| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diogo Ribeiro, Kristina Ellwanger, Désirée Glagow, Spyridon Theofilopoulos, Nina S Corsini, Ana Martin-Villalba, Christof Niehrs, Ernest Arena. Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis. PloS one. vol 6. issue 2. 2012-04-02. PMID:21347250. |
the wnt/β-catenin pathway is also known to regulate different aspects of ventral midbrain (vm) dopaminergic (da) neuron development and, in vitro, dkk1-mediated inhibition of the wnt/β-catenin pathway improves the da differentiation in mouse embryonic stem cells (mesc). |
2012-04-02 |
2023-08-12 |
mouse |
| Lisa R Beutler, Kiara C Eldred, Albert Quintana, C Dirk Keene, Shannon E Rose, Nadia Postupna, Thomas J Montine, Richard D Palmite. Severely impaired learning and altered neuronal morphology in mice lacking NMDA receptors in medium spiny neurons. PloS one. vol 6. issue 11. 2012-04-02. PMID:22132236. |
the striatum is composed predominantly of medium spiny neurons (msns) that integrate excitatory, glutamatergic inputs from the cortex and thalamus, and modulatory dopaminergic inputs from the ventral midbrain to influence behavior. |
2012-04-02 |
2023-08-12 |
mouse |
| Blake Byers, Branden Cord, Ha Nam Nguyen, Birgitt Schüle, Lief Fenno, Patrick C Lee, Karl Deisseroth, J William Langston, Renee Reijo Pera, Theo D Palme. SNCA triplication Parkinson's patient's iPSC-derived DA neurons accumulate α-synuclein and are susceptible to oxidative stress. PloS one. vol 6. issue 11. 2012-03-26. PMID:22110584. |
here we report the generation of ipsc-derived midbrain dopaminergic neurons from a patient with a triplication in the α-synuclein gene (snca). |
2012-03-26 |
2023-08-12 |
Not clear |
| J A Goldberg, H Bergma. Computational physiology of the neural networks of the primate globus pallidus: function and dysfunction. Neuroscience. vol 198. 2012-03-22. PMID:21925240. |
finally, degeneration of midbrain dopaminergic neurons and striatal dopamine depletion (as in parkinson's disease) lead to augmentation of striatal excitability and competitive dynamics. |
2012-03-22 |
2023-08-12 |
Not clear |
| L-H Yu, Z-F Lin, Y Liu, F-Y Hu, X-H He, Z-L Liu, Y-M X. The transcription factor Pitx3 is a risk modifier for Parkinson's disease in a Chinese Han population. European journal of neurology. vol 18. issue 5. 2012-03-16. PMID:21138504. |
the transcription factor pitx3 plays a crucial role in the development and survival of midbrain dopaminergic (mda) neurons, especially the mda neurons in the substantia nigra pars compacta. |
2012-03-16 |
2023-08-12 |
Not clear |
| Ane Korff, Brenda Pfeiffer, Michelle Smeyne, Mehmet Kocak, Ronald F Pfeiffer, Richard Jay Smeyn. Alterations in glutathione S-transferase pi expression following exposure to MPP+ -induced oxidative stress in the blood of Parkinson's disease patients. Parkinsonism & related disorders. vol 17. issue 10. 2012-03-13. PMID:21840241. |
the major motor symptoms of parkinson's disease do not occur until a majority of the dopaminergic neurons in the midbrain snpc have already died. |
2012-03-13 |
2023-08-12 |
Not clear |
| Jie Zhang, Ling-Ling Zhao, Zhi-Ping Hu, Jun Zhou, Li Deng, Fen Gu, Hong-Mei Dai, Min Huan. [Effects of low-dose chlorpyrifos exposure on dopaminergic neurons in the midbrain substantia nigra and neural behavioral development in neonatal rats]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 13. issue 12. 2012-03-13. PMID:22172267. |
[effects of low-dose chlorpyrifos exposure on dopaminergic neurons in the midbrain substantia nigra and neural behavioral development in neonatal rats]. |
2012-03-13 |
2023-08-12 |
rat |
| Jie Zhang, Ling-Ling Zhao, Zhi-Ping Hu, Jun Zhou, Li Deng, Fen Gu, Hong-Mei Dai, Min Huan. [Effects of low-dose chlorpyrifos exposure on dopaminergic neurons in the midbrain substantia nigra and neural behavioral development in neonatal rats]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 13. issue 12. 2012-03-13. PMID:22172267. |
to explore the effects of low-dose chlorpyrifos (cpf) exposure on dopaminergic (da) neurons in the midbrain substantia nigra and neural behavioral development in neonatal rats. |
2012-03-13 |
2023-08-12 |
rat |
| Sarah A Heimovics, Katrina G Salvante, Keith W Sockman, Lauren V Riter. Individual differences in the motivation to communicate relate to levels of midbrain and striatal catecholamine markers in male European starlings. Hormones and behavior. vol 60. issue 5. 2012-03-09. PMID:21907203. |
across vertebrates dopaminergic projections from the ventral tegmental area (vta) and midbrain central gray (gct) strongly influence motivated, reward-directed behaviors. |
2012-03-09 |
2023-08-12 |
Not clear |
| Y Jin, C Zhang, K S Ziemba, G A Goldstein, P G Sullivan, G M Smit. Directing dopaminergic fiber growth along a preformed molecular pathway from embryonic ventral mesencephalon transplants in the rat brain. Journal of neuroscience research. vol 89. issue 5. 2012-02-22. PMID:21337366. |
directing dopaminergic fiber growth along a preformed molecular pathway from embryonic ventral mesencephalon transplants in the rat brain. |
2012-02-22 |
2023-08-12 |
rat |
| Y Jin, C Zhang, K S Ziemba, G A Goldstein, P G Sullivan, G M Smit. Directing dopaminergic fiber growth along a preformed molecular pathway from embryonic ventral mesencephalon transplants in the rat brain. Journal of neuroscience research. vol 89. issue 5. 2012-02-22. PMID:21337366. |
to identify guidance molecules to promote long-distance growth of dopaminergic axons from transplanted embryonic ventral mesencephalon (vm) tissue, three pathways were created by expressing green fluorescent protein (gfp), glial cell line-derived neurotrophic factor (gdnf), or a combination of gdnf/gdnf receptor α1 (gfrα1) along the corpus callosum. |
2012-02-22 |
2023-08-12 |
rat |
| Jarod Swant, J Shawn Goodwin, Ashley North, Ahmad Abdul Ali, Joyonna Gamble-George, Sanika Chirwa, Habibeh Khoshboue. α-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter. The Journal of biological chemistry. vol 286. issue 51. 2012-02-21. PMID:21990355. |
to elucidate the potential functional consequences of dat/α-synuclein interaction, we explored α-synuclein modulation of dat activity in midbrain dopaminergic neurons obtained from th::rfp mice, immortalized da neurons, and a heterologous system expressing dat. |
2012-02-21 |
2023-08-12 |
mouse |
| Lei Phillip Wang, Fei Li, Dong Wang, Kun Xie, Deheng Wang, Xiaoming Shen, Joe Z Tsie. NMDA receptors in dopaminergic neurons are crucial for habit learning. Neuron. vol 72. issue 6. 2012-02-14. PMID:22196339. |
activities of midbrain dopaminergic neurons are regulated by the cortical and subcortical signals among which glutamatergic afferents provide excitatory inputs. |
2012-02-14 |
2023-08-12 |
mouse |
| M Feb. A bold view of the lactating brain: functional magnetic resonance imaging studies of suckling in awake dams. Journal of neuroendocrinology. vol 23. issue 11. 2012-02-10. PMID:21722215. |
suckling was observed to increase blood-oxygen-level-dependent (bold) signal intensity in the midbrain, striatum and prefrontal cortex, which are areas that receive prominent dopaminergic inputs. |
2012-02-10 |
2023-08-12 |
rat |
| Chiung-Chih Chang, Wen-Neng Chang, Chun-Chung Lui, Shu-Hua Huang, Chen-Chang Lee, Ching Chen, Jiun-Jie Wan. Clinical significance of the pallidoreticular pathway in patients with carbon monoxide intoxication. Brain : a journal of neurology. vol 134. issue Pt 12. 2012-02-09. PMID:22094539. |
the post-processing analysis of the neuroimaging included voxel-based morphometry to assess the regional atrophy, tract-based spatial statistics related to white matter involvement, tractography to investigate the rostral and caudal projections from the midbrain level and specific uptake ratios of 99mtc-trodat-1 for presynaptic dopaminergic transporter activity. |
2012-02-09 |
2023-08-12 |
Not clear |
| Krishnan Sriram, Gary X Lin, Amy M Jefferson, Jenny R Roberts, Ronnee N Andrews, Michael L Kashon, James M Antonin. Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicity. Toxicology. vol 291. issue 1-3. 2012-02-06. PMID:22085607. |
trace element analysis revealed selective mn accumulation in dopaminergic brain areas, striatum (str) and midbrain (mb), following exposure to the two fumes. |
2012-02-06 |
2023-08-12 |
rat |
| Syama Sundar Boyalla, Marion Barbara Victor, André Roemgens, Cordian Beyer, Susanne Arnol. Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability. Journal of neuroscience research. vol 89. issue 12. 2012-01-23. PMID:21598289. |
parkinson's disease is a neurodegenerative disorder characterized by a sex and brain region specificity, showing a higher incidence in men than in women, which is caused by cell death of mainly dopaminergic neurons in the mesencephalon. |
2012-01-23 |
2023-08-12 |
mouse |
| Huisheng Liu, Su-Chun Zhan. Specification of neuronal and glial subtypes from human pluripotent stem cells. Cellular and molecular life sciences : CMLS. vol 68. issue 24. 2012-01-19. PMID:21786144. |
following developmental principles, human escs, and lately ipscs, have been effectively differentiated to region- and/or transmitter-specific neuronal and glial types, including cerebral glutamatergic, striatal γ-aminobutyric acid (gaba)-ergic, forebrain cholinergic, midbrain dopaminergic, and spinal motor neurons, as well as astrocytes and oligodendrocytes. |
2012-01-19 |
2023-08-12 |
human |
| Bruno A Benítez, Helen M Belálcazar, Agustín Anastasía, Daniel T Mamah, Charles F Zorumski, Daniel H Mascó, Daniel G Herrera, Gabriel A de Erausqui. Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:21044638. |
in primary cultures of mesencephalon small-conductance calcium-activated potassium channels (sk) are expressed in dopaminergic neurons. |
2012-01-18 |
2023-08-12 |
Not clear |
| Maria Hadjiconstantinou, Norton H Nef. Nicotine and endogenous opioids: neurochemical and pharmacological evidence. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:21108953. |
striatum is rich in opioid peptides and opioid receptors, and striatal opioidergic neurons are engaged in a bidirectional communication with midbrain dopaminergic neurons, closely regulating each other's activity. |
2012-01-18 |
2023-08-12 |
Not clear |