| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yikui Zhang, Lian Zhao, Xu Wang, Wenxin Ma, Adam Lazere, Hao-Hua Qian, Jun Zhang, Mones Abu-Asab, Robert N Fariss, Jerome E Roger, Wai T Won. Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation. Science advances. vol 4. issue 3. 2019-09-05. PMID:29750189. |
using in vivo imaging and cell-fate mapping techniques, we discovered that repopulation originated from residual microglia proliferating in the central inner retina that subsequently spread by centrifugal migration to fully recapitulate pre-existing microglial distributions and morphologies. |
2019-09-05 |
2023-08-13 |
mouse |
| Emily G O'Koren, Chen Yu, Mikael Klingeborn, Alicia Y W Wong, Cameron L Prigge, Rose Mathew, Joan Kalnitsky, Rasha A Msallam, Aymeric Silvin, Jeremy N Kay, Catherine Bowes Rickman, Vadim Y Arshavsky, Florent Ginhoux, Miriam Merad, Daniel R Saba. Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration. Immunity. vol 50. issue 3. 2019-08-20. PMID:30850344. |
we combined lineage tracing, single-cell transcriptomics, and electrophysiology of the mouse retina and showed that adult retinal microglia shared a common developmental lineage and were long-lived but resided in two distinct niches. |
2019-08-20 |
2023-08-13 |
mouse |
| Jonathan B Lin, Rajendra S Apt. Visualizing the Heterogeneity of Retinal Microglia. Immunity. vol 50. issue 3. 2019-08-15. PMID:30893583. |
(2019) report that murine retinal microglia are long lived and are divided into two spatially and functionally distinct niches in the retina. |
2019-08-15 |
2023-08-13 |
Not clear |
| Lijuan Zhang, Xuan Cui, Ruben Jauregui, Karen Sophia Park, Sally Justus, Yi-Ting Tsai, Jimmy K Duong, Chun-Wei Hsu, Wen-Hsuan Wu, Christine L Xu, Chyuan-Sheng Lin, Stephen H Tsan. Genetic Rescue Reverses Microglial Activation in Preclinical Models of Retinitis Pigmentosa. Molecular therapy : the journal of the American Society of Gene Therapy. vol 26. issue 8. 2019-07-29. PMID:30001913. |
microglia cells (mgcs) play a key role in scavenging pathogens and phagocytosing cellular debris in the central nervous system and retina. |
2019-07-29 |
2023-08-13 |
mouse |
| Daniel R Saba. New concepts in macrophage ontogeny in the adult neural retina. Cellular immunology. vol 330. 2019-06-24. PMID:29703455. |
yet, little attention has been payed to the retina as compared to elsewhere in the central nervous system with respect to microglia, the macrophages of the neural parenchyma. |
2019-06-24 |
2023-08-13 |
human |
| Daniel R Saba. New concepts in macrophage ontogeny in the adult neural retina. Cellular immunology. vol 330. 2019-06-24. PMID:29703455. |
the current review covers topical concepts on adult microglia and perivascular macrophage ontogenies in the steady state retina, as well as parallels made with these macrophages in other areas of the central nervous system. |
2019-06-24 |
2023-08-13 |
human |
| Wenqin Xu, Zhicha Hu, Yang Lv, Guorui Dou, Zifeng Zhang, Haiyan Wang, Yusheng Wan. Microglial density determines the appearance of pathological neovascular tufts in oxygen-induced retinopathy. Cell and tissue research. vol 374. issue 1. 2019-06-17. PMID:29767277. |
therefore, these data suggest that the density of microglia in the retina may determine the result of vasculopathy in oir mice to some extent. |
2019-06-17 |
2023-08-13 |
mouse |
| Sean M Silverman, Wai T Won. Microglia in the Retina: Roles in Development, Maturity, and Disease. Annual review of vision science. vol 4. 2019-06-14. PMID:29852094. |
microglia in the retina: roles in development, maturity, and disease. |
2019-06-14 |
2023-08-13 |
Not clear |
| Sean M Silverman, Wai T Won. Microglia in the Retina: Roles in Development, Maturity, and Disease. Annual review of vision science. vol 4. 2019-06-14. PMID:29852094. |
microglia, the primary resident immune cell type, constitute a key population of glia in the retina. |
2019-06-14 |
2023-08-13 |
Not clear |
| Sean M Silverman, Wai T Won. Microglia in the Retina: Roles in Development, Maturity, and Disease. Annual review of vision science. vol 4. 2019-06-14. PMID:29852094. |
recent evidence indicates that microglia play significant functional roles in the retina at different life stages. |
2019-06-14 |
2023-08-13 |
Not clear |
| Sean M Silverman, Wai T Won. Microglia in the Retina: Roles in Development, Maturity, and Disease. Annual review of vision science. vol 4. 2019-06-14. PMID:29852094. |
during adulthood, ramified microglia in the plexiform layers interact closely with synapses to maintain synaptic structure and function that underlie the retina's electrophysiological response to light. |
2019-06-14 |
2023-08-13 |
Not clear |
| Hideto Koso, Ryuichi Nishinakamura, Sumiko Watanab. Sall1 Regulates Microglial Morphology Cell Autonomously in the Developing Retina. Advances in experimental medicine and biology. vol 1074. 2019-05-06. PMID:29721946. |
retinal degeneration often accompanies microglial activation and infiltration of monocyte-derived macrophages into the retina, resulting in the coexistence of microglia and monocyte-derived macrophages in the retina. |
2019-05-06 |
2023-08-13 |
mouse |
| Hideto Koso, Ryuichi Nishinakamura, Sumiko Watanab. Sall1 Regulates Microglial Morphology Cell Autonomously in the Developing Retina. Advances in experimental medicine and biology. vol 1074. 2019-05-06. PMID:29721946. |
we previously showed that the sall1 zinc-finger transcriptional factor is expressed specifically in microglia within the retinal phagocyte pool, and analyses of sall1 knockout mice revealed that microglial morphology changed from a ramified to a more amoeboid appearance in the developing retina. |
2019-05-06 |
2023-08-13 |
mouse |
| Hideto Koso, Ryuichi Nishinakamura, Sumiko Watanab. Sall1 Regulates Microglial Morphology Cell Autonomously in the Developing Retina. Advances in experimental medicine and biology. vol 1074. 2019-05-06. PMID:29721946. |
to investigate further whether sall1 functions autonomously in microglia, we generated sall1 conditional knockout mice, in which sall1 was depleted specifically in the cx3cr1+ microglial compartment of the developing retina. |
2019-05-06 |
2023-08-13 |
mouse |
| Hideto Koso, Ryuichi Nishinakamura, Sumiko Watanab. Sall1 Regulates Microglial Morphology Cell Autonomously in the Developing Retina. Advances in experimental medicine and biology. vol 1074. 2019-05-06. PMID:29721946. |
analysis of the postnatal retina revealed that sall1-deficient microglia extended their processes and their morphology became comparable to that of wild-type microglia on postnatal day 21, indicating that sall1 is essential for microglial ramification in the developing retina, but not in the postnatal retina. |
2019-05-06 |
2023-08-13 |
mouse |
| Mei Chen, Chang Luo, Jiawu Zhao, Gayathri Devarajan, Heping X. Immune regulation in the aging retina. Progress in retinal and eye research. vol 69. 2019-05-01. PMID:30352305. |
apart from the avoidance and tolerance strategies, the retina is also protected by its own defense system, i.e., microglia and the complement system. |
2019-05-01 |
2023-08-13 |
Not clear |
| Diana M Mitchell, Anna G Lovel, Deborah L Stenkam. Dynamic changes in microglial and macrophage characteristics during degeneration and regeneration of the zebrafish retina. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29804544. |
two types of glial cells, müller glia (mg) and microglia, are known to exist in the zebrafish retina. |
2019-04-08 |
2023-08-13 |
zebrafish |
| Wenxin Ma, Yikui Zhang, Chun Gao, Robert N Fariss, Johnny Tam, Wai T Won. Monocyte infiltration and proliferation reestablish myeloid cell homeostasis in the mouse retina following retinal pigment epithelial cell injury. Scientific reports. vol 7. issue 1. 2019-03-29. PMID:28814744. |
we found that myeloid cell responses to rpe injury occur in stages: (1) an early mobilization of endogenous microglia from the inner retina to the rpe layer, followed by (2) subsequent monocyte infiltration from the retinal vasculature into the inner retina that replenishes the local myeloid cell population in a ccr2-regulated manner. |
2019-03-29 |
2023-08-13 |
mouse |
| Kun-Che Chang, Biehuoy Shieh, J Mark Petras. Role of aldose reductase in diabetes-induced retinal microglia activation. Chemico-biological interactions. vol 302. 2019-03-29. PMID:30682331. |
retinal microglia (rmg), the resident immune cells in the retina, are thought to contribute to the proinflammatory phenotype in the diabetic eye. |
2019-03-29 |
2023-08-13 |
mouse |
| Akiko Takeda, Youichi Shinozaki, Kenji Kashiwagi, Nobuhiko Ohno, Kei Eto, Hiroaki Wake, Junichi Nabekura, Schuichi Koizum. Microglia mediate non-cell-autonomous cell death of retinal ganglion cells. Glia. vol 66. issue 11. 2019-03-26. PMID:30375063. |
recent accumulating evidence show that microglia greatly affect excitotoxicity in the brain, but their roles in retina have received only limited attention. |
2019-03-26 |
2023-08-13 |
Not clear |