| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinchuan Zhao, Xin Gao, Liangyou Zhao, Yiqing Wang, Jingbo Zhang, Shumin Li. Effects of Cannabidiol on Parkinson's Disease in a Transgenic Mouse Model by Gut-Brain Metabolic Analysis. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-04-01. PMID:35360659. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by a disorder of the dopaminergic system in the midbrain, causing classical pd motor symptoms. |
2022-04-01 |
2023-08-13 |
mouse |
| Yingchun Su, Yanting Liu, Dewei He, Guiqiu Hu, Hefei Wang, Bojian Ye, Yuan He, Xiyu Gao, Dianfeng Li. Hordenine inhibits neuroinflammation and exerts neuroprotective effects via inhibiting NF-κB and MAPK signaling pathways in vivo and in vitro. International immunopharmacology. vol 108. 2022-03-29. PMID:35349959. |
parkinson's disease (pd) is a usual disease caused by degeneration of the central nervous system, which features the denaturation and death of dopaminergic neurons in the substantia nigra compact (snc) of the midbrain. |
2022-03-29 |
2023-08-13 |
rat |
| Adrianne F Pike, Ildikò Szabò, Robert Veerhuis, Luigi Bubacc. The potential convergence of NLRP3 inflammasome, potassium, and dopamine mechanisms in Parkinson's disease. NPJ Parkinson's disease. vol 8. issue 1. 2022-03-25. PMID:35332154. |
potassium conductance also influences dopamine release from midbrain dopaminergic neurons. |
2022-03-25 |
2023-08-13 |
Not clear |
| Anjie Ni, Carl Erns. Evidence That Substantia Nigra Pars Compacta Dopaminergic Neurons Are Selectively Vulnerable to Oxidative Stress Because They Are Highly Metabolically Active. Frontiers in cellular neuroscience. vol 16. 2022-03-21. PMID:35308118. |
we further provide evidence to support the hypothesis that transcription factors (tfs) required to drive induction, differentiation, and maintenance of midbrain dopaminergic neural progenitor cells which give rise to terminally differentiated snpc neurons are uniquely involved in both developmental patterning and metabolism, a dual function unlike other tfs that program neurons in other brain regions. |
2022-03-21 |
2023-08-13 |
human |
| Federico Miozzo, Eva P Valencia-Alarcón, Luca Stickley, Michaëla Majcin Dorcikova, Francesco Petrelli, Damla Tas, Nicolas Loncle, Irina Nikonenko, Peter Bou Dib, Emi Nagosh. Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. Nature communications. vol 13. issue 1. 2022-03-18. PMID:35301315. |
maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor. |
2022-03-18 |
2023-08-13 |
mouse |
| Chen Yang, Yuzheng Hu, Aleksandr D Talishinsky, Christian T Potter, Coleman B Calva, Leslie A Ramsey, Andrew J Kesner, Reuben F Don, Sue Junn, Aaron Tan, Anne F Pierce, Céline Nicolas, Yosuke Arima, Seung-Chan Lee, Conghui Su, Jensine M Coudriet, Carlos A Mejia-Aponte, Dong V Wang, Hanbing Lu, Yihong Yang, Satoshi Ikemot. Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity. Nature communications. vol 13. issue 1. 2022-03-17. PMID:35296648. |
axonal terminal stimulation of mpfc neurons in downstream regions, including the anteromedial thalamic nucleus (am), reinforced behavior and activated midbrain dopaminergic neurons. |
2022-03-17 |
2023-08-13 |
mouse |
| Amritha Chakkittukandiyil, Deepak Vasudevan Sajini, Arjunan Karuppaiah, Divakar Selvara. The principal molecular mechanisms behind the activation of Keap1/Nrf2/ARE pathway leading to neuroprotective action in Parkinson's disease. Neurochemistry international. 2022-03-12. PMID:35278519. |
pd is associated with the loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain. |
2022-03-12 |
2023-08-13 |
human |
| Paulla Vieira Rodrigues, João Vitor Pereira de Godoy, Beatriz Pelegrini Bosque, Dionísio Pedro Amorim Neto, Katiane Tostes, Soledad Palameta, Sheila Garcia-Rosa, Celisa Caldana Costa Tonoli, Hernandes Faustino de Carvalho, Matheus de Castro Fonsec. Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent. Scientific reports. vol 12. issue 1. 2022-03-10. PMID:35264710. |
parkinson's disease (pd) is a neurodegenerative condition featured by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (αsyn) aggregates. |
2022-03-10 |
2023-08-13 |
Not clear |
| Walaa F Alsanie, Majid Alhomrani, Ahmed Gaber, Hamza Habeeballah, Heba A Alkhatabi, Raed I Felimban, Sherin Abdelrahman, Charlotte A E Hauser, Adeel G Chaudhary, Abdulhakeem S Alamri, Bassem M Raafat, Abdulwahab Alamri, Sirajudheen Anwar, Khaled A Alswat, Yusuf S Althobaiti, Yousif A Asir. The Effects of Prenatal Exposure to Pregabalin on the Development of Ventral Midbrain Dopaminergic Neurons. Cells. vol 11. issue 5. 2022-03-10. PMID:35269474. |
the effects of prenatal exposure to pregabalin on the development of ventral midbrain dopaminergic neurons. |
2022-03-10 |
2023-08-13 |
mouse |
| Walaa F Alsanie, Majid Alhomrani, Ahmed Gaber, Hamza Habeeballah, Heba A Alkhatabi, Raed I Felimban, Sherin Abdelrahman, Charlotte A E Hauser, Adeel G Chaudhary, Abdulhakeem S Alamri, Bassem M Raafat, Abdulwahab Alamri, Sirajudheen Anwar, Khaled A Alswat, Yusuf S Althobaiti, Yousif A Asir. The Effects of Prenatal Exposure to Pregabalin on the Development of Ventral Midbrain Dopaminergic Neurons. Cells. vol 11. issue 5. 2022-03-10. PMID:35269474. |
this study focused on ventral midbrain dopaminergic neurons, as they are responsible for cognition, movement, and behavior. |
2022-03-10 |
2023-08-13 |
mouse |
| Melissa L Caras, Max F K Happel, Bharath Chandrasekaran, Pablo Ripollés, Sarah M Keesom, Laura M Hurley, Luke Remage-Healey, Lori L Holt, Beverly A Wrigh. Non-sensory Influences on Auditory Learning and Plasticity. Journal of the Association for Research in Otolaryngology : JARO. 2022-03-02. PMID:35235100. |
we begin by presenting evidence that reward signals from the dopaminergic midbrain act on cortico-subcortical networks to shape sound-evoked responses of auditory cortical neurons, facilitate auditory category learning, and modulate the long-term storage of new words and their meanings. |
2022-03-02 |
2023-08-13 |
human |
| Ian M O'Shea, Haroon S Popal, Ingrid R Olson, Vishnu P Murty, David V Smit. Distinct alterations in cerebellar connectivity with substantia nigra and ventral tegmental area in Parkinson's disease. Scientific reports. vol 12. issue 1. 2022-03-01. PMID:35228561. |
in parkinson's disease (pd), neurodegeneration of dopaminergic neurons occurs in the midbrain, specifically targeting the substantia nigra (sn), while leaving the ventral tegmental area (vta) relatively spared in early phases of the disease. |
2022-03-01 |
2023-08-13 |
Not clear |
| Ramesh Pariyar, Tonking Bastola, Dae Ho Lee, Jungwon Se. Neuroprotective Effects of the DPP4 Inhibitor Vildagliptin in In Vivo and In Vitro Models of Parkinson's Disease. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216503. |
parkinson's disease (pd) is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta (snpc) of the midbrain. |
2022-02-26 |
2023-08-13 |
mouse |
| Haley M Geertsma, Terry R Suk, Konrad M Ricke, Kyra Horsthuis, Jean-Louis A Parmasad, Zoe A Fisk, Steve M Callaghan, Maxime W C Rousseau. Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation. Human molecular genetics. 2022-02-18. PMID:35179202. |
through histological analyses, we observed motor cortex atrophy in the absence of midbrain dopaminergic neurodegeneration. |
2022-02-18 |
2023-08-13 |
mouse |
| Erin McCarthy, Aaron Barron, Noelia Morales-Prieto, Martina Mazzocchi, Cathal M McCarthy, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells. Molecular neurobiology. 2022-02-17. PMID:35175558. |
parkinson's disease (pd) is neurodegenerative disorder with the pathological hallmarks of progressive degeneration of midbrain dopaminergic neurons from the substantia nigra (sn), and accumulation and spread of inclusions of aggregated α-synuclein (α-syn). |
2022-02-17 |
2023-08-13 |
human |
| Michele Salemi, Giuseppe Lanza, Maria Paola Mogavero, Filomena I I Cosentino, Eugenia Borgione, Roberta Iorio, Giovanna Maria Ventola, Giovanna Marchese, Maria Grazia Salluzzo, Maria Ravo, Raffaele Ferr. A Transcriptome Analysis of mRNAs and Long Non-Coding RNAs in Patients with Parkinson's Disease. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163455. |
clinical symptoms include the progressive loss of dopaminergic neurons in the substantia nigra of the midbrain, which leads to striatal dopamine deficiency and, subsequently, causes motor dysfunction. |
2022-02-15 |
2023-08-13 |
human |
| Lukas Seebauer, Yanni Schneider, Alice Drobny, Sonja Plötz, Tomas Koudelka, Andreas Tholey, Iryna Prots, Beate Winner, Friederike Zunke, Jürgen Winkler, Wei Xian. Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163733. |
in this study, we investigate the impact of asyn on microtubule organization in asyn overexpressing h4 neuroglioma cells and midbrain dopaminergic neuronal cells (mdans) generated from pd patient-derived human induced pluripotent stem cells (hipscs) carrying an asyn gene duplication ( |
2022-02-15 |
2023-08-13 |
human |
| Stephano J Chang, Ruth Mitchell, Juliette Hukin, Ash Singha. Treatment-responsive Holmes tremor in a child with low-pressure hydrocephalus: video case report and systematic review of the literature. Journal of neurosurgery. Pediatrics. 2022-02-11. PMID:35148507. |
mechanistically, the combined rest and action tremor is thought to require a double lesion of both the dopaminergic nigrostriatal system and the dentatorubrothalamic pathways, often near the midbrain where both pathways converge. |
2022-02-11 |
2023-08-13 |
Not clear |
| Qiang Miao, Zhi Chai, Li-Juan Song, Qing Wang, Guo-Bin Song, Jing Wang, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen M. The neuroprotective effects and transdifferentiation of astrocytes into dopaminergic neurons of Ginkgolide K on Parkinson' disease mice. Journal of neuroimmunology. vol 364. 2022-02-05. PMID:35121334. |
parkinson's disease (pd) is a chronic and progressive movement disorder caused by the selective loss of midbrain dopaminergic neurons of unknown etiology. |
2022-02-05 |
2023-08-13 |
mouse |
| Pik-Shan Lo, Vladimir V Rymar, Timothy E Kennedy, Abbas F Sadiko. The Netrin-1 Receptor DCC Promotes the Survival of a Subpopulation of Midbrain Dopaminergic Neurons: Relevance for Ageing and Parkinson's Disease. Journal of neurochemistry. 2022-02-04. PMID:35118677. |
the netrin-1 receptor dcc promotes the survival of a subpopulation of midbrain dopaminergic neurons: relevance for ageing and parkinson's disease. |
2022-02-04 |
2023-08-13 |
mouse |