| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gulay Hacioglu, Yasemin Seval-Celik, Gamze Tanriover, Ozlem Ozsoy, Esen Saka-Topcuoglu, Sevin Balkan, Aysel Aga. Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. Folia histochemica et cytobiologica. vol 50. issue 2. 2013-03-26. PMID:22763967. |
the dopaminergic lesion was determined by immunohistochemical analysis for tyrosine hydroxylase (th)-immunopositive cells in substantia nigra (sn). |
2013-03-26 |
2023-08-12 |
rat |
| Hei Ming-Yan, Ya-Li Luo, Xiao-Chun Zhang, Hong Liu, Ru Gao, Jing-Jiang W. Hypoxic-ischemic injury decreases anxiety-like behavior in rats when associated with loss of tyrosine-hydroxylase immunoreactive neurons of the substantia nigra. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 1. 2013-03-14. PMID:22147192. |
neonatal sprague-dawley rats were randomly divided into normal control, mild hypoxia-ischemia (hi), and severe hi groups (n = 10 in each group at each time) on postnatal day 7 (p7) to study the effect of mild and severe hi on anxiety-like behavior and the expression of tyrosine hydroxylase (th) in the substantia nigra (sn). |
2013-03-14 |
2023-08-12 |
rat |
| Eun Sook Chung, Himchan Kim, Gihyun Lee, Soojin Park, Hyunseong Kim, Hyunsu Ba. Neuro-protective effects of bee venom by suppression of neuroinflammatory responses in a mouse model of Parkinson's disease: role of regulatory T cells. Brain, behavior, and immunity. vol 26. issue 8. 2013-03-12. PMID:22974722. |
treatment with bv prevented degeneration of da neurons in the substantia nigra (sn). |
2013-03-12 |
2023-08-12 |
mouse |
| Philipp Klaissle, Anne Lesemann, Petra Huehnchen, Andreas Hermann, Alexander Storch, Barbara Steine. Physical activity and environmental enrichment regulate the generation of neural precursors in the adult mouse substantia nigra in a dopamine-dependent manner. BMC neuroscience. vol 13. 2013-03-08. PMID:23110504. |
parkinson's disease is characterized by a continuous loss of neurons within the substantia nigra (sn) leading to a depletion of dopamine. |
2013-03-08 |
2023-08-12 |
mouse |
| Xiao Hong Wang, Gang Lu, Xiang Hu, Kam Sze Tsang, Wing Hang Kwong, Feng Xia Wu, Hai Wei Meng, Shu Jiang, Shu Wei Liu, Ho Keung Ng, Wai Sang Poo. Quantitative assessment of gait and neurochemical correlation in a classical murine model of Parkinson's disease. BMC neuroscience. vol 13. 2013-03-08. PMID:23151254. |
correlations of gait parameters with tyrosine hydroxylase (th) protein levels in the substantia nigra (sn) were also investigated. |
2013-03-08 |
2023-08-12 |
Not clear |
| Mi Jin Kim, Dae Won Kim, Hoon Jae Jeong, Eun Jeong Sohn, Min Jea Shin, Eun Hee Ahn, Soon Won Kwon, Young Nam Kim, Duk-Soo Kim, Jinseu Park, Won Sik Eum, Hyun Sook Hwang, Soo Young Cho. Tat-Frataxin protects dopaminergic neuronal cells against MPTP-induced toxicity in a mouse model of Parkinson's disease. Biochimie. vol 94. issue 11. 2013-03-05. PMID:22809528. |
parkinson's disease (pd) is caused by various factors such as reactive oxygen species (ros), dysfunction of mitochondria, and aggregation of misfolded proteins, thereby leading to loss of dopaminergic (da) neurons in the substantia nigra (sn) of the brain. |
2013-03-05 |
2023-08-12 |
mouse |
| Franz Marxreiter, Martin Regensburger, Jürgen Winkle. Adult neurogenesis in Parkinson's disease. Cellular and molecular life sciences : CMLS. vol 70. issue 3. 2013-03-04. PMID:22766974. |
the diagnosis of pd is based on motor symptoms such as bradykinesia, rigidity, tremor, and postural instability associated with the striatal dopaminergic deficit that is linked to neurodegenerative processes in the substantia nigra (sn). |
2013-03-04 |
2023-08-12 |
Not clear |
| ZeGang Ma, Yu Zhou, JunXia Xi. Nifedipine prevents iron accumulation and reverses iron-overload-induced dopamine neuron degeneration in the substantia nigra of rats. Neurotoxicity research. vol 22. issue 4. 2013-02-27. PMID:22259026. |
the mechanisms of iron accumulation in substantia nigra (sn) of parkinson's diseases remain unclear. |
2013-02-27 |
2023-08-12 |
rat |
| Eun S Park, Sang R Kim, Byung K Ji. Transient receptor potential vanilloid subtype 1 contributes to mesencephalic dopaminergic neuronal survival by inhibiting microglia-originated oxidative stress. Brain research bulletin. vol 89. issue 3-4. 2013-02-27. PMID:22796104. |
the present study examined whether capsaicin (cap), an agonist of transient receptor potential vanilloid subtype 1 (trpv1) can prevent 1-methyl-4-phenylpyridinium (mpp(+))-induced dopaminergic (da) neuronal death in the substantia nigra (sn). |
2013-02-27 |
2023-08-12 |
rat |
| Mohammad Hossein Esmaeili, Mohadeseh Movahedi, Ayda Faraji, Hashem Haghdoost-Yazd. Intracerebral injection of low amounts of norharman induces moderate Parkinsonism-like behavioral symptoms in rat. Neurotoxicology and teratology. vol 34. issue 5. 2013-02-25. PMID:22789434. |
a small amount (4μl) of nh solution at 2 or 200ng/ml was unilaterally injected into either striatum or substantia nigra (sn) by stereotaxic surgery. |
2013-02-25 |
2023-08-12 |
rat |
| Ingrid Morales, Angel Fuentes, Santiago Ballaz, Jose A Obeso, Manuel Rodrigue. Striatal interaction among dopamine, glutamate and ascorbate. Neuropharmacology. vol 63. issue 8. 2013-02-20. PMID:22959966. |
microdialysis was used here to quantify the extracellular interaction among glu-da-aa in the striatum of rats, an interaction which was compared with those studied in the substantia nigra (sn). |
2013-02-20 |
2023-08-12 |
rat |
| José Luiz Pedroso, Edson Bor-Seng-Shu, Andre C Felicio, Pedro Braga-Neto, Lívia A Dutra, Camila C de Aquino, Henrique B Ferraz, Gilmar F do Prado, Manoel J Teixeira, Orlando G Barsottin. Severity of restless legs syndrome is inversely correlated with echogenicity of the substantia nigra in different neurodegenerative movement disorders. a preliminary observation. Journal of the neurological sciences. vol 319. issue 1-2. 2013-02-12. PMID:22632781. |
autopsy studies have demonstrated increased sn iron content in hyperechogenic substantia nigra. |
2013-02-12 |
2023-08-12 |
Not clear |
| Andrius Sakalauskas, Arūnas Lukoševičius, Kristina Laučkaitė, Darius Jegelevičius, Saulius Rutkauska. Automated segmentation of transcranial sonographic images in the diagnostics of Parkinson's disease. Ultrasonics. vol 53. issue 1. 2013-02-11. PMID:22578750. |
manual segmentation of brain structures (areas of the midbrain and substantia nigra (sn)) that are of special interest cause inter-observer and intra-observer variability, thus restricting the reliability of parkinson disease (pd) diagnostics. |
2013-02-11 |
2023-08-12 |
Not clear |
| Min Woo Koo, Yue Kyung Kim, Kyung Mo Ku, Won Wha Park, Yang Ki Min. Exofocal anterograde transsynaptic neuronal death in the globus pallidus: two case reports. Journal of clinical neurology (Seoul, Korea). vol 8. issue 4. 2013-02-07. PMID:23323141. |
exofocal neuronal death in the substantia nigra (sn) is a well-known form of anterograde transsynaptic cell death. |
2013-02-07 |
2023-08-12 |
Not clear |
| Lei Chen, Johann Hagenah, Alfred Mertin. Feature analysis for Parkinson's disease detection based on transcranial sonography image. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 15. issue Pt 3. 2013-01-29. PMID:23286140. |
transcranial sonography (tcs) is a new tool for the diagnosis of parkinson's disease (pd) according to a distinct hyperechogenic pattern in the substantia nigra (sn) region. |
2013-01-29 |
2023-08-12 |
Not clear |
| Olivier Pauly, Seyed-Ahmad Ahmadi, Annika Plate, Kai Boetzel, Nassir Nava. Detection of substantia nigra echogenicities in 3D transcranial ultrasound for early diagnosis of Parkinson disease. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 15. issue Pt 3. 2013-01-29. PMID:23286161. |
parkinson's disease (pd) is a neurodegenerative movement disorder caused by decay of dopaminergic cells in the substantia nigra (sn), which are basal ganglia residing within the midbrain area. |
2013-01-29 |
2023-08-12 |
Not clear |
| Candan Depboylu, Sarah Stricker, Jean-Pierre Ghobril, Wolfgang H Oertel, Josef Priller, Günter U Höglinge. Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22964486. |
parkinson disease (pd) is characterized by dopaminergic neurodegeneration in the substantia nigra (sn). |
2013-01-21 |
2023-08-12 |
mouse |
| Matteo Marti, Donata Rodi, Qin Li, Remo Guerrini, Stefania Fasano, Ilaria Morella, Alessandro Tozzi, Riccardo Brambilla, Paolo Calabresi, Michele Simonato, Erwan Bezard, Michele Morar. Nociceptin/orphanin FQ receptor agonists attenuate L-DOPA-induced dyskinesias. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 46. 2013-01-21. PMID:23152595. |
regional microinjections revealed that n/ofq attenuated dyskinesias more potently and effectively when microinjected in striatum than substantia nigra (sn) reticulata, whereas n/ofq receptor antagonists were ineffective in striatum but worsened dyskinesias when given in sn. |
2013-01-21 |
2023-08-12 |
rat |
| Sara Neumane, Stéphanie Mounayar, Caroline Jan, Justine Epinat, Bénédicte Ballanger, Nicolas Costes, Jean Féger, Stéphane Thobois, Chantal François, Véronique Sgambato-Faure, Léon Trembla. Effects of dopamine and serotonin antagonist injections into the striatopallidal complex of asymptomatic MPTP-treated monkeys. Neurobiology of disease. vol 48. issue 1. 2013-01-14. PMID:22728661. |
monkeys developed all of the motor symptoms and then fully recovered despite a large da cell loss in the substantia nigra (sn). |
2013-01-14 |
2023-08-12 |
monkey |
| Yan Zhou, Yanxin Zhang, Junquan Li, Fengyue Lv, Yongmei Zhao, Deyi Duan, Qunyuan X. A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventricular injection of lipopolysaccharide in rats. Journal of neurochemistry. vol 123. issue 5. 2013-01-10. PMID:22957701. |
parkinson's disease (pd) is characterized by selective and progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2013-01-10 |
2023-08-12 |
rat |