| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julia C Knight, Eugene L Scharf, Yang Mao-Draaye. Fas activation increases neural progenitor cell survival. Journal of neuroscience research. vol 88. issue 4. 2010-03-25. PMID:19830835. |
although there is a sizable amount of research focusing on adult neural progenitor cells (npcs) as a therapeutic approach for many neurodegenerative diseases, including multiple sclerosis, little is known about the pathways that govern npc survival and apoptosis. |
2010-03-25 |
2023-08-12 |
Not clear |
| Xuri Li, Chunsik Lee, Zhongshu Tang, Fan Zhang, Pachiappan Arjunan, Yang Li, Xu Hou, Anil Kumar, Lijin Don. VEGF-B: a survival, or an angiogenic factor? Cell adhesion & migration. vol 3. issue 4. 2010-03-05. PMID:19684473. |
(3) using different types of neuro-injury and neurodegenerative disease models, vegf-b treatment protected endangered neurons from apoptosis without inducing undesired blood vessel growth or permeability. |
2010-03-05 |
2023-08-12 |
Not clear |
| Mei-Jie Jou, Tsung-I Peng, Lee-Fen Hsu, Shuo-Bin Jou, Russel J Reiter, Chuen-Mao Yang, Chuan-Chin Chiao, Yi-Fan Lin, Chun-Chia Che. Visualization of melatonin's multiple mitochondrial levels of protection against mitochondrial Ca(2+)-mediated permeability transition and beyond in rat brain astrocytes. Journal of pineal research. vol 48. issue 1. 2010-03-04. PMID:19925580. |
as astrocytes are actively involve in regulating synaptic transmission and neurovascular coupling in the cns, these multiple mitochondrial layers of protection provided by melatonin against mca(2+)-and/or mros-mediated apoptosis in astrocytes may be crucial for future therapeutic prevention and treatment of astrocyte-mediated neurodegenerative diseases in the cns. |
2010-03-04 |
2023-08-12 |
rat |
| Emily K Schroeder, Natalie A Kelsey, Jeanne Doyle, Elise Breed, Ron J Bouchard, F Alexandra Loucks, R Alex Harbison, Daniel A Linsema. Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons. Antioxidants & redox signaling. vol 11. issue 3. 2010-03-01. PMID:18754708. |
these properties of egcg make it an interesting therapeutic candidate for neurodegenerative diseases involving neuronal apoptosis triggered by mitochondrial oxidative stress. |
2010-03-01 |
2023-08-12 |
rat |
| Lilia Alberghina, Anna Maria Colangel. The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration. BMC neuroscience. vol 7 Suppl 1. 2010-02-25. PMID:17118156. |
apoptosis is a programmed cell death that plays a critical role during the development of the nervous system and in many chronic neurodegenerative diseases, including alzheimer's disease (ad). |
2010-02-25 |
2023-08-12 |
Not clear |
| Jon Zárate, Encarnación Goicoechea, Jesús Pascual, Enrique Echevarría, Mariá D Guillé. A study of the toxic effect of oxidized sunflower oil containing 4-hydroperoxy-2-nonenal and 4-hydroxy-2-nonenal on cortical TrkA receptor expression in rats. Nutritional neuroscience. vol 12. issue 6. 2010-02-24. PMID:19925718. |
these results indicate that toxic substances present in the oxidized sunflower oil, among them 4-hydroxy-trans-2-nonenal (hne) and 4-hydroperoxy-trans-2-nonenal (hpne), could disrupt survival signalling of frontal cortex cholinergic neurons, which could lead to apoptosis and neurodegenerative diseases. |
2010-02-24 |
2023-08-12 |
rat |
| Julie Bournival, Patrik Quessy, Maria-Grazia Martinol. Protective effects of resveratrol and quercetin against MPP+ -induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons. Cellular and molecular neurobiology. vol 29. issue 8. 2010-02-17. PMID:19466539. |
these findings support the role of these natural polyphenols in preventive and/or complementary therapies for several human neurodegenerative diseases caused by oxidative stress and apoptosis. |
2010-02-17 |
2023-08-12 |
human |
| Carolina E Abrahan, Gisela E Miranda, Daniela L Agnolazza, Luis E Politi, Nora P Rotstei. Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors. Investigative ophthalmology & visual science. vol 51. issue 2. 2010-02-17. PMID:19797232. |
oxidative stress is involved in inducing apoptosis of photoreceptors in many retinal neurodegenerative diseases. |
2010-02-17 |
2023-08-12 |
Not clear |
| Tetsumori Yamashima, Shinji Oikaw. The role of lysosomal rupture in neuronal death. Progress in neurobiology. vol 89. issue 4. 2010-02-12. PMID:19772886. |
however, apoptosis is only part of the story, and inhibition of neuronal necrosis may have greater impact than apoptosis, on the treatment of stroke, traumatic brain injury, and neurodegenerative diseases. |
2010-02-12 |
2023-08-12 |
human |
| Chang-jiang Huang, Tatyana Gurlo, Leena Haataja, Safia Costes, Marie Daval, Sergey Ryazantsev, Xiuji Wu, Alexandra E Butler, Peter C Butle. Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes. The Journal of biological chemistry. vol 285. issue 1. 2010-01-26. PMID:19861418. |
the islet in type 2 diabetes (t2dm) and the brain in neurodegenerative diseases share progressive cell dysfunction, increased apoptosis, and accumulation of locally expressed amyloidogenic proteins (islet amyloid polypeptide (iapp) in t2dm). |
2010-01-26 |
2023-08-12 |
human |
| b' Zeljko Ferenci\\xc4\\x8. [Apoptosis in toxicologic pathology]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti. vol 63 Suppl 2. 2010-01-26. PMID:19999544.' |
also, the disbalance in apoptosis processes is documented in viral, autoimmune and neurodegenerative diseases, as well as in tumors. |
2010-01-26 |
2023-08-12 |
human |
| Johnson Agniswamy, Bin Fang, Irene T Webe. Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7. Apoptosis : an international journal on programmed cell death. vol 14. issue 10. 2010-01-19. PMID:19655253. |
caspase-mediated apoptosis has important roles in normal cell differentiation and aging and in many diseases including cancer, neuromuscular disorders and neurodegenerative diseases. |
2010-01-19 |
2023-08-12 |
Not clear |
| Chun-Yi Liu, Cheng-Feng Lee, Yau-Huei We. Role of reactive oxygen species-elicited apoptosis in the pathophysiology of mitochondrial and neurodegenerative diseases associated with mitochondrial DNA mutations. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 108. issue 8. 2009-12-09. PMID:19666347. |
role of reactive oxygen species-elicited apoptosis in the pathophysiology of mitochondrial and neurodegenerative diseases associated with mitochondrial dna mutations. |
2009-12-09 |
2023-08-12 |
human |
| Chun-Yi Liu, Cheng-Feng Lee, Yau-Huei We. Role of reactive oxygen species-elicited apoptosis in the pathophysiology of mitochondrial and neurodegenerative diseases associated with mitochondrial DNA mutations. Journal of the Formosan Medical Association = Taiwan yi zhi. vol 108. issue 8. 2009-12-09. PMID:19666347. |
in this review, we focus on the involvement of mtdna-mutation-associated oxidative stress and susceptibility to apoptosis in the pathophysiology of mitochondrial and neurodegenerative diseases. |
2009-12-09 |
2023-08-12 |
human |
| Juliette Gafni, Xin Cong, Sylvia F Chen, Bradford W Gibson, Lisa M Ellerb. Calpain-1 cleaves and activates caspase-7. The Journal of biological chemistry. vol 284. issue 37. 2009-11-02. PMID:19617626. |
caspase-7 is an executioner caspase that plays a key role in apoptosis, cancer, and a number of neurodegenerative diseases. |
2009-11-02 |
2023-08-12 |
Not clear |
| Christopher L Daugherty, Hilda Curtis, Tony Realini, Judie F Charlton, Sepideh Zarepars. Primary open angle glaucoma in a Caucasian population is associated with the p53 codon 72 polymorphism. Molecular vision. vol 15. 2009-10-28. PMID:19784392. |
apoptosis has been implicated as the mechanism for retinal ganglion cell death in primary open-angle glaucoma (poag), a complex neurodegenerative disease. |
2009-10-28 |
2023-08-12 |
Not clear |
| Wei Liu, Xing-Wang Zhou, Shaojun Liu, Kunhua Hu, Chong Wang, Qingyu He, Mingtao L. Calpain-truncated CRMP-3 and -4 contribute to potassium deprivation-induced apoptosis of cerebellar granule neurons. Proteomics. vol 9. issue 14. 2009-10-07. PMID:19639589. |
study of calpain-mediated cleavage events and related functions may contribute to a better understanding of neuronal apoptosis and neurodegenerative diseases. |
2009-10-07 |
2023-08-12 |
Not clear |
| M Yeste-Velasco, J Folch, G Casadesús, M A Smith, M Pallàs, A Camin. Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry. Neuroscience. vol 159. issue 3. 2009-09-21. PMID:19356694. |
increasing evidence implicates the c-jun nh(2)-terminal kinase (jnk) pathway in the regulation of apoptosis in neurodegenerative diseases. |
2009-09-21 |
2023-08-12 |
rat |
| Ivana Sirangelo, Clara Iannuzzi, Silvia Vilasi, Gaetano Irace, Gaia Giuberti, Gabriella Misso, Annamaria D'Alessandro, Alberto Abbruzzese, Michele Caragli. W7FW14F apomyoglobin amyloid aggregates-mediated apoptosis is due to oxidative stress and AKT inactivation caused by Ras and Rac. Journal of cellular physiology. vol 221. issue 2. 2009-09-09. PMID:19585524. |
our results indicate a role for ras and rac in the induction of both intracellular ros increased levels and apoptosis mediated by pfas and disclose a new scenario of intervention in neurodegenerative diseases. |
2009-09-09 |
2023-08-12 |
human |
| Kengo Homma, Kazumi Katagiri, Hideki Nishitoh, Hidenori Ichij. Targeting ASK1 in ER stress-related neurodegenerative diseases. Expert opinion on therapeutic targets. vol 13. issue 6. 2009-08-05. PMID:19456270. |
in this review, we summarize the molecular mechanisms of the upr and er stress-induced apoptosis and the possible roles of ask1 activation in neurodegenerative diseases. |
2009-08-05 |
2023-08-12 |
Not clear |