| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Ru Pan, Miao Tian, Jian-Bo Xue, Song-Min Li, Xiao-Cui Luo, Xiao Huang, Zhen-Huang Chen, Liquan Huan. Mammalian Taste Bud Cells Utilize Extragemmal 5-Hydroxy-L-Tryptophan to Biosynthesize the Neurotransmitter Serotonin. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30534058. |
and abolishment of tph2 did not affect the production of intragemmal 5-ht or alter tbcs; the mutant mice did not show any changes in behavioral responses to all five primary taste qualities: sweet, umami, bitter, salty, and sour. |
2020-09-30 |
2023-08-13 |
mouse |
| Ze Li, Hai-Yuan Yang, Ying Wang, Man-Ling Zhang, Xiao-Rui Liu, Qiang Xiong, Li-Ning Zhang, Yong Jin, Li-Sha Mou, Yan Liu, Rong-Feng Li, Yi Rao, Yi-Fan Da. Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting. Journal of biomedical research. vol 31. issue 5. 2020-09-29. PMID:28866660. |
the biosynthesis of neuronal 5-ht is regulated by the rate-limiting enzyme, tryptophan hydroxylase-2 (tph2). |
2020-09-29 |
2023-08-13 |
Not clear |
| Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. |
evidence suggests that mice deficient in tph2, the rate-limiting enzyme for brain serotonin synthesis, display disruptions in behavioral phenotypes relevant to stress-related psychiatric disorders. |
2020-09-14 |
2023-08-13 |
mouse |
| Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. |
serotonergic genes studied included tph2, the high-affinity, low-capacity, sodium-dependent serotonin transporter (slc6a4), the serotonin type 1a receptor (htr1a), and the corticosterone-sensitive, low-affinity, high-capacity sodium-independent serotonin transporter, organic cation transporter 3 (slc22a3). |
2020-09-14 |
2023-08-13 |
mouse |
| Hisatsugu Koshimizu, Nao Hirata, Keizo Takao, Keiko Toyama, Takashi Ichinose, Shigeki Furuya, Tsuyoshi Miyakaw. Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2. Neuropsychopharmacology reports. vol 39. issue 1. 2020-08-20. PMID:30472790. |
tryptophan hydroxylase 2 (tph2) is a rate-limiting enzyme for the biosynthesis of 5-hydroxytryptamine (5-ht, serotonin). |
2020-08-20 |
2023-08-13 |
mouse |
| Hisatsugu Koshimizu, Nao Hirata, Keizo Takao, Keiko Toyama, Takashi Ichinose, Shigeki Furuya, Tsuyoshi Miyakaw. Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2. Neuropsychopharmacology reports. vol 39. issue 1. 2020-08-20. PMID:30472790. |
previous studies have reported that c1473g polymorphism of the murine tph2 gene leads to decreased 5-ht levels in the brain and abnormal behavioral phenotypes, such as impaired anxiety- and depression-like behaviors. |
2020-08-20 |
2023-08-13 |
mouse |
| Niklas Kästner, S Helene Richter, Sarah Urbanik, Joachim Kunert, Jonas Waider, Klaus-Peter Lesch, Sylvia Kaiser, Norbert Sachse. Brain serotonin deficiency affects female aggression. Scientific reports. vol 9. issue 1. 2020-08-18. PMID:30718564. |
while so far most studies have investigated variation in serotonin levels, a recently created tryptophan hydroxylase 2 (tph2) knockout mouse model allows studying effects of complete brain serotonin deficiency. |
2020-08-18 |
2023-08-13 |
mouse |
| Gabriel Rodrigues Coutinho Pereira, Gustavo Duarte Bocayuva Tavares, Marta Costa de Freitas, Joelma Freire De Mesquit. In silico analysis of the tryptophan hydroxylase 2 (TPH2) protein variants related to psychiatric disorders. PloS one. vol 15. issue 3. 2020-06-17. PMID:32119710. |
the tryptophan hydroxylase 2 (tph2) enzyme catalyzes the first step of serotonin biosynthesis. |
2020-06-17 |
2023-08-13 |
human |
| Gabriel Rodrigues Coutinho Pereira, Gustavo Duarte Bocayuva Tavares, Marta Costa de Freitas, Joelma Freire De Mesquit. In silico analysis of the tryptophan hydroxylase 2 (TPH2) protein variants related to psychiatric disorders. PloS one. vol 15. issue 3. 2020-06-17. PMID:32119710. |
as the reaction catalyzed by tph2 is the rate-limiting step of serotonin biosynthesis, mutations in tph2 have been associated with several psychiatric disorders (pd). |
2020-06-17 |
2023-08-13 |
human |
| Chao-Jin Xu, Jun-Ling Wang, Jing-Pan, Min-Lia. Tph2 Genetic Ablation Contributes to Senile Plaque Load and Astrogliosis in APP/PS1 Mice. Current Alzheimer research. vol 16. issue 3. 2020-06-16. PMID:30827242. |
in addition, tryptophan hydroxylase-2 (tph2), a second tryptophan hydroxylase isoform, controls brain serotonin synthesis. |
2020-06-16 |
2023-08-13 |
mouse |
| Susann Matthes, Valentina Mosienko, Elena Popova, Marion Rivalan, Michael Bader, Natalia Alenin. Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30977636. |
tph1, predominantly expressed in the gastrointestinal tract and pineal gland, mediates 5-ht biosynthesis in non-neuronal tissues, while tph2, mainly found in the raphe nuclei of the brain stem, is accountable for the production of 5-ht in the brain. |
2020-06-11 |
2023-08-13 |
rat |
| Qinglan Chen, Fafa Tian, Qiang Yue, Qiong Zhan, Mian Wang, Bo Xiao, Chang Zen. Decreased serotonin synthesis is involved in seizure-induced respiratory arrest in DBA/1 mice. Neuroreport. vol 30. issue 12. 2020-04-16. PMID:31283708. |
tryptophan hydroxylase-2 (tph2) is the rate-limiting enzyme of central serotonin (5-hydroxytryptamine) synthesis which converts l-tryptophan to 5-hydroxytryptophan. |
2020-04-16 |
2023-08-13 |
mouse |
| Mitchell R Knisely, Yvette P Conley, Kord M Kober, Betty Smoot, Steven M Paul, Jon D Levine, Christine Miaskowsk. Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery. The journal of pain. vol 19. issue 10. 2020-04-06. PMID:29723560. |
polymorphisms in 5 genes were associated with membership in the mild pain class: ** beta-2-adrenergic receptor (adrb2) rs2400707, beta adrenergic receptor kinase 2 (adrbk2) hapa04, 5-hydroxytryptamine receptor 3a (htr3a) rs10160548, solute-like carrier (slc) family 6 member 2-noradrenaline transporter (slc6a2) rs1566652, and tryptophan hydroxylase 2 (tph2) rs11179000. |
2020-04-06 |
2023-08-13 |
Not clear |
| Lili Wang, Deping Han, Peng Yin, Kedao Teng, Jianqin Xu, Yunfei M. Decreased tryptophan hydroxylase 2 mRNA and protein expression, decreased brain serotonin concentrations, and anxiety-like behavioral changes in a rat model of simulated transport stress. Stress (Amsterdam, Netherlands). vol 22. issue 6. 2020-03-17. PMID:31184239. |
this study aimed to explore changes in concentrations of 5-hydroxytryptamine (serotonin), and the expression changes of tryptophan hydroxylase 2 (tph2) mrna and protein associated with anxiety-related behavioral responses under transport stress. |
2020-03-17 |
2023-08-13 |
rat |
| Seong W Kang, Karen D Christensen, Douglas Aldridge, Wayne J Kuenze. Effects of light intensity and dual light intensity choice on plasma corticosterone, central serotonergic and dopaminergic activities in birds, Gallus gallus. General and comparative endocrinology. vol 285. 2020-03-13. PMID:31557469. |
this study aims to investigate the effects of different light intensity and dual light intensity choice (dlic) lighting program on plasma corticosterone (cort), and tryptophan hydroxylase 2 (tph2, the rate-limiting enzyme of serotonin biosynthesis) and tyrosine hydroxylase (th, the rate-limiting enzyme of dopamine biosynthesis) gene expression in the brainstem of male chickens. |
2020-03-13 |
2023-08-13 |
Not clear |
| Yiqiong Liu, Yunong Sun, Xiaoyan Zhao, Ji-Young Kim, Lu Luo, Qian Wang, Xiaolu Meng, Yonghui Li, Nan Sui, Zhou-Feng Chen, Chuxiong Pan, Liang Li, Yan Zhan. Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin. Neuroscience bulletin. vol 35. issue 5. 2020-03-03. PMID:30977041. |
in the present study, using mice deficient in central serotonin tph2 |
2020-03-03 |
2023-08-13 |
mouse |
| Deborah G A Peeters, Sietse F de Boer, Anneke Terneusen, Adrian Newman-Tancredi, Mark A Varney, Robbert-Jan Verkes, Judith R Homber. Enhanced aggressive phenotype of Tph2 knockout rats is associated with diminished 5-HT Neuropharmacology. vol 153. 2020-03-03. PMID:31078489. |
enhanced aggressive phenotype of tph2 knockout rats is associated with diminished 5-ht brain serotonin (5-ht) plays a key role in aggressive behaviours and related psychopathologies, but its precise mechanism of action remains elusive. |
2020-03-03 |
2023-08-13 |
rat |
| Deborah G A Peeters, Sietse F de Boer, Anneke Terneusen, Adrian Newman-Tancredi, Mark A Varney, Robbert-Jan Verkes, Judith R Homber. Enhanced aggressive phenotype of Tph2 knockout rats is associated with diminished 5-HT Neuropharmacology. vol 153. 2020-03-03. PMID:31078489. |
the present study showed that tryptophan hydroxylase 2 (tph2) knockout (ko) rats, which exhibit profoundly diminished extracellular serotonin levels, display increased aggressiveness compared to their tph2 wildtype (wt) counterparts. |
2020-03-03 |
2023-08-13 |
rat |
| Erik Höglund, Øyvind Øverli, Svante Winber. Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review. Frontiers in endocrinology. vol 10. 2020-02-25. PMID:31024440. |
the rate of 5-ht biosynthesis is limited by trp availability, but only in neurons of the hindbrain raphe area predominantly expressing the isoform tph2 of the enzyme tryptophan hydroxylase (tph). |
2020-02-25 |
2023-08-13 |
Not clear |
| Megan M Haney, Joseph Sinnott, Kate L Osman, Ian Deninger, Ellyn Andel, Victoria Caywood, Alexis Mok, Brayton Ballenger, Kevin Cummings, Lori Thombs, Teresa E Leve. Mice Lacking Brain-Derived Serotonin Have Altered Swallowing Function. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. vol 161. issue 3. 2020-01-30. PMID:31035861. |
we investigated this using mice deficient in tryptophan-hydroxylase-2 (tph2), the enzyme catalyzing the rate-limiting step in 5-ht synthesis. |
2020-01-30 |
2023-08-13 |
mouse |