| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shih-Ying Wu, Tzu-Feng Wang, Lung Yu, Chauying J Jen, Jih-Ing Chuang, Fong-Sen Wu, Chih-Wei Wu, Yu-Min Ku. Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain, behavior, and immunity. vol 25. issue 1. 2011-03-10. PMID:20851176. |
parkinson's disease (pd) is characterized by a progressive and selective loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2011-03-10 |
2023-08-12 |
Not clear |
| Michael E Talkowski, Kathleen L McCann, Michael Chen, Lora McClain, Mikhil Bamne, Joel Wood, Kodavali V Chowdari, Annie Watson, Konasale M Prasad, George Kirov, Lyudmilla Georgieva, Draga Toncheva, Hader Mansour, David A Lewis, Michael Owen, Michael O'Donovan, Panagiotis Papasaikas, Patrick Sullivan, Douglas Ruderfer, Jeffrey K Yao, Sherry Leonard, Pramod Thomas, Fabio Miyajima, John Quinn, A Javier Lopez, Vishwajit L Nimgaonka. Fine-mapping reveals novel alternative splicing of the dopamine transporter. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 8. 2011-03-07. PMID:20957647. |
we confirmed alternative splicing of e3b in post-mortem human substantia nigra (sn). |
2011-03-07 |
2023-08-12 |
human |
| S Gouty, J M Brown, J Rosenberger, B M Co. MPTP treatment increases expression of pre-pro-nociceptin/orphanin FQ mRNA in a subset of substantia nigra reticulata neurons. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20417255. |
mptp increased ppn/ofq mrna expression in the substantia nigra (sn). |
2011-03-04 |
2023-08-12 |
mouse |
| Rodrigo Somoza, Carlos Juri, Mauricio Baes, Ursula Wyneken, Francisco Javier Rubi. Intranigral transplantation of epigenetically induced BDNF-secreting human mesenchymal stem cells: implications for cell-based therapies in Parkinson's disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 16. issue 11. 2011-03-04. PMID:20542127. |
the aim of the present study was to characterize signals and/or molecules that regulate brain-derived neurotrophic factor (bdnf) protein expression/delivery in hmsc cultures and evaluate the effect of epigenetically generated bdnf-secreting hmsc on the intact and lesioned substantia nigra (sn). |
2011-03-04 |
2023-08-12 |
human |
| J Hagenah, G Seide. [Sonography of the parenchyma in Parkinson's disease]. Der Nervenarzt. vol 81. issue 10. 2011-03-01. PMID:20802993. |
up to 90% of patients with idiopathic parkinson's disease but only 10-15% of the healthy population show an abnormal echogenicity (hyperechogenicity) of the substantia nigra (sn). |
2011-03-01 |
2023-08-12 |
human |
| Gamze Tanriover, Yasemin Seval-Celik, Ozlem Ozsoy, Gokhan Akkoyunlu, Feyza Savcioglu, Gulay Hacioglu, Necdet Demir, Aysel Aga. The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease. Folia histochemica et cytobiologica. vol 48. issue 3. 2011-03-01. PMID:21071351. |
parkinson's disease (pd) is the second most common neurodegenerative disorder marked by cell death in the substantia nigra (sn). |
2011-03-01 |
2023-08-12 |
rat |
| A V Droblenkov, N R Karelin. Structural characteristics of neurons and macrogliocytes in interconnected regions of the mesoaccumbocingulate dopaminergic system in rats. Neuroscience and behavioral physiology. vol 40. issue 7. 2011-02-28. PMID:20635213. |
a spatial model of the system was constructed which took into account the mean distance of frontal sections from the frontal pole; the densities of neurons and macrogliocytes were assessed in the central part of the paranigral nucleus of the ventral tegmental area (vta) and the compact zone of the substantia nigra (sn) and in the interconnected anteromedial segments of these midbrain nuclei, the cingulate fields, the nucleus accumbens (na), and layer vi of the pregenual (cg3) and layer iii of the supragenual (cg2) cingulate fields. |
2011-02-28 |
2023-08-12 |
rat |
| Dominic J Hare, Jessica L George, Rudolph Grimm, Simon Wilkins, Paul A Adlard, Robert A Cherny, Ashley I Bush, David I Finkelstein, Philip Dobl. Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain. Metallomics : integrated biometal science. vol 2. issue 11. 2011-02-28. PMID:21072366. |
each section was quantified against tissue standards resulting in a three dimensional map that represents the variation of trace element concentrations of the mouse brain in the area surrounding the substantia nigra (sn). |
2011-02-28 |
2023-08-12 |
mouse |
| O-B Tysnes, B Müller, J P Larse. Are dysautonomic and sensory symptoms present in early Parkinson's disease? Acta neurologica Scandinavica. Supplementum. issue 190. 2011-02-25. PMID:20586740. |
the motor symptoms in pd are related to the degeneration of dopaminergic cells in the substantia nigra (sn). |
2011-02-25 |
2023-08-12 |
Not clear |
| Eun S Chung, Young C Chung, Eugene Bok, Hyung H Baik, Eun S Park, Ju-Young Park, Sung-Hwa Yoon, Byung K Ji. Fluoxetine prevents LPS-induced degeneration of nigral dopaminergic neurons by inhibiting microglia-mediated oxidative stress. Brain research. vol 1363. 2011-02-24. PMID:20858471. |
here, we examined whether fluoxetine prevents lps-induced degeneration of da in the rat substantia nigra (sn) in vivo. |
2011-02-24 |
2023-08-12 |
rat |
| Jun Ping Cao, Fu Zhen Li, Yuan Yuan Zhu, Hong Hua Yuan, Zheng Quan Yu, Dian Shuai Ga. Expressions and possible roles of GDNF receptors in the developing dopaminergic neurons. Brain research bulletin. vol 83. issue 6. 2011-02-24. PMID:20884338. |
glial cell line-derived neurotrophic factor (gdnf) has an essential role in the survival and maturation of the dopaminergic (da) neurons in the substantia nigra (sn) of mammalian embryonic brain. |
2011-02-24 |
2023-08-12 |
human |
| Simone Zittel, Christian K E Moll, Norbert Brüggemann, Vera Tadic, Wolfgang Hamel, Meike Kasten, Katja Lohmann, Thora Lohnau, Susen Winkler, Christian Gerloff, Rainer Schönweiler, Johann Hagenah, Christine Klein, Alexander Münchau, Susanne A Schneide. Clinical neuroimaging and electrophysiological assessment of three DYT6 dystonia families. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 14. 2011-02-22. PMID:20687193. |
tcs revealed increased substantia nigra (sn) hyperechogenicity in all mutc. |
2011-02-22 |
2023-08-12 |
Not clear |
| Yeong-Gon Choi, Sabina Li. N(ɛ)-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model. Biochimie. vol 92. issue 10. 2011-02-16. PMID:20624443. |
results show that the immunoreactivities of the tyrosine hydroxylase and dopamine transporter significantly decreased in the striatum and the substantia nigra (sn) in the mptp model compared to the subjects in the control group. |
2011-02-16 |
2023-08-12 |
mouse |
| Sudarshan Phani, Gregory Gonye, Lorraine Iacovitt. VTA neurons show a potentially protective transcriptional response to MPTP. Brain research. vol 1343. 2011-02-15. PMID:20462502. |
in humans, da neurons of the substantia nigra (sn) and their projections to the striatum show selective vulnerability, while neighboring da neurons of the ventral tegmental area (vta) are relatively spared from degeneration. |
2011-02-15 |
2023-08-12 |
Not clear |
| M Chertoff, N Di Paolo, A Schoeneberg, A Depino, C Ferrari, W Wurst, K Pfizenmaier, U Eisel, F Pitoss. Neuroprotective and neurodegenerative effects of the chronic expression of tumor necrosis factor α in the nigrostriatal dopaminergic circuit of adult mice. Experimental neurology. vol 227. issue 2. 2011-02-14. PMID:21093436. |
the substantia nigra (sn), a cns region affected in pd, is particularly susceptible to inflammatory insults and possesses the highest density of microglial cells, but the effects of inflammation and in particular tnf-α on neuronal survival in this region remains controversial. |
2011-02-14 |
2023-08-12 |
mouse |
| Carsten Nicolas Boehler, Nico Bunzeck, Ruth M Krebs, Toemme Noesselt, Mircea A Schoenfeld, Hans-Jochen Heinze, Thomas F Münte, Marty G Woldorff, Jens-Max Hop. Substantia nigra activity level predicts trial-to-trial adjustments in cognitive control. Journal of cognitive neuroscience. vol 23. issue 2. 2011-02-11. PMID:20465358. |
in particular, dopaminergic projections from the midbrain (i.e., from the substantia nigra [sn] and the ventral tegmental area) have been proposed to play a pivotal role in modulating the activity in these areas for cognitive control purposes. |
2011-02-11 |
2023-08-12 |
Not clear |
| Christopher J Barnum, Malú G Tanse. Modeling neuroinflammatory pathogenesis of Parkinson's disease. Progress in brain research. vol 184. 2011-01-21. PMID:20887872. |
the molecular mechanisms underlying the pathogenesis of idiopathic parkinson's disease (pd) have not been completely elucidated; however, some progress has been made in identifying factors that compromise survival of the dopaminergic neurons in the substantia nigra (sn) the death of which give rise to the motor symptoms that enable clinicians to diagnose the disease in its mid- to late stages. |
2011-01-21 |
2023-08-12 |
Not clear |
| Almas Siddiqui, Jyothi K Mallajosyula, Anand Rane, Julie K Anderse. Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: implications for early intervention on disease progression. Neurobiology of disease. vol 40. issue 2. 2011-01-12. PMID:20655384. |
these include a specific, selective and progressive loss of dopaminergic neurons of the substantia nigra (sn), selective decreases in mitochondrial complex i (ci) activity and increased oxidative stress. |
2011-01-12 |
2023-08-12 |
mouse |
| Andreas Norgaard Glud, Claus Hedegaard, Mette Slot Nielsen, Jens Christian Sørensen, Christian Bendixen, Poul Henning Jensen, Knud Larsen, Carsten Reidies Bjarka. Direct gene transfer in the Gottingen minipig CNS using stereotaxic lentiviral microinjections. Acta neurobiologiae experimentalis. vol 70. issue 3. 2011-01-07. PMID:20871651. |
we aim to induce direct viral mediated gene transfer in the substantia nigra (sn) of the gottingen minipig using mri guided stereotaxic injections of lentiviral vectors encoding enhanced green fluorescent protein (egfp). |
2011-01-07 |
2023-08-12 |
Not clear |
| Michela Deleidi, Penelope J Hallett, James B Koprich, Chee-Yeun Chung, Ole Isacso. The Toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 48. 2011-01-06. PMID:21123556. |
in parkinson's disease (pd), loss of striatal dopaminergic (da) terminals and degeneration of da neurons in the substantia nigra (sn) are associated with glial reactions. |
2011-01-06 |
2023-08-12 |
rat |