| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyun-Jung Park, Giyoon Bang, Bo Ra Lee, Hyun Ok Kim, Phil Hyu Le. Neuroprotective effect of human mesenchymal stem cells in an animal model of double toxin-induced multiple system atrophy parkinsonism. Cell transplantation. vol 20. issue 6. 2011-12-09. PMID:21054946. |
in the substantia nigra (sn) and the striatum, 2.0% and 3.8% of total injected hmscs were observed, respectively. |
2011-12-09 |
2023-08-12 |
mouse |
| Raymond T Bartus, Lamar Brown, Alistair Wilson, Brian Kruegel, Joao Siffert, Eugene M Johnson, Jeffrey H Kordower, Christopher D Herzo. Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: support for nigral targeting in Parkinson's disease. Neurobiology of disease. vol 44. issue 1. 2011-12-01. PMID:21704161. |
prior to implementing this novel dosing paradigm in humans, we conducted eight nonclinical experiments with three general objectives: (1) evaluate the feasibility, safety and effectiveness of targeting the substantia nigra (sn) with aav2-nrtn, (2) better understand and appraise recent warnings of serious weight loss that might occur with targeting the sn with neurotrophic factors, and (3) define an appropriate dose of aav2-nrtn that should safely and effectively cover the sn in pd patients. |
2011-12-01 |
2023-08-12 |
human |
| Ozlem Ozsoy, Gamze Tanriover, Narin Derin, Nimet Uysal, Necdet Demir, Burcu Gemici, Ceren Kencebay, Piraye Yargicoglu, Aysel Agar, Mutay Asla. The effect of docosahexaenoic Acid on visual evoked potentials in a mouse model of Parkinson's disease: the role of cyclooxygenase-2 and nuclear factor kappa-B. Neurotoxicity research. vol 20. issue 3. 2011-11-29. PMID:21234736. |
cyclooxygenase-2 (cox-2), caspase-3 activities, nuclear factor kappa-b (nf-κb) and prostaglandin e2 (pge2) levels were determined in substantia nigra (sn) and retina. |
2011-11-29 |
2023-08-12 |
mouse |
| David W Anderson, Rebecca C Schray, Gregg Duester, Jay S Schneide. Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system. Brain research. vol 1408. 2011-11-29. PMID:21784415. |
recent reports of reduced levels of expression of both aldh1a1 mrna and protein in the substantia nigra (sn) of parkinson's disease patients suggest possible involvement of aldh1a1 in this progressive neurodegenerative disease. |
2011-11-29 |
2023-08-12 |
mouse |
| Sandra Blaess, Gabriela O Bodea, Anna Kabanova, Soline Chanet, Emilie Mugniery, Amin Derouiche, Daniel Stephen, Alexandra L Joyne. Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei. Neural development. vol 6. 2011-11-15. PMID:21689430. |
the ventral midbrain contains a diverse array of neurons, including dopaminergic neurons of the ventral tegmental area (vta) and substantia nigra (sn) and neurons of the red nucleus (rn). |
2011-11-15 |
2023-08-12 |
Not clear |
| Seyed-Ahmad Ahmadi, Maximilian Baust, Athanasios Karamalis, Annika Plate, Kai Boetzel, Tassilo Klein, Nassir Nava. Midbrain segmentation in transcranial 3D ultrasound for Parkinson diagnosis. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 14. issue Pt 3. 2011-11-15. PMID:22003720. |
the method requires spatial analysis of ultrasound hyperechogenicities produced by pathological changes within the substantia nigra (sn), which belongs to the basal ganglia within the midbrain. |
2011-11-15 |
2023-08-12 |
human |
| Lea Tenenholz Grinberg, Udo Rueb, Helmut Heinse. Brainstem: neglected locus in neurodegenerative diseases. Frontiers in neurology. vol 2. 2011-11-10. PMID:21808630. |
this was also true for pd, although the pathological hallmark of pd is degeneration of pigmented neurons of the brainstem's substantia nigra (sn). |
2011-11-10 |
2023-08-12 |
Not clear |
| Wei Zhang, Kester Phillips, Albert R Wielgus, Jie Liu, Alberto Albertini, Fabio A Zucca, Rudolph Faust, Steven Y Qian, David S Miller, Colin F Chignell, Belinda Wilson, Vernice Jackson-Lewis, Serge Przedborski, Danielle Joset, John Loike, Jau-Shyong Hong, David Sulzer, Luigi Zecc. Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotoxicity research. vol 19. issue 1. 2011-11-08. PMID:19957214. |
in parkinson's disease (pd), there is a progressive loss of neuromelanin (nm)-containing dopamine neurons in substantia nigra (sn) which is associated with microgliosis and presence of extracellular nm. |
2011-11-08 |
2023-08-12 |
mouse |
| Agnieszka Ciesielska, Gabriele Mittermeyer, Piotr Hadaczek, Adrian P Kells, John Forsayeth, Krystof S Bankiewic. Anterograde axonal transport of AAV2-GDNF in rat basal ganglia. Molecular therapy : the journal of the American Society of Gene Therapy. vol 19. issue 5. 2011-11-02. PMID:21102559. |
vector infused into striatum (st) was transported to substantia nigra (sn), both pars compacta (snc), and pars reticulata (snr). |
2011-11-02 |
2023-08-12 |
rat |
| Jeswinder Sian-Hülsmann, Silvia Mandel, Moussa B H Youdim, Peter Riedere. The relevance of iron in the pathogenesis of Parkinson's disease. Journal of neurochemistry. vol 118. issue 6. 2011-11-01. PMID:21138437. |
however, intensive investigations have provided a host of putative mechanisms that might contribute to the pathogenesis underlying the characteristic degeneration of the dopaminergic neurons in the substantia nigra (sn). |
2011-11-01 |
2023-08-12 |
Not clear |
| Stephanie C Gantz, Christopher P Ford, Kim A Neve, John T William. Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 35. 2011-10-21. PMID:21880923. |
this study examined age-dependent changes in dopamine neurons of the substantia nigra (sn) from wild-type, presymptomatic, and symptomatic mecp2(+/-) mice. |
2011-10-21 |
2023-08-12 |
mouse |
| Taco R Werkman, Andrew C McCreary, Chris G Kruse, Wytse J Wadma. NK3 receptors mediate an increase in firing rate of midbrain dopamine neurons of the rat and the guinea pig. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21218451. |
in vitro midbrain slice preparations of both species were used to record (extracellularly) the firing rates of dopamine neurons located in the substantia nigra (sn) and ventral tegmental area (vta). |
2011-10-18 |
2023-08-12 |
rat |
| K B Reynolds, L MacGillivray, M Zettler, P I Rosebush, M F Mazure. Role of the dopamine transporter in mediating the neuroleptic-induced reduction of tyrosine hydroxylase-immunoreactive midbrain neurons. Brain research. vol 1394. 2011-10-11. PMID:21396352. |
sections of the substantia nigra (sn) and ventral tegmental area (vta) were processed for tyrosine hydroxylase (th) immunoreactivity. |
2011-10-11 |
2023-08-12 |
rat |
| Fang Zheng, Katja Lammert, Barbara E Nixdorf-Bergweiler, Frank Steigerwald, Jens Volkmann, Christian Alzheime. Axonal failure during high frequency stimulation of rat subthalamic nucleus. The Journal of physiology. vol 589. issue Pt 11. 2011-10-06. PMID:21486784. |
in rat brain slices preserving stn projections to substantia nigra (sn) and entopeduncular nucleus (ep, the rodent equivalent of internal globus pallidus), stn-dbs disrupted synaptic excitation onto target neurons through an unexpected failure of axonal signalling. |
2011-10-06 |
2023-08-12 |
rat |
| Tomoko Nakamoto, Kanji Matsukawa, Nan Liang, Rie Wakasugi, L Britt Wilson, Jouji Horiuch. Coactivation of renal sympathetic neurons and somatic motor neurons by chemical stimulation of the midbrain ventral tegmental area. Journal of applied physiology (Bethesda, Md. : 1985). vol 110. issue 5. 2011-09-30. PMID:21393462. |
small volumes (60 nl) of an n-methyl-d-aspartate receptor agonist (l-homocysteic acid) and a gabaergic receptor antagonist (bicuculline) were injected into the vta and substantia nigra (sn). |
2011-09-30 |
2023-08-12 |
rat |
| Alix B W Norton, Yong Sang Jo, Emily W Clark, Cortney A Taylor, Sheri J Y Mizumor. Independent neural coding of reward and movement by pedunculopontine tegmental nucleus neurons in freely navigating rats. The European journal of neuroscience. vol 33. issue 10. 2011-09-26. PMID:21395868. |
phasic firing of dopamine (da) neurons in the ventral tegmental area (vta) and substantia nigra (sn) is likely to be crucial for reward processing that guides learning. |
2011-09-26 |
2023-08-12 |
rat |
| Anthony P Nichola. Dual immunofluorescence study of citrullinated proteins in Parkinson diseased substantia nigra. Neuroscience letters. vol 495. issue 1. 2011-09-13. PMID:21414385. |
using dual-color immunofluorescence and an established monoclonal antibody (f95) against peptidyl-citrulline moieties, the present study is the first to compare immunohistochemical staining patterns for deiminated proteins in human substantia nigra (sn) from patients with parkinson disease (pd) versus similar control specimens supplied by the harvard brain bank. |
2011-09-13 |
2023-08-12 |
human |
| Candan Depboylu, Kathrin Schorlemmer, Martin Klietz, Wolfgang H Oertel, Eberhard Weihe, Günter U Höglinger, Martin K-H Schäfe. Upregulation of microglial C1q expression has no effects on nigrostriatal dopaminergic injury in the MPTP mouse model of Parkinson disease. Journal of neuroimmunology. vol 236. issue 1-2. 2011-09-13. PMID:21640391. |
constitutive expression of c1q was restricted to microglia throughout the brain, and microglial c1q expression was early and transiently upregulated after mptp in the substantia nigra (sn) and striatum, as analyzed by immunohistochemistry and in situ hybridization. |
2011-09-13 |
2023-08-12 |
mouse |
| Mei Han, Xu-Feng Huang, Chao Den. Aripiprazole differentially affects mesolimbic and nigrostriatal dopaminergic transmission: implications for long-term drug efficacy and low extrapyramidal side-effects. The international journal of neuropsychopharmacology. vol 12. issue 7. 2011-09-06. PMID:19203411. |
aripiprazole significantly increased d2 receptor mrna expression and decreased tyrosine hydroxylase (th) mrna expression in the ventral tegmental area (vta) after 1- and 12-wk treatment, but had no effect in substantia nigra (sn) and nucleus accumbens (nac). |
2011-09-06 |
2023-08-12 |
Not clear |
| GuoQi Zhu, Ying Chen, YuYing Huang, QingLin Li, Thomas Behnisc. MPTP-meditated hippocampal dopamine deprivation modulates synaptic transmission and activity-dependent synaptic plasticity. Toxicology and applied pharmacology. vol 254. issue 3. 2011-09-06. PMID:21605582. |
mptp injection reduces the number of tyrosine hydroxylase (th)-positive neurons in the substantia nigra (sn) within 7days. |
2011-09-06 |
2023-08-12 |
Not clear |