| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carsten N Boehler, Jens-Max Hopf, Ruth M Krebs, Christian M Stoppel, Mircea A Schoenfeld, Hans-Jochen Heinze, Toemme Noessel. Task-load-dependent activation of dopaminergic midbrain areas in the absence of reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 13. 2011-05-30. PMID:21451034. |
using a visual discrimination task in which varying levels of task demands were precued, we found enhanced hemodynamic activity in the substantia nigra (sn) for high task demands in the absence of reward or similar extrinsic motivating factors. |
2011-05-30 |
2023-08-12 |
human |
| Matthis Synofzik, Jana Godau, Tobias Lindig, Ludger Schöls, Daniela Ber. Restless legs and substantia nigra hypoechogenicity are common features in Friedreich's ataxia. Cerebellum (London, England). vol 10. issue 1. 2011-05-27. PMID:20865356. |
in this work, we assessed the following: (1) the prevalence of rls; (2) the prevalence of sonographic hypoechogenicity of the substantia nigra (sn), which is known to be associated with idiopathic rls; and (3) the relation between both in 28 fa patients. |
2011-05-27 |
2023-08-12 |
Not clear |
| Adarsh M Kumar, Raymond L Ownby, Drenna Waldrop-Valverde, Benny Fernandez, Mahendra Kuma. Human immunodeficiency virus infection in the CNS and decreased dopamine availability: relationship with neuropsychological performance. Journal of neurovirology. vol 17. issue 1. 2011-05-12. PMID:21165787. |
we found that although da concentrations were 2-53% lower in the brain regions of hiv-1-infected, haart-treated individuals, compared with hiv-negative controls, a 45% decrease in da levels in the substantia nigra (sn) of hiv-1-infected individuals was significantly correlated with the low level of performance (t scores) in the speed of information processing, learning, memory, verbal fluency, and average t scores across domains. |
2011-05-12 |
2023-08-12 |
human |
| Dae-Hee Lee, Cuk-Seong Kim, Yong J Le. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 1. 2011-05-05. PMID:21056612. |
we have investigated the role of ast in preventing 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced apoptosis of the substantia nigra (sn) neurons in the mouse model of parkinson's disease (pd) and 1-methyl-4-phenylpyridinium (mpp+)-induced cytotoxicity of sh-sy5y human neuroblastoma cells. |
2011-05-05 |
2023-08-12 |
mouse |
| Pamela J McMillan, Sylvia S White, Allyn Franklin, J Lynne Greenup, James B Leverenz, Murray A Raskind, Patricia Szo. Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease. Brain research. vol 1373. 2011-05-03. PMID:21147074. |
in parkinson's disease (pd), there is a significant loss of noradrenergic neurons in the locus coeruleus (lc) in addition to the loss of dopaminergic neurons in the substantia nigra (sn). |
2011-05-03 |
2023-08-12 |
human |
| A Chocyk, D Dudys, A Przyborowska, I Majcher, M Maćkowiak, K Wędzon. Maternal separation affects the number, proliferation and apoptosis of glia cells in the substantia nigra and ventral tegmental area of juvenile rats. Neuroscience. vol 173. 2011-04-20. PMID:21108994. |
in the present study, we tested whether early life stress, that is, maternal separation (ms), affects cell number, cell proliferation and constitutive apoptotic processes in the substantia nigra (sn) and the ventral tegmental area (vta) of juvenile male and female rats. |
2011-04-20 |
2023-08-12 |
rat |
| Kee Won Kim, Hyun Woo Kim, Jing Li, Young Bae Kwo. Effect of bee venom acupuncture on methamphetamine-induced hyperactivity, hyperthermia and Fos expression in mice. Brain research bulletin. vol 84. issue 1. 2011-04-11. PMID:20950675. |
meth injection significantly increased fos expression in several brain regions including nucleus accumbens (na), caudate putamen (cpu), ventral tegmental area (vta), substantia nigra (sn) and locus coeruleus (lc). |
2011-04-11 |
2023-08-12 |
mouse |
| Dario Domenico Lofrumento, Concetta Saponaro, Antonia Cianciulli, Francesco De Nuccio, Vincenzo Mitolo, Giuseppe Nicolardi, Maria Antonietta Panar. MPTP-induced neuroinflammation increases the expression of pro-inflammatory cytokines and their receptors in mouse brain. Neuroimmunomodulation. vol 18. issue 2. 2011-04-06. PMID:20938211. |
parkinson's disease (pd) is a common neurodegenerative disease characterised by a slow and progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2011-04-06 |
2023-08-12 |
mouse |
| Xinxin Yang, Baohua Chen. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. Journal of molecular neuroscience : MN. vol 42. issue 2. 2011-04-04. PMID:20333481. |
the main clinical symptom of pd is motor dysfunction derived from the loss of dopaminergic neurons in the substantia nigra (sn) and dopamine content in the striatum subsequently. |
2011-04-04 |
2023-08-12 |
mouse |
| Reza Habib, Mark R Dixo. Neurobehavioral evidence for the "Near-Miss" effect in pathological gamblers. Journal of the experimental analysis of behavior. vol 93. issue 3. 2011-03-30. PMID:21119848. |
no behavioral differences were observed between groups of participants, however, differences in brain activity were found in the left midbrain, near the substantia nigra and ventral tegmental area (sn / vta). |
2011-03-30 |
2023-08-12 |
human |
| Yoshinori Kajimoto, Hideto Miwa, Tomoyoshi Kond. Transcranial sonography in relation to SPECT and MIBG. International review of neurobiology. vol 90. 2011-03-25. PMID:20692493. |
in addition, substantia nigra (sn) hyperechogenicity, detected with transcranial sonography (tcs), might provide a marker of susceptibility to pd. |
2011-03-25 |
2023-08-12 |
Not clear |
| Ludwig Niehaus, Kai Boelman. Diagnosis of Parkinson's disease--transcranial sonography in relation to MRI. International review of neurobiology. vol 90. 2011-03-25. PMID:20692494. |
in contrast to conventional magnetic resonance imaging (mri), tcs is able to detect highly characteristic changes in signal brightness of the substantia nigra (sn) in patients with idiopathic parkinson's disease. |
2011-03-25 |
2023-08-12 |
Not clear |
| Alexandra Gaenslen, Daniela Ber. Early diagnosis of Parkinson's disease. International review of neurobiology. vol 90. 2011-03-25. PMID:20692495. |
up to 90% of pd patients show hyperechogenicity of the substantia nigra (sn) on tcs. |
2011-03-25 |
2023-08-12 |
Not clear |
| Angela E P Bouwmans, Annemarie M M Vlaar, Karin Srulijes, Werner H Mess, W E J Webe. Transcranial sonography for the discrimination of idiopathic Parkinson's disease from the atypical parkinsonian syndromes. International review of neurobiology. vol 90. 2011-03-25. PMID:20692498. |
changes of specific structures on tcs like the substantia nigra (sn), lenticular nucleus (ln), and the third ventricle are discussed as well as how they can contribute to differentiate between ipd, multiple system atrophy (msa), progressive supranuclear palsy (psp), lewy body disease (lbd), and corticobasal degeneration (cbd). |
2011-03-25 |
2023-08-12 |
Not clear |
| Kathrin Brockmann, Johann Hagena. TCS in monogenic forms of Parkinson's disease. International review of neurobiology. vol 90. 2011-03-25. PMID:20692500. |
since hyperechogenicity of the substantia nigra (sn) represents a characteristic hallmark of sporadic pd questions arise concerning the echo pattern of monogenic forms of this disorder on tcs. |
2011-03-25 |
2023-08-12 |
Not clear |
| Heike Stockner, Isabel Wurste. Transcranial sonography in essential tremor. International review of neurobiology. vol 90. 2011-03-25. PMID:20692503. |
recent studies have consistently found hyperechogenic alterations in the area of the substantia nigra (sn) in patients with parkinson's disease (pd) using transcranial sonography (tcs). |
2011-03-25 |
2023-08-12 |
human |
| Christos Krogias, Thomas Postert, Jens Eydin. Transcranial sonography in ataxia. International review of neurobiology. vol 90. 2011-03-25. PMID:20692505. |
three tcs studies reported hyperechogenicity of substantia nigra (sn) as a frequent finding in spinocerebellar ataxia type 2, type 3, and type 17, indicating a vulnerability of the nigrostriatal system in sca patients. |
2011-03-25 |
2023-08-12 |
Not clear |
| Hey-Kyeong Jeong, Ilo Jou, Eun-hye Jo. Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra. Experimental & molecular medicine. vol 42. issue 12. 2011-03-23. PMID:20962566. |
interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mrna/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (sn), where dopaminergic neurons are located. |
2011-03-23 |
2023-08-12 |
rat |
| Emmanuelle Lagrue, Hiroyuki Abe, Madakasira Lavanya, Jawida Touhami, Sylvie Bodard, Sylvie Chalon, Jean-Luc Battini, Marc Sitbon, Pierre Castelna. Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport. Journal of biomedical science. vol 17. 2011-03-22. PMID:21129221. |
for this purpose, we monitored changes in the distribution of pit1, pit2 and glut1 in the cerebellum, the frontal cortex, the corpus callosum, the striatum and the substantia nigra (sn) of c57/bl6 mice after administration of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridinium (mptp), a mitochondrial complex i inhibitor which induces neuronal degeneration in the striato-nigral network.the pit1 ligand stained oligodendrocytes in the corpus callosum and showed a reticular pattern in the sn. |
2011-03-22 |
2023-08-12 |
mouse |
| D Berg, J Godau, P Riederer, M Gerlach, T Arzberge. Microglia activation is related to substantia nigra echogenicity. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 11. 2011-03-21. PMID:21057966. |
hyperechogenicity of the substantia nigra (sn) is a sensitive marker for parkinson's disease (pd). |
2011-03-21 |
2023-08-12 |
human |