| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Makoto Inada, Manzo Taguchi, Kohzou Harimoto, Yoko Karasawa, Masaru Takeuchi, Masataka It. Protective effects of dexamethasone on hypoxia-induced retinal edema in a mouse model. Experimental eye research. vol 178. 2019-03-25. PMID:30267655. |
in the hypoxic retina, microglia was activated and relative gene expressions of pro-inflammatory cytokines were significantly upregulated. |
2019-03-25 |
2023-08-13 |
mouse |
| Eleftherios I Paschalis, Fengyang Lei, Chengxin Zhou, Vassiliki Kapoulea, Reza Dana, James Chodosh, Demetrios G Vavvas, Claes H Dohlma. Permanent neuroglial remodeling of the retina following infiltration of CSF1R inhibition-resistant peripheral monocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 48. 2019-03-21. PMID:30442669. |
here we show that such peripheral monocytes that infiltrate into the retina after ocular injury engraft permanently, migrate to the three distinct microglia strata, and adopt a microglia-like morphology. |
2019-03-21 |
2023-08-13 |
Not clear |
| Sandra Kuehn, Sabrina Reinehr, Gesa Stute, Cara Rodust, Pia Grotegut, Alexander-Tobias Hensel, H Burkhard Dick, Stephanie C Joachi. Interaction of complement system and microglia activation in retina and optic nerve in a NMDA damage model. Molecular and cellular neurosciences. vol 89. 2019-01-10. PMID:29738834. |
interaction of complement system and microglia activation in retina and optic nerve in a nmda damage model. |
2019-01-10 |
2023-08-13 |
rat |
| Sandra Kuehn, Sabrina Reinehr, Gesa Stute, Cara Rodust, Pia Grotegut, Alexander-Tobias Hensel, H Burkhard Dick, Stephanie C Joachi. Interaction of complement system and microglia activation in retina and optic nerve in a NMDA damage model. Molecular and cellular neurosciences. vol 89. 2019-01-10. PMID:29738834. |
it is known that intravitreally injected n-methyl-d-aspartate (nmda) leads to fast retina and optic nerve degeneration and can directly activate microglia. |
2019-01-10 |
2023-08-13 |
rat |
| Jia Lin Ren, Qiu Xiao Yu, Wei Cheng Liang, Pui Ying Leung, Tsz Kin Ng, Wai Kit Chu, Chi Pui Pang, Sun On Cha. Green tea extract attenuates LPS-induced retinal inflammation in rats. Scientific reports. vol 8. issue 1. 2018-11-20. PMID:29323215. |
staining of whole-mount retina showed that the number of activated microglia cells was significantly increased at 48 hours post-injection, which was suppressed after gte treatment in a dose-dependent manner. |
2018-11-20 |
2023-08-13 |
rat |
| Matthew M LaVail, Shimpei Nishikawa, Roy H Steinberg, Muna I Naash, Jacque L Duncan, Nikolaus Trautmann, Michael T Matthes, Douglas Yasumura, Cathy Lau-Villacorta, Jeannie Chen, Ward M Peterson, Haidong Yang, John G Flanner. Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration. Experimental eye research. vol 167. 2018-10-05. PMID:29122605. |
here we present a comprehensive study of the 8 tg lines, including the time course of pr degeneration from the onset to one year of age, retinal structure by light and electron microscopy (em), hemispheric asymmetry and gradients of rod and cone degeneration, rhodopsin content, gene dosage effect, rapid activation and invasion of the outer retina by presumptive microglia, rod outer segment disc shedding and phagocytosis by the retinal pigmented epithelium (rpe), and retinal function by the electroretinogram (erg). |
2018-10-05 |
2023-08-13 |
rat |
| Yoko Okunuki, Ryo Mukai, Elizabeth A Pearsall, Garrett Klokman, Deeba Husain, Dong-Ho Park, Ekaterina Korobkina, Howard L Weiner, Oleg Butovsky, Bruce R Ksander, Joan W Miller, Kip M Conno. Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 27. 2018-09-04. PMID:29915052. |
microglia are the resident immune cells of the central nervous system, including the retina, and function in the homeostatic maintenance of the neuro-retinal microenvironment. |
2018-09-04 |
2023-08-13 |
Not clear |
| Yoko Okunuki, Ryo Mukai, Elizabeth A Pearsall, Garrett Klokman, Deeba Husain, Dong-Ho Park, Ekaterina Korobkina, Howard L Weiner, Oleg Butovsky, Bruce R Ksander, Joan W Miller, Kip M Conno. Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 27. 2018-09-04. PMID:29915052. |
depletion of retinal microglia results in increased disease severity and inhibition of macrophage infiltration, suggesting that microglia are involved in regulating neuroinflammation in the retina. |
2018-09-04 |
2023-08-13 |
Not clear |
| Su-Hua Zhu, Bing-Qian Liu, Mao-Juan Hao, Yi-Xin Fan, Cheng Qian, Peng Teng, Xiao-Wei Zhou, Liang Hu, Wen-Tao Liu, Zhi-Lan Yuan, Qing-Ping L. Paeoniflorin Suppressed High Glucose-Induced Retinal Microglia MMP-9 Expression and Inflammatory Response via Inhibition of TLR4/NF-κB Pathway Through Upregulation of SOCS3 in Diabetic Retinopathy. Inflammation. vol 40. issue 5. 2018-08-15. PMID:28639050. |
evidence has accumulated indicating that microglia inflammation within the retina plays a critical role in dr. microglial matrix metalloproteinase 9 (mmp-9) has an important role in the destruction of the integrity of the blood-retinal barrier (brb) associated with the development of dr. mmp-9 was also considered important for regulating inflammatory responses. |
2018-08-15 |
2023-08-13 |
mouse |
| Christine Altmann, Mirko H H Schmid. The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration. International journal of molecular sciences. vol 19. issue 1. 2018-08-01. PMID:29301251. |
microglia, the resident monocytes of the retina, are activated due to a complex interplay between the different cell types of the retina and diverse pathological pathways. |
2018-08-01 |
2023-08-13 |
Not clear |
| Zijing Huang, Tian Zhou, Xiaowei Sun, Yingfeng Zheng, Bing Cheng, Mei Li, Xialin Liu, Chang H. Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation. Cell death and differentiation. vol 25. issue 1. 2018-07-16. PMID:28885615. |
microglia, the resident innate immune cells in retina, are implicated as principal components of the immunological insult to retinal neural cells. |
2018-07-16 |
2023-08-13 |
mouse |
| Raquel Boia, Filipe Elvas, Maria H Madeira, Inês D Aires, Ana C Rodrigues-Neves, Pedro Tralhão, Eszter C Szabó, Younis Baqi, Christa E Müller, Ângelo R Tomé, Rodrigo A Cunha, António F Ambrósio, Ana R Santiag. Treatment with A Cell death & disease. vol 8. issue 10. 2018-06-08. PMID:28981089. |
evidences indicate that microglia-mediated neuroinflammation has a key role in the neurodegenerative process, prompting the hypothesis that the control of microglia reactivity may afford neuroprotection to the retina against the damage induced by ischemia-reperfusion (i-r). |
2018-06-08 |
2023-08-13 |
Not clear |
| Agustina Noailles, Victoria Maneu, Laura Campello, Violeta Gómez-Vicente, Pedro Lax, Nicolás Cuenc. Persistent inflammatory state after photoreceptor loss in an animal model of retinal degeneration. Scientific reports. vol 6. 2018-06-04. PMID:27624537. |
microglia act as the resident immune cells of the central nervous system, including the retina. |
2018-06-04 |
2023-08-13 |
rat |
| Caroline E Walsh, Peter F Hitchcoc. Progranulin regulates neurogenesis in the developing vertebrate retina. Developmental neurobiology. vol 77. issue 9. 2018-04-30. PMID:28380680. |
at 24 hpf pgrn-a is expressed throughout the forebrain, but by 48 hpf pgrn-a is exclusively expressed by microglia and/or microglial precursors within the brain and retina. |
2018-04-30 |
2023-08-13 |
zebrafish |
| Xiao He, Dayu Sun, Siyu Chen, Haiwei X. Activation of liver X receptor delayed the retinal degeneration of rd1 mice through modulation of the immunological function of glia. Oncotarget. vol 8. issue 19. 2018-03-05. PMID:28404878. |
recently, immune cells, including microglia, müller cells and astrocytes, in degenerative retina are demonstrated to play key roles in the development of rd and can be used as potential therapeutic targets. |
2018-03-05 |
2023-08-13 |
mouse |
| Jorge L Cueva Vargas, Nicolas Belforte, Adriana Di Pol. The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling. Neurobiology of disease. vol 93. 2018-02-27. PMID:27163643. |
here, we demonstrate that intraocular administration of ibudilast dampened macroglia and microglia reactivity in the retina and optic nerve hence decreasing production of proinflammatory cytokines in a rat model of ocular hypertension. |
2018-02-27 |
2023-08-13 |
rat |
| Jung Woo Han, Juhye Choi, Young Shin Kim, Jina Kim, Ralf Brinkmann, Jungmook Lyu, Tae Kwann Par. Comparison of the neuroinflammatory responses to selective retina therapy and continuous-wave laser photocoagulation in mouse eyes. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. vol 256. issue 2. 2018-02-14. PMID:29322247. |
this study investigated microglia and inflammatory cell responses after selective retina therapy (srt) with microsecond-pulsed laser in comparison to continuous-wave laser photocoagulation (cwpc). |
2018-02-14 |
2023-08-13 |
mouse |
| Janani Singaravelu, Lian Zhao, Robert N Fariss, T Michael Nork, Wai T Won. Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28213784. |
microglia, the principal resident immune cell in the retina, play constitutive roles in immune surveillance and synapse maintenance, and are also associated with retinal disease, including those occurring in the macula. |
2018-01-30 |
2023-08-13 |
monkey |
| Janani Singaravelu, Lian Zhao, Robert N Fariss, T Michael Nork, Wai T Won. Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28213784. |
perspectives on retinal microglia function have derived largely from rodent models and how these relate to the macula-bearing primate retina is unclear. |
2018-01-30 |
2023-08-13 |
monkey |
| Janani Singaravelu, Lian Zhao, Robert N Fariss, T Michael Nork, Wai T Won. Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28213784. |
we found that microglia density peaked in the parafoveal retina and decreased in the peripheral retina. |
2018-01-30 |
2023-08-13 |
monkey |