| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Samantaray, V H Knaryan, C Le Gal, S K Ray, N L Bani. Calpain inhibition protected spinal cord motoneurons against 1-methyl-4-phenylpyridinium ion and rotenone. Neuroscience. vol 192. 2012-01-18. PMID:21723922. |
parkinson's disease (pd), characterized by selective midbrain nigrostriatal dopaminergic degeneration, is consistently associated with moderate systemic mitochondrial dysfunction. |
2012-01-18 |
2023-08-12 |
Not clear |
| Yin-Xiu Ding, Li-Chun Wei, Ya-Zhou Wang, Rong Cao, Xi Wang, Liang-Wei Che. Molecular manipulation targeting regulation of dopaminergic differentiation and proliferation of neural stem cells or pluripotent stem cells. CNS & neurological disorders drug targets. vol 10. issue 4. 2012-01-12. PMID:21495963. |
parkinson's disease (pd) is a severe deliberating neurological disease caused by progressive degenerative death of dopaminergic neurons in the substantia nigra of midbrain. |
2012-01-12 |
2023-08-12 |
Not clear |
| Junpeng Zhao, Qunyuan X. Emerging restorative treatments for Parkinson's disease: manipulation and inducement of dopaminergic neurons from adult stem cells. CNS & neurological disorders drug targets. vol 10. issue 4. 2012-01-12. PMID:21495964. |
parkinson's disease (pd) is a common neurodegenerative disease, characterized by a selective loss of midbrain dopaminergic (da) neurons. |
2012-01-12 |
2023-08-12 |
human |
| Xinglong Wang, Bo Su, Wanhong Liu, Xiaohua He, Yuan Gao, Rudy J Castellani, George Perry, Mark A Smith, Xiongwei Zh. DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging cell. vol 10. issue 5. 2012-01-09. PMID:21615675. |
we further validated our findings in primary rat midbrain dopaminergic neurons that 0.5 μm mpp(+) induced mitochondrial fragmentation only in tyrosine hydroxylase (th)-positive dopaminergic neurons in a similar pattern to that in sh-sy5y cells but had no effects on these mitochondrial parameters in th-negative neurons. |
2012-01-09 |
2023-08-12 |
rat |
| Daniel S Zahm, Anita Y Cheng, Tristan J Lee, Comeron W Ghobadi, Zachary M Schwartz, Stefanie Geisler, Kenneth P Parsely, Clemens Gruber, Ruediger W Ve. Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors. The Journal of comparative neurology. vol 519. issue 16. 2012-01-05. PMID:21618227. |
inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors. |
2012-01-05 |
2023-08-12 |
rat |
| Daniel S Zahm, Anita Y Cheng, Tristan J Lee, Comeron W Ghobadi, Zachary M Schwartz, Stefanie Geisler, Kenneth P Parsely, Clemens Gruber, Ruediger W Ve. Inputs to the midbrain dopaminergic complex in the rat, with emphasis on extended amygdala-recipient sectors. The Journal of comparative neurology. vol 519. issue 16. 2012-01-05. PMID:21618227. |
the midbrain dopaminergic neuronal groups a8, a9, a10, and a10dc occupy, respectively, the retrorubral field (rrf), substantia nigra compacta (snc), ventral tegmental area (vta), and ventrolateral periaqueductal gray (pagvl). |
2012-01-05 |
2023-08-12 |
rat |
| R M Krebs, D Heipertz, H Schuetze, E Duze. Novelty increases the mesolimbic functional connectivity of the substantia nigra/ventral tegmental area (SN/VTA) during reward anticipation: Evidence from high-resolution fMRI. NeuroImage. vol 58. issue 2. 2011-12-21. PMID:21723396. |
reward and novelty are potent learning signals that critically rely on dopaminergic midbrain responses. |
2011-12-21 |
2023-08-12 |
human |
| Andreas Pedroni, Susan Koeneke, Agne Velickaite, Lutz Jänck. Differential magnitude coding of gains and omitted rewards in the ventral striatum. Brain research. vol 1411. 2011-12-21. PMID:21831362. |
physiologic studies revealed that neurons in the dopaminergic midbrain of non-human primates encode reward prediction errors. |
2011-12-21 |
2023-08-12 |
human |
| Andreas Pedroni, Susan Koeneke, Agne Velickaite, Lutz Jänck. Differential magnitude coding of gains and omitted rewards in the ventral striatum. Brain research. vol 1411. 2011-12-21. PMID:21831362. |
congruently, neuroimaging studies in humans demonstrated that bold-responses in the ventral striatum encode reward prediction errors in similar fashion as dopaminergic midbrain neurons, suggesting that these bold-responses may be driven by dopaminergic midbrain activity. |
2011-12-21 |
2023-08-12 |
human |
| Andreas Pedroni, Susan Koeneke, Agne Velickaite, Lutz Jänck. Differential magnitude coding of gains and omitted rewards in the ventral striatum. Brain research. vol 1411. 2011-12-21. PMID:21831362. |
however, neuroimaging results are ambiguous with respect to the adaptive scaling of reward prediction errors, leading to the conjecture that under certain circumstances other than dopaminergic midbrain input may drive ventral striatal bold-responses. |
2011-12-21 |
2023-08-12 |
human |
| Mario F Wulliman. Basal ganglia: insights into origins from lamprey brains. Current biology : CB. vol 21. issue 13. 2011-12-20. PMID:21741583. |
the lamprey brain has now been shown to have basal ganglia circuitry, with an output that acts tonically on midbrain and brainstem motor centers and is modulated by ascending dopaminergic input. |
2011-12-20 |
2023-08-12 |
Not clear |
| S R L Stacpoole, B Bilican, D J Webber, A Luzhynskaya, X L He, A Compston, R Karadottir, R J M Franklin, S Chandra. Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen. Nature protocols. vol 6. issue 8. 2011-12-15. PMID:21799491. |
efficient derivation of npcs, spinal motor neurons and midbrain dopaminergic neurons from hescs at 3% oxygen. |
2011-12-15 |
2023-08-12 |
human |
| S R L Stacpoole, B Bilican, D J Webber, A Luzhynskaya, X L He, A Compston, R Karadottir, R J M Franklin, S Chandra. Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen. Nature protocols. vol 6. issue 8. 2011-12-15. PMID:21799491. |
alternatively, addition of fibroblast growth factor-8 and pm generates midbrain dopaminergic neurons. |
2011-12-15 |
2023-08-12 |
human |
| b' Elena Mi\\xc3\\xb1ones-Moyano, S\\xc3\\xadlvia Porta, Georgia Escaram\\xc3\\xads, Raquel Rabionet, Susana Iraola, Birgit Kagerbauer, Yolanda Espinosa-Parrilla, Isidre Ferrer, Xavier Estivill, Eul\\xc3\\xa0lia Mart\\xc3\\xa. MicroRNA profiling of Parkinson\'s disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function. Human molecular genetics. vol 20. issue 15. 2011-12-14. PMID:21558425.' |
parkinson's disease (pd) is the second most common neurodegenerative disorder, characterized by the presence of protein inclusions or lewy bodies and a progressive loss of dopaminergic neurons in the midbrain. |
2011-12-14 |
2023-08-12 |
Not clear |
| Anna Rieckmann, Sari Karlsson, Per Karlsson, Yvonne Brehmer, Håkan Fischer, Lars Farde, Lars Nyberg, Lars Bäckma. Dopamine D1 receptor associations within and between dopaminergic pathways in younger and elderly adults: links to cognitive performance. Cerebral cortex (New York, N.Y. : 1991). vol 21. issue 9. 2011-12-09. PMID:21258043. |
furthermore, interregional correlations in d1 bp between da pathways were uniformly high in younger adults, indicating that d1 receptor densities in striatal, limbic, and cortical areas are not regulated independently, despite dopaminergic innervation from different midbrain areas. |
2011-12-09 |
2023-08-12 |
Not clear |
| Yi Guo, Wei-Dong Le, Joseph Jankovic, Hua-Rong Yang, Hong-Bo Xu, Wen-Jie Xie, Zhi Song, Hao Den. Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 9. 2011-12-08. PMID:21469209. |
paired-like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons. |
2011-12-08 |
2023-08-12 |
Not clear |
| Stéphanie Vuillermot, Joram Feldon, Urs Meye. Relationship between sensorimotor gating deficits and dopaminergic neuroanatomy in Nurr1-deficient mice. Experimental neurology. vol 232. issue 1. 2011-12-07. PMID:21820432. |
to test this hypothesis, we followed a within-subject approach in which sensorimotor gating performance was correlated with post-mortem expression of several dopaminergic markers in relevant striatal and midbrain regions. |
2011-12-07 |
2023-08-12 |
mouse |
| David W Anderson, Rebecca C Schray, Gregg Duester, Jay S Schneide. Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system. Brain research. vol 1408. 2011-11-29. PMID:21784415. |
in the brain, aldh1a1 participates in the metabolism of catecholamines including dopamine (da) and norepinephrine, but is uniquely expressed in a subset of dopaminergic (daergic) neurons in the ventral mesencephalon where it converts 3,4-dihydroxyphenylacetaldehyde, a potentially toxic aldehyde, to 3,4-dihydroxyphenylacetic acid, a non toxic metabolite. |
2011-11-29 |
2023-08-12 |
mouse |
| Ines Jaeger, Charles Arber, Jessica R Risner-Janiczek, Judit Kuechler, Diana Pritzsche, I-Cheng Chen, Thulasi Naveenan, Mark A Ungless, Meng L. Temporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cells. Development (Cambridge, England). vol 138. issue 20. 2011-11-28. PMID:21880784. |
temporally controlled modulation of fgf/erk signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cells. |
2011-11-28 |
2023-08-12 |
mouse |
| Lixiang Ma, Yan Liu, Su-Chun Zhan. Directed differentiation of dopamine neurons from human pluripotent stem cells. Methods in molecular biology (Clifton, N.J.). vol 767. 2011-11-24. PMID:21822892. |
midbrain dopaminergic (mda) neurons play a critical role in regulating postural reflexes and movement as well as modulating psychological processes. |
2011-11-24 |
2023-08-12 |
human |