| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chitrakshi Pant, Moumita Chakrabarti, Jolly Janette Mendonza, Bogonda Ganganna, Srihari Pabbaraja, Manika Pal Bhadr. ACS chemical neuroscience. vol 12. issue 23. 2021-12-01. PMID:34763419. |
parkinson's disease is a chronic and progressive neurodegenerative disease, induced by slow and progressive death of the dopaminergic (da) neurons from the midbrain region called substantia nigra (snc) leading to difficulty in locomotion. |
2021-12-01 |
2023-08-13 |
Not clear |
| A Raquel Esteves, Mário F Munoz-Pinto, Daniela Nunes-Costa, Emanuel Candeias, Diana F Silva, João D Magalhães, A Raquel Pereira-Santos, I Luisa Ferreira, Susana Alarico, Igor Tiago, Nuno Empadinhas, Sandra Morais Cardos. Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria. Gut. 2021-12-01. PMID:34836918. |
idiopathic parkinson's disease (pd) is characterised by alpha-synuclein (asyn) aggregation and death of dopaminergic neurons in the midbrain. |
2021-12-01 |
2023-08-13 |
Not clear |
| Le Wang, Xiaoli Gong, Yang Liu, Tianshu Du, Zhen Zhang, Ting Zhang, Xiaomin Wan. CD200 maintains the region-specific phenotype of microglia in the midbrain and its role in Parkinson's disease. Glia. vol 68. issue 9. 2021-11-30. PMID:32112601. |
we utilized a cd200-deficient mouse line to analyze the phenotypic role of cd200 in the regulation of normal neuron-microglia homeostasis in the midbrain and in the dopaminergic degeneration in an α-synuclein overexpression model of pd. |
2021-11-30 |
2023-08-13 |
mouse |
| Sumire Matsumoto, Tomomi Tsunemats. Association between Sleep, Alzheimer's, and Parkinson's Disease. Biology. vol 10. issue 11. 2021-11-30. PMID:34827122. |
parkinson's disease (pd) is a movement disorder typically resulting in rigidity and tremor, which is pathologically linked to the aggregation of α-synuclein, particularly in dopaminergic neurons in the midbrain. |
2021-11-30 |
2023-08-13 |
Not clear |
| Anna Maria Lavezz. Altered Development of Mesencephalic Dopaminergic Neurons in SIDS: New Insights into Understanding Sudden Infant Death Pathogenesis. Biomedicines. vol 9. issue 11. 2021-11-30. PMID:34829763. |
dopaminergic structures in midbrain sections of a large series of sudden infant deaths (36 sids and 26 controls) were identified using polyclonal rabbit antibodies against tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, and the dopamine transporter, a membrane protein specifically expressed in dopaminergic cells. |
2021-11-30 |
2023-08-13 |
human |
| Sjoerd R Murris, John T Arsenault, Wim Vanduffe. Frequency- and State-Dependent Network Effects of Electrical Stimulation Targeting the Ventral Tegmental Area in Macaques. Cerebral cortex (New York, N.Y. : 1991). vol 30. issue 8. 2021-11-29. PMID:32279076. |
the ventral tegmental area (vta) is a midbrain structure at the heart of the dopaminergic system underlying adaptive behavior. |
2021-11-29 |
2023-08-13 |
monkey |
| Kamil Pradel, Gniewosz Drwiȩga, Tomasz Błasia. Superior Colliculus Controls the Activity of the Rostromedial Tegmental Nuclei in an Asymmetrical Manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 18. 2021-11-29. PMID:33741724. |
dopaminergic (da) neurons of the midbrain are involved in controlling orienting and approach of animals toward relevant external stimuli. |
2021-11-29 |
2023-08-13 |
rat |
| Hsiu-Chuan Wu, Kuo-Hsuan Chang, Mu-Chun Chiang, Chiung-Mei Che. Alterations of Plasma Galectin-3 and C3 Levels in Patients with Parkinson's Disease. Brain sciences. vol 11. issue 11. 2021-11-29. PMID:34827514. |
parkinson's disease (pd) is characterized by progressive neurodegeneration of dopaminergic neurons in the ventral midbrain. |
2021-11-29 |
2023-08-13 |
Not clear |
| Soo Jin Park, Uram Jin, Sang Myun Par. Interaction between coxsackievirus B3 infection and α-synuclein in models of Parkinson's disease. PLoS pathogens. vol 17. issue 10. 2021-11-26. PMID:34695168. |
pd is pathologically characterized by the death of midbrain dopaminergic neurons and the accumulation of intracellular protein inclusions called lewy bodies or lewy neurites. |
2021-11-26 |
2023-08-13 |
mouse |
| Sheila M Fleming, Ashley Davis, Emily Simon. Targeting alpha-synuclein via the immune system in Parkinson's disease: Current vaccine therapies. Neuropharmacology. vol 202. 2021-11-26. PMID:34742741. |
parkinson's disease (pd) is the second most common neurodegenerative disorder and is defined pathologically by the abnormal accumulation of the presynaptic protein alpha-synuclein (asyn) in the form of lewy bodies and lewy neurites and loss of midbrain dopaminergic neurons in the substantia nigra pars compacta. |
2021-11-26 |
2023-08-13 |
Not clear |
| Olympia Colizoli, Jan Willem de Gee, Wietske van der Zwaag, Tobias H Donne. Functional magnetic resonance imaging responses during perceptual decision-making at 3 and 7 T in human cortex, striatum, and brainstem. Human brain mapping. 2021-11-25. PMID:34816533. |
we also found stronger responses during relatively easier than harder decisions at 7 t for dopaminergic midbrain nuclei, in line with reward expectation. |
2021-11-25 |
2023-08-13 |
human |
| Samaneh Mirzaei, Ketav Kulkarni, Kun Zhou, Peter J Crack, Marie-Isabel Aguilar, David I Finkelstein, John S Forsyth. Biomaterial Strategies for Restorative Therapies in Parkinson's Disease. ACS chemical neuroscience. vol 12. issue 22. 2021-11-23. PMID:34634903. |
parkinson's disease (pd) is a progressive neurological disorder, in which dopaminergic midbrain neurons degenerate, leading to dopamine depletion that is associated with neuronal death. |
2021-11-23 |
2023-08-13 |
Not clear |
| Alexander K Hurben, Luke N Erber, Natalia Y Tretyakova, Todd M Dora. Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS chemical biology. vol 16. issue 11. 2021-11-23. PMID:34726906. |
selective death of midbrain dopaminergic neurons is a hallmark pathology of parkinson's disease (pd), but the molecular mechanisms that initiate the cascade of events resulting in neurodegeneration in pd remain unclear. |
2021-11-23 |
2023-08-13 |
Not clear |
| Alexander K Hurben, Luke N Erber, Natalia Y Tretyakova, Todd M Dora. Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine. ACS chemical biology. vol 16. issue 11. 2021-11-23. PMID:34726906. |
therefore, characterizing dpas is a critical first step in understanding the susceptibility of midbrain dopaminergic neurons during pd. |
2021-11-23 |
2023-08-13 |
Not clear |
| Hareram Birla, Chetan Keswani, Saumitra Sen Singh, Walia Zahra, Hagera Dilnashin, Aaina Singh Rathore, Richa Singh, Monika Rajput, Priyanka Keshri, Surya Pratap Sing. Unraveling the Neuroprotective Effect of ACS chemical neuroscience. vol 12. issue 22. 2021-11-23. PMID:34747594. |
unraveling the neuroprotective effect of stress-induced dopaminergic (daergic) neuronal death in the midbrain region is the primary cause of parkinson's disease (pd). |
2021-11-23 |
2023-08-13 |
Not clear |
| Xuezhu Cai, Ian C Harding, Aymen H Sadaka, Bradley Colarusso, Praveen Kulkarni, Eno Ebong, Ju Qiao, Nick R O'Hare, Craig F Ferri. Mild repetitive head impacts alter perivascular flow in the midbrain dopaminergic system in awake rats. Brain communications. vol 3. issue 4. 2021-11-23. PMID:34806002. |
mild repetitive head impacts alter perivascular flow in the midbrain dopaminergic system in awake rats. |
2021-11-23 |
2023-08-13 |
rat |
| Xuezhu Cai, Ian C Harding, Aymen H Sadaka, Bradley Colarusso, Praveen Kulkarni, Eno Ebong, Ju Qiao, Nick R O'Hare, Craig F Ferri. Mild repetitive head impacts alter perivascular flow in the midbrain dopaminergic system in awake rats. Brain communications. vol 3. issue 4. 2021-11-23. PMID:34806002. |
we hypothesized that repetitive mild head impacts, without evidence of structural brain damage, would increase microgliosis and aqp4 expression and depolarization and alter perivascular flow in the midbrain dopaminergic system. |
2021-11-23 |
2023-08-13 |
rat |
| Xuezhu Cai, Ian C Harding, Aymen H Sadaka, Bradley Colarusso, Praveen Kulkarni, Eno Ebong, Ju Qiao, Nick R O'Hare, Craig F Ferri. Mild repetitive head impacts alter perivascular flow in the midbrain dopaminergic system in awake rats. Brain communications. vol 3. issue 4. 2021-11-23. PMID:34806002. |
the midbrain dopaminergic system showed a significant decrease in the influx of contrast agent as compared to sham controls together with a significant increase in microgliosis, aqp4 expression and depolarization. |
2021-11-23 |
2023-08-13 |
rat |
| Xuezhu Cai, Ian C Harding, Aymen H Sadaka, Bradley Colarusso, Praveen Kulkarni, Eno Ebong, Ju Qiao, Nick R O'Hare, Craig F Ferri. Mild repetitive head impacts alter perivascular flow in the midbrain dopaminergic system in awake rats. Brain communications. vol 3. issue 4. 2021-11-23. PMID:34806002. |
the histology showed a significant level of neuroinflammation in the midbrain dopaminergic system 3 weeks post mild repetitive head impact but no loss in tyrosine hydroxylase. |
2021-11-23 |
2023-08-13 |
rat |
| Mai K Nguyen, Kevin McAvoy, Szu-Chi Liao, Zak Doric, Iris Lo, Huihui Li, Giovanni Manfredi, Ken Nakamur. Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2. Human molecular genetics. 2021-11-18. PMID:34791217. |
mouse midbrain dopaminergic neurons survive loss of the pd-associated mitochondrial protein chchd2. |
2021-11-18 |
2023-08-13 |
mouse |