| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuki Kurauchi, Akinori Hisatsune, Yoichiro Isohama, Tomohiro Sawa, Takaaki Akaike, Koichi Shudo, Hiroshi Katsuk. Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF. Journal of neurochemistry. vol 116. issue 3. 2011-02-17. PMID:20649843. |
these results suggest that, by recruiting cyclic gmp and pkg, neuronal nitric oxide synthase-derived nitric oxide plays a novel and essential role in rar signaling leading to erk-dependent bdnf up-regulation in midbrain dopaminergic neurons. |
2011-02-17 |
2023-08-12 |
rat |
| Carsten Nicolas Boehler, Nico Bunzeck, Ruth M Krebs, Toemme Noesselt, Mircea A Schoenfeld, Hans-Jochen Heinze, Thomas F Münte, Marty G Woldorff, Jens-Max Hop. Substantia nigra activity level predicts trial-to-trial adjustments in cognitive control. Journal of cognitive neuroscience. vol 23. issue 2. 2011-02-11. PMID:20465358. |
in particular, dopaminergic projections from the midbrain (i.e., from the substantia nigra [sn] and the ventral tegmental area) have been proposed to play a pivotal role in modulating the activity in these areas for cognitive control purposes. |
2011-02-11 |
2023-08-12 |
Not clear |
| Paul F Kramer, Christine H Christensen, Lisa A Hazelwood, Alice Dobi, Roland Bock, David R Sibley, Yolanda Mateo, Veronica A Alvare. Dopamine D2 receptor overexpression alters behavior and physiology in Drd2-EGFP mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 1. 2011-02-04. PMID:21209197. |
d2r overexpression was accompanied by behavioral hypersensitivity to d2r-like agonists, as well as enhanced electrophysiological responses to d2r activation in midbrain dopaminergic neurons. |
2011-02-04 |
2023-08-12 |
mouse |
| Nicola Simola, Annalisa Pinna, Sandro Fen. Pharmacological therapy of Parkinson's disease: current options and new avenues. Recent patents on CNS drug discovery. vol 5. issue 3. 2011-01-31. PMID:20726838. |
parkinson's disease is a neurodegenerative pathology which affects the dopaminergic neurons in the mesencephalon, leading to a progressive and relentless motor disability and to non-motor symptoms of different severity. |
2011-01-31 |
2023-08-12 |
Not clear |
| Collin J Lobb, Carlos A Paladin. Application of a NMDA receptor conductance in rat midbrain dopaminergic neurons using the dynamic clamp technique. Journal of visualized experiments : JoVE. issue 46. 2011-01-31. PMID:21206469. |
application of a nmda receptor conductance in rat midbrain dopaminergic neurons using the dynamic clamp technique. |
2011-01-31 |
2023-08-12 |
rat |
| Carol A Seger, Earl K Mille. Category learning in the brain. Annual review of neuroscience. vol 33. 2011-01-27. PMID:20572771. |
it is subserved by plasticity in many neural systems, including neocortical regions (sensory, prefrontal, parietal, and motor cortex), the medial temporal lobe, the basal ganglia, and midbrain dopaminergic systems. |
2011-01-27 |
2023-08-12 |
Not clear |
| Oliver Cooper, Gunnar Hargus, Michela Deleidi, Alexandra Blak, Teresia Osborn, Elizabeth Marlow, Kristen Lee, Adam Levy, Eduardo Perez-Torres, Alyssa Yow, Ole Isacso. Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Molecular and cellular neurosciences. vol 45. issue 3. 2011-01-21. PMID:20603216. |
differentiation of human es and parkinson's disease ips cells into ventral midbrain dopaminergic neurons requires a high activity form of shh, fgf8a and specific regionalization by retinoic acid. |
2011-01-21 |
2023-08-12 |
human |
| Oliver Cooper, Gunnar Hargus, Michela Deleidi, Alexandra Blak, Teresia Osborn, Elizabeth Marlow, Kristen Lee, Adam Levy, Eduardo Perez-Torres, Alyssa Yow, Ole Isacso. Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Molecular and cellular neurosciences. vol 45. issue 3. 2011-01-21. PMID:20603216. |
the cardinal motor symptoms of parkinson's disease (pd) are caused by the vulnerability to dysfunction and degeneration of ventral midbrain (vm) dopaminergic (da) neurons. |
2011-01-21 |
2023-08-12 |
human |
| R Rössler, E Boddeke, S Copra. Differentiation of non-mesencephalic neural stem cells towards dopaminergic neurons. Neuroscience. vol 170. issue 2. 2011-01-20. PMID:20643196. |
it is generally thought that in vitro differentiation of neural stem cells into meso-diencephalic dopaminergic neurons, requires recapitulation of dopaminergic differentiation pathway normally occurring in the ventral mesencephalon during embryogenesis. |
2011-01-20 |
2023-08-12 |
human |
| Enza Lonardo, Clare L Parish, Salvatore Ponticelli, Daniela Marasco, Diogo Ribeiro, Menotti Ruvo, Sandro De Falco, Ernest Arenas, Gabriella Minchiott. A small synthetic cripto blocking Peptide improves neural induction, dopaminergic differentiation, and functional integration of mouse embryonic stem cells in a rat model of Parkinson's disease. Stem cells (Dayton, Ohio). vol 28. issue 8. 2011-01-13. PMID:20641036. |
interestingly, genetic ablation of cripto results in increased neuralization and midbrain dopaminergic (da) differentiation of mescs, as well as improved da cell replacement therapy (crt) in a model of parkinson's disease (pd). |
2011-01-13 |
2023-08-12 |
mouse |
| Anna Y Kuznetsova, Marco A Huertas, Alexey S Kuznetsov, Carlos A Paladini, Carmen C Canavie. Regulation of firing frequency in a computational model of a midbrain dopaminergic neuron. Journal of computational neuroscience. vol 28. issue 3. 2011-01-11. PMID:20217204. |
dopaminergic (da) neurons of the mammalian midbrain exhibit unusually low firing frequencies in vitro. |
2011-01-11 |
2023-08-12 |
Not clear |
| Magdalena Misiak, Cordian Beyer, Susanne Arnol. Gender-specific role of mitochondria in the vulnerability of 6-hydroxydopamine-treated mesencephalic neurons. Biochimica et biophysica acta. vol 1797. issue 6-7. 2011-01-10. PMID:20416276. |
besides the known effects of 6-ohda on mitochondria and neuronal survivability, we aimed to demonstrate that the mitochondrial neurotoxin affects the morphology and survival of primary dopaminergic and non-dopaminergic neurons in the mesencephalon in a gender-specific manner by influencing the transcription of mitochondrial genes, atp and reactive oxygen species production. |
2011-01-10 |
2023-08-12 |
Not clear |
| Collin J Lobb, Charles J Wilson, Carlos A Paladin. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. Journal of neurophysiology. vol 104. issue 1. 2011-01-07. PMID:20445035. |
a dynamic role for gaba receptors on the firing pattern of midbrain dopaminergic neurons. |
2011-01-07 |
2023-08-12 |
human |
| Hitoshi Morikawa, Richard A Morriset. Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs. International review of neurobiology. vol 91. 2010-12-21. PMID:20813245. |
the dopaminergic system originating in the midbrain ventral tegmental area (vta) has been extensively studied over the past decades as a critical neural substrate involved in the development of alcoholism and addiction to other drugs of abuse. |
2010-12-21 |
2023-08-12 |
Not clear |
| Daniel P Eisenberg, Philip D Kohn, Erica B Baller, Joel A Bronstein, Joseph C Masdeu, Karen F Berma. Seasonal effects on human striatal presynaptic dopamine synthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 44. 2010-12-08. PMID:21048126. |
past studies in rodents have demonstrated circannual variation in central dopaminergic activity as well as a host of compelling interactions between melatonin--a scotoperiod-responsive neurohormone closely tied to seasonal adaptation--and dopamine in the striatum and in midbrain neuronal populations with striatal projections. |
2010-12-08 |
2023-08-12 |
human |
| Kathleen A Maguire-Zeiss, Howard J Federof. Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 8. 2010-11-30. PMID:20549523. |
when activated, microglia release pro-inflammatory diffusible mediators that promote dysfunction and contribute to the death of the pd vulnerable dopaminergic neurons in the midbrain. |
2010-11-30 |
2023-08-12 |
Not clear |
| Manisha Nautiyal, Andrew J Sweatt, James A MacKenzie, R Mark Payne, Sylvia Szucs, Reuben Matalon, Reidar Wallin, Susan M Hutso. Neuronal localization of the mitochondrial protein NIPSNAP1 in rat nervous system. The European journal of neuroscience. vol 32. issue 4. 2010-11-30. PMID:20646061. |
dopaminergic neurons in midbrain and noradrenergic neurons in the brainstem, which are affected in pku, also express nipsnap1. |
2010-11-30 |
2023-08-12 |
mouse |
| Kerstin Krauel, Hendrik C Feldhaus, Andrea Simon, Claudia Rehe, Martin Glaser, Hans-Henning Flechtner, Hans-Jochen Heinze, Ludwig Niehau. Increased echogenicity of the substantia nigra in children and adolescents with attention-deficit/hyperactivity disorder. Biological psychiatry. vol 68. issue 4. 2010-11-22. PMID:20227683. |
recent neurobiological models on attention-deficit/hyperactivity disorder (adhd) as well as findings from imaging studies suggest a crucial involvement of dopaminergic midbrain nuclei, especially the substantia nigra (sn), in the pathogenesis of adhd symptoms. |
2010-11-22 |
2023-08-12 |
Not clear |
| Michelle E Page, Li Bao, Pierrette Andre, Joshua Pelta-Heller, Emily Sluzas, Pedro Gonzalez-Alegre, Alexey Bogush, Loren E Khan, Lorraine Iacovitti, Margaret E Rice, Michelle E Ehrlic. Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice. Neurobiology of disease. vol 39. issue 3. 2010-11-16. PMID:20460154. |
we utilized the tyrosine hydroxylase (th) promoter to direct transgene expression specifically to dopaminergic neurons of the midbrain to identify cell-autonomous abnormalities. |
2010-11-16 |
2023-08-12 |
mouse |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
the goal of this study is to validate the use of (18)f-fecnt as a pet radiotracer to assess the degree of striatal dopamine terminals denervation and midbrain dopaminergic cell loss in mptp-treated parkinsonian monkeys. |
2010-11-12 |
2023-08-12 |
monkey |