| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keiji Mori, Yoko S Kaneko, Akira Nakashima, Hiroshi Nagasaki, Toshiharu Nagatsu, Ikuko Nagatsu, Akira Ot. Subventricular zone under the neuroinflammatory stress and Parkinson's disease. Cellular and molecular neurobiology. vol 32. issue 5. 2012-10-17. PMID:22189676. |
this review summarizes the effects of neuroinflammatory stress on the subventricular zone (svz), where new neurons are constitutively produced in the adult brain, especially focusing on the relation with parkinson's disease (pd), because the svz is under the control of dopaminergic afferents from the substantia nigra (sn). |
2012-10-17 |
2023-08-12 |
Not clear |
| P Szot, L Knight, A Franklin, C Sikkema, S Foster, C W Wilkinson, S S White, M A Raskin. Lesioning noradrenergic neurons of the locus coeruleus in C57Bl/6 mice with unilateral 6-hydroxydopamine injection, to assess molecular, electrophysiological and biochemical changes in noradrenergic signaling. Neuroscience. vol 216. 2012-10-17. PMID:22542679. |
direct administration of 6ohda into the lc results in the specific reduction of noradrenergic neurons in the lc (as measured by electrophysiology, immunoreactivity and in situ hybridization), the lateral tegmental neurons and dopaminergic neurons in the substantia nigra (sn) and ventral tegmental region were unaffected. |
2012-10-17 |
2023-08-12 |
mouse |
| Patricia Muñoz, Sandro Huenchuguala, Irmgard Paris, Carlos Cuevas, Monica Villa, Pablo Caviedes, Juan Segura-Aguilar, Yousef Tizab. Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson's disease. Neurotoxicity research. vol 22. issue 2. 2012-10-10. PMID:22528249. |
parkinson's disease is a debilitating progressive neurodegenerative disorder that results from the loss of or damage to dopaminergic cells containing neuromelanin in the substantia nigra (sn). |
2012-10-10 |
2023-08-12 |
Not clear |
| Dimitra Giannakopoulou, Véronique Daguin-Nerrière, Adamantia Mitsacos, Elias D Kouvelas, Isabelle Neveu, Panagiotis Giompres, Philippe Brache. Ectopic expression of TrKA in the adult rat basal ganglia induces both nerve growth factor-dependent and -independent neuronal responses. Journal of neuroscience research. vol 90. issue 8. 2012-10-05. PMID:22419059. |
to address this question, adeno-associated virus (aav) vectors were used to express trka in the substantia nigra (sn) and striatum of adult rats. |
2012-10-05 |
2023-08-12 |
rat |
| Zuoli Sun, Jun Jia, Xiaoli Gong, Yanjun Jia, Jiahui Deng, Xuan Wang, Xiaomin Wan. Inhibition of glutamate and acetylcholine release in behavioral improvement induced by electroacupuncture in parkinsonian rats. Neuroscience letters. vol 520. issue 1. 2012-10-04. PMID:22583765. |
high-frequency ea stimulation at dazhui (gv14) and baihui (gv20) acupoints decreased rotational behavior induced by apomorphine (apo) and improved motor coordination, protected axotomized dopaminergic neurons from degeneration in the substantia nigra (sn), it did not increase striatal dopamine (da) levels. |
2012-10-04 |
2023-08-12 |
rat |
| Hong Yuan, Li-Wu Liang, Zheng-Jing Chen, Hui-Ru Ji, Mei-Kang Wang, Hai-Ying Zhang, Cao Li, Jian-Yang X. R-apomorphine protects against 6-hydroxydopamine-induced nigrostriatal damage in rat. Neuroscience bulletin. vol 22. issue 6. 2012-10-02. PMID:17690718. |
objective the aim of the present study was not only to assess the retrograde degenerative changes in the dopaminergic neurons of the substantia nigra (sn) and ventral tegmental area (vta) after injection of 6-hydroxydopamine (6-ohda) into the striatum, but also to use this 6-ohda model of parkinson's disease to explore the possible neuroprotective effect of r-apomorphine (r-apo). |
2012-10-02 |
2023-08-12 |
rat |
| M Takahashi, T Yamada, K Nakanishi, K Fujita, K Nakajima, E Nobusawa, T Yamamoto, T Kato, H Okad. Influenza a virus infection of primary cultured cells from rat fetal brain. Parkinsonism & related disorders. vol 3. issue 2. 2012-10-02. PMID:18591062. |
we previously reported that the neurovirulent influenza a virus strain, aiwsn/33 has strong affinity for the substantia nigra (sn) in mouse brain. |
2012-10-02 |
2023-08-12 |
mouse |
| J M Deniau, C Hammond-Le Guyader, J Feger, J S McKenzi. Bilateral projection of nigro-collicular neurons: An electrophysiological analysis in the rat. Neuroscience letters. vol 5. issue 1-2. 2012-10-02. PMID:19604969. |
effective stimulations were located in ipsi- or contralateral sc deep layers lying above the central gray (cg) or more laterally; nigro-collicular neurons are exclusively located in the pars reticulata of the substantia nigra (sn) and some of them project both to ipsi- and contralateral sc. |
2012-10-02 |
2023-08-12 |
rat |
| D Weissmann, E Mach, C Oberlander, Y Demassey, J F Pujo. Evidence for hyperdensity of 5HT1B binding sites in the substantia nigra of the rat after 5,7-dihydroxytryptamine intraventricular injection. Neurochemistry international. vol 9. issue 1. 2012-10-02. PMID:20493117. |
high affinity serotonin (5ht) binding sites have been found highly concentrated in the substantia nigra (sn) of the rat brain in each classical anatomical subdivisions of this structure, sn reticulata (snr), sn lateralis (snl), sn compacta (snc). |
2012-10-02 |
2023-08-12 |
rat |
| T F Oo, R E Burk. Animal models of induced apoptotic death in the substantia nigra. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318770. |
the purpose of the models we have developed of induced apoptosis in dopamine neurons of the substantia nigra (sn) is to try to translate what is being learned about the molecular mechanisms of apoptosis in simpler systems to these neurons. |
2012-10-02 |
2023-08-12 |
human |
| T F Oo, R E Burk. Apoptotic morphology in phenotypically defined dopaminergic neurons of the substantia nigra. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318771. |
in the preceding chapter we described three paradigms by which we have studied programmed cell death in the substantia nigra (sn) of living animals: natural cell death and death induced either by developmental injury to the target striatum or by dopamine terminal destruction with the neurotoxin 6-hydroxydopamine (6-ohda). |
2012-10-02 |
2023-08-12 |
Not clear |
| J L Mendoza-Ramírez, R Aguilar-Roblero, A Zainos-Rosales, R Drucker-Colí. Fetal substantia nigra and adrenal medullary grafts placed contralateral to the nigrostriatal lesion side induce a decrease in turning behavior but not in dopamine receptor density. Restorative neurology and neuroscience. vol 3. issue 4. 2012-10-02. PMID:21551635. |
motor asymmetries as well as changes in the density of postsynaptic dopamine receptors produced by unilateral denervation of the striatum have been reduced by both substantia nigra (sn) and adrenal medullary (am) grafts. |
2012-10-02 |
2023-08-12 |
rat |
| W F Silverman, Y Solberg, Y Pollac. Metabolic profile of fetal dopamine neurons transplanted to the adult rat striatum. Restorative neurology and neuroscience. vol 9. issue 2. 2012-10-02. PMID:21551837. |
in the present study, we have examined the expression and distribution of the metabolic marker neuron-specific enolase (nse) in solid-tissue transplants of fetal substantia nigra (sn) to the striatum of intact and 6-hydroxydopamine lesioned mature rats. |
2012-10-02 |
2023-08-12 |
rat |
| W J Free. Substantia nigra grafts and Parkinson's disease: from animal experiments to human therapeutic trials. Restorative neurology and neuroscience. vol 3. issue 3. 2012-10-02. PMID:21551873. |
during the decade since the first reports of functional effects of substantia nigra (sn) transplantation in animal models of parkinson's disease, the procedure has progressed to human clinical trials. |
2012-10-02 |
2023-08-12 |
human |
| b' Rigoberto Salado-Castillo, Manuel S\\xc3\\xa1nchez-Alav\\xc3\\xa9z, Gina L Quirarte, Mar\\xc3\\xada Isabel Mart\\xc3\\xadnez Garc\\xc3\\xada, Roberto A Prado-Alcal\\xc3\\xa. Enhanced training protects memory against amnesia produced by concurrent inactivation of amygdala and striatum, amygdala and substantia nigra, or striatum and substantia nigra. Frontiers in behavioral neuroscience. vol 5. 2012-10-02. PMID:22203796.' |
we now report on the effects of enhanced training on retention after temporary inactivation of cerebral nuclei known to be involved in memory, namely the substantia nigra (sn), striatum (str), and amygdala (amy). |
2012-10-02 |
2023-08-12 |
Not clear |
| Vilma C Muñetón-Gómez, Ernesto Doncel-Pérez, Ana P Fernandez, Julia Serrano, Andrea Pozo-Rodrigálvarez, Lara Vellosillo-Huerta, Julian S Taylor, Gloria P Cardona-Gómez, Manuel Nieto-Sampedro, Ricardo Martínez-Murill. Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations. Frontiers in cellular neuroscience. vol 6. 2012-10-02. PMID:22876219. |
in this study we assess ischemic damage of the nigrostriatal pathway in a model of lacunar stroke evoked by damaging the perforating arteries in the territory of the substantia nigra (sn) of the rat after stereotaxic administration of endothelin-1 (et-1), a potent vasoconstrictor peptide. |
2012-10-02 |
2023-08-12 |
human |
| Henriqueta D Cardoso, Priscila P Passos, Claudia J Lagranha, Anete C Ferraz, Eraldo F Santos Júnior, Rafael S Oliveira, Pablo E L Oliveira, Rita de C F Santos, David F Santana, Juliana M C Borba, Ana P Rocha-de-Melo, Rubem C A Guedes, Daniela M A F Navarro, Geanne K N Santos, Roseane Borner, Cristovam W Picanço-Diniz, Eduardo I Beltrão, Janilson F Silva, Marcelo C A Rodrigues, Belmira L S Andrade da Cost. Differential vulnerability of substantia nigra and corpus striatum to oxidative insult induced by reduced dietary levels of essential fatty acids. Frontiers in human neuroscience. vol 6. 2012-10-02. PMID:22969716. |
in our previous study on rat brains, we observed that a two-generation efa dietary restriction reduced the number and size of dopaminergic neurons in the substantia nigra (sn) rostro-dorso-medial. |
2012-10-02 |
2023-08-12 |
rat |
| Christina E Khodr, Jyothi Pedapati, Ye Han, Martha C Boh. Inclusion of a portion of the native SNCA 3'UTR reduces toxicity of human S129A SNCA on striatal-projecting dopamine neurons in rat substantia nigra. Developmental neurobiology. vol 72. issue 6. 2012-09-28. PMID:22021082. |
adult, male rats were injected into one substantia nigra (sn) with aav-wtsnca, aav-s129a hsnca, or aav-s129d hsnca either with or without a portion of the native 3'utr. |
2012-09-28 |
2023-08-12 |
human |
| George Stoica, Gina Lungu, Nicole L Bjorklund, Giulio Taglialatela, Xing Zhang, Veronica Chiu, Herbert H Hill, James O Schenk, Ian Murra. Potential role of α-synuclein in neurodegeneration: studies in a rat animal model. Journal of neurochemistry. vol 122. issue 4. 2012-09-27. PMID:22639889. |
the neurodegeneration in this model is characterized by the presence of perikarya and neurites lewis bodies (lb) and diffuse marked accumulation of perikaryal α-syn in the substantia nigra (sn), brain stem (bs), and striatum (st) along with neuronal loss. |
2012-09-27 |
2023-08-12 |
human |
| Kimberly N Huggins, Tiffany A Mathews, Jason L Locke, Kendall T Szeliga, David P Friedman, Allyson J Bennett, Sara R Jone. Effects of early life stress on drinking and serotonin system activity in rhesus macaques: 5-hydroxyindoleacetic acid in cerebrospinal fluid predicts brain tissue levels. Alcohol (Fayetteville, N.Y.). vol 46. issue 4. 2012-09-25. PMID:22445804. |
brain samples were taken from the dorsal caudate, putamen, substantia nigra (sn) pars reticulata, sn pars compacta and hippocampus. |
2012-09-25 |
2023-08-12 |
monkey |