| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
postmortem stereological cell counts of dopaminergic neurons in the ventral midbrain, and intensity measurements of dat and tyrosine hydroxylase (th) immunoreactivity in the striatum were performed and correlated with striatal and ventral midbrain pet data. |
2010-11-12 |
2023-08-12 |
monkey |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
three additional monkeys were used as controls for midbrain dopaminergic cell counts, and striatal dat or th immunoreactivity measurements. |
2010-11-12 |
2023-08-12 |
monkey |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
the (18)f-fecnt binding potential of the ventral midbrain and striatal regions was tightly correlated with postmortem stereological cell counts of nigral dopaminergic neurons (r²=0.91), and striatal dat (r²=0.83) or th (r²=0.88) immunoreactivity intensity measurements. |
2010-11-12 |
2023-08-12 |
monkey |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
these findings demonstrate that (18)f-fecnt is a highly sensitive pet imaging ligand to quantify both striatal dopamine denervation and midbrain dopaminergic cell loss associated with parkinsonism. |
2010-11-12 |
2023-08-12 |
monkey |
| N Iu Ivliev. [Mesocorticolimbic dopaminergic system in adaptive behavior]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 60. issue 3. 2010-11-02. PMID:20737889. |
the midbrain dopaminergic system is traditionally considered as a 'common neural currency' for rewards of most kinds. |
2010-11-02 |
2023-08-12 |
Not clear |
| Cédric Lamy, Jacqueline Scuvée-Moreau, Sébastien Dilly, Jean-François Liégeois, Vincent Seuti. The sigma agonist 1,3-di-o-tolyl-guanidine directly blocks SK channels in dopaminergic neurons and in cell lines. European journal of pharmacology. vol 641. issue 1. 2010-10-28. PMID:20546722. |
because many interactions between sigma receptors and brain dopaminergic systems have been reported, we set out to examine putative effects of sigma receptor ligands on the sk mediated mahp in midbrain dopaminergic neurons. |
2010-10-28 |
2023-08-12 |
rat |
| Shahrooz Vahedi, Mehrnoosh Rajabian, Arman Misaghian, Daniel Grbec, Horst H Simon, Kambiz N Alavia. Parkinson's disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons. Journal of biomedical science. vol 17. 2010-10-28. PMID:20716345. |
parkinson's disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons. |
2010-10-28 |
2023-08-12 |
human |
| Shahrooz Vahedi, Mehrnoosh Rajabian, Arman Misaghian, Daniel Grbec, Horst H Simon, Kambiz N Alavia. Parkinson's disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons. Journal of biomedical science. vol 17. 2010-10-28. PMID:20716345. |
the pathological hallmark of the disease is degeneration of midbrain dopaminergic neurons. |
2010-10-28 |
2023-08-12 |
human |
| Patricia Rojas, Eliza Joodmardi, Thomas Perlmann, Sven Ove Ogre. Rapid increase of Nurr1 mRNA expression in limbic and cortical brain structures related to coping with depression-like behavior in mice. Journal of neuroscience research. vol 88. issue 10. 2010-10-26. PMID:20175204. |
nurr1 is essential to the differentiation, maturation, and maintenance of midbrain dopaminergic neurons and is expressed in different brain regions. |
2010-10-26 |
2023-08-12 |
mouse |
| Tatsuya Ohnuki, Atsushi Nakamura, Shigeru Okuyama, Shoji Nakamur. Gene expression profiling in progressively MPTP-lesioned macaques reveals molecular pathways associated with sporadic Parkinson's disease. Brain research. vol 1346. 2010-10-19. PMID:20513370. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons. |
2010-10-19 |
2023-08-12 |
monkey |
| Ada Ledonne, Mauro Federici, Michela Giustizieri, Mauro Pessia, Paola Imbrici, Mark J Millan, Giorgio Bernardi, Nicola B Mercur. Trace amines depress D(2)-autoreceptor-mediated responses on midbrain dopaminergic cells. British journal of pharmacology. vol 160. issue 6. 2010-10-19. PMID:20590640. |
trace amines depress d(2)-autoreceptor-mediated responses on midbrain dopaminergic cells. |
2010-10-19 |
2023-08-12 |
Not clear |
| Takashi Taten. A small-conductance Ca2+-dependent K+ current regulates dopamine neuron activity: a combined approach of dynamic current clamping and intracellular imaging of calcium signals. Neuroreport. vol 21. issue 10. 2010-10-18. PMID:20508546. |
to analyze the small-conductance calcium-dependent k current observed in dopaminergic neurons of the rat midbrain, we have developed a new dynamic current clamping method that incorporates recording of intracellular ca levels. |
2010-10-18 |
2023-08-12 |
rat |
| J H Sun, Q Gao, J Zhang, L H Bao, H M Dong, N Liang, G B Li, Z H Li, Y M Ga. Ephrinb3 induces mesostriatal dopaminergic projection to the striatum. Biochemical and biophysical research communications. vol 400. issue 2. 2010-10-13. PMID:20719236. |
dopaminergic neurons in midbrain are subdivided into three subsets, forming mesostriatal, mesocortical and mesolimbic projections, respectively. |
2010-10-13 |
2023-08-12 |
Not clear |
| Katsuaki Suzuki, Kyoko Okada, Tomoyasu Wakuda, Chie Shinmura, Yosuke Kameno, Keiko Iwata, Taro Takahashi, Shiro Suda, Hideo Matsuzaki, Yasuhide Iwata, Kenji Hashimoto, Norio Mor. Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats: reversal by fluoxetine. PloS one. vol 5. issue 2. 2010-09-30. PMID:20174647. |
destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats: reversal by fluoxetine. |
2010-09-30 |
2023-08-12 |
rat |
| Han Cheng, Lei Wang, Chih-chen Wan. Domain a' of protein disulfide isomerase plays key role in inhibiting alpha-synuclein fibril formation. Cell stress & chaperones. vol 15. issue 4. 2010-09-28. PMID:19960284. |
alpha-synuclein (alpha syn) is the main component of lewy bodies formed in midbrain dopaminergic neurons which is a pathological characteristic of parkinson's disease. |
2010-09-28 |
2023-08-12 |
Not clear |
| Jacob Bendor, José E Lizardi-Ortiz, Robert I Westphalen, Markus Brandstetter, Hugh C Hemmings, David Sulzer, Marc Flajolet, Paul Greengar. AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release. The EMBO journal. vol 29. issue 16. 2010-09-24. PMID:20664521. |
of the five mammalian muscarinic acetylcholine (ach) receptors, m(5) is the only subtype expressed in midbrain dopaminergic neurons, where it functions to potentiate dopamine release. |
2010-09-24 |
2023-08-12 |
Not clear |
| Sigrid C Schwarz, Johannes Schwar. Translation of stem cell therapy for neurological diseases. Translational research : the journal of laboratory and clinical medicine. vol 156. issue 3. 2010-09-23. PMID:20801412. |
the restoration of dopaminergic neurons in patients with parkinson's disease via implantation of embryonic midbrain tissue was taken from animal experiments to clinical applications, showing a limited efficacy. |
2010-09-23 |
2023-08-12 |
Not clear |
| Deranda B Lester, Tiffany D Rogers, Charles D Blah. Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS neuroscience & therapeutics. vol 16. issue 3. 2010-09-22. PMID:20370804. |
dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area of the midbrain form the nigrostriatal and mesocorticolimbic dopaminergic pathways that, respectively, project to dorsal and ventral striatum (including prefrontal cortex). |
2010-09-22 |
2023-08-12 |
Not clear |
| Deranda B Lester, Tiffany D Rogers, Charles D Blah. Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS neuroscience & therapeutics. vol 16. issue 3. 2010-09-22. PMID:20370804. |
these midbrain dopaminergic nuclei and their respective forebrain and cortical target areas are well established as serving a critical role in mediating voluntary motor control, as evidenced in parkinson's disease, and incentive-motivated behaviors and cognitive functions, as exhibited in drug addiction and schizophrenia, respectively. |
2010-09-22 |
2023-08-12 |
Not clear |
| Deranda B Lester, Tiffany D Rogers, Charles D Blah. Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS neuroscience & therapeutics. vol 16. issue 3. 2010-09-22. PMID:20370804. |
although it cannot be disputed that excitatory and inhibitory amino acid-based neurotransmitters, such as glutamate and gaba, play a vital role in modulating activity of midbrain dopaminergic neurons, recent evidence suggests that acetylcholine may be as important in regulating dopaminergic transmission. |
2010-09-22 |
2023-08-12 |
Not clear |