| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoshihisa Kitamur. [Dopaminergic neuroprotection and reconstruction of neural network tiara]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 130. issue 10. 2010-12-30. PMID:20930477. |
parkinson's disease (pd) is an age-related neurodegenerative disorder in whose brain massive loss of dopaminergic neurons and formation of lewy bodies occur in the substantia nigra (sn). |
2010-12-30 |
2023-08-12 |
mouse |
| Bonnie G Garcia, M Diana Neely, Ariel Y Deutc. Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine loss. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 10. 2010-12-28. PMID:20118184. |
striatal medium spiny neurons (msns) receive glutamatergic afferents from the cerebral cortex and dopaminergic inputs from the substantia nigra (sn). |
2010-12-28 |
2023-08-12 |
Not clear |
| Stephan Klebe, Sandra Thier, Delia Lorenz, Michael Nothnagel, Stefan Schreiber, Christine Klein, Johann Hagenah, Meike Kasten, Daniela Berg, Karin Srulijes, Thomas Gasser, Günther Deuschl, Gregor Kuhlenbäume. LINGO1 is not associated with Parkinson's disease in German patients. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 6. 2010-12-06. PMID:20468067. |
lingo1 is overexpressed in the substantia nigra (sn) of pd patients and inhibition of lingo1 confers neuroprotection in a rodent model of pd. |
2010-12-06 |
2023-08-12 |
Not clear |
| Do-Young Kwon, Woo-Keun Seo, Ho-Kyoung Yoon, Moon-Ho Park, Seong-Beom Koh, Kun-Woo Par. Transcranial brain sonography in Parkinson's disease with restless legs syndrome. Movement disorders : official journal of the Movement Disorder Society. vol 25. issue 10. 2010-12-02. PMID:20544813. |
substantia nigra (sn) hyperechogenicity assessed by transcranial brain sonography (tcs) is a characteristic finding in idiopathic parkinson's disease (pd). |
2010-12-02 |
2023-08-12 |
human |
| Brandon S Pruett, Michael F Salvator. GFR α-1 receptor expression in the aging nigrostriatal and mesoaccumbens pathways. Journal of neurochemistry. vol 115. issue 3. 2010-12-02. PMID:20731758. |
we recently reported that age-related bradykinesia was associated with reduced dopamine (da) tissue content, ser31 tyrosine hydroxylase (th) phosphorylation, and total th levels in substantia nigra (sn) only. |
2010-12-02 |
2023-08-12 |
rat |
| Sabina Luchetti, Koen Bossers, Giovanni Vanni Frajese, Dick F Swaa. Neurosteroid biosynthetic pathway changes in substantia nigra and caudate nucleus in Parkinson's disease. Brain pathology (Zurich, Switzerland). vol 20. issue 5. 2010-11-24. PMID:20406233. |
we have carried out an extensive study of the neurosteroid biosynthetic pathways in substantia nigra (sn), caudate nucleus (cn) and putamen (pu) of 7 parkinson's disease (pd) patients and 7 matched controls. |
2010-11-24 |
2023-08-12 |
human |
| Constantin Mänz, Jana Godau, Daniela Berg, Benjamin Bender, Ulrike Ernemann, Uwe Klos. The regional distribution of T2-relaxation times in MR images of the substantia nigra and crus cerebri. Neuroradiology. vol 52. issue 8. 2010-11-22. PMID:19859701. |
when scanning the size of the substantia nigra (sn), for example in parkinson's disease, it is important to precisely locate its true anatomic location. |
2010-11-22 |
2023-08-12 |
Not clear |
| Kerstin Krauel, Hendrik C Feldhaus, Andrea Simon, Claudia Rehe, Martin Glaser, Hans-Henning Flechtner, Hans-Jochen Heinze, Ludwig Niehau. Increased echogenicity of the substantia nigra in children and adolescents with attention-deficit/hyperactivity disorder. Biological psychiatry. vol 68. issue 4. 2010-11-22. PMID:20227683. |
recent neurobiological models on attention-deficit/hyperactivity disorder (adhd) as well as findings from imaging studies suggest a crucial involvement of dopaminergic midbrain nuclei, especially the substantia nigra (sn), in the pathogenesis of adhd symptoms. |
2010-11-22 |
2023-08-12 |
Not clear |
| Ning Song, Jun Wang, Hong Jiang, Junxia Xi. Ferroportin1 and hephaestin overexpression attenuate iron-induced oxidative stress in MES23.5 dopaminergic cells. Journal of cellular biochemistry. vol 110. issue 5. 2010-11-15. PMID:20564203. |
elevated iron was found in the substantia nigra (sn) of patients with parkinson's disease (pd). |
2010-11-15 |
2023-08-12 |
Not clear |
| Daniela Berg, Alexandra Gaensle. Place value of transcranial sonography in early diagnosis of Parkinson's disease. Neuro-degenerative diseases. vol 7. issue 5. 2010-11-04. PMID:20616564. |
substantia nigra (sn) hyperechogenicity is the characteristic feature of idiopathic pd, which can help in the differentiation of atypical parkinsonian syndromes like multiple system atrophy or progressive supranuclear palsy. |
2010-11-04 |
2023-08-12 |
Not clear |
| Joanne Clark, Elizabeth L Clore, Kangni Zheng, Anthony Adame, Eliezer Masliah, David K Simo. Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice. PloS one. vol 5. issue 8. 2010-11-04. PMID:20808797. |
levels of glutathione are lower in the substantia nigra (sn) early in parkinson's disease (pd) and this may contribute to mitochondrial dysfunction and oxidative stress. |
2010-11-04 |
2023-08-12 |
mouse |
| Eleni A Markakis, Kenneth P Vives, Jeremy Bober, Stefan Leichtle, Csaba Leranth, Jeff Beecham, John D Elsworth, Robert H Roth, R Jude Samulski, D Eugene Redmon. Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain. Molecular therapy : the journal of the American Society of Gene Therapy. vol 18. issue 3. 2010-10-29. PMID:20010918. |
vector injections were placed in the substantia nigra (sn) and the caudate nucleus (cd). |
2010-10-29 |
2023-08-12 |
Not clear |
| Chao Li, S Biswas, Xingang Li, A K Dutta, Weidong L. Novel D3 dopamine receptor-preferring agonist D-264: Evidence of neuroprotective property in Parkinson's disease animal models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactacystin. Journal of neuroscience research. vol 88. issue 11. 2010-10-20. PMID:20623619. |
we found that d-264 significantly improved behavioral performance, attenuated both mptp- and lactacystin-induced da neuron loss, and blocked proteasomal inhibition and microglial activation in the substantia nigra (sn). |
2010-10-20 |
2023-08-12 |
mouse |
| Simone van de Loo, Uwe Walter, Stefanie Behnke, Johann Hagenah, Matthias Lorenz, Matthias Sitzer, Rüdiger Hilker, Daniela Ber. Reproducibility and diagnostic accuracy of substantia nigra sonography for the diagnosis of Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 81. issue 10. 2010-10-19. PMID:20543186. |
transcranial sonography (tcs) shows characteristic hyperechogenicity of the substantia nigra (sn) in patients with parkinson's disease (pd). |
2010-10-19 |
2023-08-12 |
Not clear |
| Joanna Iczkiewicz, Lauren Broom, Jonathan D Cooper, Andrew Ming Sham Wong, Sarah Rose, Peter Jenne. The RGD-containing peptide fragment of osteopontin protects tyrosine hydroxylase positive cells against toxic insult in primary ventral mesencephalic cultures and in the rat substantia nigra. Journal of neurochemistry. vol 114. issue 6. 2010-10-19. PMID:20626561. |
we have previously shown that the multi-functional phosphoprotein osteopontin (opn) is present in the substantia nigra (sn) and that its mrna and protein expression are up-regulated following toxic insult. |
2010-10-19 |
2023-08-12 |
rat |
| Danny Galleguillos, José A Fuentealba, Luis M Gómez, Mathias Saver, Andrea Gómez, Kevin Nash, Corinna Burger, Katia Gysling, María E André. Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain. Journal of neurochemistry. vol 114. issue 4. 2010-10-06. PMID:20533997. |
using an adeno-associated vector-delivered anti-nurr1 ribozyme, we knocked-down nurr1 expression unilaterally in the substantia nigra (sn) of adult rats. |
2010-10-06 |
2023-08-12 |
human |
| I Nestrasil, S Michaeli, T Liimatainen, C E Rydeen, C M Kotz, J P Nixon, T Hanson, Paul J Tuit. T1rho and T2rho MRI in the evaluation of Parkinson's disease. Journal of neurology. vol 257. issue 6. 2010-09-29. PMID:20058018. |
using t(1rho) and t(2rho) on a 4t mri scanner, we assessed the substantia nigra (sn) of nine non-demented moderately affected pd and ten gender- and age-matched control participants. |
2010-09-29 |
2023-08-12 |
human |
| Vincent Seutin, Dominique Enge. Differences in Na+ conductance density and Na+ channel functional properties between dopamine and GABA neurons of the rat substantia nigra. Journal of neurophysiology. vol 103. issue 6. 2010-09-09. PMID:20357070. |
dopamine (da) neurons and gaba neurons of the substantia nigra (sn) promote distinct functions in the control of movement and have different firing properties and action potential (ap) waveforms. |
2010-09-09 |
2023-08-12 |
rat |
| Liviu Aron, Pontus Klein, Thu-Trang Pham, Edgar R Kramer, Wolfgang Wurst, Rüdiger Klei. Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLoS biology. vol 8. issue 4. 2010-09-01. PMID:20386724. |
the mechanisms underlying the selective death of substantia nigra (sn) neurons in parkinson disease (pd) remain elusive. |
2010-09-01 |
2023-08-12 |
mouse |
| Michela Di Salvio, Luca G Di Giovannantonio, Daniela Omodei, Dario Acampora, Antonio Simeon. Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain. The International journal of developmental biology. vol 54. issue 5. 2010-08-30. PMID:19924631. |
despite great efforts, the molecular basis and the genetic factors differentially controlling identity, survival and vulnerability to neurodegeneration of mdda neurons of the substantia nigra (sn) and ventral tegmental area (vta) are poorly understood. |
2010-08-30 |
2023-08-12 |
mouse |