| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mai K Nguyen, Kevin McAvoy, Szu-Chi Liao, Zak Doric, Iris Lo, Huihui Li, Giovanni Manfredi, Ken Nakamur. Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2. Human molecular genetics. 2021-11-18. PMID:34791217. |
mouse midbrain dopaminergic neurons survive loss of the pd-associated mitochondrial protein chchd2. |
2021-11-18 |
2023-08-13 |
mouse |
| Jing-Shan Lu, Qi-Yu Chen, Xiang Chen, Xu-Hui Li, Zhaoxiang Zhou, Qin Liu, Yuwan Lin, Miaomiao Zhou, Ping-Yi Xu, Min Zhu. Cellular and synaptic mechanisms for Parkinson's disease-related chronic pain. Molecular pain. vol 17. 2021-11-17. PMID:33784837. |
the degeneration of dopaminergic neuron acts as the essential mechanism of parkinson's disease in the midbrain dopaminergic pathway. |
2021-11-17 |
2023-08-13 |
Not clear |
| Ahsan Bin Tufail, Yong-Kui Ma, Qiu-Na Zhang, Adil Khan, Lei Zhao, Qiang Yang, Muhammad Adeel, Rahim Khan, Inam Ulla. 3D convolutional neural networks-based multiclass classification of Alzheimer's and Parkinson's diseases using PET and SPECT neuroimaging modalities. Brain informatics. vol 8. issue 1. 2021-11-17. PMID:34725741. |
another common subtype of dementia like ad, parkinson's disease (pd) is determined by the disappearance of dopaminergic neurons in the region known as substantia nigra pars compacta located in the midbrain. |
2021-11-17 |
2023-08-13 |
human |
| Ludi Zhang, Jing Wang, Chenxu Niu, Yu Zhang, Tiantian Zhu, Dongyang Huang, Jing Ma, Hui Sun, Nikita Gamper, Xiaona Du, Hailin Zhan. Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice. Cell reports. vol 37. issue 5. 2021-11-17. PMID:34731609. |
in parallel, we observe increased activity of the dopaminergic (da) neuron in the midbrain ventral tegmental area (vta), and inhibition of this elevated vta da neuron activity reverses the behavioral manifestations of depression. |
2021-11-17 |
2023-08-13 |
mouse |
| Xiaojun Diao, Fei Wang, Andrea Becerra-Calixto, Claudio Soto, Abhisek Mukherje. Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Familial Parkinson's Disease Patients Display α-Synuclein Pathology and Abnormal Mitochondrial Morphology. Cells. vol 10. issue 9. 2021-11-15. PMID:34572052. |
here, we generated midbrain dopaminergic (mda) neuronal cultures from induced pluripotent stem cells (ipscs) derived from familial pd (fpd) patients and healthy controls. |
2021-11-15 |
2023-08-13 |
mouse |
| Jie Dong, Xinyao Liu, Yuanyuan Wang, Huaibin Cai, Weidong L. Nurr1 Glia. vol 68. issue 10. 2021-11-11. PMID:32181533. |
nurr1 nuclear receptor-related 1 protein (nurr1) is essential for the development and maintenance of midbrain dopaminergic (daergic) neurons. |
2021-11-11 |
2023-08-13 |
Not clear |
| Claire E Stelly, Jonathan P Fado. Neurobiology: Novel peptide pathways impact threat discrimination. Current biology : CB. vol 31. issue 19. 2021-11-11. PMID:34637710. |
a new study finds that novel stress-related peptide pathways to the dopaminergic midbrain play a fundamental role in threat generalization. |
2021-11-11 |
2023-08-13 |
Not clear |
| Steve Seo, Rachel J Sizemore, Karen L Reader, Roseanna A Smither, Hollie E Wicky, Stephanie M Hughes, David K Bilkey, Louise C Parr-Brownlie, Dorothy E Oorscho. A schizophrenia risk factor induces marked anatomical deficits at GABAergic-dopaminergic synapses in the rat ventral tegmental area: Essential evidence for new targeted therapies. The Journal of comparative neurology. vol 529. issue 18. 2021-11-09. PMID:34338311. |
to develop new therapies for schizophrenia, evidence accumulated over decades highlights the essential need to investigate the gabaergic synapses that presynaptically influence midbrain dopaminergic neurons. |
2021-11-09 |
2023-08-13 |
rat |
| Steve Seo, Rachel J Sizemore, Karen L Reader, Roseanna A Smither, Hollie E Wicky, Stephanie M Hughes, David K Bilkey, Louise C Parr-Brownlie, Dorothy E Oorscho. A schizophrenia risk factor induces marked anatomical deficits at GABAergic-dopaminergic synapses in the rat ventral tegmental area: Essential evidence for new targeted therapies. The Journal of comparative neurology. vol 529. issue 18. 2021-11-09. PMID:34338311. |
using a novel combination of lentiviruses, peroxidase-immunogold double labeling, three-dimensional serial section transmission electron microscopy and stereology, we observed clear anatomical alterations in synaptic inputs on dopaminergic neurons in the midbrain posterior ventral tegmental area (pvta). |
2021-11-09 |
2023-08-13 |
rat |
| Steve Seo, Rachel J Sizemore, Karen L Reader, Roseanna A Smither, Hollie E Wicky, Stephanie M Hughes, David K Bilkey, Louise C Parr-Brownlie, Dorothy E Oorscho. A schizophrenia risk factor induces marked anatomical deficits at GABAergic-dopaminergic synapses in the rat ventral tegmental area: Essential evidence for new targeted therapies. The Journal of comparative neurology. vol 529. issue 18. 2021-11-09. PMID:34338311. |
the extensive anatomical deficits provide a potential basis for new therapies targeted at synaptic inputs on midbrain pvta dopaminergic neurons, in contrast to current striatum-targeted antipsychotic drugs. |
2021-11-09 |
2023-08-13 |
rat |
| Yutaka Itokazu, Takahiro Fuchigami, John C Morgan, Robert K Y. Intranasal infusion of GD3 and GM1 gangliosides downregulates alpha-synuclein and controls tyrosine hydroxylase gene in a PD model mouse. Molecular therapy : the journal of the American Society of Gene Therapy. vol 29. issue 10. 2021-11-03. PMID:34111562. |
parkinson's disease (pd) is characterized by lewy bodies (composed predominantly of alpha-synuclein [asyn]) and loss of pigmented midbrain dopaminergic neurons comprising the nigrostriatal pathway. |
2021-11-03 |
2023-08-13 |
mouse |
| Yutaka Itokazu, Takahiro Fuchigami, John C Morgan, Robert K Y. Intranasal infusion of GD3 and GM1 gangliosides downregulates alpha-synuclein and controls tyrosine hydroxylase gene in a PD model mouse. Molecular therapy : the journal of the American Society of Gene Therapy. vol 29. issue 10. 2021-11-03. PMID:34111562. |
gm1 also significantly enhances expression of tyrosine hydroxylase (th) in the substantia nigra pars compacta of the a53t asyn overexpressing mouse, following restored nuclear expression of nuclear receptor related 1 (nurr1, also known as nr4a2), an essential transcription factor for differentiation, maturation, and maintenance of midbrain dopaminergic neurons. |
2021-11-03 |
2023-08-13 |
mouse |
| Conor F Underwood, Louise C Parr-Brownli. Primary motor cortex in Parkinson's disease: Functional changes and opportunities for neurostimulation. Neurobiology of disease. vol 147. 2021-11-01. PMID:33152506. |
the neural representations of movement in m1 single-cell and field potential recordings are directly and indirectly influenced by the midbrain dopaminergic neurons that degenerate in pd. |
2021-11-01 |
2023-08-13 |
Not clear |
| K Ushna S Islam, Norisa Meli, Sandra Blaes. The Development of the Mesoprefrontal Dopaminergic System in Health and Disease. Frontiers in neural circuits. vol 15. 2021-10-30. PMID:34712123. |
midbrain dopaminergic neurons located in the substantia nigra and the ventral tegmental area are the main source of dopamine in the brain. |
2021-10-30 |
2023-08-13 |
Not clear |
| Xiansi Zeng, Wenshuo Geng, Jinjing Jia, Zhanqi Wan. Advances in Stem Cells Transplantation for the Therapy of Parkinson's Disease. Current stem cell research & therapy. vol 16. issue 8. 2021-10-29. PMID:33687901. |
the main pathological feature is the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. |
2021-10-29 |
2023-08-13 |
Not clear |
| Yu-Ling Hsu, Huey-Shan Hung, Chia-Wen Tsai, Shih-Ping Liu, Yu-Ting Chiang, Yun-Hua Kuo, Woei-Cherng Shyu, Shinn-Zong Lin, Ru-Huei F. Peiminine Reduces ARTS-Mediated Degradation of XIAP by Modulating the PINK1/Parkin Pathway to Ameliorate 6-Hydroxydopamine Toxicity and α-Synuclein Accumulation in Parkinson's Disease Models In Vivo and In Vitro. International journal of molecular sciences. vol 22. issue 19. 2021-10-28. PMID:34638579. |
the treatment strategies being developed are based on the typical pathologic features of pd, including the death of dopaminergic (da) neurons in the substantia nigra of the midbrain and the accumulation of α-synuclein in neurons. |
2021-10-28 |
2023-08-13 |
Not clear |
| Ruth Hanssen, Alina Chloé Kretschmer, Lionel Rigoux, Kerstin Albus, Sharmili Edwin Thanarajah, Tamara Sitnikow, Corina Melzer, Oliver A Cornely, Jens C Brüning, Marc Tittgemeye. GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans. Molecular metabolism. vol 45. 2021-10-25. PMID:33453418. |
incentive motivation refers to the processes that translate an expected reward into the effort spent to obtain the reward; the magnitude and probability of a reward involved in prompting motivated behaviour are encoded by the dopaminergic (da) midbrain and its mesoaccumbens da projections. |
2021-10-25 |
2023-08-13 |
Not clear |
| Mareike Fauser, Francisco Pan-Montojo, Christian Richter, Philipp J Kahle, Sigrid C Schwarz, Johannes Schwarz, Alexander Storch, Andreas Herman. Chronic-Progressive Dopaminergic Deficiency Does Not Induce Midbrain Neurogenesis. Cells. vol 10. issue 4. 2021-10-22. PMID:33807497. |
chronic-progressive dopaminergic deficiency does not induce midbrain neurogenesis. |
2021-10-22 |
2023-08-13 |
Not clear |
| Francesco Longo, Maria Mancini, Pierre L Ibraheem, Sameer Aryal, Caterina Mesini, Jyoti C Patel, Elena Penhos, Nazia Rahman, Maggie Mamcarz, Emanuela Santini, Margaret E Rice, Eric Klan. Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function. Molecular psychiatry. 2021-10-22. PMID:33879865. |
herein, using multiple genetic approaches we show that selective deletion of the perk in mouse midbrain dopaminergic (da) neurons results in multiple cognitive and motor phenotypes. |
2021-10-22 |
2023-08-13 |
mouse |
| Susan R Goulding, Jayanth Anantha, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson's disease. Neural regeneration research. vol 17. issue 1. 2021-10-22. PMID:34100424. |
the disease is characterized by the progressive loss of midbrain dopaminergic neurons from the substantia nigra, and their axons, which innervate the striatum, resulting in the characteristic motor and non-motor symptoms of parkinson's disease. |
2021-10-22 |
2023-08-13 |
rat |