| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shih-Jen Tsai, Chen-Jee Hong, Ying-Jay Liou, Younger W-Y Yu, Tai-Jui Chen, Sheue-Jane Hou, Feng-Chang Ye. Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 4. 2009-08-10. PMID:19272410. |
tryptophan hydroxylase-2 (tph2) is the rate-limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and has been implicated in the pathogenesis of major depressive disorder (mdd) and in the mechanism of antidepressant action. |
2009-08-10 |
2023-08-12 |
Not clear |
| Shih-Jen Tsai, Chen-Jee Hong, Ying-Jay Liou, Younger W-Y Yu, Tai-Jui Chen, Sheue-Jane Hou, Feng-Chang Ye. Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 4. 2009-08-10. PMID:19272410. |
our findings show that tph2 genetic variants may play a role in mdd susceptibility and in acute therapeutic response to selective serotonin reuptake inhibitors. |
2009-08-10 |
2023-08-12 |
Not clear |
| Jeffrey A McKinney, Banu Turel, Ingeborg Winge, Per M Knappskog, Jan Haavi. Functional properties of missense variants of human tryptophan hydroxylase 2. Human mutation. vol 30. issue 5. 2009-07-30. PMID:19319927. |
tryptophan hydroxylase 2 (tph2) catalyzes the rate-limiting step in serotonin biosynthesis in the nervous system. |
2009-07-30 |
2023-08-12 |
human |
| Natalia Alenina, Dana Kikic, Mihail Todiras, Valentina Mosienko, Fatimunnisa Qadri, Ralph Plehm, Philipp Boyé, Larissa Vilianovitch, Reinhard Sohr, Katja Tenner, Heide Hörtnagl, Michael Bade. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 25. 2009-07-17. PMID:19520831. |
serotonin synthesis in mammals is initiated by 2 distinct tryptophan hydroxylases (tph), tph1 and tph2. |
2009-07-17 |
2023-08-12 |
mouse |
| Natalia Alenina, Dana Kikic, Mihail Todiras, Valentina Mosienko, Fatimunnisa Qadri, Ralph Plehm, Philipp Boyé, Larissa Vilianovitch, Reinhard Sohr, Katja Tenner, Heide Hörtnagl, Michael Bade. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 25. 2009-07-17. PMID:19520831. |
by genetically ablating tph2, we created mice (tph2(-/-)) that lack serotonin in the central nervous system. |
2009-07-17 |
2023-08-12 |
mouse |
| Natalia Alenina, Dana Kikic, Mihail Todiras, Valentina Mosienko, Fatimunnisa Qadri, Ralph Plehm, Philipp Boyé, Larissa Vilianovitch, Reinhard Sohr, Katja Tenner, Heide Hörtnagl, Michael Bade. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 25. 2009-07-17. PMID:19520831. |
these data confirm that the majority of central serotonin is generated by tph2. |
2009-07-17 |
2023-08-12 |
mouse |
| Siobhan Roche, Patrick McKeo. Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder. Psychiatric genetics. vol 19. issue 3. 2009-06-26. PMID:19352219. |
we investigated whether variants within the tryptophan hydroxylase-2 (tph2) gene, which is required for the synthesis of serotonin (5-ht), are associated with susceptibility to developing bpad. |
2009-06-26 |
2023-08-12 |
Not clear |
| M A Tikhonova, E L Al'perina, T G Tolstikova, D V Bazovkina, V Iu Di, G V Idova, A V Kulikov, N K Popov. [Effects of chronic fluoxetine treatment on catalepsy and immune response in mice genetically predisposed to freezing reaction: the role of 5-HT1A and 5-HT2A receptors and tph2 and SERT genes]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 59. issue 2. 2009-06-19. PMID:19445393. |
no effect on cortical 5-ht1a and 5-ht2a receptor mrna levels and on 5-ht1a receptor, tph2 (tryptophan hydroxylase-2) and sert (serotonin transporter) mesencephalic gene expression was observed in asc mice. |
2009-06-19 |
2023-08-12 |
mouse |
| Guo-Lin Chen, Gregory M Mille. 5'-Untranslated region of the tryptophan hydroxylase-2 gene harbors an asymmetric bidirectional promoter but not internal ribosome entry site in vitro. Gene. vol 435. issue 1-2. 2009-06-18. PMID:19344641. |
tryptophan hydroxylase-2 (tph2) catalyzes the synthesis of neuronal serotonin, a major neurotransmitter involved in many brain functions and psychiatric disorders. |
2009-06-18 |
2023-08-12 |
human |
| Ho-Kyoung Yoon, Yong-Ku Ki. TPH2 -703G/T SNP may have important effect on susceptibility to suicidal behavior in major depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 3. 2009-06-16. PMID:19162119. |
in this study, we aimed to investigate the association of serotonin 2a receptor gene -1438a/g snp (htr2a -1438a/g), tryptophan hydroxylase 2 gene -703g/t snp (tph2 -703g/t) and serotonin 1a receptor c-1019g (htr1a c-1019g) with suicidal behavior. |
2009-06-16 |
2023-08-12 |
Not clear |
| Anne Must, Gunnar Tasa, Aavo Lang, Eero Vasar, Sulev Kõks, Eduard Maron, Marika Väl. Variation in tryptophan hydroxylase-2 gene is not associated to male completed suicide in Estonian population. Neuroscience letters. vol 453. issue 2. 2009-06-12. PMID:19356604. |
tryptophan hydroxylase isoform 2 (tph2) is the rate-limiting enzyme in the biosynthetic pathway of serotonin, being expressed in serotonergic neurons of raphe nuclei. |
2009-06-12 |
2023-08-12 |
human |
| Daria V Osipova, Alexander V Kulikov, Nina K Popov. C1473G polymorphism in mouse tph2 gene is linked to tryptophan hydroxylase-2 activity in the brain, intermale aggression, and depressive-like behavior in the forced swim test. Journal of neuroscience research. vol 87. issue 5. 2009-06-01. PMID:19006079. |
tryptophan hydroxylase-2 (tph2) is the rate-limiting enzyme of brain serotonin synthesis. |
2009-06-01 |
2023-08-12 |
mouse |
| Lise Gutknecht, Claudia Kriegebaum, Jonas Waider, Angelika Schmitt, Klaus-Peter Lesc. Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 4. 2009-05-20. PMID:19181488. |
in support of tph2 specificity in brain 5-ht synthesis, raphe neurons of tph2 knockout mice were completely devoid of 5-ht, with no compensatory activation of tph1 expression. |
2009-05-20 |
2023-08-12 |
mouse |
| Lise Gutknecht, Claudia Kriegebaum, Jonas Waider, Angelika Schmitt, Klaus-Peter Lesc. Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 4. 2009-05-20. PMID:19181488. |
in conclusion, our findings indicate that brain 5-ht synthesis across the lifespan is exclusively maintained by tph2. |
2009-05-20 |
2023-08-12 |
mouse |
| Geza Nagy, Zsolt Ronai, Aniko Somogyi, Maria Sasvari-Szekely, Omar Abdul Rahman, Attila Mate, Timea Varga, Zsofia Nemod. P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 8. 2009-04-15. PMID:18801407. |
in the present study, candidate polymorphisms of the serotonin transporter, the tryptophan hydroxylase 2 (tph2) genes, as well as of the brain-derived neurotrophic factor bdnf, and the p2rx7 purinergic receptor genes were analyzed in hungarian diabetic population. |
2009-04-15 |
2023-08-12 |
Not clear |
| R Hiroi, J F Neumaie. Estrogen decreases 5-HT1B autoreceptor mRNA in selective subregion of rat dorsal raphe nucleus: inverse association between gene expression and anxiety behavior in the open field. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19049819. |
we have recently shown that estrogen decreases anxiety and increases expression of tryptophan hydroxylase-2 (tph2), the rate-limiting enzyme for 5-ht synthesis. |
2009-04-15 |
2023-08-12 |
rat |
| R Hiroi, J F Neumaie. Estrogen decreases 5-HT1B autoreceptor mRNA in selective subregion of rat dorsal raphe nucleus: inverse association between gene expression and anxiety behavior in the open field. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19049819. |
therefore, we examined the effects of estrogen on 5-ht(1b) mrna in the rat drn, focusing on specific subregions, and whether 5-ht(1b) mrna levels correlated with tph2 mrna levels and with anxiety-like behavior. |
2009-04-15 |
2023-08-12 |
rat |
| R Hiroi, J F Neumaie. Estrogen decreases 5-HT1B autoreceptor mRNA in selective subregion of rat dorsal raphe nucleus: inverse association between gene expression and anxiety behavior in the open field. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19049819. |
in contrast, estrogen selectively decreased 5-ht(1b) mrna in the mid-ventromedial subregion of the drn, where 5-ht(1b) mrna was associated with higher anxiety-like behavior and inversely correlated with tph2 mrna levels. |
2009-04-15 |
2023-08-12 |
rat |
| R Hiroi, J F Neumaie. Estrogen decreases 5-HT1B autoreceptor mRNA in selective subregion of rat dorsal raphe nucleus: inverse association between gene expression and anxiety behavior in the open field. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19049819. |
these results suggest that estrogen may reduce 5-ht(1b) autoreceptor and increase tph2 synthesis in a coordinated fashion, thereby increasing the capacity for 5-ht synthesis and release in distinct forebrain regions that modulate specific components of anxiety behavior. |
2009-04-15 |
2023-08-12 |
rat |
| Tomas Furmark, Susanne Henningsson, Lieuwe Appel, Fredrik Ahs, Clas Linnman, Anna Pissiota, Vanda Faria, Lars Oreland, Massimo Bani, Emilio Merlo Pich, Elias Eriksson, Mats Fredrikso. Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder. Journal of psychiatry & neuroscience : JPN. vol 34. issue 1. 2009-03-12. PMID:19125211. |
the short (s) allele of the 5-ht transporter linked polymorphic region (5-httlpr) and the t variant of the g-703t polymorphism in the tryptophan hydroxylase-2 (tph2) gene have previously been associated with amygdala hyperresponsivity to negative faces in healthy controls. |
2009-03-12 |
2023-08-12 |
Not clear |