| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomoko Nakamoto, Kanji Matsukawa, Nan Liang, Rie Wakasugi, L Britt Wilson, Jouji Horiuch. Coactivation of renal sympathetic neurons and somatic motor neurons by chemical stimulation of the midbrain ventral tegmental area. Journal of applied physiology (Bethesda, Md. : 1985). vol 110. issue 5. 2011-09-30. PMID:21393462. |
small volumes (60 nl) of an n-methyl-d-aspartate receptor agonist (l-homocysteic acid) and a gabaergic receptor antagonist (bicuculline) were injected into the vta and substantia nigra (sn). |
2011-09-30 |
2023-08-12 |
rat |
| Alix B W Norton, Yong Sang Jo, Emily W Clark, Cortney A Taylor, Sheri J Y Mizumor. Independent neural coding of reward and movement by pedunculopontine tegmental nucleus neurons in freely navigating rats. The European journal of neuroscience. vol 33. issue 10. 2011-09-26. PMID:21395868. |
phasic firing of dopamine (da) neurons in the ventral tegmental area (vta) and substantia nigra (sn) is likely to be crucial for reward processing that guides learning. |
2011-09-26 |
2023-08-12 |
rat |
| Anthony P Nichola. Dual immunofluorescence study of citrullinated proteins in Parkinson diseased substantia nigra. Neuroscience letters. vol 495. issue 1. 2011-09-13. PMID:21414385. |
using dual-color immunofluorescence and an established monoclonal antibody (f95) against peptidyl-citrulline moieties, the present study is the first to compare immunohistochemical staining patterns for deiminated proteins in human substantia nigra (sn) from patients with parkinson disease (pd) versus similar control specimens supplied by the harvard brain bank. |
2011-09-13 |
2023-08-12 |
human |
| Candan Depboylu, Kathrin Schorlemmer, Martin Klietz, Wolfgang H Oertel, Eberhard Weihe, Günter U Höglinger, Martin K-H Schäfe. Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease. Journal of neuroimmunology. vol 236. issue 1-2. 2011-09-13. PMID:21640391. |
constitutive expression of c1q was restricted to microglia throughout the brain, and microglial c1q expression was early and transiently upregulated after mptp in the substantia nigra (sn) and striatum, as analyzed by immunohistochemistry and in situ hybridization. |
2011-09-13 |
2023-08-12 |
mouse |
| Mei Han, Xu-Feng Huang, Chao Den. Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: implications for long-term drug efficacy and low extrapyramidal side-effects. The international journal of neuropsychopharmacology. vol 12. issue 7. 2011-09-06. PMID:19203411. |
aripiprazole significantly increased d2 receptor mrna expression and decreased tyrosine hydroxylase (th) mrna expression in the ventral tegmental area (vta) after 1- and 12-wk treatment, but had no effect in substantia nigra (sn) and nucleus accumbens (nac). |
2011-09-06 |
2023-08-12 |
Not clear |
| GuoQi Zhu, Ying Chen, YuYing Huang, QingLin Li, Thomas Behnisc. MPTP-meditated hippocampal dopamine deprivation modulates synaptic transmission and activity-dependent synaptic plasticity. Toxicology and applied pharmacology. vol 254. issue 3. 2011-09-06. PMID:21605582. |
mptp injection reduces the number of tyrosine hydroxylase (th)-positive neurons in the substantia nigra (sn) within 7days. |
2011-09-06 |
2023-08-12 |
Not clear |
| Evangelos Sotiriou, Demetrios K Vassilatis, Miquel Vila, Leonidas Stefani. Selective noradrenergic vulnerability in α-synuclein transgenic mice. Neurobiology of aging. vol 31. issue 12. 2011-08-29. PMID:19152986. |
classical pathological signs of parkinson's disease (pd) include loss of dopaminergic neurons in substantia nigra (sn) and noradrenergic neurons in locus coeruleus (lc), and deposition of lewy bodies rich in the presynaptic protein alpha-synuclein (asyn). |
2011-08-29 |
2023-08-12 |
mouse |
| A Van der Perren, J Toelen, M Carlon, C Van den Haute, F Coun, B Heeman, V Reumers, L H Vandenberghe, J M Wilson, Z Debyser, V Baekeland. Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9. Gene therapy. vol 18. issue 5. 2011-08-22. PMID:21326331. |
in light of the further development of a viral vector-mediated rat model for pd, we performed a comprehensive comparison of the transduction and tropism for dopaminergic neurons (dns) in the adult wistar rat substantia nigra (sn) of seven raav vector serotypes (raav 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9). |
2011-08-22 |
2023-08-12 |
rat |
| Ann-Charlotte Granholm, Vandana Zaman, Jennifer Godbee, Michael Smith, Riad Ramadan, Claudia Umphlet, Patrick Randall, Narayan R Bhat, Baerbel Rohrer, Lawrence D Middaugh, Heather A Boge. Prenatal LPS increases inflammation in the substantia nigra of Gdnf heterozygous mice. Brain pathology (Zurich, Switzerland). vol 21. issue 3. 2011-08-18. PMID:20969653. |
there was a progressive degeneration of tyrosine hydroxylase (th)-positive neurons in the substantia nigra (sn) with age in gdnf(+/-) but not in wt mice, with no observed effects on locus coeruleus (lc) noradrenergic neurons or da neurons of the ventral tegmental area. |
2011-08-18 |
2023-08-12 |
mouse |
| Jun Hu, Chenlei Zhu, Yuan Liu, Fang Wang, Zuhu Huang, Weimin Fan, Jie W. Dynamic alterations of gene expression of nicotinic acetylcholine receptor α7, α4 and β2 subunits in an acute MPTP-lesioned mouse model. Neuroscience letters. vol 494. issue 3. 2011-08-17. PMID:21406211. |
(1) mptp treatment transiently increased nachr α7 (after last injection of mptp 3 and 24 h), α4 and β2 (24 h) mrna expression in the substantia nigra (sn) and striatum. |
2011-08-17 |
2023-08-12 |
mouse |
| Zhanyun Lv, Hong Jiang, Huamin Xu, Ning Song, Junxia Xi. Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 3. 2011-08-16. PMID:20556443. |
the staging of lewy-related pathology in sporadic parkinson's disease (pd) reveals that many brain nuclei are affected in pd during different stages, except the ventral tegmental area (vta), which is close related to the substantia nigra (sn) and enriched in dopamine (da) neurons. |
2011-08-16 |
2023-08-12 |
mouse |
| Daniela Ber. Hyperechogenicity of the substantia nigra: pitfalls in assessment and specificity for Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 3. 2011-08-16. PMID:20830493. |
during the last decade, substantia nigra (sn) hyperechogenicity has been established as a valuable supplementary diagnostic marker for parkinson's disease. |
2011-08-16 |
2023-08-12 |
human |
| Zang-Hee Cho, Se-Hong Oh, Jong-Min Kim, Sung-Yeon Park, Dae-Hyuk Kwon, Hye-Jin Jeong, Young-Bo Kim, Je-Geun Chi, Chan-Woong Park, John Huston, Kendall H Lee, Beom S Jeo. Direct visualization of Parkinson's disease by in vivo human brain imaging using 7.0T magnetic resonance imaging. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 4. 2011-08-15. PMID:21506148. |
parkinson's disease (pd) is a neurodegenerative disorder resulting from progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2011-08-15 |
2023-08-12 |
human |
| Agnieszka Chocyk, Dorota Dudys, Aleksandra Przyborowska, Marzena Maćkowiak, Krzysztof Wędzon. Impact of maternal separation on neural cell adhesion molecules expression in dopaminergic brain regions of juvenile, adolescent and adult rats. Pharmacological reports : PR. vol 62. issue 6. 2011-08-10. PMID:21273681. |
in juvenile rats, ms decreased the levels of ncam-140 in the substantia nigra (sn) of females and ncam-180 in the ventral tegmental area of males. |
2011-08-10 |
2023-08-12 |
rat |
| Xi-Jin Wang, Shi Zhang, Zhi-Qiang Yan, Yan-Xin Zhao, Hai-Yan Zhou, Ying Wang, Guo-Qiang Lu, Jing-Dong Zhan. Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK. Free radical biology & medicine. vol 50. issue 9. 2011-08-08. PMID:21295135. |
parkinson disease (pd) neurodegeneration may be associated with impairment of cd200-cd200r-mediated microglia silencing in the substantia nigra (sn). |
2011-08-08 |
2023-08-12 |
rat |
| Meenakshi Tiwari, Brian Herman, William W Morga. A knockout of the caspase 2 gene produces increased resistance of the nigrostriatal dopaminergic pathway to MPTP-induced toxicity. Experimental neurology. vol 229. issue 2. 2011-08-05. PMID:21419766. |
subsequently, wt and nl mice were treated daily with 20 mg/kg mptp for 3 days and 25 mg/kg mptp for 2 additional days, and th+ neurons in the substantia nigra (sn) were estimated using unbiased stereology. |
2011-08-05 |
2023-08-12 |
mouse |
| Yuangang Zhu, Chunli Duan, Li Lü, Hua Gao, Chunli Zhao, Shun Yu, Kenji Uéda, Piu Chan, Hui Yan. α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator. The international journal of biochemistry & cell biology. vol 43. issue 5. 2011-08-01. PMID:21310263. |
in rats overexpressing α-syn in the substantia nigra (sn) through adeno-associated virus (aav) transduction, about 50% of tyrosine hydroxylase positive neurons were lost after 24 weeks. |
2011-08-01 |
2023-08-12 |
rat |
| Sun Shan, Tang Hong-Min, Feng Yi, Gao Jun-Peng, Fan Yue, Tang Yan-Hong, Yang Yun-Ke, Li Wen-Wei, Wang Xiang-Yu, Ma Jun, Wang Guo-Hua, Huang Ya-Ling, Li Hua-Wei, Cai Ding-Fan. New evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease. Neurobiology of aging. vol 32. issue 3. 2011-07-19. PMID:19368990. |
in our study, we injected 1-methyl-4-phenylpyridinium (mpp(+)) into unilateral substantia nigra (sn) which induced ipsilateral endogenous fractalkine expression on neuron and observe the increase of cx3cr1 expression in response to mpp(+) by western blotting analysis. |
2011-07-19 |
2023-08-12 |
rat |
| Johann Hagenah, Inke R König, Charlotte Kötter, Günter Seidel, Christine Klein, Norbert Brüggeman. Basal ganglia hyperechogenicity does not distinguish between patients with primary dystonia and healthy individuals. Journal of neurology. vol 258. issue 4. 2011-07-19. PMID:21042808. |
the basal ganglia including the substantia nigra (sn) and the ventricular system were investigated by tcs in 84 primary dystonia patients and 43 neurologically healthy controls. |
2011-07-19 |
2023-08-12 |
Not clear |
| E Kirche. Do mtDNA Mutations Participate in the Pathogenesis of Sporadic Parkinson's Disease? Current genomics. vol 10. issue 8. 2011-07-14. PMID:20514220. |
mitochondrial complex-i defects are known to occur in the substantia nigra (sn) of pd patients and are also debated in some extracerebral tissues. |
2011-07-14 |
2023-08-12 |
Not clear |