| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomás González-Hernández, Ignacio Cruz-Muros, Domingo Afonso-Oramas, Josmar Salas-Hernandez, Javier Castro-Hernande. Vulnerability of mesostriatal dopaminergic neurons in Parkinson's disease. Frontiers in neuroanatomy. vol 4. 2011-07-14. PMID:21079748. |
the term vulnerability was first associated with the midbrain dopaminergic neurons 85 years ago, before they were identified as monoaminergic neurons, when foix and nicolesco (1925) reported the loss of neuromelanin containing neurons in the midbrain of patients with post-encephalitic parkinson's disease (pd). |
2011-07-14 |
2023-08-12 |
Not clear |
| Tomás González-Hernández, Ignacio Cruz-Muros, Domingo Afonso-Oramas, Josmar Salas-Hernandez, Javier Castro-Hernande. Vulnerability of mesostriatal dopaminergic neurons in Parkinson's disease. Frontiers in neuroanatomy. vol 4. 2011-07-14. PMID:21079748. |
a few years later, hassler (1938) showed that degeneration is more intense in the ventral tier of the substantia nigra compacta than in its dorsal tier and the ventral tegmental area (vta), outlining the concept of differential vulnerability of midbrain dopaminergic (da-) neurons. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jean-Luc Dreye. New insights into the roles of microRNAs in drug addiction and neuroplasticity. Genome medicine. vol 2. issue 12. 2011-07-14. PMID:21205279. |
recent studies have identified changes of several specific mirna expression profiles and polymorphisms affecting the interactions between mirnas and their targets in various brain disorders, including addiction: mir-16 causes adaptive changes in production of the serotonin transporter; mir-133b is specifically expressed in midbrain dopaminergic neurons, and regulates the production of tyrosine hydroxylase and the dopamine transporter; mir-212 affects production of striatal brain-derived neurotrophic factor and synaptic plasticity upon cocaine. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jasmin Delic, Herbert Zimmerman. Nucleotides affect neurogenesis and dopaminergic differentiation of mouse fetal midbrain-derived neural precursor cells. Purinergic signalling. vol 6. issue 4. 2011-07-14. PMID:21437012. |
the fetal midbrain is a preferred source for isolating and producing dopaminergic neurons for subsequent grafting and replacement of damaged or lost dopaminergic midbrain neurons. |
2011-07-14 |
2023-08-12 |
mouse |
| Bobby Thomas, M Flint Bea. Molecular insights into Parkinson's disease. F1000 medicine reports. vol 3. 2011-07-14. PMID:21655332. |
parkinson's disease is a neurodegenerative movement disorder characterized by loss of midbrain dopaminergic neurons leading to motor abnormalities and autonomic dysfunctions. |
2011-07-14 |
2023-08-12 |
Not clear |
| Anna Zinger, Carlos Barcia, Maria Trinidad Herrero, Gilles J Guillemi. The involvement of neuroinflammation and kynurenine pathway in Parkinson's disease. Parkinson's disease. vol 2011. 2011-07-14. PMID:21687761. |
parkinson's disease (pd) is a common neurodegenerative disorder characterised by loss of dopaminergic neurons and localized neuroinflammation occurring in the midbrain several years before the actual onset of symptoms. |
2011-07-14 |
2023-08-12 |
Not clear |
| James P Dugan, Andrea Stratton, Hilary P Riley, W Todd Farmer, Grant S Mastic. Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals. Molecular and cellular neurosciences. vol 46. issue 1. 2011-07-05. PMID:21118670. |
midbrain dopaminergic axons are guided longitudinally through the diencephalon by slit/robo signals. |
2011-07-05 |
2023-08-12 |
mouse |
| Kouta Kanno, Shoichi Ishiur. Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats. Journal of neuroscience research. vol 89. issue 4. 2011-06-10. PMID:21290414. |
we also found that each hesr was expressed in the dopaminergic neurons in the mouse midbrain. |
2011-06-10 |
2023-08-12 |
mouse |
| T Kato, Y Abe, H Sotoyama, A Kakita, R Kominami, S Hirokawa, M Ozaki, H Takahashi, H Naw. Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: implication in neurodevelopmental hypothesis for schizophrenia. Molecular psychiatry. vol 16. issue 3. 2011-06-03. PMID:20142818. |
human midbrain dopaminergic neurons highly express nrg1 receptors (erbb4). |
2011-06-03 |
2023-08-12 |
mouse |
| Tomoyuki Furuyashiki, Shuh Narumiy. Stress responses: the contribution of prostaglandin E(2) and its receptors. Nature reviews. Endocrinology. vol 7. issue 3. 2011-06-02. PMID:21116297. |
during psychological stress, ep1 suppresses impulsive behaviors via the midbrain dopaminergic systems. |
2011-06-02 |
2023-08-12 |
mouse |
| Kavita Prasad, Elizabeth Tarasewicz, Pamela A Ohman Strickland, Michael O'Neill, Stephen N Mitchell, Kalpana Merchant, Samnang Tep, Kathryn Hilton, Akash Datwani, Manuel Buttini, Sarah Mueller-Steiner, Eric K Richfiel. Biochemical and morphological consequences of human α-synuclein expression in a mouse α-synuclein null background. The European journal of neuroscience. vol 33. issue 4. 2011-05-31. PMID:21272100. |
hemizygous congenic mice did not exhibit any change in the number or size of dopaminergic neurons in the ventral midbrain at 9 months of age. |
2011-05-31 |
2023-08-12 |
mouse |
| Sameer A Sheth, Tarek Abuelem, John T Gale, Emad N Eskanda. Basal ganglia neurons dynamically facilitate exploration during associative learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 13. 2011-05-30. PMID:21451026. |
it also receives projections from midbrain dopaminergic neurons, whose phasic activity reflects a reward prediction error signal. |
2011-05-30 |
2023-08-12 |
monkey |
| Carsten N Boehler, Jens-Max Hopf, Ruth M Krebs, Christian M Stoppel, Mircea A Schoenfeld, Hans-Jochen Heinze, Toemme Noessel. Task-load-dependent activation of dopaminergic midbrain areas in the absence of reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 13. 2011-05-30. PMID:21451034. |
task-load-dependent activation of dopaminergic midbrain areas in the absence of reward. |
2011-05-30 |
2023-08-12 |
human |
| Dustin R Wakeman, Hemraj B Dodiya, Jeffrey H Kordowe. Cell transplantation and gene therapy in Parkinson's disease. The Mount Sinai journal of medicine, New York. vol 78. issue 1. 2011-05-24. PMID:21259269. |
parkinson's disease is a progressive neurodegenerative disorder affecting, in part, dopaminergic motor neurons of the ventral midbrain and their terminal projections that course to the striatum. |
2011-05-24 |
2023-08-12 |
Not clear |
| Li Jiao, Yong Zhang, Chun Hu, Yong-Gang Wang, Aijun Huang, Cheng H. Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth. Cell research. vol 21. issue 2. 2011-05-19. PMID:20877310. |
glial cell line-derived neurotrophic factor (gdnf) was originally recognized for its ability to promote survival of midbrain dopaminergic neurons, but it has since been demonstrated to be crucial for the survival and differentiation of many neuronal subpopulations, including motor neurons, sympathetic neurons, sensory neurons and enteric neurons. |
2011-05-19 |
2023-08-12 |
Not clear |
| Li Jiao, Yong Zhang, Chun Hu, Yong-Gang Wang, Aijun Huang, Cheng H. Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth. Cell research. vol 21. issue 2. 2011-05-19. PMID:20877310. |
endogenous rap1gap co-immunoprecipitated with ret in neural tissues, and ret and rap1gap were co-expressed in dopaminergic neurons of the mesencephalon. |
2011-05-19 |
2023-08-12 |
Not clear |
| Clelia Pellicano, Dario Benincasa, Vincenzo Pisani, Francesca R Buttarelli, Morena Giovannelli, Francesco E Pontier. Prodromal non-motor symptoms of Parkinson's disease. Neuropsychiatric disease and treatment. vol 3. issue 1. 2011-05-17. PMID:19300544. |
thus the original view of pd as a disease characterized by selective damage of the dopaminergic neurons in the mesencephalon should be updated into the concept of a severe multisystemic neurodegenerative disorder. |
2011-05-17 |
2023-08-12 |
Not clear |
| Kathryn C Dickerson, Jian Li, Mauricio R Delgad. Parallel contributions of distinct human memory systems during probabilistic learning. NeuroImage. vol 55. issue 1. 2011-05-13. PMID:21056678. |
given the connectivity of both structures with dopaminergic midbrain centers, we further applied a reinforcement learning algorithm often used to highlight the role of dopamine in human reward related learning paradigms. |
2011-05-13 |
2023-08-12 |
human |
| Emily Gale, Meng L. Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells. Molecular brain. vol 1. 2011-05-02. PMID:18826576. |
the midbrain dopaminergic (mda) neurons of the substantia nigra and the ventral tegmental area play a fundamental role in the control of voluntary movement and the regulation of emotion, and are severely affected in parkinson's disease. |
2011-05-02 |
2023-08-12 |
mouse |
| Joshua M Shulman, Philip L De Jager, Mel B Fean. Parkinson's disease: genetics and pathogenesis. Annual review of pathology. vol 6. 2011-04-25. PMID:21034221. |
although the disease remains defined clinically by its cardinal motor manifestations and pathologically by midbrain dopaminergic cell loss in association with lewy bodies, it is now recognized that pd has substantially more widespread impact, causing a host of nonmotor symptoms and associated pathology in multiple regions throughout the nervous system. |
2011-04-25 |
2023-08-12 |
Not clear |