| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weidong Le, Deanne Nguyen, Xiyao Wendy Lin, Pawan Rawal, Maosheng Huang, Yujian Ding, Wenjie Xie, Hao Deng, Joseph Jankovi. Transcription factor PITX3 gene in Parkinson's disease. Neurobiology of aging. vol 32. issue 4. 2011-08-08. PMID:19394114. |
pitx3 is a transcription factor important for the differentiation and survival of midbrain dopaminergic neurons during the development. |
2011-08-08 |
2023-08-12 |
Not clear |
| Xi-Jin Wang, Shi Zhang, Zhi-Qiang Yan, Yan-Xin Zhao, Hai-Yan Zhou, Ying Wang, Guo-Qiang Lu, Jing-Dong Zhan. Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK. Free radical biology & medicine. vol 50. issue 9. 2011-08-08. PMID:21295135. |
impaired cd200-cd200r-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, nadph oxidase, and p38 mapk. |
2011-08-08 |
2023-08-12 |
rat |
| Marc Guitart-Masip, Lluis Fuentemilla, Dominik R Bach, Quentin J M Huys, Peter Dayan, Raymond J Dolan, Emrah Duze. Action dominates valence in anticipatory representations in the human striatum and dopaminergic midbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 21. 2011-08-04. PMID:21613500. |
action dominates valence in anticipatory representations in the human striatum and dopaminergic midbrain. |
2011-08-04 |
2023-08-12 |
human |
| Thomas Carlsson, Friederike R Schindler, Matthias Höllerhage, Candan Depboylu, Oscar Arias-Carrión, Stefan Schnurrbusch, Thomas W Rösler, Wojciech Wozny, Gerhard P Schwall, Karlfried Groebe, Wolfgang H Oertel, Patrik Brundin, André Schrattenholz, Günter U Höglinge. Systemic administration of neuregulin-1β1 protects dopaminergic neurons in a mouse model of Parkinson's disease. Journal of neurochemistry. vol 117. issue 6. 2011-08-03. PMID:21517849. |
the nrg1 receptor erbb4 is abundantly expressed on midbrain dopaminergic neurons. |
2011-08-03 |
2023-08-12 |
mouse |
| Thomas Carlsson, Friederike R Schindler, Matthias Höllerhage, Candan Depboylu, Oscar Arias-Carrión, Stefan Schnurrbusch, Thomas W Rösler, Wojciech Wozny, Gerhard P Schwall, Karlfried Groebe, Wolfgang H Oertel, Patrik Brundin, André Schrattenholz, Günter U Höglinge. Systemic administration of neuregulin-1β1 protects dopaminergic neurons in a mouse model of Parkinson's disease. Journal of neurochemistry. vol 117. issue 6. 2011-08-03. PMID:21517849. |
in conclusion, we have identified nrg1β(1)-ecd as a neurotrophic factor for adult mouse and human midbrain dopaminergic neurons with peripheral administratability, warranting further investigation as therapeutic option for parkinson's disease patients. |
2011-08-03 |
2023-08-12 |
mouse |
| Bianca C Wittmann, Raymond J Dolan, Emrah Düze. Behavioral specifications of reward-associated long-term memory enhancement in humans. Learning & memory (Cold Spring Harbor, N.Y.). vol 18. issue 5. 2011-08-02. PMID:21502336. |
recent functional imaging studies link reward-related activation of the midbrain substantia nigra-ventral tegmental area (sn/vta), the site of origin of ascending dopaminergic projections, with improved long-term episodic memory. |
2011-08-02 |
2023-08-12 |
Not clear |
| Yueguang Liu, Tianwen Huang, Xiaolin Zhao, Leping Chen. MicroRNAs modulate the Wnt signaling pathway through targeting its inhibitors. Biochemical and biophysical research communications. vol 408. issue 2. 2011-07-26. PMID:21501592. |
we and several other reports recently have demonstrated that wnt1-cre-mediated loss of dicer, the key enzyme for mirna biosynthesis, results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation. |
2011-07-26 |
2023-08-12 |
mouse |
| Sabina Anwar, Owen Peters, Steven Millership, Natalia Ninkina, Natalie Doig, Natalie Connor-Robson, Sarah Threlfell, Gurdeep Kooner, Robert M Deacon, David M Bannerman, J Paul Bolam, Sreeganga S Chandra, Stephanie J Cragg, Richard Wade-Martins, Vladimir L Buchma. Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 20. 2011-07-21. PMID:21593311. |
adult triple-synuclein-null (tko) mice displayed no overt phenotype and no change in the number of midbrain dopaminergic neurons. |
2011-07-21 |
2023-08-12 |
mouse |
| N Iu Ivliev. [Neurobiology of addictive behavior]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 61. issue 2. 2011-07-19. PMID:21675220. |
current neurophysiologic evidence suggests that the development of addiction is to some extent due to neurochemical stimulation of the midbrain dopaminergic system that is traditionally considered as a 'common neural currency' for rewards of most kinds. |
2011-07-19 |
2023-08-12 |
Not clear |
| Ana Sofia Correia, Sergey V Anisimov, Laurent Roybon, Jia-Yi Li, Patrik Brundi. Fibroblast growth factor-20 increases the yield of midbrain dopaminergic neurons derived from human embryonic stem cells. Frontiers in neuroanatomy. vol 1. 2011-07-14. PMID:18958198. |
fibroblast growth factor-20 increases the yield of midbrain dopaminergic neurons derived from human embryonic stem cells. |
2011-07-14 |
2023-08-12 |
mouse |
| Ana Sofia Correia, Sergey V Anisimov, Laurent Roybon, Jia-Yi Li, Patrik Brundi. Fibroblast growth factor-20 increases the yield of midbrain dopaminergic neurons derived from human embryonic stem cells. Frontiers in neuroanatomy. vol 1. 2011-07-14. PMID:18958198. |
in the central nervous system, fibroblast growth factor (fgf)-20 has been reported to act preferentially on midbrain dopaminergic neurons. |
2011-07-14 |
2023-08-12 |
mouse |
| Ana Sofia Correia, Sergey V Anisimov, Laurent Roybon, Jia-Yi Li, Patrik Brundi. Fibroblast growth factor-20 increases the yield of midbrain dopaminergic neurons derived from human embryonic stem cells. Frontiers in neuroanatomy. vol 1. 2011-07-14. PMID:18958198. |
the cultured cells also expressed other midbrain dopaminergic markers (pitx3, en1, msx1, and aldh1), suggesting that some had differentiated into midbrain dopaminergic neurons. |
2011-07-14 |
2023-08-12 |
mouse |
| Thomas F Münte, Marcus Heldmann, Hermann Hinrichs, Josep Marco-Pallares, Ulrike M Krämer, Volker Sturm, Hans-Jochen Heinz. Nucleus Accumbens is Involved in Human Action Monitoring: Evidence from Invasive Electrophysiological Recordings. Frontiers in human neuroscience. vol 1. 2011-07-14. PMID:18958225. |
action monitoring, that is, error detection and correction, is thought to be supported by a system involving the dopaminergic midbrain, the basal ganglia, and the medial prefrontal cortex. |
2011-07-14 |
2023-08-12 |
human |
| Thomas F Münte, Marcus Heldmann, Hermann Hinrichs, Josep Marco-Pallares, Ulrike M Krämer, Volker Sturm, Hans-Jochen Heinz. Nucleus Accumbens is Involved in Human Action Monitoring: Evidence from Invasive Electrophysiological Recordings. Frontiers in human neuroscience. vol 1. 2011-07-14. PMID:18958225. |
importantly, cross-correlation analysis showed that error-related activity in the nacc preceded surface activity by 40 ms. we propose that the nacc is involved in action monitoring, possibly by using error signals from the dopaminergic midbrain to adjust the relative impact of limbic and prefrontal inputs on frontal control systems in order to optimize goal-directed behavior. |
2011-07-14 |
2023-08-12 |
human |
| Ana Sofia Correia, Sergey V Anisimov, Jia-Yi Li, Patrik Brundi. Growth factors and feeder cells promote differentiation of human embryonic stem cells into dopaminergic neurons: a novel role for fibroblast growth factor-20. Frontiers in neuroscience. vol 2. issue 1. 2011-07-14. PMID:18982104. |
dopaminergic neurons can be derived from hescs and display a characteristic midbrain phenotype. |
2011-07-14 |
2023-08-12 |
mouse |
| Torsten Falk, Shiling Zhang, Scott J Sherma. Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson's disease. Molecular neurodegeneration. vol 4. 2011-07-14. PMID:20003314. |
(1) we challenged rat midbrain cultures with rotenone (20 nm), a pesticide that has been shown to be toxic for dopaminergic neurons and that has been a well-characterized model of pd. |
2011-07-14 |
2023-08-12 |
rat |
| Susanne Graef, Guido Biele, Lea K Krugel, Frank Marzinzik, Michael Wahl, Johann Wotka, Fabian Klostermann, Hauke R Heekere. Differential influence of levodopa on reward-based learning in Parkinson's disease. Frontiers in human neuroscience. vol 4. 2011-07-14. PMID:21048900. |
the mesocorticolimbic dopamine (da) system linking the dopaminergic midbrain to the prefrontal cortex and subcortical striatum has been shown to be sensitive to reinforcement in animals and humans. |
2011-07-14 |
2023-08-12 |
Not clear |
| Tomás González-Hernández, Ignacio Cruz-Muros, Domingo Afonso-Oramas, Josmar Salas-Hernandez, Javier Castro-Hernande. Vulnerability of mesostriatal dopaminergic neurons in Parkinson's disease. Frontiers in neuroanatomy. vol 4. 2011-07-14. PMID:21079748. |
the term vulnerability was first associated with the midbrain dopaminergic neurons 85 years ago, before they were identified as monoaminergic neurons, when foix and nicolesco (1925) reported the loss of neuromelanin containing neurons in the midbrain of patients with post-encephalitic parkinson's disease (pd). |
2011-07-14 |
2023-08-12 |
Not clear |
| Tomás González-Hernández, Ignacio Cruz-Muros, Domingo Afonso-Oramas, Josmar Salas-Hernandez, Javier Castro-Hernande. Vulnerability of mesostriatal dopaminergic neurons in Parkinson's disease. Frontiers in neuroanatomy. vol 4. 2011-07-14. PMID:21079748. |
a few years later, hassler (1938) showed that degeneration is more intense in the ventral tier of the substantia nigra compacta than in its dorsal tier and the ventral tegmental area (vta), outlining the concept of differential vulnerability of midbrain dopaminergic (da-) neurons. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jean-Luc Dreye. New insights into the roles of microRNAs in drug addiction and neuroplasticity. Genome medicine. vol 2. issue 12. 2011-07-14. PMID:21205279. |
recent studies have identified changes of several specific mirna expression profiles and polymorphisms affecting the interactions between mirnas and their targets in various brain disorders, including addiction: mir-16 causes adaptive changes in production of the serotonin transporter; mir-133b is specifically expressed in midbrain dopaminergic neurons, and regulates the production of tyrosine hydroxylase and the dopamine transporter; mir-212 affects production of striatal brain-derived neurotrophic factor and synaptic plasticity upon cocaine. |
2011-07-14 |
2023-08-12 |
Not clear |