| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zijing Huang, Tian Zhou, Xiaowei Sun, Yingfeng Zheng, Bing Cheng, Mei Li, Xialin Liu, Chang H. Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation. Cell death and differentiation. vol 25. issue 1. 2018-07-16. PMID:28885615. |
microglia, the resident innate immune cells in retina, are implicated as principal components of the immunological insult to retinal neural cells. |
2018-07-16 |
2023-08-13 |
mouse |
| Raquel Boia, Filipe Elvas, Maria H Madeira, Inês D Aires, Ana C Rodrigues-Neves, Pedro Tralhão, Eszter C Szabó, Younis Baqi, Christa E Müller, Ângelo R Tomé, Rodrigo A Cunha, António F Ambrósio, Ana R Santiag. Treatment with A Cell death & disease. vol 8. issue 10. 2018-06-08. PMID:28981089. |
evidences indicate that microglia-mediated neuroinflammation has a key role in the neurodegenerative process, prompting the hypothesis that the control of microglia reactivity may afford neuroprotection to the retina against the damage induced by ischemia-reperfusion (i-r). |
2018-06-08 |
2023-08-13 |
Not clear |
| Agustina Noailles, Victoria Maneu, Laura Campello, Violeta Gómez-Vicente, Pedro Lax, Nicolás Cuenc. Persistent inflammatory state after photoreceptor loss in an animal model of retinal degeneration. Scientific reports. vol 6. 2018-06-04. PMID:27624537. |
microglia act as the resident immune cells of the central nervous system, including the retina. |
2018-06-04 |
2023-08-13 |
rat |
| Caroline E Walsh, Peter F Hitchcoc. Progranulin regulates neurogenesis in the developing vertebrate retina. Developmental neurobiology. vol 77. issue 9. 2018-04-30. PMID:28380680. |
at 24 hpf pgrn-a is expressed throughout the forebrain, but by 48 hpf pgrn-a is exclusively expressed by microglia and/or microglial precursors within the brain and retina. |
2018-04-30 |
2023-08-13 |
zebrafish |
| Xiao He, Dayu Sun, Siyu Chen, Haiwei X. Activation of liver X receptor delayed the retinal degeneration of rd1 mice through modulation of the immunological function of glia. Oncotarget. vol 8. issue 19. 2018-03-05. PMID:28404878. |
recently, immune cells, including microglia, müller cells and astrocytes, in degenerative retina are demonstrated to play key roles in the development of rd and can be used as potential therapeutic targets. |
2018-03-05 |
2023-08-13 |
mouse |
| Jorge L Cueva Vargas, Nicolas Belforte, Adriana Di Pol. The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling. Neurobiology of disease. vol 93. 2018-02-27. PMID:27163643. |
here, we demonstrate that intraocular administration of ibudilast dampened macroglia and microglia reactivity in the retina and optic nerve hence decreasing production of proinflammatory cytokines in a rat model of ocular hypertension. |
2018-02-27 |
2023-08-13 |
rat |
| Jung Woo Han, Juhye Choi, Young Shin Kim, Jina Kim, Ralf Brinkmann, Jungmook Lyu, Tae Kwann Par. Comparison of the neuroinflammatory responses to selective retina therapy and continuous-wave laser photocoagulation in mouse eyes. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. vol 256. issue 2. 2018-02-14. PMID:29322247. |
this study investigated microglia and inflammatory cell responses after selective retina therapy (srt) with microsecond-pulsed laser in comparison to continuous-wave laser photocoagulation (cwpc). |
2018-02-14 |
2023-08-13 |
mouse |
| Janani Singaravelu, Lian Zhao, Robert N Fariss, T Michael Nork, Wai T Won. Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28213784. |
microglia, the principal resident immune cell in the retina, play constitutive roles in immune surveillance and synapse maintenance, and are also associated with retinal disease, including those occurring in the macula. |
2018-01-30 |
2023-08-13 |
monkey |
| Janani Singaravelu, Lian Zhao, Robert N Fariss, T Michael Nork, Wai T Won. Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28213784. |
perspectives on retinal microglia function have derived largely from rodent models and how these relate to the macula-bearing primate retina is unclear. |
2018-01-30 |
2023-08-13 |
monkey |
| Janani Singaravelu, Lian Zhao, Robert N Fariss, T Michael Nork, Wai T Won. Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28213784. |
we found that microglia density peaked in the parafoveal retina and decreased in the peripheral retina. |
2018-01-30 |
2023-08-13 |
monkey |
| Janani Singaravelu, Lian Zhao, Robert N Fariss, T Michael Nork, Wai T Won. Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging. Brain structure & function. vol 222. issue 6. 2018-01-30. PMID:28213784. |
comparing retinal microglia between young and middle-aged animals, microglial density increased in the macular, but not in the peripheral retina with age, while microglial morphology across all locations remained relatively unchanged. |
2018-01-30 |
2023-08-13 |
monkey |
| Yanhe Wang, Zhiyuan Yin, Lixiong Gao, Dayu Sun, Xisu Hu, Langyue Xue, Jiaman Dai, YuXiao Zeng, Siyu Chen, Boju Pan, Min Chen, Jing Xie, Haiwei X. Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 44. issue 2. 2018-01-18. PMID:29145208. |
curcumin delays retinal degeneration by regulating microglia activation in the retina of rd1 mice. |
2018-01-18 |
2023-08-13 |
mouse |
| Samantha J Dando, Cecilia Naranjo Golborne, Holly R Chinnery, Marc J Ruitenberg, Paul G McMenami. A case of mistaken identity: CD11c-eYFP(+) cells in the normal mouse brain parenchyma and neural retina display the phenotype of microglia, not dendritic cells. Glia. vol 64. issue 8. 2018-01-04. PMID:27189804. |
a case of mistaken identity: cd11c-eyfp(+) cells in the normal mouse brain parenchyma and neural retina display the phenotype of microglia, not dendritic cells. |
2018-01-04 |
2023-08-13 |
mouse |
| Hideto Koso, Asano Tsuhako, Chen-Yi Lai, Yukihiro Baba, Makoto Otsu, Kazuko Ueno, Masao Nagasaki, Yutaka Suzuki, Sumiko Watanab. Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina. Glia. vol 64. issue 11. 2018-01-04. PMID:27459098. |
bone marrow transplantation revealed the invasion of monocyte-derived macrophages into the retina, with microglia and the infiltrating macrophages showing distinct distribution patterns in the retina. |
2018-01-04 |
2023-08-13 |
mouse |
| Ana I Arroba, Ángela M Valverd. Modulation of microglia in the retina: new insights into diabetic retinopathy. Acta diabetologica. vol 54. issue 6. 2017-12-26. PMID:28349217. |
modulation of microglia in the retina: new insights into diabetic retinopathy. |
2017-12-26 |
2023-08-13 |
Not clear |
| Ana I Arroba, Lourdes Rodríguez-de la Rosa, Silvia Murillo-Cuesta, Laura Vaquero-Villanueva, Juan M Hurlé, Isabel Varela-Nieto, Ángela M Valverd. Autophagy resolves early retinal inflammation in Igf1-deficient mice. Disease models & mechanisms. vol 9. issue 9. 2017-12-04. PMID:27483352. |
microglia localization and status of activation in the retinas of 12-month-old igf1(+/+) and igf1(-/-) mice, analyzed by immunostaining of cd11b and iba-1, showed a specific distribution pattern in the outer plexiform layer (opl), inner plexiform layer (ipl) and inner nuclear layer (inl), and revealed an increased number of activated microglia cells in the retina of 12-month-old blind igf1(-/-) mice. |
2017-12-04 |
2023-08-13 |
mouse |
| Yen-Zhen Lu, Riccardo Natoli, Michele Madigan, Nilisha Fernando, Kartik Saxena, Riemke Aggio-Bruce, Haihan Jiao, Jan Provis, Krisztina Valte. Photobiomodulation with 670 nm light ameliorates Müller cell-mediated activation of microglia and macrophages in retinal degeneration. Experimental eye research. vol 165. 2017-12-01. PMID:28888911. |
müller cells, the supporting cells of the retina, play a key role in responding to retinal stress by releasing chemokines, including ccl2, to recruit microglia and macrophages (mg/mΦ) into the damaged retina. |
2017-12-01 |
2023-08-13 |
rat |
| Tine Van Bergen, Tjing-Tjing Hu, Isabelle Etienne, Geert E Reyns, Lieve Moons, Jean H M Feye. Neutralization of placental growth factor as a novel treatment option in diabetic retinopathy. Experimental eye research. vol 165. 2017-12-01. PMID:28965804. |
similar results were observed in the mouse stz model on the number of microglia and macrophages in the retina. |
2017-12-01 |
2023-08-13 |
mouse |
| Ping Hu, Nicholas H Hunt, Frank Arfuso, Lynn C Shaw, Mohammad Nasir Uddin, Meidong Zhu, Raj Devasahayam, Samuel J Adamson, Vicky L Benson, Tailoi Chan-Ling, Maria B Gran. Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina. Investigative ophthalmology & visual science. vol 58. issue 12. 2017-10-18. PMID:28980000. |
increased indoleamine 2,3-dioxygenase and quinolinic acid expression in microglia and müller cells of diabetic human and rodent retina. |
2017-10-18 |
2023-08-13 |
human |
| María Martín-Estebané, Julio Navascués, Ana Sierra-Martín, Sandra M Martín-Guerrero, Miguel A Cuadros, María-Carmen Carrasco, José L Marín-Tev. Onset of microglial entry into developing quail retina coincides with increased expression of active caspase-3 and is mediated by extracellular ATP and UDP. PloS one. vol 12. issue 8. 2017-10-10. PMID:28763502. |
microglial cell precursors located in the area of the base of the pecten and the optic nerve head (bp/onh) start to enter the retina of quail embryos at the 7th day of incubation (e7), subsequently colonizing the entire retina by central-to-peripheral tangential migration, as previously shown by our group. |
2017-10-10 |
2023-08-13 |
Not clear |