vol 70. issue 3. 2013-03-04. PMID:22766974. |
the diagnosis of pd is based on motor symptoms such as bradykinesia, rigidity, tremor, and postural instability associated with the striatal dopaminergic deficit that is linked to neurodegenerative processes in the substantia nigra (sn). |
2013-03-04 |
2023-08-12 |
Not clear |
| ZeGang Ma, Yu Zhou, JunXia Xi. Nifedipine prevents iron accumulation and reverses iron-overload-induced dopamine neuron degeneration in the substantia nigra of rats. Neurotoxicity research. vol 22. issue 4. 2013-02-27. PMID:22259026. |
the mechanisms of iron accumulation in substantia nigra (sn) of parkinson's diseases remain unclear. |
2013-02-27 |
2023-08-12 |
rat |
| Eun S Park, Sang R Kim, Byung K Ji. Transient receptor potential vanilloid subtype 1 contributes to mesencephalic dopaminergic neuronal survival by inhibiting microglia-originated oxidative stress. Brain research bulletin. vol 89. issue 3-4. 2013-02-27. PMID:22796104. |
the present study examined whether capsaicin (cap), an agonist of transient receptor potential vanilloid subtype 1 (trpv1) can prevent 1-methyl-4-phenylpyridinium (mpp(+))-induced dopaminergic (da) neuronal death in the substantia nigra (sn). |
2013-02-27 |
2023-08-12 |
rat |
| Mohammad Hossein Esmaeili, Mohadeseh Movahedi, Ayda Faraji, Hashem Haghdoost-Yazd. Intracerebral injection of low amounts of norharman induces moderate Parkinsonism-like behavioral symptoms in rat. Neurotoxicology and teratology. vol 34. issue 5. 2013-02-25. PMID:22789434. |
a small amount (4μl) of nh solution at 2 or 200ng/ml was unilaterally injected into either striatum or substantia nigra (sn) by stereotaxic surgery. |
2013-02-25 |
2023-08-12 |
rat |
| Ingrid Morales, Angel Fuentes, Santiago Ballaz, Jose A Obeso, Manuel Rodrigue. Striatal interaction among dopamine, glutamate and ascorbate. Neuropharmacology. vol 63. issue 8. 2013-02-20. PMID:22959966. |
microdialysis was used here to quantify the extracellular interaction among glu-da-aa in the striatum of rats, an interaction which was compared with those studied in the substantia nigra (sn). |
2013-02-20 |
2023-08-12 |
rat |
| José Luiz Pedroso, Edson Bor-Seng-Shu, Andre C Felicio, Pedro Braga-Neto, Lívia A Dutra, Camila C de Aquino, Henrique B Ferraz, Gilmar F do Prado, Manoel J Teixeira, Orlando G Barsottin. Severity of restless legs syndrome is inversely correlated with echogenicity of the substantia nigra in different neurodegenerative movement disorders. a preliminary observation. Journal of the neurological sciences. vol 319. issue 1-2. 2013-02-12. PMID:22632781. |
autopsy studies have demonstrated increased sn iron content in hyperechogenic substantia nigra. |
2013-02-12 |
2023-08-12 |
Not clear |
| Andrius Sakalauskas, Arūnas Lukoševičius, Kristina Laučkaitė, Darius Jegelevičius, Saulius Rutkauska. Automated segmentation of transcranial sonographic images in the diagnostics of Parkinson's disease. Ultrasonics. vol 53. issue 1. 2013-02-11. PMID:22578750. |
manual segmentation of brain structures (areas of the midbrain and substantia nigra (sn)) that are of special interest cause inter-observer and intra-observer variability, thus restricting the reliability of parkinson disease (pd) diagnostics. |
2013-02-11 |
2023-08-12 |
Not clear |
| Min Woo Koo, Yue Kyung Kim, Kyung Mo Ku, Won Wha Park, Yang Ki Min. Exofocal anterograde transsynaptic neuronal death in the globus pallidus: two case reports. Journal of clinical neurology (Seoul, Korea). vol 8. issue 4. 2013-02-07. PMID:23323141. |
exofocal neuronal death in the substantia nigra (sn) is a well-known form of anterograde transsynaptic cell death. |
2013-02-07 |
2023-08-12 |
Not clear |