| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L MacGillivray, K B Reynolds, M Sickand, P I Rosebush, M F Mazure. Inhibition of the serotonin transporter induces microglial activation and downregulation of dopaminergic neurons in the substantia nigra. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584867. |
we studied the time course of changes in dopaminergic neurons in the substantia nigra (sn) after initiation of two different sert inhibitors, citalopram and fluoxetine. |
2012-06-18 |
2023-08-12 |
rat |
| Jan Liman, Andreas Wellmer, Kevin Rostasy, Mathias Bähr, Pawel Kerme. Transcranial ultrasound in neurodegeneration with brain iron accumulation (NBIA). European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. vol 16. issue 2. 2012-06-12. PMID:21816641. |
data were analysed by two blinded investigators regarding hyperechogenicity and size of the substantia nigra (sn). |
2012-06-12 |
2023-08-12 |
Not clear |
| Sang Ryong Kim, Vincent Ries, Hsiao-Chun Cheng, Tatyana Kareva, Tinmarla F Oo, W Haung Yu, Karen Duff, Nikolai Kholodilov, Robert E Burk. Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling. Neurobiology of disease. vol 44. issue 2. 2012-06-11. PMID:21782946. |
therefore, to explore the possible role of endogenous akt signaling in maintaining the viability and functionality of substantia nigra (sn) dopamine neurons, one of the principal systems affected in pd, we have used an adeno-associated viral vector to transduce them with a dominant negative (dn) form of akt, the pleckstrin homology (ph) domain alone (dn(ph)-akt). |
2012-06-11 |
2023-08-12 |
mouse |
| M O Izawa, H Miwa, Y Kajimoto, T Kond. Combination of transcranial sonography, olfactory testing, and MIBG myocardial scintigraphy as a diagnostic indicator for Parkinson's disease. European journal of neurology. vol 19. issue 3. 2012-06-07. PMID:21978091. |
substantia nigra (sn) hyperechogenicity visualized by transcranial sonography (tcs), olfactory dysfunction, and the reduced uptake of (123) i-metaiodobenzylguanidine (mibg) in myocardial scintigraphy have been suggested as potential biomarkers for the identification of parkinson's disease (pd). |
2012-06-07 |
2023-08-12 |
Not clear |
| Kenichi Kashihara, Takayoshi Shinya, Fumiyo Higak. Reduction of neuromelanin-positive nigral volume in patients with MSA, PSP and CBD. Internal medicine (Tokyo, Japan). vol 50. issue 16. 2012-06-04. PMID:21841326. |
in the previous study, we demonstrated the reduction of the neuromelanin-positive volume of substantia nigra (sn) pars compacta (snc) in patients with parkinson's disease (pd) using 3-tesla mri. |
2012-06-04 |
2023-08-12 |
Not clear |
| J Noh, S Y Chang, S Y Wang, J M Chun. Dual function of Zn2+ on the intrinsic excitability of dopaminergic neurons in rat substantia nigra. Neuroscience. vol 175. 2012-06-01. PMID:21081151. |
despite the presence of zn(2+) in high levels in parkinson brain, it is not yet clearly answered whether and how zn(2+) alters the electrical activity of neurons in substantia nigra (sn). |
2012-06-01 |
2023-08-12 |
rat |
| A Chocyk, A Przyborowska, D Dudys, I Majcher, M Maćkowiak, K Wędzon. The impact of maternal separation on the number of tyrosine hydroxylase-expressing midbrain neurons during different stages of ontogenesis. Neuroscience. vol 182. 2012-05-31. PMID:21396433. |
we included in the study the sub-regions of the substantia nigra (sn) and the ventral tegmental area (vta). |
2012-05-31 |
2023-08-12 |
rat |
| Supriya Swarnkar, Sarika Singh, Sharad Sharma, Ramesh Mathur, Ishan K Patro, Chandishwar Nat. Rotenone induced neurotoxicity in rat brain areas: a histopathological study. Neuroscience letters. vol 501. issue 3. 2012-05-31. PMID:21435374. |
striatum (str) and substantia nigra (sn) using he (hematoxylin and eosin) and cv (cresyl violet) staining after 1, 7, and 14 day of unilateral intranigral administration of rotenone (3, 6 and 12 μg/5 μl) in adult male sd rats. |
2012-05-31 |
2023-08-12 |
rat |
| Qing He, Tingting Du, Xiaojun Yu, Anmu Xie, Ning Song, Qi Kang, Jintai Yu, Lan Tan, Junxia Xie, Hong Jian. DMT1 polymorphism and risk of Parkinson's disease. Neuroscience letters. vol 501. issue 3. 2012-05-31. PMID:21777657. |
growing evidence suggests that iron accumulation in the substantia nigra (sn) is involved in the pathology of parkinson's diseases (pd). |
2012-05-31 |
2023-08-12 |
human |
| Sara Al-Sweidi, Marc Morissette, Mélanie Bourque, Thérèse Di Paol. Estrogen receptors and gonadal steroids in vulnerability and protection of dopamine neurons in a mouse model of Parkinson's disease. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21586296. |
specific radioligand binding autoradiography and in situ hybridization for dat, vmat2 and th were assayed in the striatum and the substantia nigra (sn). |
2012-05-25 |
2023-08-12 |
mouse |
| Hsin-Yi Huang, Shinn-Zong Lin, Wu-Fu Chen, Kuo-Wei Li, Jon-Son Kuo, Mei-Jen Wan. Urocortin modulates dopaminergic neuronal survival via inhibition of glycogen synthase kinase-3β and histone deacetylase. Neurobiology of aging. vol 32. issue 9. 2012-05-17. PMID:19875195. |
although ucn is principally expressed in dopaminergic neurons in rat substantia nigra (sn), the function of ucn in modulating dopaminergic neuronal survival remains unclear. |
2012-05-17 |
2023-08-12 |
rat |
| Stephan Steidl, Anthony D Miller, Charles D Blaha, John S Yeoman. M₅ muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. PloS one. vol 6. issue 11. 2012-05-08. PMID:22102904. |
however, cholinergic inputs from the laterodorsal (ldt) and pedunculopontine (ppt) tegmental nucleus to the vta and substantia nigra (sn) importantly contribute, as either ldt or ppt lesions strongly attenuate morphine-induced forebrain dopamine elevations. |
2012-05-08 |
2023-08-12 |
mouse |
| Almas Siddiqui, Jyothi K Mallajosyula, Anand Rane, Julie K Anderse. Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression. Neurobiology of disease. vol 43. issue 2. 2012-05-07. PMID:21809503. |
we previously demonstrated that elevation of astrocytic monoamine oxidase b (mao-b) levels in adoxycycline (dox)-inducible transgenic mouse model following 14 days of dox induction results in several neuropathologic features similar to those observed in the parkinsonian midbrain (mallajosyula et al., 2008).these include a specific, selective and progressive loss of dopaminergic neurons of the substantia nigra (sn),selective decreases in mitochondrial complex i (ci) activity and increased oxidative stress. |
2012-05-07 |
2023-08-12 |
mouse |
| Chang-Liang Xu, Qi-Zhi Wang, Ling-Mei Sun, Xiu-Min Li, Ji-Min Deng, Lu-Fan Li, Jin Zhang, Rong Xu, Shi-Ping M. Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax. Pharmacology, biochemistry, and behavior. vol 100. issue 3. 2012-05-04. PMID:22001429. |
on 14th day, the rats were sacrificed, substantia nigra (sn) and striatum were dissected, and then dopamine (da) and its metabolites in striatum and malonyldialdehyde (mda) contents, reduced glutathione (gsh) level and gene expression level in sn were estimated. |
2012-05-04 |
2023-08-12 |
rat |
| Masayuki Miyamoto, Tomoyuki Miyamoto, Masaoki Iwanami, Shin-Ichi Muramatsu, Sayaka Asari, Imaharu Nakano, Koichi Hirat. Preclinical substantia nigra dysfunction in rapid eye movement sleep behaviour disorder. Sleep medicine. vol 13. issue 1. 2012-05-02. PMID:22033122. |
transcranial sonography (tcs) has been shown to reveal hyperechogenicity of the substantia nigra (sn) in people with parkinson's disease and in approximately 10% of healthy subjects. |
2012-05-02 |
2023-08-12 |
human |
| Knut Busse, Robert Heilmann, Sabine Kleinschmidt, Mazen Abu-Mugheisib, Jacqueline Höppner, Christian Wunderlich, Irene Gemende, Lara Kaulitz, Alexander Wolters, Reiner Benecke, Uwe Walte. Value of combined midbrain sonography, olfactory and motor function assessment in the differential diagnosis of early Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 83. issue 4. 2012-04-27. PMID:22362921. |
characteristic features of parkinson's disease (pd) are asymmetric parkinsonian motor signs, hyposmia and substantia nigra (sn) hyperechogenicity on transcranial ultrasound. |
2012-04-27 |
2023-08-12 |
Not clear |
| Dae-Hyuk Kwon, Jong-Min Kim, Se-Hong Oh, Hye-Jin Jeong, Sung-Yeon Park, Eung-Seok Oh, Je-Geun Chi, Young-Bo Kim, Beom S Jeon, Zang-Hee Ch. Seven-Tesla magnetic resonance images of the substantia nigra in Parkinson disease. Annals of neurology. vol 71. issue 2. 2012-04-26. PMID:22367998. |
to investigate anatomical changes in the substantia nigra (sn) of parkinson disease (pd) patients with age-matched controls by using ultra-high field magnetic resonance imaging (mri). |
2012-04-26 |
2023-08-12 |
Not clear |
| Silvia Tapia-González, Rosa M Giráldez-Pérez, M Isabel Cuartero, M José Casarejos, M Ángeles Mena, Xiao-Fan Wang, Amelia Sánchez-Capel. Dopamine and α-synuclein dysfunction in Smad3 null mice. Molecular neurodegeneration. vol 6. 2012-04-24. PMID:21995845. |
parkinson's disease (pd) is characterized by dopaminergic neurodegeneration in the substantia nigra (sn). |
2012-04-24 |
2023-08-12 |
mouse |
| Alexander Ternianov, José M Pérez-Ortiz, María E Solesio, María S García-Gutiérrez, Antonio Ortega-Álvaro, Francisco Navarrete, Carlos Leiva, María F Galindo, Jorge Manzanare. Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20980074. |
tyrosine hydroxylase (th), glial fibrillary acidic protein (gfap), and ionized calcium-binding adapter molecule 1 (iba-1) were measured by immunocytochemistry in the cpu and/or substantia nigra (sn) of cb2xp mice and wt mice. |
2012-04-19 |
2023-08-12 |
mouse |
| Christina E Khodr, Mohan K Sapru, Jyothi Pedapati, Ye Han, Neva C West, Adrian P Kells, Krystof S Bankiewicz, Martha C Boh. An α-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons. Brain research. vol 1395. 2012-04-19. PMID:21565333. |
effects of silencing ectopically expressed hsnca in rat substantia nigra (sn) were examined as a novel therapeutic approach to parkinson's disease (pd). |
2012-04-19 |
2023-08-12 |
rat |