| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emiliano Tesoro-Cruz, Leticia Manuel-Apolinar, Norma Oviedo, Sandra Orozco-Suárez, Minerva Crespo Ramírez, Vilma Carolina Bekker-Méndez, M Magdalena Aguirre-García, Sandra Angélica Rojas-Osornio, Vladimir Paredes-Cervantes, Miguel Pérez de la Mor. Increase of 5-HT levels is induced both in mouse brain and HEK-293 cells following their exposure to a non-viral tryptophan hydroxylase construct. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34625528. |
therefore, the tph2 gene could be an ideal target for analyzing the effects of a 5-ht deficiency on brain function. |
2021-10-21 |
2023-08-13 |
mouse |
| Emiliano Tesoro-Cruz, Leticia Manuel-Apolinar, Norma Oviedo, Sandra Orozco-Suárez, Minerva Crespo Ramírez, Vilma Carolina Bekker-Méndez, M Magdalena Aguirre-García, Sandra Angélica Rojas-Osornio, Vladimir Paredes-Cervantes, Miguel Pérez de la Mor. Increase of 5-HT levels is induced both in mouse brain and HEK-293 cells following their exposure to a non-viral tryptophan hydroxylase construct. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34625528. |
further research will be needed on the possible application of this treatment for psychiatric diseases involving a tph2 dysfunction or serotonin deficiency. |
2021-10-21 |
2023-08-13 |
mouse |
| Anna Haduch, Renata Pukło, Natalia Alenina, Agnieszka Nikiforuk, Piotr Popik, Michael Bader, Władysława A Danie. The effect of ageing and cerebral serotonin deficit on the activity of cytochrome P450 2D (CYP2D) in the brain and liver of male rats. Neurochemistry international. vol 141. 2021-10-18. PMID:33091481. |
kinetics of 5-methoxytryptamine o-demethylation to serotonin was studied and the cyp2d activity was measured in brain and liver microsomes of dark agouti wild type (wt) rats (mature 3.5-month-old and senescent 21-month-old rats) and in tryptophan hydroxylase 2 (tph2)-deficient senescent rats. |
2021-10-18 |
2023-08-13 |
rat |
| Ming-Fen Ho, Cheng Zhang, Lingxin Zhang, Lixuan Wei, Ying Zhou, Irene Moon, Jennifer R Geske, Doo-Sup Choi, Joanna Biernacka, Mark Frye, Zhexing Wen, Victor M Karpyak, Hu Li, Richard Weinshilbou. TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response. Molecular psychiatry. vol 26. issue 7. 2021-10-15. PMID:32753686. |
ethanol treatment resulted in decreased 5-ht concentrations in human induced pluripotent stem cell (ipsc)-derived neuron culture media, and the downregulation of gene expression of tspan5, ddc, maoa, maob, tph1, and tph2 in those cells. |
2021-10-15 |
2023-08-13 |
human |
| Aude Muzerelle, Mariano Soiza-Reilly, Cornelia Hainer, Pierre-Louis Ruet, Klaus-Peter Lesch, Michael Bader, Natalia Alenina, Sophie Scotto-Lomassese, Patricia Gaspa. Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival. Scientific reports. vol 11. issue 1. 2021-10-14. PMID:33727585. |
this nursing defect is due to acute rather constitutive 5-ht depletion, as it is reproduced by adult knockdown of tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. |
2021-10-14 |
2023-08-13 |
mouse |
| Congcong Liu, Lei Xu, Jialin Li, Feng Zhou, Xi Yang, Xiaoxiao Zheng, Meina Fu, Keshuang Li, Cornelia Sindermann, Christian Montag, Yina Ma, Dirk Scheele, Richard P Ebstein, Shuxia Yao, Keith M Kendrick, Benjamin Becke. Serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior - a TPH2 imaging genetics approach. Psychological medicine. vol 51. issue 14. 2021-10-12. PMID:32981537. |
serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior - a tph2 imaging genetics approach. |
2021-10-12 |
2023-08-13 |
Not clear |
| Tatyana Strekalova, Evgeniy Svirin, Jonas Waider, Anna Gorlova, Raymond Cespuglio, Allan Kalueff, Igor Pomytkin, Angelika G Schmitt-Boehrer, Klaus-Peter Lesch, Daniel C Anthon. Altered behaviour, dopamine and norepinephrine regulation in stressed mice heterozygous in TPH2 gene. Progress in neuro-psychopharmacology & biological psychiatry. vol 108. 2021-09-02. PMID:33127424. |
increased impulsivity, excessive aggression, and other behavioural characteristics are associated with variants within the tryptophan hydroxylase-2 (tph2) gene, a key enzyme in brain serotonin synthesis. |
2021-09-02 |
2023-08-13 |
mouse |
| Tatyana Strekalova, Evgeniy Svirin, Jonas Waider, Anna Gorlova, Raymond Cespuglio, Allan Kalueff, Igor Pomytkin, Angelika G Schmitt-Boehrer, Klaus-Peter Lesch, Daniel C Anthon. Altered behaviour, dopamine and norepinephrine regulation in stressed mice heterozygous in TPH2 gene. Progress in neuro-psychopharmacology & biological psychiatry. vol 108. 2021-09-02. PMID:33127424. |
recently, we showed excessive aggression and altered serotonin brain metabolism in heterozygous tph2-deficient male mice (tph2 |
2021-09-02 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
this study aims to evaluate maternal hfd effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (jnk, pjnk and tnf-α), serotonin system molecules (tryptophan hydroxylase 2 (tph2), key-enzyme of serotonin synthesis, serotonin transporter (sert); 5-ht1a serotonergic receptor (5-ht1a)) and brain derived neurotrophic factor (bdnf) on recently weaned mice offspring hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
however, the tph2 increase in hfd-offspring did not alter hippocampal serotonin levels quantified through elisa. |
2021-08-11 |
2023-08-13 |
mouse |
| Luana Olegário da Silva, Raquel da Silva Aragão, Manuella da Luz Duarte Barros, Kelli Nogueira Ferraz-Pereira, Isabeli Lins Pinheiro, Lígia Cristina Monteiro Galind. Maternal exposure to high-fat diet modifies anxiety-like/depression-like behaviors and compounds of Serotonergic System in offspring: A preclinical systematic review. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 5. 2021-08-06. PMID:33788300. |
maternal consumption of hfd was found to be associated with an inconsistent pattern of the expression of tph2 as well as reduced the immunoreactivity of 5-ht in the prefrontal cortex and increased 5-ht1a receptor expression in the dorsal raphe of offspring. |
2021-08-06 |
2023-08-13 |
Not clear |
| Eeva-Leena Kataja, Jukka M Leppänen, Katri Kantojärvi, Juho Pelto, Tuomo Häikiö, Riikka Korja, Saara Nolvi, Hasse Karlsson, Tiina Paunio, Linnea Karlsso. The role of TPH2 variant rs4570625 in shaping infant attention to social signals. Infant behavior & development. vol 60. 2021-06-07. PMID:32711172. |
tph2, the rate-limiting enzyme in the synthesis of serotonin, has been connected to several psychiatric outcomes. |
2021-06-07 |
2023-08-13 |
Not clear |
| Ling Shen, Hai-Bo Qiu, Hui-Hong Xu, Kai Wei, Liang Zhao, Cheng-Cheng Zhu, Cheng-Jian Li, Zhi-Jie L. Nicotine withdrawal induces hyperalgesia via downregulation of descending serotonergic pathway in the nucleus raphe magnus. Neuropharmacology. vol 189. 2021-06-04. PMID:33722649. |
these rats showed less tryptophan hydroxylase 2 (tph2) positive neurons and reduced tph2 expression in the nucleus raphe magnus (nrm), and thus resulted in decreased 5-hydroxytryptamine (5-ht) levels in cerebrospinal fluid. |
2021-06-04 |
2023-08-13 |
rat |
| Gilciane Ceolin, Giulia Pipolo Rodrigues Mano, Natália Schmitt Hames, Luciana da Conceição Antunes, Elisa Brietzke, Débora Kurrle Rieger, Júlia Dubois Moreir. Vitamin D, Depressive Symptoms, and Covid-19 Pandemic. Frontiers in neuroscience. vol 15. 2021-06-01. PMID:34054418. |
the signaling of 1,25-dihydroxyvitamin d3, the active form of vitamin d, through vitamin d receptor (vdr) induces the expression of the gene of tryptophan hydroxylase 2 (tph2), influences the expression of serotonin reuptake transporter (sert) as well as the levels of monoamine oxidase-a (mao-a), the enzyme responsible for serotonin catabolism. |
2021-06-01 |
2023-08-13 |
Not clear |
| Jiawei Li, Ting Dong, Tharushi P Keerthisinghe, Hao Chen, Ming Li, Wenqing Chu, Jingfeng Yang, Zongfu Hu, Shane Allen Snyder, Wu Dong, Mingliang Fan. Long-term oxytetracycline exposure potentially alters brain thyroid hormone and serotonin homeostasis in zebrafish. Journal of hazardous materials. vol 399. 2021-05-14. PMID:32485476. |
for the serotonin (5-ht) synthesis, the expression of tryptophan hydroxylase (tph2) was 41 % and 9.3 % of the control group for 1 and 100 μg/l otc exposed groups; respectively. |
2021-05-14 |
2023-08-13 |
zebrafish |
| Hailan Liu, Chunmei Wang, Meng Yu, Yongjie Yang, Yang He, Hesong Liu, Chen Liang, Longlong Tu, Nan Zhang, Lina Wang, Julia Wang, Feng Liu, Fang Hu, Yong X. TPH2 in the Dorsal Raphe Nuclei Regulates Energy Balance in a Sex-Dependent Manner. Endocrinology. vol 162. issue 1. 2021-05-14. PMID:33034617. |
abstractcentral 5-hydroxytryptamine (5-ht), which is primarily synthesized by tryptophan hydroxylase 2 (tph2) in the dorsal raphe nuclei (drn), plays a pivotal role in the regulation of food intake and body weight. |
2021-05-14 |
2023-08-13 |
mouse |
| Madhusmita P Sahu, Yago Pazos-Boubeta, Anna Steinzeig, Katja Kaurinkoski, Michela Palmisano, Olgierd Borowecki, Timo Petteri Piepponen, Eero Castré. Depletion of TrkB Receptors From Adult Serotonergic Neurons Increases Brain Serotonin Levels, Enhances Energy Metabolism and Impairs Learning and Memory. Frontiers in molecular neuroscience. vol 14. 2021-05-04. PMID:33935645. |
the transgenic mice show increased 5-ht and tph2 levels with abnormal behavioral phenotype. |
2021-05-04 |
2023-08-13 |
mouse |
| Shuhua Lai, Liangpan Shi, Zhixian Jiang, Zhihang Li. Glycyrrhizin treatment ameliorates post-traumatic stress disorder-like behaviours and restores circadian oscillation of intracranial serotonin. Clinical and experimental pharmacology & physiology. vol 47. issue 1. 2021-05-03. PMID:31494960. |
in addition, glycyrrhizin treatment restored the circadian rhythm changes of serotonin and tph2. |
2021-05-03 |
2023-08-13 |
human |
| Sarah Bonk, Johannes Hertel, Helena U Zacharias, Jan Terock, Deborah Janowitz, Georg Homuth, Matthias Nauck, Henry Völzke, Henriette Meyer Zu Schwabedissen, Sandra Van der Auwera, Hans Jörgen Grab. Vitamin D moderates the interaction between 5-HTTLPR and childhood abuse in depressive disorders. Scientific reports. vol 10. issue 1. 2021-04-27. PMID:33372187. |
vitamin d has been shown to stimulate the expression of the tryptophan hydroxylase 2 (tph2) gene, which is the rate-limiting enzyme for serotonin production in the brain. |
2021-04-27 |
2023-08-13 |
Not clear |
| Anna Gorlova, Gabriela Ortega, Jonas Waider, Natalia Bazhenova, Ekaterina Veniaminova, Andrey Proshin, Allan V Kalueff, Daniel C Anthony, Klaus-Peter Lesch, Tatyana Strekalov. Stress-induced aggression in heterozygous TPH2 mutant mice is associated with alterations in serotonin turnover and expression of 5-HT6 and AMPA subunit 2A receptors. Journal of affective disorders. vol 272. 2021-02-15. PMID:32553388. |
stress-induced aggression in heterozygous tph2 mutant mice is associated with alterations in serotonin turnover and expression of 5-ht6 and ampa subunit 2a receptors. |
2021-02-15 |
2023-08-13 |
mouse |