| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lei Chen, Johann Hagenah, Alfred Mertin. Feature analysis for Parkinson's disease detection based on transcranial sonography image. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 15. issue Pt 3. 2013-01-29. PMID:23286140. |
transcranial sonography (tcs) is a new tool for the diagnosis of parkinson's disease (pd) according to a distinct hyperechogenic pattern in the substantia nigra (sn) region. |
2013-01-29 |
2023-08-12 |
Not clear |
| Olivier Pauly, Seyed-Ahmad Ahmadi, Annika Plate, Kai Boetzel, Nassir Nava. Detection of substantia nigra echogenicities in 3D transcranial ultrasound for early diagnosis of Parkinson disease. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 15. issue Pt 3. 2013-01-29. PMID:23286161. |
parkinson's disease (pd) is a neurodegenerative movement disorder caused by decay of dopaminergic cells in the substantia nigra (sn), which are basal ganglia residing within the midbrain area. |
2013-01-29 |
2023-08-12 |
Not clear |
| Candan Depboylu, Sarah Stricker, Jean-Pierre Ghobril, Wolfgang H Oertel, Josef Priller, Günter U Höglinge. Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22964486. |
parkinson disease (pd) is characterized by dopaminergic neurodegeneration in the substantia nigra (sn). |
2013-01-21 |
2023-08-12 |
mouse |
| Matteo Marti, Donata Rodi, Qin Li, Remo Guerrini, Stefania Fasano, Ilaria Morella, Alessandro Tozzi, Riccardo Brambilla, Paolo Calabresi, Michele Simonato, Erwan Bezard, Michele Morar. Nociceptin/orphanin FQ receptor agonists attenuate L-DOPA-induced dyskinesias. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 46. 2013-01-21. PMID:23152595. |
regional microinjections revealed that n/ofq attenuated dyskinesias more potently and effectively when microinjected in striatum than substantia nigra (sn) reticulata, whereas n/ofq receptor antagonists were ineffective in striatum but worsened dyskinesias when given in sn. |
2013-01-21 |
2023-08-12 |
rat |
| Sara Neumane, Stéphanie Mounayar, Caroline Jan, Justine Epinat, Bénédicte Ballanger, Nicolas Costes, Jean Féger, Stéphane Thobois, Chantal François, Véronique Sgambato-Faure, Léon Trembla. Effects of dopamine and serotonin antagonist injections into the striatopallidal complex of asymptomatic MPTP-treated monkeys. Neurobiology of disease. vol 48. issue 1. 2013-01-14. PMID:22728661. |
monkeys developed all of the motor symptoms and then fully recovered despite a large da cell loss in the substantia nigra (sn). |
2013-01-14 |
2023-08-12 |
monkey |
| Yan Zhou, Yanxin Zhang, Junquan Li, Fengyue Lv, Yongmei Zhao, Deyi Duan, Qunyuan X. A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventricular injection of lipopolysaccharide in rats. Journal of neurochemistry. vol 123. issue 5. 2013-01-10. PMID:22957701. |
parkinson's disease (pd) is characterized by selective and progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2013-01-10 |
2023-08-12 |
rat |
| Philip Long, Parwez Samnakay, Peter Jenner, Sarah Ros. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. The European journal of neuroscience. vol 36. issue 6. 2013-01-09. PMID:22779921. |
osteopontin (opn) expression is reduced in surviving dopaminergic neurones in the substantia nigra (sn) in parkinson's disease (pd), and protects against mpp(+) -induced cell death in primary mesencephalic cultures and 6-ohda-induced cell loss in the rat, while inactivation of opn aggravates cell death. |
2013-01-09 |
2023-08-12 |
human |
| Q David Walker, Misha L Johnson, Amanda E D Van Swearingen, Andrew E Arrant, Joseph M Caster, Cynthia M Kuh. Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22342988. |
dopamine neuron number and density in substantia nigra (sn) and ventral tegmental area (vta) were determined in the same animals using tyrosine-hydroxylase immunohistochemistry and unbiased stereology. |
2012-12-20 |
2023-08-12 |
rat |
| John Man Tak Chu, Ying Shing Chan, Liang Wei Chen, Ken Kin Lam Yun. Neurokinin receptor 3 peptide exacerbates 6-hydroxydopamine-induced dopaminergic degeneration in rats through JNK pathway. Journal of neurochemistry. vol 123. issue 3. 2012-12-19. PMID:22762252. |
neurokinin 3 (nk3) receptor is predominantly expressed in striatum and substantia nigra (sn). |
2012-12-19 |
2023-08-12 |
rat |
| P Riederer, J Sian-Hülsman. The significance of neuronal lateralisation in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 8. 2012-11-29. PMID:22367437. |
the destruction of the dopaminergic neurons in the substantia nigra (sn) and consequent depletion of striatal dopamine elicits the main movement deficits related to parkinson's disease (pd). |
2012-11-29 |
2023-08-12 |
Not clear |
| b' I Peltonen, T T My\\xc3\\xb6h\\xc3\\xa4nen, P T M\\xc3\\xa4nnist\\xc3\\xb. Different interactions of prolyl oligopeptidase and neurotensin in dopaminergic function of the rat nigrostriatal and mesolimbic pathways. Neurochemical research. vol 37. issue 9. 2012-11-20. PMID:22729983.' |
a colocalization of prep with neurotensin and neurotensin receptor 1 (nts1) in the rat striatum, nucleus accumbens (nacc), substantia nigra (sn) and ventral tegmental area (vta) was studied with immunofluorescence. |
2012-11-20 |
2023-08-12 |
rat |
| J Deignan, R Luján, C Bond, A Riegel, M Watanabe, J T Williams, J Maylie, J P Adelma. SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons. Neuroscience. vol 217. 2012-11-19. PMID:22554781. |
the firing properties of dopamine (da) neurons in the substantia nigra (sn) pars compacta are strongly influenced by the activity of apamin-sensitive small conductance ca(2+)-activated k(+) (sk) channels. |
2012-11-19 |
2023-08-12 |
mouse |
| Erik K Kastman, Auriel A Willette, Christopher L Coe, Barbara B Bendlin, Kris J Kosmatka, Donald G McLaren, Guofan Xu, Elisa Canu, Aaron S Field, Andrew L Alexander, Mary Lou Voytko, T Mark Beasley, Ricki J Colman, Richard H Weindruch, Sterling C Johnso. A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 34. 2012-11-19. PMID:23082321. |
both the cr and control monkeys showed age-related increases in iron concentrations in globus pallidus (gp) and substantia nigra (sn), although the cr group had significantly less iron deposition in the gp, sn, red nucleus, and temporal cortex. |
2012-11-19 |
2023-08-12 |
monkey |
| Sheila V Kusnoor, Michael Bubser, Ariel Y Deutc. The effects of nigrostriatal dopamine depletion on the thalamic parafascicular nucleus. Brain research. vol 1446. 2012-11-13. PMID:22353754. |
neuronal loss in parkinson's disease (pd) is seen in a number of brain regions in addition to the substantia nigra (sn). |
2012-11-13 |
2023-08-12 |
rat |
| Katarzyna Kuter, Wacław Kolasiewicz, Krystyna Gołembiowska, Anna Dziubina, Gert Schulze, Klemencja Berghauzen, Jadwiga Wardas, Krystyna Ossowsk. Partial lesion of the dopaminergic innervation of the ventral striatum induces "depressive-like" behavior of rats. Pharmacological reports : PR. vol 63. issue 6. 2012-11-07. PMID:22358086. |
levels of dopamine, dopac and hva were decreased in the nucleus accumbens (nac) 2 weeks after 6-ohda but were not changed in the cp, frontal cortex (fcx) and substantia nigra (sn). |
2012-11-07 |
2023-08-12 |
rat |
| Patricia Szot, Allyn Franklin, Carl Sikkema, Charles W Wilkinson, Murray A Raskin. Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results in a Correlation of Dopaminergic Neuronal Number to Striatal Dopamine Concentration. Frontiers in pharmacology. vol 3. 2012-11-07. PMID:23129999. |
the number of dopaminergic neurons in the substantia nigra (sn) and ventral tegmental area (vta), and noradrenergic neurons in the lc were determined. |
2012-11-07 |
2023-08-12 |
mouse |
| Julia Schiemann, Falk Schlaudraff, Verena Klose, Markus Bingmer, Susumu Seino, Peter J Magill, Kareem A Zaghloul, Gaby Schneider, Birgit Liss, Jochen Roepe. K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration. Nature neuroscience. vol 15. issue 9. 2012-11-05. PMID:22902720. |
we found that, in medial da neurons of the substantia nigra (sn), activity of atp-sensitive potassium (k-atp) channels enabled nmda-mediated bursting in vitro as well as spontaneous in vivo burst firing in anesthetized mice. |
2012-11-05 |
2023-08-12 |
mouse |
| Pichest Metarugcheep, Suchat Hanchaiphiboolkul, Akravudh Viriyavejakul, Somsak Chanyawattiwong. The usage of proton magnetic resonance spectroscopy in Parkinson's disease. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. vol 95. issue 7. 2012-11-01. PMID:22919991. |
however this technique has never been used to evaluate the substantia nigra (sn) in pd patients. |
2012-11-01 |
2023-08-12 |
Not clear |
| Shanshan Wang, Michael S Okun, Oleg Suslov, Tong Zheng, Nikolaus R McFarland, Vinata Vedam-Mai, Kelly D Foote, Steven N Roper, Anthony T Yachnis, Florian A Siebzehnrubl, Dennis A Steindle. Neurogenic potential of progenitor cells isolated from postmortem human Parkinsonian brains. Brain research. vol 1464. 2012-10-23. PMID:22652067. |
substantia nigra, "sn") and are able to differentiate into both glia and neurons, but only under particular growth conditions including co-culturing with embryonic stem cell-derived neural precursors ("esnps"); this suggests that pd multipotent neural stem/progenitor cells do reside within the sn and other areas, but by themselves appear to lack key factors required for neuronal differentiation. |
2012-10-23 |
2023-08-12 |
human |
| b' Vladimir S Kosti\\xc4\\x87, Marina Svetel, Milija Mijajlovi\\xc4\\x87, Aleksandra Pavlovi\\xc4\\x87, Milica Je\\xc4\\x8dmenica-Luki\\xc4\\x87, Du\\xc5\\xa1ko Kozi\\xc4\\x87, Du\\xc5\\xa1an Kozi\\xc4\\x8. Transcranial sonography in pantothenate kinase-associated neurodegeneration. Journal of neurology. vol 259. issue 5. 2012-10-17. PMID:22057405.' |
after it was reported that increased tissue iron concentrations were associated with increased echogenicity of the substantia nigra (sn) obtained with transcranial sonography (tcs) in animal and postmortem studies, our goal was to use this method in a disorder characterized with iron accumulation in human brain tissue. |
2012-10-17 |
2023-08-12 |
human |