| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kee Won Kim, Hyun Woo Kim, Jing Li, Young Bae Kwo. Effect of bee venom acupuncture on methamphetamine-induced hyperactivity, hyperthermia and Fos expression in mice. Brain research bulletin. vol 84. issue 1. 2011-04-11. PMID:20950675. |
meth injection significantly increased fos expression in several brain regions including nucleus accumbens (na), caudate putamen (cpu), ventral tegmental area (vta), substantia nigra (sn) and locus coeruleus (lc). |
2011-04-11 |
2023-08-12 |
mouse |
| Dario Domenico Lofrumento, Concetta Saponaro, Antonia Cianciulli, Francesco De Nuccio, Vincenzo Mitolo, Giuseppe Nicolardi, Maria Antonietta Panar. MPTP-induced neuroinflammation increases the expression of pro-inflammatory cytokines and their receptors in mouse brain. Neuroimmunomodulation. vol 18. issue 2. 2011-04-06. PMID:20938211. |
parkinson's disease (pd) is a common neurodegenerative disease characterised by a slow and progressive degeneration of dopaminergic neurons in the substantia nigra (sn). |
2011-04-06 |
2023-08-12 |
mouse |
| Xinxin Yang, Baohua Chen. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. Journal of molecular neuroscience : MN. vol 42. issue 2. 2011-04-04. PMID:20333481. |
the main clinical symptom of pd is motor dysfunction derived from the loss of dopaminergic neurons in the substantia nigra (sn) and dopamine content in the striatum subsequently. |
2011-04-04 |
2023-08-12 |
mouse |
| Reza Habib, Mark R Dixo. Neurobehavioral evidence for the "Near-Miss" effect in pathological gamblers. Journal of the experimental analysis of behavior. vol 93. issue 3. 2011-03-30. PMID:21119848. |
no behavioral differences were observed between groups of participants, however, differences in brain activity were found in the left midbrain, near the substantia nigra and ventral tegmental area (sn / vta). |
2011-03-30 |
2023-08-12 |
human |
| Yoshinori Kajimoto, Hideto Miwa, Tomoyoshi Kond. Transcranial sonography in relation to SPECT and MIBG. International review of neurobiology. vol 90. 2011-03-25. PMID:20692493. |
in addition, substantia nigra (sn) hyperechogenicity, detected with transcranial sonography (tcs), might provide a marker of susceptibility to pd. |
2011-03-25 |
2023-08-12 |
Not clear |
| Ludwig Niehaus, Kai Boelman. Diagnosis of Parkinson's disease--transcranial sonography in relation to MRI. International review of neurobiology. vol 90. 2011-03-25. PMID:20692494. |
in contrast to conventional magnetic resonance imaging (mri), tcs is able to detect highly characteristic changes in signal brightness of the substantia nigra (sn) in patients with idiopathic parkinson's disease. |
2011-03-25 |
2023-08-12 |
Not clear |
| Alexandra Gaenslen, Daniela Ber. Early diagnosis of Parkinson's disease. International review of neurobiology. vol 90. 2011-03-25. PMID:20692495. |
up to 90% of pd patients show hyperechogenicity of the substantia nigra (sn) on tcs. |
2011-03-25 |
2023-08-12 |
Not clear |
| Angela E P Bouwmans, Annemarie M M Vlaar, Karin Srulijes, Werner H Mess, W E J Webe. Transcranial sonography for the discrimination of idiopathic Parkinson's disease from the atypical parkinsonian syndromes. International review of neurobiology. vol 90. 2011-03-25. PMID:20692498. |
changes of specific structures on tcs like the substantia nigra (sn), lenticular nucleus (ln), and the third ventricle are discussed as well as how they can contribute to differentiate between ipd, multiple system atrophy (msa), progressive supranuclear palsy (psp), lewy body disease (lbd), and corticobasal degeneration (cbd). |
2011-03-25 |
2023-08-12 |
Not clear |
| Kathrin Brockmann, Johann Hagena. TCS in monogenic forms of Parkinson's disease. International review of neurobiology. vol 90. 2011-03-25. PMID:20692500. |
since hyperechogenicity of the substantia nigra (sn) represents a characteristic hallmark of sporadic pd questions arise concerning the echo pattern of monogenic forms of this disorder on tcs. |
2011-03-25 |
2023-08-12 |
Not clear |
| Heike Stockner, Isabel Wurste. Transcranial sonography in essential tremor. International review of neurobiology. vol 90. 2011-03-25. PMID:20692503. |
recent studies have consistently found hyperechogenic alterations in the area of the substantia nigra (sn) in patients with parkinson's disease (pd) using transcranial sonography (tcs). |
2011-03-25 |
2023-08-12 |
human |
| Christos Krogias, Thomas Postert, Jens Eydin. Transcranial sonography in ataxia. International review of neurobiology. vol 90. 2011-03-25. PMID:20692505. |
three tcs studies reported hyperechogenicity of substantia nigra (sn) as a frequent finding in spinocerebellar ataxia type 2, type 3, and type 17, indicating a vulnerability of the nigrostriatal system in sca patients. |
2011-03-25 |
2023-08-12 |
Not clear |
| Hey-Kyeong Jeong, Ilo Jou, Eun-hye Jo. Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra. Experimental & molecular medicine. vol 42. issue 12. 2011-03-23. PMID:20962566. |
interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mrna/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (sn), where dopaminergic neurons are located. |
2011-03-23 |
2023-08-12 |
rat |
| Emmanuelle Lagrue, Hiroyuki Abe, Madakasira Lavanya, Jawida Touhami, Sylvie Bodard, Sylvie Chalon, Jean-Luc Battini, Marc Sitbon, Pierre Castelna. Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport. Journal of biomedical science. vol 17. 2011-03-22. PMID:21129221. |
for this purpose, we monitored changes in the distribution of pit1, pit2 and glut1 in the cerebellum, the frontal cortex, the corpus callosum, the striatum and the substantia nigra (sn) of c57/bl6 mice after administration of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridinium (mptp), a mitochondrial complex i inhibitor which induces neuronal degeneration in the striato-nigral network.the pit1 ligand stained oligodendrocytes in the corpus callosum and showed a reticular pattern in the sn. |
2011-03-22 |
2023-08-12 |
mouse |
| D Berg, J Godau, P Riederer, M Gerlach, T Arzberge. Microglia activation is related to substantia nigra echogenicity. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 11. 2011-03-21. PMID:21057966. |
hyperechogenicity of the substantia nigra (sn) is a sensitive marker for parkinson's disease (pd). |
2011-03-21 |
2023-08-12 |
human |
| Shih-Ying Wu, Tzu-Feng Wang, Lung Yu, Chauying J Jen, Jih-Ing Chuang, Fong-Sen Wu, Chih-Wei Wu, Yu-Min Ku. Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway. Brain, behavior, and immunity. vol 25. issue 1. 2011-03-10. PMID:20851176. |
parkinson's disease (pd) is characterized by a progressive and selective loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2011-03-10 |
2023-08-12 |
Not clear |
| Michael E Talkowski, Kathleen L McCann, Michael Chen, Lora McClain, Mikhil Bamne, Joel Wood, Kodavali V Chowdari, Annie Watson, Konasale M Prasad, George Kirov, Lyudmilla Georgieva, Draga Toncheva, Hader Mansour, David A Lewis, Michael Owen, Michael O'Donovan, Panagiotis Papasaikas, Patrick Sullivan, Douglas Ruderfer, Jeffrey K Yao, Sherry Leonard, Pramod Thomas, Fabio Miyajima, John Quinn, A Javier Lopez, Vishwajit L Nimgaonka. Fine-mapping reveals novel alternative splicing of the dopamine transporter. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 8. 2011-03-07. PMID:20957647. |
we confirmed alternative splicing of e3b in post-mortem human substantia nigra (sn). |
2011-03-07 |
2023-08-12 |
human |
| S Gouty, J M Brown, J Rosenberger, B M Co. MPTP treatment increases expression of pre-pro-nociceptin/orphanin FQ mRNA in a subset of substantia nigra reticulata neurons. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20417255. |
mptp increased ppn/ofq mrna expression in the substantia nigra (sn). |
2011-03-04 |
2023-08-12 |
mouse |
| Rodrigo Somoza, Carlos Juri, Mauricio Baes, Ursula Wyneken, Francisco Javier Rubi. Intranigral transplantation of epigenetically induced BDNF-secreting human mesenchymal stem cells: implications for cell-based therapies in Parkinson's disease. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. vol 16. issue 11. 2011-03-04. PMID:20542127. |
the aim of the present study was to characterize signals and/or molecules that regulate brain-derived neurotrophic factor (bdnf) protein expression/delivery in hmsc cultures and evaluate the effect of epigenetically generated bdnf-secreting hmsc on the intact and lesioned substantia nigra (sn). |
2011-03-04 |
2023-08-12 |
human |
| J Hagenah, G Seide. [Sonography of the parenchyma in Parkinson's disease]. Der Nervenarzt. vol 81. issue 10. 2011-03-01. PMID:20802993. |
up to 90% of patients with idiopathic parkinson's disease but only 10-15% of the healthy population show an abnormal echogenicity (hyperechogenicity) of the substantia nigra (sn). |
2011-03-01 |
2023-08-12 |
human |
| Gamze Tanriover, Yasemin Seval-Celik, Ozlem Ozsoy, Gokhan Akkoyunlu, Feyza Savcioglu, Gulay Hacioglu, Necdet Demir, Aysel Aga. The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease. Folia histochemica et cytobiologica. vol 48. issue 3. 2011-03-01. PMID:21071351. |
parkinson's disease (pd) is the second most common neurodegenerative disorder marked by cell death in the substantia nigra (sn). |
2011-03-01 |
2023-08-12 |
rat |