| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jarod Swant, J Shawn Goodwin, Ashley North, Ahmad Abdul Ali, Joyonna Gamble-George, Sanika Chirwa, Habibeh Khoshboue. α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter. The Journal of biological chemistry. vol 286. issue 51. 2012-02-21. PMID:21990355. |
to elucidate the potential functional consequences of dat/α-synuclein interaction, we explored α-synuclein modulation of dat activity in midbrain dopaminergic neurons obtained from th::rfp mice, immortalized da neurons, and a heterologous system expressing dat. |
2012-02-21 |
2023-08-12 |
mouse |
| Lei Phillip Wang, Fei Li, Dong Wang, Kun Xie, Deheng Wang, Xiaoming Shen, Joe Z Tsie. NMDA receptors in dopaminergic neurons are crucial for habit learning. Neuron. vol 72. issue 6. 2012-02-14. PMID:22196339. |
activities of midbrain dopaminergic neurons are regulated by the cortical and subcortical signals among which glutamatergic afferents provide excitatory inputs. |
2012-02-14 |
2023-08-12 |
mouse |
| M Feb. A bold view of the lactating brain: functional magnetic resonance imaging studies of suckling in awake dams. Journal of neuroendocrinology. vol 23. issue 11. 2012-02-10. PMID:21722215. |
suckling was observed to increase blood-oxygen-level-dependent (bold) signal intensity in the midbrain, striatum and prefrontal cortex, which are areas that receive prominent dopaminergic inputs. |
2012-02-10 |
2023-08-12 |
rat |
| Chiung-Chih Chang, Wen-Neng Chang, Chun-Chung Lui, Shu-Hua Huang, Chen-Chang Lee, Ching Chen, Jiun-Jie Wan. Clinical significance of the pallidoreticular pathway in patients with carbon monoxide intoxication. Brain : a journal of neurology. vol 134. issue Pt 12. 2012-02-09. PMID:22094539. |
the post-processing analysis of the neuroimaging included voxel-based morphometry to assess the regional atrophy, tract-based spatial statistics related to white matter involvement, tractography to investigate the rostral and caudal projections from the midbrain level and specific uptake ratios of 99mtc-trodat-1 for presynaptic dopaminergic transporter activity. |
2012-02-09 |
2023-08-12 |
Not clear |
| Krishnan Sriram, Gary X Lin, Amy M Jefferson, Jenny R Roberts, Ronnee N Andrews, Michael L Kashon, James M Antonin. Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicity. Toxicology. vol 291. issue 1-3. 2012-02-06. PMID:22085607. |
trace element analysis revealed selective mn accumulation in dopaminergic brain areas, striatum (str) and midbrain (mb), following exposure to the two fumes. |
2012-02-06 |
2023-08-12 |
rat |
| Syama Sundar Boyalla, Marion Barbara Victor, André Roemgens, Cordian Beyer, Susanne Arnol. Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability. Journal of neuroscience research. vol 89. issue 12. 2012-01-23. PMID:21598289. |
parkinson's disease is a neurodegenerative disorder characterized by a sex and brain region specificity, showing a higher incidence in men than in women, which is caused by cell death of mainly dopaminergic neurons in the mesencephalon. |
2012-01-23 |
2023-08-12 |
mouse |
| Huisheng Liu, Su-Chun Zhan. Specification of neuronal and glial subtypes from human pluripotent stem cells. Cellular and molecular life sciences : CMLS. vol 68. issue 24. 2012-01-19. PMID:21786144. |
following developmental principles, human escs, and lately ipscs, have been effectively differentiated to region- and/or transmitter-specific neuronal and glial types, including cerebral glutamatergic, striatal γ-aminobutyric acid (gaba)-ergic, forebrain cholinergic, midbrain dopaminergic, and spinal motor neurons, as well as astrocytes and oligodendrocytes. |
2012-01-19 |
2023-08-12 |
human |
| Bruno A Benítez, Helen M Belálcazar, Agustín Anastasía, Daniel T Mamah, Charles F Zorumski, Daniel H Mascó, Daniel G Herrera, Gabriel A de Erausqui. Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:21044638. |
in primary cultures of mesencephalon small-conductance calcium-activated potassium channels (sk) are expressed in dopaminergic neurons. |
2012-01-18 |
2023-08-12 |
Not clear |
| Maria Hadjiconstantinou, Norton H Nef. Nicotine and endogenous opioids: neurochemical and pharmacological evidence. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:21108953. |
striatum is rich in opioid peptides and opioid receptors, and striatal opioidergic neurons are engaged in a bidirectional communication with midbrain dopaminergic neurons, closely regulating each other's activity. |
2012-01-18 |
2023-08-12 |
Not clear |
| S Samantaray, V H Knaryan, C Le Gal, S K Ray, N L Bani. Calpain inhibition protected spinal cord motoneurons against 1-methyl-4-phenylpyridinium ion and rotenone. Neuroscience. vol 192. 2012-01-18. PMID:21723922. |
parkinson's disease (pd), characterized by selective midbrain nigrostriatal dopaminergic degeneration, is consistently associated with moderate systemic mitochondrial dysfunction. |
2012-01-18 |
2023-08-12 |
Not clear |
| Yin-Xiu Ding, Li-Chun Wei, Ya-Zhou Wang, Rong Cao, Xi Wang, Liang-Wei Che. Molecular manipulation targeting regulation of dopaminergic differentiation and proliferation of neural stem cells or pluripotent stem cells. CNS & neurological disorders drug targets. vol 10. issue 4. 2012-01-12. PMID:21495963. |
parkinson's disease (pd) is a severe deliberating neurological disease caused by progressive degenerative death of dopaminergic neurons in the substantia nigra of midbrain. |
2012-01-12 |
2023-08-12 |
Not clear |
| Junpeng Zhao, Qunyuan X. Emerging restorative treatments for Parkinson's disease: manipulation and inducement of dopaminergic neurons from adult stem cells. CNS & neurological disorders drug targets. vol 10. issue 4. 2012-01-12. PMID:21495964. |
parkinson's disease (pd) is a common neurodegenerative disease, characterized by a selective loss of midbrain dopaminergic (da) neurons. |
2012-01-12 |
2023-08-12 |
human |
| Xinglong Wang, Bo Su, Wanhong Liu, Xiaohua He, Yuan Gao, Rudy J Castellani, George Perry, Mark A Smith, Xiongwei Zh. DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging cell. vol 10. issue 5. 2012-01-09. PMID:21615675. |
we further validated our findings in primary rat midbrain dopaminergic neurons that 0.5 μm mpp(+) induced mitochondrial fragmentation only in tyrosine hydroxylase (th)-positive dopaminergic neurons in a similar pattern to that in sh-sy5y cells but had no effects on these mitochondrial parameters in th-negative neurons. |
2012-01-09 |
2023-08-12 |
rat |
| Daniel S Zahm, Anita Y Cheng, Tristan J Lee, Comeron W Ghobadi, Zachary M Schwartz, Stefanie Geisler, Kenneth P Parsely, Clemens Gruber, Ruediger W Ve. Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors. The Journal of comparative neurology. vol 519. issue 16. 2012-01-05. PMID:21618227. |
inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors. |
2012-01-05 |
2023-08-12 |
rat |
| Daniel S Zahm, Anita Y Cheng, Tristan J Lee, Comeron W Ghobadi, Zachary M Schwartz, Stefanie Geisler, Kenneth P Parsely, Clemens Gruber, Ruediger W Ve. Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors. The Journal of comparative neurology. vol 519. issue 16. 2012-01-05. PMID:21618227. |
the midbrain dopaminergic neuronal groups a8, a9, a10, and a10dc occupy, respectively, the retrorubral field (rrf), substantia nigra compacta (snc), ventral tegmental area (vta), and ventrolateral periaqueductal gray (pagvl). |
2012-01-05 |
2023-08-12 |
rat |
| R M Krebs, D Heipertz, H Schuetze, E Duze. Novelty increases the mesolimbic functional connectivity of the substantia nigra/ventral tegmental area (SN/VTA) during reward anticipation: Evidence from high-resolution fMRI. NeuroImage. vol 58. issue 2. 2011-12-21. PMID:21723396. |
reward and novelty are potent learning signals that critically rely on dopaminergic midbrain responses. |
2011-12-21 |
2023-08-12 |
human |
| Andreas Pedroni, Susan Koeneke, Agne Velickaite, Lutz Jänck. Differential magnitude coding of gains and omitted rewards in the ventral striatum. Brain research. vol 1411. 2011-12-21. PMID:21831362. |
physiologic studies revealed that neurons in the dopaminergic midbrain of non-human primates encode reward prediction errors. |
2011-12-21 |
2023-08-12 |
human |
| Andreas Pedroni, Susan Koeneke, Agne Velickaite, Lutz Jänck. Differential magnitude coding of gains and omitted rewards in the ventral striatum. Brain research. vol 1411. 2011-12-21. PMID:21831362. |
congruently, neuroimaging studies in humans demonstrated that bold-responses in the ventral striatum encode reward prediction errors in similar fashion as dopaminergic midbrain neurons, suggesting that these bold-responses may be driven by dopaminergic midbrain activity. |
2011-12-21 |
2023-08-12 |
human |
| Andreas Pedroni, Susan Koeneke, Agne Velickaite, Lutz Jänck. Differential magnitude coding of gains and omitted rewards in the ventral striatum. Brain research. vol 1411. 2011-12-21. PMID:21831362. |
however, neuroimaging results are ambiguous with respect to the adaptive scaling of reward prediction errors, leading to the conjecture that under certain circumstances other than dopaminergic midbrain input may drive ventral striatal bold-responses. |
2011-12-21 |
2023-08-12 |
human |
| Mario F Wulliman. Basal ganglia: insights into origins from lamprey brains. Current biology : CB. vol 21. issue 13. 2011-12-20. PMID:21741583. |
the lamprey brain has now been shown to have basal ganglia circuitry, with an output that acts tonically on midbrain and brainstem motor centers and is modulated by ascending dopaminergic input. |
2011-12-20 |
2023-08-12 |
Not clear |