| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Takahashi, T Yamada, K Nakanishi, K Fujita, K Nakajima, E Nobusawa, T Yamamoto, T Kato, H Okad. Influenza a virus infection of primary cultured cells from rat fetal brain. Parkinsonism & related disorders. vol 3. issue 2. 2012-10-02. PMID:18591062. |
we previously reported that the neurovirulent influenza a virus strain, aiwsn/33 has strong affinity for the substantia nigra (sn) in mouse brain. |
2012-10-02 |
2023-08-12 |
mouse |
| J M Deniau, C Hammond-Le Guyader, J Feger, J S McKenzi. Bilateral projection of nigro-collicular neurons: An electrophysiological analysis in the rat. Neuroscience letters. vol 5. issue 1-2. 2012-10-02. PMID:19604969. |
effective stimulations were located in ipsi- or contralateral sc deep layers lying above the central gray (cg) or more laterally; nigro-collicular neurons are exclusively located in the pars reticulata of the substantia nigra (sn) and some of them project both to ipsi- and contralateral sc. |
2012-10-02 |
2023-08-12 |
rat |
| D Weissmann, E Mach, C Oberlander, Y Demassey, J F Pujo. Evidence for hyperdensity of 5HT1B binding sites in the substantia nigra of the rat after 5,7-dihydroxytryptamine intraventricular injection. Neurochemistry international. vol 9. issue 1. 2012-10-02. PMID:20493117. |
high affinity serotonin (5ht) binding sites have been found highly concentrated in the substantia nigra (sn) of the rat brain in each classical anatomical subdivisions of this structure, sn reticulata (snr), sn lateralis (snl), sn compacta (snc). |
2012-10-02 |
2023-08-12 |
rat |
| T F Oo, R E Burk. Animal models of induced apoptotic death in the substantia nigra. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318770. |
the purpose of the models we have developed of induced apoptosis in dopamine neurons of the substantia nigra (sn) is to try to translate what is being learned about the molecular mechanisms of apoptosis in simpler systems to these neurons. |
2012-10-02 |
2023-08-12 |
human |
| T F Oo, R E Burk. Apoptotic morphology in phenotypically defined dopaminergic neurons of the substantia nigra. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318771. |
in the preceding chapter we described three paradigms by which we have studied programmed cell death in the substantia nigra (sn) of living animals: natural cell death and death induced either by developmental injury to the target striatum or by dopamine terminal destruction with the neurotoxin 6-hydroxydopamine (6-ohda). |
2012-10-02 |
2023-08-12 |
Not clear |
| J L Mendoza-Ramírez, R Aguilar-Roblero, A Zainos-Rosales, R Drucker-Colí. Fetal substantia nigra and adrenal medullary grafts placed contralateral to the nigrostriatal lesion side induce a decrease in turning behavior but not in dopamine receptor density. Restorative neurology and neuroscience. vol 3. issue 4. 2012-10-02. PMID:21551635. |
motor asymmetries as well as changes in the density of postsynaptic dopamine receptors produced by unilateral denervation of the striatum have been reduced by both substantia nigra (sn) and adrenal medullary (am) grafts. |
2012-10-02 |
2023-08-12 |
rat |
| W F Silverman, Y Solberg, Y Pollac. Metabolic profile of fetal dopamine neurons transplanted to the adult rat striatum. Restorative neurology and neuroscience. vol 9. issue 2. 2012-10-02. PMID:21551837. |
in the present study, we have examined the expression and distribution of the metabolic marker neuron-specific enolase (nse) in solid-tissue transplants of fetal substantia nigra (sn) to the striatum of intact and 6-hydroxydopamine lesioned mature rats. |
2012-10-02 |
2023-08-12 |
rat |
| W J Free. Substantia nigra grafts and Parkinson's disease: from animal experiments to human therapeutic trials. Restorative neurology and neuroscience. vol 3. issue 3. 2012-10-02. PMID:21551873. |
during the decade since the first reports of functional effects of substantia nigra (sn) transplantation in animal models of parkinson's disease, the procedure has progressed to human clinical trials. |
2012-10-02 |
2023-08-12 |
human |
| b' Rigoberto Salado-Castillo, Manuel S\\xc3\\xa1nchez-Alav\\xc3\\xa9z, Gina L Quirarte, Mar\\xc3\\xada Isabel Mart\\xc3\\xadnez Garc\\xc3\\xada, Roberto A Prado-Alcal\\xc3\\xa. Enhanced training protects memory against amnesia produced by concurrent inactivation of amygdala and striatum, amygdala and substantia nigra, or striatum and substantia nigra. Frontiers in behavioral neuroscience. vol 5. 2012-10-02. PMID:22203796.' |
we now report on the effects of enhanced training on retention after temporary inactivation of cerebral nuclei known to be involved in memory, namely the substantia nigra (sn), striatum (str), and amygdala (amy). |
2012-10-02 |
2023-08-12 |
Not clear |
| Vilma C Muñetón-Gómez, Ernesto Doncel-Pérez, Ana P Fernandez, Julia Serrano, Andrea Pozo-Rodrigálvarez, Lara Vellosillo-Huerta, Julian S Taylor, Gloria P Cardona-Gómez, Manuel Nieto-Sampedro, Ricardo Martínez-Murill. Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations. Frontiers in cellular neuroscience. vol 6. 2012-10-02. PMID:22876219. |
in this study we assess ischemic damage of the nigrostriatal pathway in a model of lacunar stroke evoked by damaging the perforating arteries in the territory of the substantia nigra (sn) of the rat after stereotaxic administration of endothelin-1 (et-1), a potent vasoconstrictor peptide. |
2012-10-02 |
2023-08-12 |
human |
| Henriqueta D Cardoso, Priscila P Passos, Claudia J Lagranha, Anete C Ferraz, Eraldo F Santos Júnior, Rafael S Oliveira, Pablo E L Oliveira, Rita de C F Santos, David F Santana, Juliana M C Borba, Ana P Rocha-de-Melo, Rubem C A Guedes, Daniela M A F Navarro, Geanne K N Santos, Roseane Borner, Cristovam W Picanço-Diniz, Eduardo I Beltrão, Janilson F Silva, Marcelo C A Rodrigues, Belmira L S Andrade da Cost. Differential vulnerability of substantia nigra and corpus striatum to oxidative insult induced by reduced dietary levels of essential fatty acids. Frontiers in human neuroscience. vol 6. 2012-10-02. PMID:22969716. |
in our previous study on rat brains, we observed that a two-generation efa dietary restriction reduced the number and size of dopaminergic neurons in the substantia nigra (sn) rostro-dorso-medial. |
2012-10-02 |
2023-08-12 |
rat |
| Christina E Khodr, Jyothi Pedapati, Ye Han, Martha C Boh. Inclusion of a portion of the native SNCA 3'UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia nigra. Developmental neurobiology. vol 72. issue 6. 2012-09-28. PMID:22021082. |
adult, male rats were injected into one substantia nigra (sn) with aav-wtsnca, aav-s129a hsnca, or aav-s129d hsnca either with or without a portion of the native 3'utr. |
2012-09-28 |
2023-08-12 |
human |
| George Stoica, Gina Lungu, Nicole L Bjorklund, Giulio Taglialatela, Xing Zhang, Veronica Chiu, Herbert H Hill, James O Schenk, Ian Murra. Potential role of α-synuclein in neurodegeneration: studies in a rat animal model. Journal of neurochemistry. vol 122. issue 4. 2012-09-27. PMID:22639889. |
the neurodegeneration in this model is characterized by the presence of perikarya and neurites lewis bodies (lb) and diffuse marked accumulation of perikaryal α-syn in the substantia nigra (sn), brain stem (bs), and striatum (st) along with neuronal loss. |
2012-09-27 |
2023-08-12 |
human |
| Kimberly N Huggins, Tiffany A Mathews, Jason L Locke, Kendall T Szeliga, David P Friedman, Allyson J Bennett, Sara R Jone. Effects of early life stress on drinking and serotonin system activity in rhesus macaques: 5-hydroxyindoleacetic acid in cerebrospinal fluid predicts brain tissue levels. Alcohol (Fayetteville, N.Y.). vol 46. issue 4. 2012-09-25. PMID:22445804. |
brain samples were taken from the dorsal caudate, putamen, substantia nigra (sn) pars reticulata, sn pars compacta and hippocampus. |
2012-09-25 |
2023-08-12 |
monkey |
| Chao Sun, Ning Song, Anmu Xie, Junxia Xie, Hong Jian. High hepcidin level accounts for the nigral iron accumulation in acute peripheral iron intoxication rats. Toxicology letters. vol 212. issue 3. 2012-09-25. PMID:22659129. |
our previous publication revealed that acute iron intoxication induced iron deposit and dopaminergic neuron degeneration in the substantia nigra (sn) of a rat model. |
2012-09-25 |
2023-08-12 |
rat |
| Jie Li, Junfeng Yang, Peng Zhao, Shen Li, Renyun Zhang, Xiaobin Zhang, Dan Liu, Benshu Zhan. Neuromelanin enhances the toxicity of α-synuclein in SK-N-SH cells. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 6. 2012-09-20. PMID:22200858. |
the key pathological feature of parkinson's disease (pd) is selective degeneration of the neuromelanin (nm)-pigmented dopaminergic neurons in the substantia nigra (sn). |
2012-09-20 |
2023-08-12 |
human |
| G Webster Ross, Robert D Abbott, Helen Petrovitch, Caroline M Tanner, Lon R Whit. Pre-motor features of Parkinson's disease: the Honolulu-Asia Aging Study experience. Parkinsonism & related disorders. vol 18 Suppl 1. 2012-08-27. PMID:22166434. |
additionally, brain autopsies have been sought since 1991 allowing use of incidental lewy bodies and neuronal loss in the substantia nigra (sn) and locus coeruleus (lc) as additional endpoints for the pd process. |
2012-08-27 |
2023-08-12 |
Not clear |
| A Machado, A J Herrera, J L Venero, M Santiago, R M de Pablos, R F Villarán, A M Espinosa-Oliva, S Argüelles, M Sarmiento, M J Delgado-Cortés, R Mauriño, J Can. Inflammatory Animal Model for Parkinson's Disease: The Intranigral Injection of LPS Induced the Inflammatory Process along with the Selective Degeneration of Nigrostriatal Dopaminergic Neurons. ISRN neurology. vol 2011. 2012-08-23. PMID:22389821. |
the implication of neuroinflammation on this disease was originally established in 1988, when the presence of activated microglia in the substantia nigra (sn) of parkinsonians was reported by mcgeer et al. |
2012-08-23 |
2023-08-12 |
Not clear |
| Melissa L Perreault, Theresa Fan, Mohammed Alijaniaram, Brian F O'Dowd, Susan R Georg. Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2. PloS one. vol 7. issue 3. 2012-08-20. PMID:22428025. |
activation of the d1r-d2r heteromer in these neurons resulted in the simultaneous, but differential regulation of proteins involved in gaba and glutamate production or vesicular uptake in the nucleus accumbens (nac), ventral tegmental area (vta), caudate putamen and substantia nigra (sn). |
2012-08-20 |
2023-08-12 |
Not clear |
| Jun Wang, Hong Jiang, Jun-Xia Xi. [Correlation between iron levels and degeneration of dopaminergic neurons in rat nigrostriatal system during the early 6-OHDA lesions in medial forebrain bundle]. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 4. 2012-08-16. PMID:12937822. |
the results showed that 1 d or 3 d after lesions in mfb, there was a 45% or 66% reduction, respectively, in the density of tyrosine hydroxylase (th) immunoreactive cells in the substantia nigra (sn) of the lesioned side accompanied by an increase in iron staining intensity and iron concentration; while there was no change in dopamine (da) release in the striatum (str) of the lesioned side compared with the unlesioned side and the normal rats. |
2012-08-16 |
2023-08-12 |
rat |